Andreas I Constantinou

Summary

Affiliation: University of Cyprus
Country: Cyprus

Publications

  1. ncbi request reprint The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumours
    Andreas I Constantinou
    Department of Surgical Oncology, University of Illinois at Chicago, 840 South Wood Street, Chicago, IL 60612, USA
    Eur J Cancer 41:647-54. 2005
  2. pmc Equol enhances tamoxifen's anti-tumor activity by induction of caspase-mediated apoptosis in MCF-7 breast cancer cells
    Christiana Charalambous
    Department of Biological Sciences, University of Cyprus, 75 Kallipoleos Str, PO Box 20537, Lefkosia 1678, Cyprus
    BMC Cancer 13:238. 2013
  3. ncbi request reprint The effect of the phytoestrogens genistein, daidzein, and equol on the growth of tamoxifen-resistant T47D/PKC alpha
    Debra A Tonetti
    Department of Biopharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Nutr Cancer 58:222-9. 2007
  4. ncbi request reprint Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles
    Joanna E Burdette
    Department of Medicinal Chemistry and Pharmacognosy and UIC NIH Center for Botanical and Dietary Supplements Research, College of Pharmacy, 833 South Wood Street, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Agric Food Chem 50:7022-8. 2002
  5. ncbi request reprint Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer
    Vasu Punj
    Department of Surgical Oncology, University of Illinois at Chicago, 840 South Wood Street, M C 820, Chicago, IL 60612, USA
    Oncogene 23:2367-78. 2004
  6. doi request reprint Identification of the factors responsible for the in vitro pro-oxidant and cytotoxic activities of the olive polyphenols oleuropein and hydroxytyrosol
    Elena M Odiatou
    Department of Biological Sciences, University of Cyprus, Kalllipoleos Avenue, 1678 Nicosia, Cyprus
    Cancer Lett 330:113-21. 2013
  7. ncbi request reprint Efficacy of garbanzo and soybean flour in suppression of aberrant crypt foci in the colons of CF-1 mice
    Genoveva Murillo
    Department of Surgical Oncology, College of Medicine, University of Illinois at Chicago, IL 60612, USA
    Anticancer Res 24:3049-55. 2004
  8. doi request reprint Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance
    Chara A Pitta
    University of Cyprus, Department of Biological Sciences, Lefkosia, Cyprus
    Cancer Lett 337:167-76. 2013
  9. ncbi request reprint Targeting colon cancer cells with genistein-17.1A immunoconjugate
    Michelle S Gentile
    Department of Surgical Oncology, College of Medcine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Int J Oncol 22:955-9. 2003
  10. ncbi request reprint Phenoxodiol (2H-1-benzopyran-7-0,1,3-(4-hydroxyphenyl)), a novel isoflavone derivative, inhibits DNA topoisomerase II by stabilizing the cleavable complex
    Andreas I Constantinou
    Department of Surgical Oncology, College of Medicine, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Anticancer Res 22:2581-5. 2002

Collaborators

  • John M Pezzuto
  • Norman R Farnsworth
  • Gang Li
  • Wenkui Li
  • Haiyan Xu
  • Andreas Evdokiou
  • Vasu Punj
  • Chara A Pitta
  • Christiana Charalambous
  • Joanna E Burdette
  • Elena M Odiatou
  • Katerina A Nicolaou
  • Genoveva Murillo
  • Debra A Tonetti
  • Michelle S Gentile
  • Judy L Bolton
  • Jianghua Liu
  • Richard B van Breemen
  • Panagiotis Papageorgis
  • Alexios L Skaltsounis
  • Alex L Skaltsounis
  • Vasilis Liapis
  • Prokopios Magiatis
  • Paul A Costeas
  • Laura Koumas
  • Constantina Constantinou
  • Sok Bee Lim
  • Huiping Zhao
  • Yiyun Zhang
  • Olivia Pan
  • Rajendra G Mehta
  • Juliana K Choi
  • George I Salti
  • Albert Green
  • Bellur S Prabhakar
  • Chenthamarakshan Vasu
  • Tapas K Das Gupta
  • Daniel S Fabricant
  • Samad Hedayat
  • Zhi Zhen Lu
  • Harry H S Fong
  • Krishna P L Bhat
  • Eula Lim
  • Dan Lantvit
  • Shao Nong Chen
  • Nancy Booth
  • Bethany E P White

Detail Information

Publications12

  1. ncbi request reprint The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumours
    Andreas I Constantinou
    Department of Surgical Oncology, University of Illinois at Chicago, 840 South Wood Street, Chicago, IL 60612, USA
    Eur J Cancer 41:647-54. 2005
    ....
  2. pmc Equol enhances tamoxifen's anti-tumor activity by induction of caspase-mediated apoptosis in MCF-7 breast cancer cells
    Christiana Charalambous
    Department of Biological Sciences, University of Cyprus, 75 Kallipoleos Str, PO Box 20537, Lefkosia 1678, Cyprus
    BMC Cancer 13:238. 2013
    ....
  3. ncbi request reprint The effect of the phytoestrogens genistein, daidzein, and equol on the growth of tamoxifen-resistant T47D/PKC alpha
    Debra A Tonetti
    Department of Biopharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Nutr Cancer 58:222-9. 2007
    ..Interestingly, coadministration of TAM with either daidzein or genistein produced tumors of greater size than with TAM alone. These findings suggest that simultaneous consumption of isoflavone supplements with TAM may not be safe...
  4. ncbi request reprint Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles
    Joanna E Burdette
    Department of Medicinal Chemistry and Pharmacognosy and UIC NIH Center for Botanical and Dietary Supplements Research, College of Pharmacy, 833 South Wood Street, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Agric Food Chem 50:7022-8. 2002
    ..These data suggest that black cohosh can protect against cellular DNA damage caused by reactive oxygen species by acting as antioxidants...
  5. ncbi request reprint Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer
    Vasu Punj
    Department of Surgical Oncology, University of Illinois at Chicago, 840 South Wood Street, M C 820, Chicago, IL 60612, USA
    Oncogene 23:2367-78. 2004
    ....
  6. doi request reprint Identification of the factors responsible for the in vitro pro-oxidant and cytotoxic activities of the olive polyphenols oleuropein and hydroxytyrosol
    Elena M Odiatou
    Department of Biological Sciences, University of Cyprus, Kalllipoleos Avenue, 1678 Nicosia, Cyprus
    Cancer Lett 330:113-21. 2013
    ..Our findings raise considerable questions regarding the use of culture media with sodium bicarbonate or sodium pyruvate as components, for the in vitro study of these and possibly other plant polyphenols...
  7. ncbi request reprint Efficacy of garbanzo and soybean flour in suppression of aberrant crypt foci in the colons of CF-1 mice
    Genoveva Murillo
    Department of Surgical Oncology, College of Medicine, University of Illinois at Chicago, IL 60612, USA
    Anticancer Res 24:3049-55. 2004
    ..In the present study, the azoxymethane (AOM)-induced aberrant crypt foci (ACF) in CF-1 mice was utilized as a model to assess and compare the effects of garbanzo flour to that of soy flour...
  8. doi request reprint Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance
    Chara A Pitta
    University of Cyprus, Department of Biological Sciences, Lefkosia, Cyprus
    Cancer Lett 337:167-76. 2013
    ..This novel finding reveals that ER-β is fundamental in overcoming acquired tamoxifen resistance and provides insights for new therapeutic protocols against breast cancer. ..
  9. ncbi request reprint Targeting colon cancer cells with genistein-17.1A immunoconjugate
    Michelle S Gentile
    Department of Surgical Oncology, College of Medcine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Int J Oncol 22:955-9. 2003
    ..Gen-17.1A significantly inhibited colon cancer cell growth in vitro and in vivo. Our findings suggest that conjugating genistein to 17.1A monoclonal antibody enhances its effects against colon cancer cells...
  10. ncbi request reprint Phenoxodiol (2H-1-benzopyran-7-0,1,3-(4-hydroxyphenyl)), a novel isoflavone derivative, inhibits DNA topoisomerase II by stabilizing the cleavable complex
    Andreas I Constantinou
    Department of Surgical Oncology, College of Medicine, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Anticancer Res 22:2581-5. 2002
    ..These results demonstrate that phenoxodiol is a topo II-specific poison and suggest that this novel agent may find applications in cancer chemotherapy...
  11. doi request reprint Induction of discrete apoptotic pathways by bromo-substituted indirubin derivatives in invasive breast cancer cells
    Katerina A Nicolaou
    Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus
    Biochem Biophys Res Commun 425:76-82. 2012
    ..In conclusion, this study provides important insights regarding the molecular pathways leading to cell cycle arrest and apoptosis by two indirubin derivatives that can find clinical applications in targeted cancer therapeutics...
  12. ncbi request reprint Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats
    Joanna E Burdette
    Department of Medicinal Chemistry and Pharmacognosy and UIC National Institutes of Health Center for Botanical and Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Nutr 132:27-30. 2002
    ..Neither antiestrogenic nor additive estrogenic properties were observed in any of the tissues studied. These data suggest that red clover extract is weakly estrogenic in the ovariectomized rat model...