Value of p16(INK)⁴(a) in the pathology of invasive penile squamous cell carcinomas: A report of 202 casesAntonio L Cubilla
Instituto de Patologia e Investigacion, Asuncion, Paraguay
Am J Surg Pathol 35:253-61. 2011
..In this study, we evaluated p16(INK)⁴(a) immunohistochemical expression, which is simpler and less costly, as a potential marker of high-risk HPV (HR-HPV) infection in penile SCC...
- The role of pathologic prognostic factors in squamous cell carcinoma of the penis
Antonio L Cubilla
Department of Pathology, Facultad de Ciencias Medicas, Instituto de Patologia e Investigacion, Universidad Nacional de Asuncion, Martín Brizuela 325, Asuncion, Paraguay
World J Urol 27:169-77. 2009
..The aim of this review was to identify prognostic pathologic factors which are independent from other clinical or molecular variables...
- The basaloid cell is the best tissue marker for human papillomavirus in invasive penile squamous cell carcinoma: a study of 202 cases from Paraguay
Antonio L Cubilla
Instituto de Patologia e Investigacion, Asuncion, Paraguay
Am J Surg Pathol 34:104-14. 2010
..Our results also suggest that, in penile SCC, the basaloid cell is the best tissue marker for oncogenic HPV infection...
- Warty-basaloid carcinoma: clinicopathological features of a distinctive penile neoplasm. Report of 45 cases
Alcides Chaux
Instituto de Patologia e Investigacion, Asuncion, Paraguay
Mod Pathol 23:896-904. 2010
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- Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a new nomenclature
Alcides Chaux
Instituto de Patologia e Investigacion, Asuncion, Paraguay
Am J Surg Pathol 34:385-92. 2010
..Although more studies are necessary to confirm these observations, p16 overexpression seems to be a useful tool for discriminating differentiated from warty, basaloid, and warty-basaloid PeIN...
- Differentiated precursor lesions and low-grade variants of squamous cell carcinomas are frequent findings in foreskins of patients from a region of high penile cancer incidence
Judith Oertell
Instituto de Previsión Social, Asuncion, Paraguay
Histopathology 58:925-33. 2011
..The aims of the present study were to determine the prevalence of various precancerous and cancerous lesions exclusively affecting the foreskin, and to describe their pathological features...
- Comparison of subtypes of penile squamous cell carcinoma from high and low incidence geographical regions
Alcides Chaux
Instituto de Patologia e Investigacion, Asuncion, Paraguay
Int J Surg Pathol 18:268-77. 2010
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- Type-specific human papillomavirus distribution in invasive cervical carcinomas in Paraguay. A study of 432 cases
Elena Kasamatsu
Health Sciences Research Institute, IICS, National University of Asuncion, Asuncion, Paraguay
J Med Virol 84:1628-35. 2012
..1%. The study provide a profile of the HPV situation in the country, with robust clinical, pathological and virological data which would permit a better cervical cancer screening and vaccination programs...
- Distribution and characterization of subtypes of penile intraepithelial neoplasia and their association with invasive carcinomas: a pathological study of 139 lesions in 121 patients
Alcides Chaux
Instituto de Patologia e Investigacion, Asuncion, Paraguay Department of Pathology
Hum Pathol 43:1020-7. 2012
..The proper pathological characterization of these lesions may provide important clues to the understanding of the pathogenesis and natural history of penile cancer...
- Histologic grade in penile squamous cell carcinoma: visual estimation versus digital measurement of proportions of grades, adverse prognosis with any proportion of grade 3 and correlation of a Gleason-like system with nodal metastasis
Alcides Chaux
Instituto de Patologia e Investigacion, Universidad Nacional de Asuncion, Paraguay
Am J Surg Pathol 33:1042-8. 2009
..When histologically evaluating penile carcinomas, we recommend a careful search of areas of grade 3. Any focus of grade 3 should be sufficient to grade the neoplasm as a high-grade tumor...
- Basaloid squamous cell carcinoma of the penis with papillary features: a clinicopathologic study of 12 cases
Antonio L Cubilla
Instituto de Patologia e Investigacion, Universidad Nacional de Asuncion, Asuncion, Paraguay
Am J Surg Pathol 36:869-75. 2012
..Unlike typical basaloid carcinomas, the overall prognosis was excellent. However, deeply invasive tumors were associated with regional nodal metastasis indicating a potential for tumor-related death...
- Warty/basaloid penile intraepithelial neoplasia is more prevalent than differentiated penile intraepithelial neoplasia in nonendemic regions for penile cancer when compared with endemic areas: a comparative study between pathologic series from Paris and P
Ana Soskin
Instituto de Patologia e Investigacion, Asuncion, Paraguay
Hum Pathol 43:190-6. 2012
..Further prospective studies in matched populations and from different geographic regions are needed to further clarify the reasons for this discrepancy...
- Papillary squamous cell carcinoma, not otherwise specified (NOS) of the penis: clinicopathologic features, differential diagnosis, and outcome of 35 cases
Alcides Chaux
Instituto de Patologia e Investigacion, Asuncion, Paraguay
Am J Surg Pathol 34:223-30. 2010
..Helpful morphologic features for differential diagnosis are provided...
- The prognostic index: a useful pathologic guide for prediction of nodal metastases and survival in penile squamous cell carcinoma
Alcides Chaux
Department of Pathology, Instituto de Patologia e Investigacion, Universidad Nacional, Asuncion, Paraguay
Am J Surg Pathol 33:1049-57. 2009
..If sentinel node biopsy cannot be performed for various reasons the Prognostic Index might represent a useful pathologic guide to the clinicians in the often difficult decision to perform an inguinal dissection or not...
- Comparison of morphologic features and outcome of resected recurrent and nonrecurrent squamous cell carcinoma of the penis: a study of 81 cases
Alcides Chaux
Instituto de Patologia e Investigacion, Universidad Nacional de Asuncion, Paraguay
Am J Surg Pathol 33:1299-306. 2009
..Re-excision of the recurrent tumor permitted the control of the disease only in one-third of the patients...
Epithelial lesions associated with invasive penile squamous cell carcinoma: a pathologic study of 288 casesAntonio L Cubilla
Instituto de Patologia e Investigacion, Facultad de Ciencias Medicas, Universidad Nacional de Asuncion, Paraguay
Int J Surg Pathol 12:351-64. 2004
..The association and histologic similarities between high-grade SIL of the basaloid, warty, or mixed forms with their invasive counterparts indicate these lesions are their likely precursors...
- Metastatic tumors to the penis: a report of 17 cases and review of the literature
Alcides Chaux
Instituto de Patologia e Investigacion, Asuncion, Paraguay
Int J Surg Pathol 19:597-606. 2011
..Clinical evidence of penile involvement in a patient with a known malignancy is an ominous sign and should alert the clinicians to the dismal prognosis...
- Developments in the pathology of penile squamous cell carcinomas
Alcides Chaux
Instituto de Patologia e Investigacion, Martín Brizuela 325, Asuncion, Paraguay
Urology 76:S7-S14. 2010
..In addition, recommendations for handling penile cancer specimens, frozen section specimens, and pathology reports are provided...
- Autopsy findings in 14 patients with penile squamous cell carcinoma
Alcides Chaux
Instituto de Patologia e Investigacion and Facultad de Ciencias Medicas, Universidad Nacional de Asuncion, Asuncion, Paraguay
Int J Surg Pathol 19:164-9. 2011
..A natural history model for penile cancer routes of spread is proposed: local intrapeneal, regional and systemic nodes, regional skin, liver, lungs, heart, and other multiple sites...
- Carcinoma cuniculatum: a distinctive variant of penile squamous cell carcinoma: report of 7 cases
Jose E Barreto
Instituto de Patologia e Investigacion and Facultad de Ciencias Medicas, Universidad Nacional de Asuncion, Asuncion, Paraguay
Am J Surg Pathol 31:71-5. 2007
..Unlike most subtypes of penile SCCs and despite the deep invasion, none of the tumors showed groin or systemic dissemination at time of diagnosis...
- Pseudohyperplastic squamous cell carcinoma of the penis associated with lichen sclerosus. An extremely well-differentiated, nonverruciform neoplasm that preferentially affects the foreskin and is frequently misdiagnosed: a report of 10 cases of a distinct
Antonio L Cubilla
, Asuncion, Paraguay
Am J Surg Pathol 28:895-900. 2004
..Because it was present in all cases, lichen sclerosus may play a precancerous role...
- Advances in the pathology of penile carcinomas
Alcides Chaux
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Hum Pathol 43:771-89. 2012
..We also discuss the role of pathologic features in the prognosis of penile cancer, the characteristics of penile precursor lesions, and the use of immunohistochemistry for the diagnosis of invasive and precursor lesions...
