Caridad Zayas

Summary

Affiliation: Finlay Institute
Country: Cuba

Publications

  1. pmc Pilot scale production of the vaccine adjuvant Proteoliposome derived Cochleates (AFCo1) from Neisseria meningitidis serogroup B
    Caridad Zayas
    Finlay Institute, Ave 27 No 19805, La Lisa, Havana, Cuba, AP 16017, CP11600
    BMC Immunol 14:S4. 2013
  2. ncbi request reprint Scale up of proteoliposome derived Cochleate production
    Caridad Zayas
    Immunology Department, Finlay Institute, P O Box 16017, Havana, Cuba
    Vaccine 24:S2-94-5. 2006
  3. doi request reprint Mucosal immunization using proteoliposome and cochleate structures from Neisseria meningitidis serogroup B induce mucosal and systemic responses
    Judith Del Campo
    Immunology Department, Finlay Institute, PO Box 16017, Havana, Cuba
    Methods 49:301-8. 2009
  4. ncbi request reprint Proteliposome-derived Cochleate as an immunomodulator for nasal vaccine
    Oliver Perez
    Immunology Department, Finlay Institute, P O Box 16017, Havana, Cuba
    Vaccine 24:S2-52-3. 2006
  5. doi request reprint Intranasal administration of proteoliposome-derived cochleates from Vibrio cholerae O1 induce mucosal and systemic immune responses in mice
    Reinaldo Acevedo
    Immunology Department, Bacterial Vaccines Division of Finlay Institute, Havana, Cuba
    Methods 49:309-15. 2009
  6. ncbi request reprint Proteoliposome derived cochleate as novel adjuvant
    Gustavo Bracho
    Immunology Department, Finlay Institute, P O Box 16017, Havana, Cuba
    Vaccine 24:S2-30-1. 2006
  7. pmc Immunogenicity and cross-reactivity against Mycobacterium tuberculosis of proteoliposomes derived from Mycobacterium bovis BCG
    Fátima Reyes
    Finlay Institute Ave 27 No 19805, Havana, Cuba AP 16017, CP11600
    BMC Immunol 14:S7. 2013
  8. doi request reprint AFCo1 as nasal adjuvant of capsular polysaccharide from Neisseria meningitidis serogroup C induces systemic and mucosal immune responses
    Belkis Romeu
    Immunology Department, Havana, Cuba
    Scand J Infect Dis 43:809-13. 2011
  9. ncbi request reprint Immunological evaluation of bacterial derived Cochleate and proteoliposome as mucosal adjuvants
    Judith Del Campo
    Immunology Department, Finlay Institute, P O Box 16017, Havana, Cuba
    Vaccine 24:S2-50-1. 2006
  10. ncbi request reprint Strategy for determination of an efficient Cochleate particle size
    Danay Gil
    Immunology Department, Finlay Institute, P O Box 16017, Havana, Cuba
    Vaccine 24:S2-92-3. 2006

Collaborators

Detail Information

Publications20

  1. pmc Pilot scale production of the vaccine adjuvant Proteoliposome derived Cochleates (AFCo1) from Neisseria meningitidis serogroup B
    Caridad Zayas
    Finlay Institute, Ave 27 No 19805, La Lisa, Havana, Cuba, AP 16017, CP11600
    BMC Immunol 14:S4. 2013
    ..The adjuvant action over Neisseria (self) antigens and with co-administered (heterologous) antigens such as ovalbumin and a synthetic peptide from haemolytic Streptococcus B was also demonstrated...
  2. ncbi request reprint Scale up of proteoliposome derived Cochleate production
    Caridad Zayas
    Immunology Department, Finlay Institute, P O Box 16017, Havana, Cuba
    Vaccine 24:S2-94-5. 2006
    ..This work demonstrates that CFS is very efficient process to obtain Cochleate structures with a yield of more than 80% and the immunogenicity comparable to that obtained by dialysis membrane...
  3. doi request reprint Mucosal immunization using proteoliposome and cochleate structures from Neisseria meningitidis serogroup B induce mucosal and systemic responses
    Judith Del Campo
    Immunology Department, Finlay Institute, PO Box 16017, Havana, Cuba
    Methods 49:301-8. 2009
    ..These results support the use of AFCo1 as a potent Th1 inducing adjuvant particularly suitable for mucosal immunization...
  4. ncbi request reprint Proteliposome-derived Cochleate as an immunomodulator for nasal vaccine
    Oliver Perez
    Immunology Department, Finlay Institute, P O Box 16017, Havana, Cuba
    Vaccine 24:S2-52-3. 2006
    ..Thus, our results suggest that PL-derived Cochleate can be used as a promising immunomodulator and delivery system for the development of mucosal, particularly nasal vaccines...
  5. doi request reprint Intranasal administration of proteoliposome-derived cochleates from Vibrio cholerae O1 induce mucosal and systemic immune responses in mice
    Reinaldo Acevedo
    Immunology Department, Bacterial Vaccines Division of Finlay Institute, Havana, Cuba
    Methods 49:309-15. 2009
    ..These results show for the first time that AFCo2 can be obtained from V. cholerae O1 proteoliposomes and have the potential to protect against the pathogen when administered intranasally...
  6. ncbi request reprint Proteoliposome derived cochleate as novel adjuvant
    Gustavo Bracho
    Immunology Department, Finlay Institute, P O Box 16017, Havana, Cuba
    Vaccine 24:S2-30-1. 2006
    ..The results and the easy capability for new antigen incorporation on CS support its use as adjuvant for immunization with a large variety of pathogen derived antigens and different routes of immunization...
  7. pmc Immunogenicity and cross-reactivity against Mycobacterium tuberculosis of proteoliposomes derived from Mycobacterium bovis BCG
    Fátima Reyes
    Finlay Institute Ave 27 No 19805, Havana, Cuba AP 16017, CP11600
    BMC Immunol 14:S7. 2013
    ..Sera of immunized animals showed high IgG response and strong cross-reactivity against different MTB antigens.These results showed that BCG PLs could be potential vaccine candidates against TB...
  8. doi request reprint AFCo1 as nasal adjuvant of capsular polysaccharide from Neisseria meningitidis serogroup C induces systemic and mucosal immune responses
    Belkis Romeu
    Immunology Department, Havana, Cuba
    Scand J Infect Dis 43:809-13. 2011
    ..In summary, AFCo1 as nasal adjuvant was demonstrated to be capable of eliciting mucosal and systemic specific responses against a TI antigen...
  9. ncbi request reprint Immunological evaluation of bacterial derived Cochleate and proteoliposome as mucosal adjuvants
    Judith Del Campo
    Immunology Department, Finlay Institute, P O Box 16017, Havana, Cuba
    Vaccine 24:S2-50-1. 2006
    ..These results show that Cochleate and PL are capable of inducing both systemic and mucosal antibody responses as well as a Th1 type of immunity as evidenced by high gammaIFN and IgG2a antibody responses...
  10. ncbi request reprint Strategy for determination of an efficient Cochleate particle size
    Danay Gil
    Immunology Department, Finlay Institute, P O Box 16017, Havana, Cuba
    Vaccine 24:S2-92-3. 2006
    ..The best treatment parameter for mechanical stress of the Cochleate was prolonged treatment with untrasonic low frequency waves...
  11. ncbi request reprint Novel adjuvant based on a proteoliposome-derived cochleate structure containing native lipopolysaccharide as a pathogen-associated molecular pattern
    Oliver Perez
    Immunology Department, Finlay Institute, Havana, Cuba
    Immunol Cell Biol 82:603-10. 2004
    ..In conclusion, our results support the use of PLCS as a potent Th1 adjuvant for parenteral and mucosal vaccines...
  12. pmc Evaluation of the humoral immune response and cross reactivity against Mycobacterium tuberculosis of mice immunized with liposomes containing glycolipids of Mycobacterium smegmatis
    Reinier Borrero
    Molecular Biology Department, Finlay Institute, La Lisa, La Habana, Cuba, P O Box 16017
    BMC Immunol 14:S13. 2013
    ..The results of this study demonstrated the presence of immunogenic glycolipids in Ms, which could be included to enhance the protective effects of subunit vaccine formulations against tuberculosis...
  13. pmc Immune adjuvant effect of V. cholerae O1 derived Proteoliposome coadministered by intranasal route with Vi polysaccharide from Salmonella Typhi
    Reinaldo Acevedo
    Research and Development Vice presidency of Finlay Institute, Havana, Cuba
    BMC Immunol 14:S10. 2013
    ..In conclusion, this work demonstrates that PLc can be used as a mucosal adjuvant to potentiate the immune response against a polysaccharide antigen like Poli Vi...
  14. doi request reprint The golden era of vaccine adjuvants
    Osmir Cabrera
    Department of Immunology, Finlay Institute, PO Box 16017, Havana, Cuba
    Expert Rev Vaccines 10:1007-9. 2011
    ..This article highlights the most important issues presented...
  15. pmc AFCo1, a meningococcal B-derived cochleate adjuvant, strongly enhances antibody and T-cell immunity against Plasmodium falciparum merozoite surface protein 4 and 5
    Gustavo Bracho
    Department of Immunology, Finlay Institute, Havana City, Cuba
    Malar J 8:35. 2009
    ....
  16. doi request reprint Mucosal and systemic immune responses of mice to tetanus toxoid coadministered nasally with AFCo1
    Belkis Romeu
    Immunology Department, Finlay Institute, Calle 17 esquina 198 Rpto Siboney, Havana 11600, Cuba
    Can J Microbiol 57:256-61. 2011
    ..These data support the fact that AFCo1 is a potent mucosal adjuvant in nasal immunization to a coadministered protein antigen...
  17. ncbi request reprint Bacterial derived proteoliposome for allergy vaccines
    Miriam Lastre
    Immunology Department, Finlay Institute, P O Box 16017, Havana, Cuba
    Vaccine 24:S2-34-5. 2006
    ..The low dose was more effective than high dose. These results clearly support the potential use of PL as possible adjuvants for anti-allergic vaccines...
  18. pmc Cochleates derived from Vibrio cholerae O1 proteoliposomes: the impact of structure transformation on mucosal immunisation
    Reinaldo Acevedo
    Research and Development Vice presidency of Finlay Institute, Havana, Cuba
    PLoS ONE 7:e46461. 2012
    ....
  19. pmc Standardization of Neisseria meningitidis serogroup B colorimetric serum bactericidal assay
    Tamara Rodríguez
    Department of Basic and Clinical Immunology, Finlay Institute, 27 avenue 198 and 202, La Lisa, P O Box 16017, Havana City, Cuba
    Clin Diagn Lab Immunol 9:109-14. 2002
    ..974, P < 0.01). The standardized cSBA allows easy, fast, and efficient evaluation of samples...
  20. pmc Evaluation of specific humoral immune response and cross reactivity against Mycobacterium tuberculosis antigens induced in mice immunized with liposomes composed of total lipids extracted from Mycobacterium smegmatis
    Maria de los Angeles Garcia
    Molecular Biology Department Finlay Institute, Ave 27 No 19805, La Lisa, La Havana, Cuba, AP 16017, CP11600
    BMC Immunol 14:S11. 2013
    ..001) suggesting the expression of these antigens in vivo during active MTb infection. The results obtained provide some evidence for the potential use of liposomes containing total lipid extracts of Ms as a TB vaccine candidate...