Valerie Cullen

Summary

Publications

  1. pmc Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
    Valerie Cullen
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Mol Brain 2:5. 2009
  2. doi request reprint Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing
    Valerie Cullen
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Ann Neurol 69:940-53. 2011
  3. doi request reprint Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration
    Brit Mollenhauer
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Exp Neurol 213:315-25. 2008

Detail Information

Publications3

  1. pmc Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
    Valerie Cullen
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Mol Brain 2:5. 2009
    ..To date, few enzymes have been examined for their ability to degrade aSyn. Here, we explore the effects of CTSD gene expression, which encodes the lysosomal protease cathepsin D (CathD), on aSyn processing...
  2. doi request reprint Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing
    Valerie Cullen
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Ann Neurol 69:940-53. 2011
    ..A loss in lysosomal acid-β-glucosidase enzyme (GCase) activity due to biallelic GBA1 mutations underlies Gaucher disease. We explored mechanisms for the gene's association with increased synucleinopathy risk...
  3. doi request reprint Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration
    Brit Mollenhauer
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Exp Neurol 213:315-25. 2008
    ..Our results will likely aid future biomarker explorations in neurodegenerative conditions and facilitate target validation studies...