Antonio L Cubilla

Summary

Publications

  1. doi request reprint Value of p16(INK)⁴(a) in the pathology of invasive penile squamous cell carcinomas: A report of 202 cases
    Antonio L Cubilla
    Instituto de Patologia e Investigacion, Asuncion, Paraguay
    Am J Surg Pathol 35:253-61. 2011
  2. doi request reprint The basaloid cell is the best tissue marker for human papillomavirus in invasive penile squamous cell carcinoma: a study of 202 cases from Paraguay
    Antonio L Cubilla
    Instituto de Patologia e Investigacion, Asuncion, Paraguay
    Am J Surg Pathol 34:104-14. 2010
  3. doi request reprint The role of pathologic prognostic factors in squamous cell carcinoma of the penis
    Antonio L Cubilla
    Department of Pathology, Facultad de Ciencias Medicas, Instituto de Patologia e Investigacion, Universidad Nacional de Asuncion, Martín Brizuela 325, Asuncion, Paraguay
    World J Urol 27:169-77. 2009
  4. ncbi request reprint Warty-basaloid carcinoma: clinicopathological features of a distinctive penile neoplasm. Report of 45 cases
    Alcides Chaux
    Instituto de Patologia e Investigacion, Asuncion, Paraguay
    Mod Pathol 23:896-904. 2010
  5. doi request reprint Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a new nomenclature
    Alcides Chaux
    Instituto de Patologia e Investigacion, Asuncion, Paraguay
    Am J Surg Pathol 34:385-92. 2010
  6. doi request reprint Differentiated precursor lesions and low-grade variants of squamous cell carcinomas are frequent findings in foreskins of patients from a region of high penile cancer incidence
    Judith Oertell
    Instituto de Previsión Social, Asuncion, Paraguay
    Histopathology 58:925-33. 2011
  7. doi request reprint Comparison of subtypes of penile squamous cell carcinoma from high and low incidence geographical regions
    Alcides Chaux
    Instituto de Patologia e Investigacion, Asuncion, Paraguay
    Int J Surg Pathol 18:268-77. 2010
  8. pmc Epidemiologic profile, sexual history, pathologic features, and human papillomavirus status of 103 patients with penile carcinoma
    Alcides Chaux
    Instituto de Patologia e Investigacion, Asuncion, Paraguay
    World J Urol 31:861-7. 2013
  9. ncbi request reprint Type-specific human papillomavirus distribution in invasive cervical carcinomas in Paraguay. A study of 432 cases
    Elena Kasamatsu
    Health Sciences Research Institute, IICS, National University of Asuncion, Asuncion, Paraguay
    J Med Virol 84:1628-35. 2012
  10. doi request reprint Distribution and characterization of subtypes of penile intraepithelial neoplasia and their association with invasive carcinomas: a pathological study of 139 lesions in 121 patients
    Alcides Chaux
    Instituto de Patologia e Investigacion, Asuncion, Paraguay Department of Pathology
    Hum Pathol 43:1020-7. 2012

Collaborators

Detail Information

Publications25

  1. doi request reprint Value of p16(INK)⁴(a) in the pathology of invasive penile squamous cell carcinomas: A report of 202 cases
    Antonio L Cubilla
    Instituto de Patologia e Investigacion, Asuncion, Paraguay
    Am J Surg Pathol 35:253-61. 2011
    ..In this study, we evaluated p16(INK)⁴(a) immunohistochemical expression, which is simpler and less costly, as a potential marker of high-risk HPV (HR-HPV) infection in penile SCC...
  2. doi request reprint The basaloid cell is the best tissue marker for human papillomavirus in invasive penile squamous cell carcinoma: a study of 202 cases from Paraguay
    Antonio L Cubilla
    Instituto de Patologia e Investigacion, Asuncion, Paraguay
    Am J Surg Pathol 34:104-14. 2010
    ..Our results also suggest that, in penile SCC, the basaloid cell is the best tissue marker for oncogenic HPV infection...
  3. doi request reprint The role of pathologic prognostic factors in squamous cell carcinoma of the penis
    Antonio L Cubilla
    Department of Pathology, Facultad de Ciencias Medicas, Instituto de Patologia e Investigacion, Universidad Nacional de Asuncion, Martín Brizuela 325, Asuncion, Paraguay
    World J Urol 27:169-77. 2009
    ..The aim of this review was to identify prognostic pathologic factors which are independent from other clinical or molecular variables...
  4. ncbi request reprint Warty-basaloid carcinoma: clinicopathological features of a distinctive penile neoplasm. Report of 45 cases
    Alcides Chaux
    Instituto de Patologia e Investigacion, Asuncion, Paraguay
    Mod Pathol 23:896-904. 2010
    ....
  5. doi request reprint Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a new nomenclature
    Alcides Chaux
    Instituto de Patologia e Investigacion, Asuncion, Paraguay
    Am J Surg Pathol 34:385-92. 2010
    ..Although more studies are necessary to confirm these observations, p16 overexpression seems to be a useful tool for discriminating differentiated from warty, basaloid, and warty-basaloid PeIN...
  6. doi request reprint Differentiated precursor lesions and low-grade variants of squamous cell carcinomas are frequent findings in foreskins of patients from a region of high penile cancer incidence
    Judith Oertell
    Instituto de Previsión Social, Asuncion, Paraguay
    Histopathology 58:925-33. 2011
    ..The aims of the present study were to determine the prevalence of various precancerous and cancerous lesions exclusively affecting the foreskin, and to describe their pathological features...
  7. doi request reprint Comparison of subtypes of penile squamous cell carcinoma from high and low incidence geographical regions
    Alcides Chaux
    Instituto de Patologia e Investigacion, Asuncion, Paraguay
    Int J Surg Pathol 18:268-77. 2010
    ....
  8. pmc Epidemiologic profile, sexual history, pathologic features, and human papillomavirus status of 103 patients with penile carcinoma
    Alcides Chaux
    Instituto de Patologia e Investigacion, Asuncion, Paraguay
    World J Urol 31:861-7. 2013
    ..There are no adequate scientific explanations for this geographical variation. The goal of this study was to evaluate the interplay among risk factors, morphology of the primary tumor, and HPV status...
  9. ncbi request reprint Type-specific human papillomavirus distribution in invasive cervical carcinomas in Paraguay. A study of 432 cases
    Elena Kasamatsu
    Health Sciences Research Institute, IICS, National University of Asuncion, Asuncion, Paraguay
    J Med Virol 84:1628-35. 2012
    ..1%. The study provide a profile of the HPV situation in the country, with robust clinical, pathological and virological data which would permit a better cervical cancer screening and vaccination programs...
  10. doi request reprint Distribution and characterization of subtypes of penile intraepithelial neoplasia and their association with invasive carcinomas: a pathological study of 139 lesions in 121 patients
    Alcides Chaux
    Instituto de Patologia e Investigacion, Asuncion, Paraguay Department of Pathology
    Hum Pathol 43:1020-7. 2012
    ..The proper pathological characterization of these lesions may provide important clues to the understanding of the pathogenesis and natural history of penile cancer...
  11. doi request reprint Histologic grade in penile squamous cell carcinoma: visual estimation versus digital measurement of proportions of grades, adverse prognosis with any proportion of grade 3 and correlation of a Gleason-like system with nodal metastasis
    Alcides Chaux
    Instituto de Patologia e Investigacion, Universidad Nacional de Asuncion, Paraguay
    Am J Surg Pathol 33:1042-8. 2009
    ..When histologically evaluating penile carcinomas, we recommend a careful search of areas of grade 3. Any focus of grade 3 should be sufficient to grade the neoplasm as a high-grade tumor...
  12. doi request reprint Basaloid squamous cell carcinoma of the penis with papillary features: a clinicopathologic study of 12 cases
    Antonio L Cubilla
    Instituto de Patologia e Investigacion, Universidad Nacional de Asuncion, Asuncion, Paraguay
    Am J Surg Pathol 36:869-75. 2012
    ..Unlike typical basaloid carcinomas, the overall prognosis was excellent. However, deeply invasive tumors were associated with regional nodal metastasis indicating a potential for tumor-related death...
  13. doi request reprint Warty/basaloid penile intraepithelial neoplasia is more prevalent than differentiated penile intraepithelial neoplasia in nonendemic regions for penile cancer when compared with endemic areas: a comparative study between pathologic series from Paris and P
    Ana Soskin
    Instituto de Patologia e Investigacion, Asuncion, Paraguay
    Hum Pathol 43:190-6. 2012
    ..Further prospective studies in matched populations and from different geographic regions are needed to further clarify the reasons for this discrepancy...
  14. doi request reprint Papillary squamous cell carcinoma, not otherwise specified (NOS) of the penis: clinicopathologic features, differential diagnosis, and outcome of 35 cases
    Alcides Chaux
    Instituto de Patologia e Investigacion, Asuncion, Paraguay
    Am J Surg Pathol 34:223-30. 2010
    ..Helpful morphologic features for differential diagnosis are provided...
  15. doi request reprint The prognostic index: a useful pathologic guide for prediction of nodal metastases and survival in penile squamous cell carcinoma
    Alcides Chaux
    Department of Pathology, Instituto de Patologia e Investigacion, Universidad Nacional, Asuncion, Paraguay
    Am J Surg Pathol 33:1049-57. 2009
    ..If sentinel node biopsy cannot be performed for various reasons the Prognostic Index might represent a useful pathologic guide to the clinicians in the often difficult decision to perform an inguinal dissection or not...
  16. doi request reprint Comparison of morphologic features and outcome of resected recurrent and nonrecurrent squamous cell carcinoma of the penis: a study of 81 cases
    Alcides Chaux
    Instituto de Patologia e Investigacion, Universidad Nacional de Asuncion, Paraguay
    Am J Surg Pathol 33:1299-306. 2009
    ..Re-excision of the recurrent tumor permitted the control of the disease only in one-third of the patients...
  17. ncbi request reprint Epithelial lesions associated with invasive penile squamous cell carcinoma: a pathologic study of 288 cases
    Antonio L Cubilla
    Instituto de Patologia e Investigacion, Facultad de Ciencias Medicas, Universidad Nacional de Asuncion, Paraguay
    Int J Surg Pathol 12:351-64. 2004
    ..The association and histologic similarities between high-grade SIL of the basaloid, warty, or mixed forms with their invasive counterparts indicate these lesions are their likely precursors...
  18. doi request reprint Metastatic tumors to the penis: a report of 17 cases and review of the literature
    Alcides Chaux
    Instituto de Patologia e Investigacion, Asuncion, Paraguay
    Int J Surg Pathol 19:597-606. 2011
    ..Clinical evidence of penile involvement in a patient with a known malignancy is an ominous sign and should alert the clinicians to the dismal prognosis...
  19. doi request reprint Developments in the pathology of penile squamous cell carcinomas
    Alcides Chaux
    Instituto de Patologia e Investigacion, Martín Brizuela 325, Asuncion, Paraguay
    Urology 76:S7-S14. 2010
    ..In addition, recommendations for handling penile cancer specimens, frozen section specimens, and pathology reports are provided...
  20. ncbi request reprint Immunohistochemical expression of the mammalian target of rapamycin pathway in penile squamous cell carcinomas: a tissue microarray study of 112 cases
    Alcides Chaux
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA Office of Scientific Research, Norte University, Asuncion, Paraguay
    Histopathology 64:863-71. 2014
    ....
  21. doi request reprint Autopsy findings in 14 patients with penile squamous cell carcinoma
    Alcides Chaux
    Instituto de Patologia e Investigacion and Facultad de Ciencias Medicas, Universidad Nacional de Asuncion, Asuncion, Paraguay
    Int J Surg Pathol 19:164-9. 2011
    ..A natural history model for penile cancer routes of spread is proposed: local intrapeneal, regional and systemic nodes, regional skin, liver, lungs, heart, and other multiple sites...
  22. ncbi request reprint Carcinoma cuniculatum: a distinctive variant of penile squamous cell carcinoma: report of 7 cases
    Jose E Barreto
    Instituto de Patologia e Investigacion and Facultad de Ciencias Medicas, Universidad Nacional de Asuncion, Asuncion, Paraguay
    Am J Surg Pathol 31:71-5. 2007
    ..Unlike most subtypes of penile SCCs and despite the deep invasion, none of the tumors showed groin or systemic dissemination at time of diagnosis...
  23. doi request reprint Combining routine morphology, p16(INK4a) immunohistochemistry, and in situ hybridization for the detection of human papillomavirus infection in penile carcinomas: a tissue microarray study using classifier performance analyses
    Alcides Chaux
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD Norte University School of Medicine, Asuncion, Paraguay Electronic address
    Urol Oncol 32:171-7. 2014
    ..Herein, we evaluated the predictive abilities of tumor morphology, immunohistochemistry for p16(INK4a) expression, and in situ hybridization (ISH) for HR-HPV detection in defining HPV status, as established by PCR...
  24. ncbi request reprint Pseudohyperplastic squamous cell carcinoma of the penis associated with lichen sclerosus. An extremely well-differentiated, nonverruciform neoplasm that preferentially affects the foreskin and is frequently misdiagnosed: a report of 10 cases of a distinct
    Antonio L Cubilla
    Instituto de Patologia e Investigacion and Facultad de Ciencias Medicas, Asuncion, Paraguay
    Am J Surg Pathol 28:895-900. 2004
    ..Because it was present in all cases, lichen sclerosus may play a precancerous role...
  25. doi request reprint Advances in the pathology of penile carcinomas
    Alcides Chaux
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Hum Pathol 43:771-89. 2012
    ..We also discuss the role of pathologic features in the prognosis of penile cancer, the characteristics of penile precursor lesions, and the use of immunohistochemistry for the diagnosis of invasive and precursor lesions...