Research Topics
| R GamezSummaryAffiliation: National Center for Scientific Research Country: Cuba Publications
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Detail Information
Publications
Long-term carcinogenicity of D-003, a mixture of high molecular weight acids from sugarcane wax, in Sprague Dawley rats: a 24 months studyR Gamez
Centre of Natural Products, National Centre for Scientific Research, Cubanacan, Playa, Havana City, Cuba
Food Chem Toxicol 45:2352-8. 2007..In conclusion, D-003 is not toxic or carcinogenic when given orally to Sprague Dawley rats up to 1500 mg/kg for 2 years, and 1500 mg/kg was a not-observable effect dose...- Effects of addition of policosanol to omega-3 fatty acid therapy on the lipid profile of patients with type II hypercholesterolaemiaG Castano
Surgical Medical Research Center, Havana City, Cuba
Drugs R D 6:207-19. 2005..Omega-3 FA also have lipid-modifying effects, mostly relating to TG reduction. Thus, potential benefits could be expected from combined therapy with omega-3 FA and policosanol... - Effects of chronic administration of D-003, a mixture of sugar cane wax high molecular acids, in beagle dogsR Gamez
Center for Natural Products, National Center for Scientific Research, Havana City, Cuba
Drugs Exp Clin Res 30:75-88. 2004..In conclusion, D-003 administered for 9 months to beagle dogs induced the expected effects with no evidence of drug-related toxicity... - Effects of concurrent therapy with policosanol and omega-3 fatty acids on lipid profile and platelet aggregation in rabbitsR Gamez
Center of Natural Products, National Center of Scientific Research, Havana City, Cuba
Drugs R D 6:11-9. 2005..In view of the effects of policosanol and omega-3 FA on lipid profile and platelet function, potential benefits of combined therapy were expected... - A comparison of the effects of D-003 and policosanol (5 and 10 mg/day) in patients with type II hypercholesterolemia: a randomized, double-blinded studyG Castano
Medical Surgical Research Center, Havana City, Cuba
Drugs Exp Clin Res 31:31-44. 2005..D-003 could be useful for treating type II hypercholesterolemia, but this subject deserves further clinical research... 
One year oral Toxicity of D-004, a lipid extract from Roystonea regia fruits, in Sprague Dawley ratsA Gutierrez
Centre of Natural Products, National Centre for Scientific Research, PO Box 6990, 198 Ave and 19 St Cubanacan, Playa, Havana, Cuba
Food Chem Toxicol 49:2855-61. 2011..The highest dose tested (2000 mg/kg) was a no-observed adverse effect level in this study...- Study of the long-term carcinogenicity potential of D-003, a mixture of high molecular weight sugarcane wax acids, in miceM Noa
Centre of Natural Products, National Centre for Scientific Research, Cubanacan, Playa, Havana City, Cuba
Food Chem Toxicol 47:687-92. 2009..It can be concluded that D-003 did not result toxic or carcinogenic when given orally to OF1 mice for 18 months and that the highest dose was a NOAEL, consistent with results of the oral carcinogenicity study of D-003 in rats... - Acute and oral subchronic toxicity of D-003 in ratsR Gamez
Center of Natural Products, National Center for Scientific Research, PO Box 6880, 198 Ave and 19 St Cubanacan, Playa, Havana City, Cuba
Toxicol Lett 118:31-41. 2000..It is concluded that D-003 orally administered to rats was safe and that no drug-related toxicity was detected even at the highest doses investigated in both acute (2000 mg/kg) and subchronic (1250 mg/kg) studies... - Policosanol prevents bone loss in ovariectomized ratsM Noa
Center of Natural Products of the National Center for Scientific Research, Havana City, Cuba
Drugs Exp Clin Res 30:117-23. 2004..In conclusion, policosanol prevented bone loss and decreased bone resorption in ovariectomized rats, suggesting that it should be potentially useful in preventing bone loss in postmenopausal women... - Evaluation of the reproductive and developmental toxicity of the D-003, a mixture of long-chain fatty acids, in rats and rabbitsM D Rodriguez
Centre of Natural Products, National Centre for Scientific Research, Ave 25 and 158, P O B 6414, Cubanacan, Havana, Cuba
Food Chem Toxicol 42:1977-85. 2004..After assessment of the potential of high doses of D-003 to act on developing embryo and reproduction process, no evidence supports the conclusion that D-003 is a reproductive and developmental toxicant/teratogen... - Oral acute and subchronic toxicity of D-004, a lipid extract from Roystonea regia fruits, in ratsR Gamez
Center for Natural Products, National Center for Scientific Research, Havana City, Cuba
Drugs Exp Clin Res 31:101-8. 2005..Thus, this dose can be considered as a nonobservable-effect dose in rats... - Effects of policosanol 20 versus 40 mg/day in the treatment of patients with type II hypercholesterolemia: a 6-month double-blind studyG Castano
Medical Surgical Research Center, National Center for Scientific Research, Havana City, Cuba
Int J Clin Pharmacol Res 21:43-57. 2001..In conclusion, although the tolerability profile remains excellent, according to the present results policosanol at a dose of 40 mg/day does not offer significant additional cholesterol-lowering efficacy over the 20 mg/day dose... - Effects of D-003, a mixture of high molecular weight aliphatic acids from sugar cane wax, on bones from ovariectomized ratsM Noa
Center for Natural Products, National Center for Scientific Research, Havana City, Cuba
Drugs Exp Clin Res 30:35-41. 2004..In conclusion, D-003 (50 and 200 mg/kg/day) prevented bone loss and decreased bone resorption in ovariectomized rats, which suggests that this substance could be promising in preventing or treating osteoporosis... - Concomitant use of policosanol and beta-blockers in older patientsG Castano
Center for Natural Products, National Center for Scientific Research, Havana City, Cuba
Int J Clin Pharmacol Res 24:65-77. 2004.... - Effects of D-003, a mixture of long-chain aliphatic primary acids, fluvastatin and the combined therapy of D-003 plus fluvastatin on the lipid profile of normocholesterolemic rabbitsS Mendoza
Center of Natural Products, National Center of Scientific Research, Havana City, Cuba
Int J Tissue React 25:81-9. 2003..Combined therapy did not improve the response of LDL-C and TC with respect to monotherapies, but induced better responses of HDL-C and triglycerides than fluvastatin alone had on HDL-C or D-003 alone had on triglycerides... - Perinatal/postnatal study of D-003, a mixture of long-chain fatty acids, in ratsM D Rodriguez
Centre of Natural Products, National Centre for Scientific Research, Cubanacan, Havana, Cuba
J Med Food 9:223-30. 2006..This peri- and postnatal study conducted with D-003 in rats indicated that treatment of the dam during late gestation and lactation did not show adversely effects on reproductive performance or fetal development over two generations... - Lack of developmental toxicity of D-003: a mixture of long-chain fatty acids in ratsM D Rodriguez
Centre of Natural Products, National Centre for Scientific Research, Ave 25 and 158 POB 6414, Cubanacan, Havana, Cuba
Food Chem Toxicol 41:89-93. 2003..It is concluded that D-003 administered up to 1000 mg/kg/day did not induce any evidence of developmental toxicity...