R Gamez

Summary

Affiliation: National Center for Scientific Research
Country: Cuba

Publications

  1. ncbi request reprint Long-term carcinogenicity of D-003, a mixture of high molecular weight acids from sugarcane wax, in Sprague Dawley rats: a 24 months study
    R Gamez
    Centre of Natural Products, National Centre for Scientific Research, Cubanacan, Playa, Havana City, Cuba
    Food Chem Toxicol 45:2352-8. 2007
  2. ncbi request reprint Effects of addition of policosanol to omega-3 fatty acid therapy on the lipid profile of patients with type II hypercholesterolaemia
    G Castano
    Surgical Medical Research Center, Havana City, Cuba
    Drugs R D 6:207-19. 2005
  3. ncbi request reprint Effects of chronic administration of D-003, a mixture of sugar cane wax high molecular acids, in beagle dogs
    R Gamez
    Center for Natural Products, National Center for Scientific Research, Havana City, Cuba
    Drugs Exp Clin Res 30:75-88. 2004
  4. ncbi request reprint Effects of concurrent therapy with policosanol and omega-3 fatty acids on lipid profile and platelet aggregation in rabbits
    R Gamez
    Center of Natural Products, National Center of Scientific Research, Havana City, Cuba
    Drugs R D 6:11-9. 2005
  5. ncbi request reprint A comparison of the effects of D-003 and policosanol (5 and 10 mg/day) in patients with type II hypercholesterolemia: a randomized, double-blinded study
    G Castano
    Medical Surgical Research Center, Havana City, Cuba
    Drugs Exp Clin Res 31:31-44. 2005
  6. doi request reprint One year oral Toxicity of D-004, a lipid extract from Roystonea regia fruits, in Sprague Dawley rats
    A Gutierrez
    Centre of Natural Products, National Centre for Scientific Research, PO Box 6990, 198 Ave and 19 St Cubanacan, Playa, Havana, Cuba
    Food Chem Toxicol 49:2855-61. 2011
  7. doi request reprint Study of the long-term carcinogenicity potential of D-003, a mixture of high molecular weight sugarcane wax acids, in mice
    M Noa
    Centre of Natural Products, National Centre for Scientific Research, Cubanacan, Playa, Havana City, Cuba
    Food Chem Toxicol 47:687-92. 2009
  8. ncbi request reprint Acute and oral subchronic toxicity of D-003 in rats
    R Gamez
    Center of Natural Products, National Center for Scientific Research, PO Box 6880, 198 Ave and 19 St Cubanacan, Playa, Havana City, Cuba
    Toxicol Lett 118:31-41. 2000
  9. ncbi request reprint Policosanol prevents bone loss in ovariectomized rats
    M Noa
    Center of Natural Products of the National Center for Scientific Research, Havana City, Cuba
    Drugs Exp Clin Res 30:117-23. 2004
  10. ncbi request reprint Evaluation of the reproductive and developmental toxicity of the D-003, a mixture of long-chain fatty acids, in rats and rabbits
    M D Rodriguez
    Centre of Natural Products, National Centre for Scientific Research, Ave 25 and 158, P O B 6414, Cubanacan, Havana, Cuba
    Food Chem Toxicol 42:1977-85. 2004

Collaborators

  • M Noa
  • N Mendoza
  • A Gutierrez
  • C Aleman
  • G Castano
  • M D Rodriguez
  • S Mendoza
  • R Mas
  • E Goicochea
  • J Illnait
  • L Fernandez
  • J Fernandez
  • M Mesa
  • H Garcia
  • J E Gonzalez
  • C P Acosta
  • G Marrero
  • E F León
  • A Gomez
  • Y Rodriguez
  • S Valdes
  • E Lopez
  • J A Gutierrez
  • E Arango
  • I Rodeiro
  • E Alvarez

Detail Information

Publications17

  1. ncbi request reprint Long-term carcinogenicity of D-003, a mixture of high molecular weight acids from sugarcane wax, in Sprague Dawley rats: a 24 months study
    R Gamez
    Centre of Natural Products, National Centre for Scientific Research, Cubanacan, Playa, Havana City, Cuba
    Food Chem Toxicol 45:2352-8. 2007
    ..In conclusion, D-003 is not toxic or carcinogenic when given orally to Sprague Dawley rats up to 1500 mg/kg for 2 years, and 1500 mg/kg was a not-observable effect dose...
  2. ncbi request reprint Effects of addition of policosanol to omega-3 fatty acid therapy on the lipid profile of patients with type II hypercholesterolaemia
    G Castano
    Surgical Medical Research Center, Havana City, Cuba
    Drugs R D 6:207-19. 2005
    ..Omega-3 FA also have lipid-modifying effects, mostly relating to TG reduction. Thus, potential benefits could be expected from combined therapy with omega-3 FA and policosanol...
  3. ncbi request reprint Effects of chronic administration of D-003, a mixture of sugar cane wax high molecular acids, in beagle dogs
    R Gamez
    Center for Natural Products, National Center for Scientific Research, Havana City, Cuba
    Drugs Exp Clin Res 30:75-88. 2004
    ..In conclusion, D-003 administered for 9 months to beagle dogs induced the expected effects with no evidence of drug-related toxicity...
  4. ncbi request reprint Effects of concurrent therapy with policosanol and omega-3 fatty acids on lipid profile and platelet aggregation in rabbits
    R Gamez
    Center of Natural Products, National Center of Scientific Research, Havana City, Cuba
    Drugs R D 6:11-9. 2005
    ..In view of the effects of policosanol and omega-3 FA on lipid profile and platelet function, potential benefits of combined therapy were expected...
  5. ncbi request reprint A comparison of the effects of D-003 and policosanol (5 and 10 mg/day) in patients with type II hypercholesterolemia: a randomized, double-blinded study
    G Castano
    Medical Surgical Research Center, Havana City, Cuba
    Drugs Exp Clin Res 31:31-44. 2005
    ..D-003 could be useful for treating type II hypercholesterolemia, but this subject deserves further clinical research...
  6. doi request reprint One year oral Toxicity of D-004, a lipid extract from Roystonea regia fruits, in Sprague Dawley rats
    A Gutierrez
    Centre of Natural Products, National Centre for Scientific Research, PO Box 6990, 198 Ave and 19 St Cubanacan, Playa, Havana, Cuba
    Food Chem Toxicol 49:2855-61. 2011
    ..The highest dose tested (2000 mg/kg) was a no-observed adverse effect level in this study...
  7. doi request reprint Study of the long-term carcinogenicity potential of D-003, a mixture of high molecular weight sugarcane wax acids, in mice
    M Noa
    Centre of Natural Products, National Centre for Scientific Research, Cubanacan, Playa, Havana City, Cuba
    Food Chem Toxicol 47:687-92. 2009
    ..It can be concluded that D-003 did not result toxic or carcinogenic when given orally to OF1 mice for 18 months and that the highest dose was a NOAEL, consistent with results of the oral carcinogenicity study of D-003 in rats...
  8. ncbi request reprint Acute and oral subchronic toxicity of D-003 in rats
    R Gamez
    Center of Natural Products, National Center for Scientific Research, PO Box 6880, 198 Ave and 19 St Cubanacan, Playa, Havana City, Cuba
    Toxicol Lett 118:31-41. 2000
    ..It is concluded that D-003 orally administered to rats was safe and that no drug-related toxicity was detected even at the highest doses investigated in both acute (2000 mg/kg) and subchronic (1250 mg/kg) studies...
  9. ncbi request reprint Policosanol prevents bone loss in ovariectomized rats
    M Noa
    Center of Natural Products of the National Center for Scientific Research, Havana City, Cuba
    Drugs Exp Clin Res 30:117-23. 2004
    ..In conclusion, policosanol prevented bone loss and decreased bone resorption in ovariectomized rats, suggesting that it should be potentially useful in preventing bone loss in postmenopausal women...
  10. ncbi request reprint Evaluation of the reproductive and developmental toxicity of the D-003, a mixture of long-chain fatty acids, in rats and rabbits
    M D Rodriguez
    Centre of Natural Products, National Centre for Scientific Research, Ave 25 and 158, P O B 6414, Cubanacan, Havana, Cuba
    Food Chem Toxicol 42:1977-85. 2004
    ..After assessment of the potential of high doses of D-003 to act on developing embryo and reproduction process, no evidence supports the conclusion that D-003 is a reproductive and developmental toxicant/teratogen...
  11. ncbi request reprint Oral acute and subchronic toxicity of D-004, a lipid extract from Roystonea regia fruits, in rats
    R Gamez
    Center for Natural Products, National Center for Scientific Research, Havana City, Cuba
    Drugs Exp Clin Res 31:101-8. 2005
    ..Thus, this dose can be considered as a nonobservable-effect dose in rats...
  12. ncbi request reprint Effects of policosanol 20 versus 40 mg/day in the treatment of patients with type II hypercholesterolemia: a 6-month double-blind study
    G Castano
    Medical Surgical Research Center, National Center for Scientific Research, Havana City, Cuba
    Int J Clin Pharmacol Res 21:43-57. 2001
    ..In conclusion, although the tolerability profile remains excellent, according to the present results policosanol at a dose of 40 mg/day does not offer significant additional cholesterol-lowering efficacy over the 20 mg/day dose...
  13. ncbi request reprint Effects of D-003, a mixture of high molecular weight aliphatic acids from sugar cane wax, on bones from ovariectomized rats
    M Noa
    Center for Natural Products, National Center for Scientific Research, Havana City, Cuba
    Drugs Exp Clin Res 30:35-41. 2004
    ..In conclusion, D-003 (50 and 200 mg/kg/day) prevented bone loss and decreased bone resorption in ovariectomized rats, which suggests that this substance could be promising in preventing or treating osteoporosis...
  14. ncbi request reprint Concomitant use of policosanol and beta-blockers in older patients
    G Castano
    Center for Natural Products, National Center for Scientific Research, Havana City, Cuba
    Int J Clin Pharmacol Res 24:65-77. 2004
    ....
  15. ncbi request reprint Effects of D-003, a mixture of long-chain aliphatic primary acids, fluvastatin and the combined therapy of D-003 plus fluvastatin on the lipid profile of normocholesterolemic rabbits
    S Mendoza
    Center of Natural Products, National Center of Scientific Research, Havana City, Cuba
    Int J Tissue React 25:81-9. 2003
    ..Combined therapy did not improve the response of LDL-C and TC with respect to monotherapies, but induced better responses of HDL-C and triglycerides than fluvastatin alone had on HDL-C or D-003 alone had on triglycerides...
  16. ncbi request reprint Perinatal/postnatal study of D-003, a mixture of long-chain fatty acids, in rats
    M D Rodriguez
    Centre of Natural Products, National Centre for Scientific Research, Cubanacan, Havana, Cuba
    J Med Food 9:223-30. 2006
    ..This peri- and postnatal study conducted with D-003 in rats indicated that treatment of the dam during late gestation and lactation did not show adversely effects on reproductive performance or fetal development over two generations...
  17. ncbi request reprint Lack of developmental toxicity of D-003: a mixture of long-chain fatty acids in rats
    M D Rodriguez
    Centre of Natural Products, National Centre for Scientific Research, Ave 25 and 158 POB 6414, Cubanacan, Havana, Cuba
    Food Chem Toxicol 41:89-93. 2003
    ..It is concluded that D-003 administered up to 1000 mg/kg/day did not induce any evidence of developmental toxicity...