Jorge Berlanga-Acosta

Summary

Affiliation: Center for Genetic Engineering and Biotechnology
Country: Cuba

Publications

  1. ncbi request reprint Epidermal growth factor intralesional infiltrations can prevent amputation in patients with advanced diabetic foot wounds
    Jorge Berlanga Acosta
    Division of Pharmaceutics, Center for Genetic Engineering and Biotechnology, Havana City, Cuba
    Int Wound J 3:232-9. 2006
  2. doi request reprint Expression of cell proliferation cycle negative regulators in fibroblasts of an ischemic diabetic foot ulcer. A clinical case report
    Jorge Berlanga-Acosta
    Tissue repair and cytoprotection project, Biomedical Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba
    Int Wound J 10:232-6. 2013
  3. pmc Glucose toxic effects on granulation tissue productive cells: the diabetics' impaired healing
    Jorge Berlanga-Acosta
    Tissue Repair and Cytoprotection Research Group, Center for Genetic Engineering and Biotechnology, Playa, CP 10600 Havana, Cuba
    Biomed Res Int 2013:256043. 2013
  4. doi request reprint Diabetic lower extremity wounds: the rationale for growth factors-based infiltration treatment
    Jorge Berlanga-Acosta
    Tissue Repair and Cytoprotection Research Group, Pharmaceutical Division, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Havana City, Havana, Cuba
    Int Wound J 8:612-20. 2011
  5. doi request reprint Epidermal growth factor in clinical practice - a review of its biological actions, clinical indications and safety implications
    Jorge Berlanga-Acosta
    Tissue Repair and Cyto protection Research Project, Pharmaceutical Division, Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana, Cuba
    Int Wound J 6:331-46. 2009
  6. doi request reprint The pro-inflammatory environment in recalcitrant diabetic foot wounds
    Jorge Berlanga Acosta
    Biomedical Research Direction, Pharmaceutical Division, Center for Genetic Engineering and Biotechnology, Avenida 31 e 158 y 190, Playa, PO Box 6162, Havana 10600, Cuba
    Int Wound J 5:530-9. 2008
  7. ncbi request reprint Attenuation of internal organ damages by exogenously administered epidermal growth factor (EGF) in burned rodents
    Jorge Berlanga
    Center for Genetic Engineering and Biotechnology, P O Box 6162, 10600, Havana, Cuba
    Burns 28:435-42. 2002
  8. ncbi request reprint Growth-hormone-releasing peptide 6 (GHRP6) prevents oxidant cytotoxicity and reduces myocardial necrosis in a model of acute myocardial infarction
    Jorge Berlanga
    Center for Genetic Engineering and Biotechnology, Ave 31 e 158 and 190, P O Box 6162, Cubanacan, Playa, Havana, Cuba
    Clin Sci (Lond) 112:241-50. 2007
  9. ncbi request reprint Methylglyoxal administration induces diabetes-like microvascular changes and perturbs the healing process of cutaneous wounds
    Jorge Berlanga
    Centre for Genetic Engineering and Biotechnology, Ave 31 e 158 and 190 Playa 10600, Havana, Cuba
    Clin Sci (Lond) 109:83-95. 2005
  10. doi request reprint Intra-lesional injections of recombinant human epidermal growth factor promote granulation and healing in advanced diabetic foot ulcers: multicenter, randomised, placebo-controlled, double-blind study
    José I Fernández-Montequín
    JI Fernández Montequín, MD, National Institute for Angiology and Vascular Surgery, Havana, Cuba
    Int Wound J 6:432-43. 2009

Collaborators

  • Diana Garcia Del Barco
  • Gregory S Schultz
  • Blas Y Betancourt
  • Joseph J Boyle
  • Hussam H Ajamieh
  • Paul J Thornalley
  • Enrique Montero
  • Frank Hernandez
  • Aluet Borrego
  • Ray J Playford
  • Jorge Berlanga
  • José I Fernández-Montequín
  • Pedro Lopez-Saura
  • Diana Garcia del Barco
  • Danay Cibrian
  • Jorge Berlanga Acosta
  • Gerardo Guillen
  • Jose S Alba
  • Ricardo Silva-Rodríguez
  • Elizeth García-Iglesias
  • William Savigne
  • Jorge Aguiar
  • Lourdes Morejón-Vega
  • Olga S León Fernández
  • Pedro A Lopez-Saura
  • Heriberto Artaza-Sanz
  • Ernesto López-Mola
  • Cecilio González-Benavides
  • Carmen Valenzuela-Silva
  • José Fernández-Montequin
  • Luis Herrera
  • Freya Freyre
  • Nelson Merino
  • Javier Marin
  • Héctor Pérez-Saad
  • Valia Rodríguez
  • Jorge Martin
  • Viviana Falcon
  • Mileydis Stable-Walcott
  • Envida Carballosa-Peña
  • Clara Ballagas-Flores
  • Marielis Hernández-Oria
  • Yoryana Ramírez-Sanchez
  • Karina Miranda-Hernández
  • Maria Margarita Ríos-Cabrera
  • Omar Hernández-González
  • Maria Elena Pardo-Portuondo
  • Doris Perdomo-Leyva
  • Vivian Soto-Infante
  • Janet Batista-Lorenzo
  • Jose R Ferra-Gonzalez
  • Susana Martinez
  • Irelio Borroto-Carpio
  • Natasha Sancho-Soutelo
  • Ivonne Marrero-Rodríguez
  • Leovaldo Álvarez-Falcón
  • Yaritsy Abreu-Gómez
  • Dulce Garcia-Esplugas
  • Idalín Conde-Guerra
  • Delfina Costales-Elizarde
  • Wilfredo Suárez-del Castillo
  • Maria Amparo Pascual
  • Anaísi Hernández-Borges
  • Jorge L Valdés-Nápoles
  • Andrés Lamas-Acevedo
  • Ana Gloria Alfonso-León
  • Mireya Alonso-Rios
  • Martha Hernandez-Miranda
  • Osmel Castillo-Luque
  • Agustín Llanes
  • Carlos M Hernández-Cañete
  • Marta Péérez-Linares
  • Mirta Domínguez-Salgueras
  • Sandra Durañones-Góóngora
  • Luis Thaureaux-Montes de Oca
  • Martina Garcia-Insua
  • Ledis Garbey-Delas
  • Nancy Ramírez-Martínez
  • Jorge A Silva-Valido
  • Grisel Soto-Arguelles
  • Miriam Avila-Nuñez
  • Nancy Machin-González
  • Marta M Moreira-Martinez
  • Enf Nixia Salas-Ge
  • Magalys de la Barca-Barrera
  • Rider Hernández-Martínez
  • Maydel de la C Armas-Ramírez
  • Julia Zapata-Vinent
  • Francisco A Váázquez-Milanes
  • Marianela Garcia

Detail Information

Publications20

  1. ncbi request reprint Epidermal growth factor intralesional infiltrations can prevent amputation in patients with advanced diabetic foot wounds
    Jorge Berlanga Acosta
    Division of Pharmaceutics, Center for Genetic Engineering and Biotechnology, Havana City, Cuba
    Int Wound J 3:232-9. 2006
    ..5 +/- 4.9 days. Wound recurrence after 1 year of follow-up appeared in only one patient. Preliminary evidences suggest that EGF intralesional infiltrations may be effective in reducing diabetic lower limb amputation...
  2. doi request reprint Expression of cell proliferation cycle negative regulators in fibroblasts of an ischemic diabetic foot ulcer. A clinical case report
    Jorge Berlanga-Acosta
    Tissue repair and cytoprotection project, Biomedical Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba
    Int Wound J 10:232-6. 2013
    ..We postulate that the downregulation of the Akt/mTOR/cyclin D1 axis by the proximal activation of p53 and p21 due to stressor factors, impose an arrest/pro-senescence programme that translated in a torpid and slow healing process...
  3. pmc Glucose toxic effects on granulation tissue productive cells: the diabetics' impaired healing
    Jorge Berlanga-Acosta
    Tissue Repair and Cytoprotection Research Group, Center for Genetic Engineering and Biotechnology, Playa, CP 10600 Havana, Cuba
    Biomed Res Int 2013:256043. 2013
    ..Ulcer prevention by primary care surveillance, education, and attention programs is of outmost importance to reduce worldwide amputation figures...
  4. doi request reprint Diabetic lower extremity wounds: the rationale for growth factors-based infiltration treatment
    Jorge Berlanga-Acosta
    Tissue Repair and Cytoprotection Research Group, Pharmaceutical Division, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Havana City, Havana, Cuba
    Int Wound J 8:612-20. 2011
    ..Ten years of clinical experience have validated laboratory and theoretical concepts, while most importantly have improved quality-of-life to thousands of diabetic patients...
  5. doi request reprint Epidermal growth factor in clinical practice - a review of its biological actions, clinical indications and safety implications
    Jorge Berlanga-Acosta
    Tissue Repair and Cyto protection Research Project, Pharmaceutical Division, Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana, Cuba
    Int Wound J 6:331-46. 2009
    ..The ability of EGF to heal injured tissues in life-threatening scenarios or to assist in preventing physical and social disability advocates for its clinical use under a rational medical risk/benefit balance...
  6. doi request reprint The pro-inflammatory environment in recalcitrant diabetic foot wounds
    Jorge Berlanga Acosta
    Biomedical Research Direction, Pharmaceutical Division, Center for Genetic Engineering and Biotechnology, Avenida 31 e 158 y 190, Playa, PO Box 6162, Havana 10600, Cuba
    Int Wound J 5:530-9. 2008
    ..These medical interventions are demanded to reduce amputations in an expanding diabetic population...
  7. ncbi request reprint Attenuation of internal organ damages by exogenously administered epidermal growth factor (EGF) in burned rodents
    Jorge Berlanga
    Center for Genetic Engineering and Biotechnology, P O Box 6162, 10600, Havana, Cuba
    Burns 28:435-42. 2002
    ..These data indicate the salutary effects of EGF by attenuating internal complications associated to thermal injuries. Further studies are warranted to fully elucidate the usefulness of this therapy...
  8. ncbi request reprint Growth-hormone-releasing peptide 6 (GHRP6) prevents oxidant cytotoxicity and reduces myocardial necrosis in a model of acute myocardial infarction
    Jorge Berlanga
    Center for Genetic Engineering and Biotechnology, Ave 31 e 158 and 190, P O Box 6162, Cubanacan, Playa, Havana, Cuba
    Clin Sci (Lond) 112:241-50. 2007
    ..01). In conclusion, GHRP6 exhibits antioxidant effects which may partially contribute to reduce myocardial ischaemic damage...
  9. ncbi request reprint Methylglyoxal administration induces diabetes-like microvascular changes and perturbs the healing process of cutaneous wounds
    Jorge Berlanga
    Centre for Genetic Engineering and Biotechnology, Ave 31 e 158 and 190 Playa 10600, Havana, Cuba
    Clin Sci (Lond) 109:83-95. 2005
    ..We conclude that exposure to increased MG in vivo is associated with the onset of microvascular damage and other diabetes-like complications within a normoglycaemic context...
  10. doi request reprint Intra-lesional injections of recombinant human epidermal growth factor promote granulation and healing in advanced diabetic foot ulcers: multicenter, randomised, placebo-controlled, double-blind study
    José I Fernández-Montequín
    JI Fernández Montequín, MD, National Institute for Angiology and Vascular Surgery, Havana, Cuba
    Int Wound J 6:432-43. 2009
    ..Most adverse events were mild and no drug-related severe adverse reactions were reported. It was concluded that recombinant human EGF (rhEGF) local injections offer a favourable risk-benefit balance in patients with advanced DFU...
  11. ncbi request reprint Intralesional injections of Citoprot-P (recombinant human epidermal growth factor) in advanced diabetic foot ulcers with risk of amputation
    José I Fernández-Montequín
    Service of Diabetic Microangiopathy, National Institute for Angiology and Vascular Surgery, Havana, Cuba
    Int Wound J 4:333-43. 2007
    ..The most frequent were sepsis (33%), burning sensation (29%), tremors, chills and local pain (25% each). rhEGF local injection enhances advanced DFU healing and reduces the risk of major amputation. No dose dependency was observed...
  12. doi request reprint Boosting controlled autoimmunity: a new therapeutic target for CNS disorders
    Diana Garcia del Barco
    Center for Genetic Engineering and Biotechnology, Avenue 31 e 158 and 190, PO Box 6162, Cubancan, Playa 10600, Havana City, Cuba
    Expert Rev Neurother 8:819-25. 2008
    ..Understanding the regulation of protective autoimmunity within the CNS is likely to lead to novel therapeutic approaches to neuroinflammatory and neurodegenerative diseases...
  13. ncbi request reprint Ubiquitous expression of human SCA2 gene under the regulation of the SCA2 self promoter cause specific Purkinje cell degeneration in transgenic mice
    Jorge Aguiar
    Department of Gene Therapy, Division of Pharmaceutics, Center for Genetic Engineering and Biotechnology, CIGB, Ave 31 between 158 and 190, Havana City, CP 10 600 Havana, Cuba
    Neurosci Lett 392:202-6. 2006
    ..Specific degeneration of Purkinje neurons and transgene over-expression in the brain, liver and skeletal muscle, rather than in lungs and kidneys was also observed, resembling the expression pattern of the ataxin 2 in humans...
  14. doi request reprint Therapeutic effect of the combined use of growth hormone releasing peptide-6 and epidermal growth factor in an axonopathy model
    Diana Garcia del Barco
    Center for Genetic Engineering and Biotechnology, Ave 31 e 158 and 190, Cubanacan, Playa P O Box 6162, 10600 Havana, Cuba
    Neurotox Res 19:195-209. 2011
    ..The latter results confirm the proximal character of 1,2 DAB neuropathy, and suggest that combined therapy with EGF and GHRP-6 might be a good therapeutic strategy for the treatment of ALS...
  15. doi request reprint Intralesional administration of epidermal growth factor-based formulation (Heberprot-P) in chronic diabetic foot ulcer: treatment up to complete wound closure
    José I Fernández-Montequín
    National Institute for Angiology and Vascular Surgery, Havana, Cuba
    Int Wound J 6:67-72. 2009
    ..The therapeutic scheme of intralesional Heberprot-P administration up to complete closure can be safe and suitable to improve the therapeutic goal in terms of healing of chronic DFU...
  16. ncbi request reprint Use of growth-hormone-releasing peptide-6 (GHRP-6) for the prevention of multiple organ failure
    Danay Cibrian
    Center for Genetic Engineering and Biotechnology, Ave 31 e 158 and 190 Playa 10600, Havana, Cuba
    Clin Sci (Lond) 110:563-73. 2006
    ..In view of these findings, further studies appear justified...
  17. ncbi request reprint Ozone oxidative preconditioning is mediated by A1 adenosine receptors in a rat model of liver ischemia/ reperfusion
    Olga S León Fernández
    Center for Research and Biological Evaluation CIEB IFAL, University of Havana, Havana, Cuba
    Transpl Int 21:39-48. 2008
    ..NO produced by OzoneOP may play a role in the pathways of cellular signalling which promote preservation of the cellular redox balance, mitochondrial function, glutathione pools as well as the regulation of NF-kappaB and HSP-70...
  18. pmc Prophylactic use of epidermal growth factor reduces ischemia/reperfusion intestinal damage
    Jorge Berlanga
    Center for Genetic Engineering and Biotechnology, Havana, Cuba
    Am J Pathol 161:373-9. 2002
    ..These studies provide preliminary evidence that EGF is a novel therapy for the early treatment or prevention of intestinal damage and multiorgan failure resulting from mesenteric hypoperfusion...
  19. ncbi request reprint Role of protein synthesis in the protection conferred by ozone-oxidative-preconditioning in hepatic ischaemia/reperfusion
    Hussam H Ajamieh
    Center for Research and Biological Evaluation CIEB IFAL, University of Havana, Havana, Cuba
    Transpl Int 18:604-12. 2005
    ..Cellular redox balance disappeared when CHX was introduced. Protein synthesis is involved in the protective mechanisms mediated by OzoneOP. Ozone treatment preserved mitochondrial functions and cellular redox balance...
  20. ncbi request reprint Ozone/oxygen mixture modifies the subcellular redistribution of Bax protein in renal tissue from rats treated with cisplatin
    Aluet Borrego
    National Laboratory for the Control of Drugs, Center for the Control and Development of Drugs, Havana, Cuba
    Arch Med Res 37:717-22. 2006
    ..r.) ozone/oxygen mixture protected and induced a significant recovery in cisplatin-induced renal damage and was related to a significant increase in the antioxidant system in renal tissue...