Andreas I Constantinou
Affiliation: University of Cyprus
- The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumoursAndreas I Constantinou
Department of Surgical Oncology, University of Illinois at Chicago, 840 South Wood Street, Chicago, IL 60612, USA
Eur J Cancer 41:647-54. 2005....
- Equol enhances tamoxifen's anti-tumor activity by induction of caspase-mediated apoptosis in MCF-7 breast cancer cellsChristiana Charalambous
Department of Biological Sciences, University of Cyprus, 75 Kallipoleos Str, PO Box 20537, Lefkosia 1678, Cyprus
BMC Cancer 13:238. 2013....
- The effect of the phytoestrogens genistein, daidzein, and equol on the growth of tamoxifen-resistant T47D/PKC alphaDebra A Tonetti
Department of Biopharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
Nutr Cancer 58:222-9. 2007..Interestingly, coadministration of TAM with either daidzein or genistein produced tumors of greater size than with TAM alone. These findings suggest that simultaneous consumption of isoflavone supplements with TAM may not be safe...
- Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principlesJoanna E Burdette
Department of Medicinal Chemistry and Pharmacognosy and UIC NIH Center for Botanical and Dietary Supplements Research, College of Pharmacy, 833 South Wood Street, University of Illinois at Chicago, Chicago, Illinois 60612, USA
J Agric Food Chem 50:7022-8. 2002..These data suggest that black cohosh can protect against cellular DNA damage caused by reactive oxygen species by acting as antioxidants...
- Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancerVasu Punj
Department of Surgical Oncology, University of Illinois at Chicago, 840 South Wood Street, M C 820, Chicago, IL 60612, USA
Oncogene 23:2367-78. 2004....
- Identification of the factors responsible for the in vitro pro-oxidant and cytotoxic activities of the olive polyphenols oleuropein and hydroxytyrosolElena M Odiatou
Department of Biological Sciences, University of Cyprus, Kalllipoleos Avenue, 1678 Nicosia, Cyprus
Cancer Lett 330:113-21. 2013..Our findings raise considerable questions regarding the use of culture media with sodium bicarbonate or sodium pyruvate as components, for the in vitro study of these and possibly other plant polyphenols...
- Efficacy of garbanzo and soybean flour in suppression of aberrant crypt foci in the colons of CF-1 miceGenoveva Murillo
Department of Surgical Oncology, College of Medicine, University of Illinois at Chicago, IL 60612, USA
Anticancer Res 24:3049-55. 2004..In the present study, the azoxymethane (AOM)-induced aberrant crypt foci (ACF) in CF-1 mice was utilized as a model to assess and compare the effects of garbanzo flour to that of soy flour...
- Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistanceChara A Pitta
University of Cyprus, Department of Biological Sciences, Lefkosia, Cyprus
Cancer Lett 337:167-76. 2013..This novel finding reveals that ER-β is fundamental in overcoming acquired tamoxifen resistance and provides insights for new therapeutic protocols against breast cancer. ..
- Targeting colon cancer cells with genistein-17.1A immunoconjugateMichelle S Gentile
Department of Surgical Oncology, College of Medcine, University of Illinois at Chicago, Chicago, IL 60612, USA
Int J Oncol 22:955-9. 2003..Gen-17.1A significantly inhibited colon cancer cell growth in vitro and in vivo. Our findings suggest that conjugating genistein to 17.1A monoclonal antibody enhances its effects against colon cancer cells...
- Phenoxodiol (2H-1-benzopyran-7-0,1,3-(4-hydroxyphenyl)), a novel isoflavone derivative, inhibits DNA topoisomerase II by stabilizing the cleavable complexAndreas I Constantinou
Department of Surgical Oncology, College of Medicine, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Anticancer Res 22:2581-5. 2002..These results demonstrate that phenoxodiol is a topo II-specific poison and suggest that this novel agent may find applications in cancer chemotherapy...
- Induction of discrete apoptotic pathways by bromo-substituted indirubin derivatives in invasive breast cancer cellsKaterina A Nicolaou
Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus
Biochem Biophys Res Commun 425:76-82. 2012..In conclusion, this study provides important insights regarding the molecular pathways leading to cell cycle arrest and apoptosis by two indirubin derivatives that can find clinical applications in targeted cancer therapeutics...
- Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley ratsJoanna E Burdette
Department of Medicinal Chemistry and Pharmacognosy and UIC National Institutes of Health Center for Botanical and Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
J Nutr 132:27-30. 2002..Neither antiestrogenic nor additive estrogenic properties were observed in any of the tissues studied. These data suggest that red clover extract is weakly estrogenic in the ovariectomized rat model...