Edwin Cuppen

Summary

Publications

  1. Lips E, Michaut M, Hoogstraat M, Mulder L, Besselink N, Koudijs M, et al. Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response. Breast Cancer Res. 2015;17:134 pubmed publisher
    ..In this homogenous cohort of TNBCs few recurrent mutations were found. However, PIK3CA mutations were associated with BRCA proficiency, which can have clinical consequences in the near future. ..
  2. Hermsen R, de Ligt J, Spee W, Blokzijl F, Schäfer S, Adami E, et al. Genomic landscape of rat strain and substrain variation. BMC Genomics. 2015;16:357 pubmed publisher
    ..In addition, we find that the degree of substrain variation is highly variable between strains, which is of importance for the correct interpretation of experimental data from different labs. ..
  3. Linsen S, de Wit E, de Bruijn E, Cuppen E. Small RNA expression and strain specificity in the rat. BMC Genomics. 2010;11:249 pubmed publisher
  4. Mokry M, Nijman I, van Dijken A, Benjamins R, Heidstra R, Scheres B, et al. Identification of factors required for meristem function in Arabidopsis using a novel next generation sequencing fast forward genetics approach. BMC Genomics. 2011;12:256 pubmed publisher
    ..Furthermore, we show that experiments can be multiplexed and easily scaled for the identification of multiple individual mutants in a single sequencing run. ..
  5. Hoogstraat M, Hinrichs J, Besselink N, Radersma van Loon J, de Voijs C, Peeters T, et al. Simultaneous detection of clinically relevant mutations and amplifications for routine cancer pathology. J Mol Diagn. 2015;17:10-8 pubmed publisher
    ..The ability to obtain comprehensive and rapid mutational overviews is key for improving the efficiency of cancer patient care through tailoring treatments based on the genetic characteristics of individual tumors. ..
  6. van Heesch S, Simonis M, van Roosmalen M, Pillalamarri V, Brand H, Kuijk E, et al. Genomic and functional overlap between somatic and germline chromosomal rearrangements. Cell Rep. 2014;9:2001-10 pubmed publisher
    ..We propose that the same genomic positions are prone to genomic rearrangements in germline and soma but that timing and context of breakage determines whether developmental defects or cancer are promoted. ..