Christina A Cuomo

Summary

Publications

  1. pmc Comparative genomic analysis of human fungal pathogens causing paracoccidioidomycosis
    Christopher A Desjardins
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    PLoS Genet 7:e1002345. 2011
  2. pmc Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection
    Diego A Martinez
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    MBio 3:e00259-12. 2012
  3. pmc Microsporidian genome analysis reveals evolutionary strategies for obligate intracellular growth
    Christina A Cuomo
    The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Genome Res 22:2478-88. 2012
  4. pmc Conserved loci of leaf and stem rust fungi of wheat share synteny interrupted by lineage-specific influx of repeat elements
    John P Fellers
    USDA ARS, Hard Winter Wheat Genetics Research Unit, Department of Plant Pathology, Manhattan, KS 66506, USA
    BMC Genomics 14:60. 2013
  5. pmc Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium
    Li Jun Ma
    The Broad Institute, Cambridge, Massachusetts 02141, USA
    Nature 464:367-73. 2010
  6. pmc DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage
    Michael C Zody
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Massachusetts 02142, USA
    Nature 440:1045-9. 2006
  7. pmc Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a whole-genome duplication
    Li Jun Ma
    The Broad Institute of MIT and Harvard, Cambridge, MA, USA
    PLoS Genet 5:e1000549. 2009
  8. ncbi request reprint The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization
    Christina A Cuomo
    Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA
    Science 317:1400-2. 2007
  9. ncbi request reprint Comparative genomic and transcriptomic analysis of wangiella dermatitidis, a major cause of phaeohyphomycosis and a model black yeast human pathogen
    Zehua Chen
    Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142
    G3 (Bethesda) 4:561-78. 2014
  10. ncbi request reprint Analysis of the DNA sequence and duplication history of human chromosome 15
    Michael C Zody
    Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, Massachusetts 02141, USA
    Nature 440:671-5. 2006

Detail Information

Publications10

  1. pmc Comparative genomic analysis of human fungal pathogens causing paracoccidioidomycosis
    Christopher A Desjardins
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    PLoS Genet 7:e1002345. 2011
    ..These capabilities for degrading plant and animal substrates suggest a duality in lifestyle that could enable pathogenic species of Onygenales to transfer from soil to animal hosts...
  2. pmc Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection
    Diego A Martinez
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    MBio 3:e00259-12. 2012
    ..These genome analyses identify gene families that are important to our understanding of how dermatophytes cause chronic infections, how they interact with epithelial cells, and how they respond to the host immune response...
  3. pmc Microsporidian genome analysis reveals evolutionary strategies for obligate intracellular growth
    Christina A Cuomo
    The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Genome Res 22:2478-88. 2012
    ..Together these events may explain the emergence and success of these diverse intracellular parasites...
  4. pmc Conserved loci of leaf and stem rust fungi of wheat share synteny interrupted by lineage-specific influx of repeat elements
    John P Fellers
    USDA ARS, Hard Winter Wheat Genetics Research Unit, Department of Plant Pathology, Manhattan, KS 66506, USA
    BMC Genomics 14:60. 2013
    ..Three genomic loci of Pt conserved proteins were characterized to gain insight into gene content, genome complexity and expansion...
  5. pmc Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium
    Li Jun Ma
    The Broad Institute, Cambridge, Massachusetts 02141, USA
    Nature 464:367-73. 2010
    ..oxysporum. These findings put the evolution of fungal pathogenicity into a new perspective...
  6. pmc DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage
    Michael C Zody
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Massachusetts 02142, USA
    Nature 440:1045-9. 2006
    ..Examination of the main classes of duplicated segments provides insight into the dynamics underlying expansion of chromosome-specific, low-copy repeats in the human genome...
  7. pmc Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a whole-genome duplication
    Li Jun Ma
    The Broad Institute of MIT and Harvard, Cambridge, MA, USA
    PLoS Genet 5:e1000549. 2009
    ..Expanded families of cell-wall synthesis enzymes, essential for fungal cell integrity but absent in mammalian hosts, reveal potential targets for novel and R. oryzae-specific diagnostic and therapeutic treatments...
  8. ncbi request reprint The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization
    Christina A Cuomo
    Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA
    Science 317:1400-2. 2007
    ..These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts...
  9. ncbi request reprint Comparative genomic and transcriptomic analysis of wangiella dermatitidis, a major cause of phaeohyphomycosis and a model black yeast human pathogen
    Zehua Chen
    Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142
    G3 (Bethesda) 4:561-78. 2014
    ..This work reveals how W. dermatitidis has adapted to stress and survives in diverse environments, including during human infections. ..
  10. ncbi request reprint Analysis of the DNA sequence and duplication history of human chromosome 15
    Michael C Zody
    Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, Massachusetts 02141, USA
    Nature 440:671-5. 2006
    ..Finally, we demonstrate that some remaining gaps in the genome sequence are probably due to structural polymorphisms between haplotypes; this may explain a significant fraction of the gaps remaining in the human genome...