Marc Cruts

Summary

Publications

  1. pmc Locus-specific mutation databases for neurodegenerative brain diseases
    Marc Cruts
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium
    Hum Mutat 33:1340-4. 2012
  2. ncbi request reprint Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family
    Nathalie Brouwers
    VIB Department of Molecular Genetics, Neurodegenerative Brain Diseases Group, University of Antwerp CDE, Universiteitsplein 1, BE 2610 Antwerpen, Belgium
    Arch Neurol 64:1436-46. 2007
  3. doi request reprint Distinct clinical characteristics of C9orf72 expansion carriers compared with GRN, MAPT, and nonmutation carriers in a Flanders-Belgian FTLD cohort
    Tim Van Langenhove
    VIB Department of Molecular Genetics, Neurodegenerative Brain Diseases Group, University of Antwerp CDE, Universiteitsplein 1, Antwerp, Belgium
    JAMA Neurol 70:365-73. 2013
  4. pmc Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample
    Rosa Rademakers
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerp, Belgium
    Am J Hum Genet 77:643-52. 2005
  5. doi request reprint Contribution of TARDBP to Alzheimer's disease genetic etiology
    Nathalie Brouwers
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium
    J Alzheimers Dis 21:423-30. 2010
  6. ncbi request reprint Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21
    Marc Cruts
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Universiteitsplein 1, BE 2610 Antwerpen, Belgium
    Nature 442:920-4. 2006
  7. ncbi request reprint Characterization of ubiquitinated intraneuronal inclusions in a novel Belgian frontotemporal lobar degeneration family
    Daniel Pirici
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology (VIB8, Institute Born-Bunge, University of Antwerp, Belgium
    J Neuropathol Exp Neurol 65:289-301. 2006
  8. ncbi request reprint A Belgian ancestral haplotype harbours a highly prevalent mutation for 17q21-linked tau-negative FTLD
    Julie van der Zee
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium
    Brain 129:841-52. 2006
  9. doi request reprint Serum biomarker for progranulin-associated frontotemporal lobar degeneration
    Kristel Sleegers
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB Flanders Institute for Biotechnology, University of Antwerp, Universiteitsplein 1, Antwerp, Belgium
    Ann Neurol 65:603-9. 2009
  10. doi request reprint Ataxin-2 polyQ expansions in FTLD-ALS spectrum disorders in Flanders-Belgian cohorts
    Tim Van Langenhove
    Department of Molecular Genetics, VIB, Universiteitsplein 1, Antwerpen, Belgium
    Neurobiol Aging 33:1004.e17-20. 2012

Collaborators

Detail Information

Publications35

  1. pmc Locus-specific mutation databases for neurodegenerative brain diseases
    Marc Cruts
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium
    Hum Mutat 33:1340-4. 2012
    ..Finally, with the exception of the PD genes PARK2 and PINK1, all other genes are associated with more than one clinical diagnosis or characteristics thereof...
  2. ncbi request reprint Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family
    Nathalie Brouwers
    VIB Department of Molecular Genetics, Neurodegenerative Brain Diseases Group, University of Antwerp CDE, Universiteitsplein 1, BE 2610 Antwerpen, Belgium
    Arch Neurol 64:1436-46. 2007
    ..Progranulin gene (PGRN) haploinsufficiency was recently associated with ubiquitin-positive frontotemporal lobar degeneration linked to chromosome 17q21 (FTLDU-17)...
  3. doi request reprint Distinct clinical characteristics of C9orf72 expansion carriers compared with GRN, MAPT, and nonmutation carriers in a Flanders-Belgian FTLD cohort
    Tim Van Langenhove
    VIB Department of Molecular Genetics, Neurodegenerative Brain Diseases Group, University of Antwerp CDE, Universiteitsplein 1, Antwerp, Belgium
    JAMA Neurol 70:365-73. 2013
    ....
  4. pmc Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample
    Rosa Rademakers
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerp, Belgium
    Am J Hum Genet 77:643-52. 2005
    ....
  5. doi request reprint Contribution of TARDBP to Alzheimer's disease genetic etiology
    Nathalie Brouwers
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium
    J Alzheimers Dis 21:423-30. 2010
    ..In conclusion, the genetic contribution of TARDBP to AD was restricted to the rare mutation p.Ala90Val (3/739, 0.4%) of unclear pathogenic nature that affects the nuclear localization signal in TDP-43...
  6. ncbi request reprint Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21
    Marc Cruts
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Universiteitsplein 1, BE 2610 Antwerpen, Belgium
    Nature 442:920-4. 2006
    ..Furthermore, in a Belgian series of familial FTD patients, PGRN mutations were 3.5 times more frequent than mutations in MAPT, underscoring a principal involvement of PGRN in FTD pathogenesis...
  7. ncbi request reprint Characterization of ubiquitinated intraneuronal inclusions in a novel Belgian frontotemporal lobar degeneration family
    Daniel Pirici
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology (VIB8, Institute Born-Bunge, University of Antwerp, Belgium
    J Neuropathol Exp Neurol 65:289-301. 2006
    ..Whereas the precise nature of the protein remains elusive, characterization of such familial FTLD-U patients would be helpful in identifying a common denominator in the pathogenesis of familial and the more prevalent sporadic FTLD-U...
  8. ncbi request reprint A Belgian ancestral haplotype harbours a highly prevalent mutation for 17q21-linked tau-negative FTLD
    Julie van der Zee
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium
    Brain 129:841-52. 2006
    ..Together, these results strongly suggest that the DR2-DR8 founder haplotype at 17q21 harbours a tau-negative FTLD causing mutation that is a much more frequent cause of FTLD in Belgium than MAPT mutations...
  9. doi request reprint Serum biomarker for progranulin-associated frontotemporal lobar degeneration
    Kristel Sleegers
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB Flanders Institute for Biotechnology, University of Antwerp, Universiteitsplein 1, Antwerp, Belgium
    Ann Neurol 65:603-9. 2009
    ..Mutations that lead to a loss of progranulin (PGRN) explain a considerable portion of the occurrence of frontotemporal lobar degeneration. We tested a biomarker allowing rapid detection of a loss of PGRN...
  10. doi request reprint Ataxin-2 polyQ expansions in FTLD-ALS spectrum disorders in Flanders-Belgian cohorts
    Tim Van Langenhove
    Department of Molecular Genetics, VIB, Universiteitsplein 1, Antwerpen, Belgium
    Neurobiol Aging 33:1004.e17-20. 2012
    ..Our results provide further support to the notion that ATXN2 associated polyglutamine amplification is specific to the ALS-end of the FTLD-ALS disease spectrum...
  11. ncbi request reprint Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia
    Julie van der Zee
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium
    Hum Mutat 28:416. 2007
    ..Our findings extend the mutation spectrum in PGRN leading to loss of functional PGRN as the basis for FTD...
  12. ncbi request reprint Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40
    Samir Kumar-Singh
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute of Biotechnology, University of Antwerp, Antwerpen, Belgium
    Hum Mutat 27:686-95. 2006
    ..Also, the in vitro method we describe here is a valid tool for assaying the pathogenic potential of clinical PSEN mutations in a molecular diagnostic setting...
  13. doi request reprint Identification of 2 Loci at chromosomes 9 and 14 in a multiplex family with frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Ilse Gijselinck
    University of Antwerp, B 2610 Antwerp, Belgium
    Arch Neurol 67:606-16. 2010
    ..Frontotemporal lobar degeneration (FTLD) is a neurodegenerative brain disorder that can be accompanied by signs of amyotrophic lateral sclerosis (ALS)...
  14. ncbi request reprint High-density SNP haplotyping suggests altered regulation of tau gene expression in progressive supranuclear palsy
    Rosa Rademakers
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Belgium
    Hum Mol Genet 14:3281-92. 2005
    ..Thus, risk variants on different H1 htSNP haplotypes and protective variants on H2 contribute to population risk for PSP...
  15. ncbi request reprint Frontotemporal lobar degeneration with ubiquitin-positive inclusions: a molecular genetic update
    Julie van der Zee
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Laboratory of Neurogenetics, Institute Born Bunge, and University of Antwerp, Antwerp, Belgium
    Neurodegener Dis 4:227-35. 2007
    ..This review focuses on the molecular genetic processes underlying FTLD-U pathology...
  16. pmc The genetics and neuropathology of frontotemporal lobar degeneration
    Anne Sieben
    Institute Born Bunge, University of Antwerp, Antwerpen, Belgium
    Acta Neuropathol 124:353-72. 2012
    ..In this review, we summarize the current state of the rapidly progressing field of genetic, neuropathological and clinical research of this intriguing condition...
  17. ncbi request reprint Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
    Ilse Gijselinck
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Belgium
    Neurobiol Aging 30:1329-31. 2009
    ..Our data implicate that TDP-43 has no primary genetic role in the pathophysiological mechanisms underlying central nervous system neurodegeneration in these diseases...
  18. ncbi request reprint Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum
    Bart Dermaut
    Department of Molecular Genetics (VIB 8, Flanders Interuniversity Institute for Biotechnology, Neurodegenerative Brain Diseases Group, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, B-2610 Antwerpen, Belgium
    Trends Genet 21:664-72. 2005
    ..Together, these studies suggest that AD and FTD are linked in a genetic spectrum of presenile degenerative brain disorders in which tau appears to be the central player...
  19. ncbi request reprint Alzheimer-associated C allele of the promoter polymorphism -22C>T causes a critical neuron-specific decrease of presenilin 1 expression
    Jessie Theuns
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Hum Mol Genet 12:869-77. 2003
    ..Together, these studies provide evidence that the increased risk for AD associated with PSEN1 may result from genetic variations in the regulatory region, leading to altered expression levels of PSEN1 in neurons...
  20. doi request reprint A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study
    Ilse Gijselinck
    Department of Molecular Genetics, VIB, Antwerp, Belgium
    Lancet Neurol 11:54-65. 2012
    ..A locus on chromosome 9p21 has been associated with both disorders, and we aimed to identify the causal gene within this region...
  21. doi request reprint C9orf72 G4C2 repeat expansions in Alzheimer's disease and mild cognitive impairment
    Rita Cacace
    Department of Molecular Genetics, VIB, Antwerp, Belgium
    Neurobiol Aging 34:1712.e1-7. 2013
    ..Non-pathogenic repeat length variability did not affect risk of AD or MCI, nor AD biomarker levels in CSF, indicating that C9orf72 is not a direct AD risk factor...
  22. ncbi request reprint Genomic architecture of human 17q21 linked to frontotemporal dementia uncovers a highly homologous family of low-copy repeats in the tau region
    Marc Cruts
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium
    Hum Mol Genet 14:1753-62. 2005
    ..The presence of multiple homologous LCRs in the region predicts that other potentially more complex genomic rearrangements might be underlying FTDU-17...
  23. ncbi request reprint PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease
    Bart Dermaut
    Department of Molecular Genetics, Flanders Interuniversity Institute of Biotechnology VIB8, University of Antwerp, Antwerpen, Belgium
    Ann Neurol 53:409-12. 2003
    ..2; 95% CI, 1.4-7.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.3-5.3; p < 0.01) and 3.5 (95% CI, 1.3-9.3; p = 0.01), respectively...
  24. ncbi request reprint Progranulin mutations in ubiquitin-positive frontotemporal dementia linked to chromosome 17q21
    Marc Cruts
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium
    Curr Alzheimer Res 3:485-91. 2006
    ..These findings open promising novel targets for therapeutic intervention against neurodegeneration...
  25. pmc A pan-European study of the C9orf72 repeat associated with FTLD: geographic prevalence, genomic instability, and intermediate repeats
    Julie van der Zee
    Department of Molecular Genetics, VIB, Antwerp, Belgium
    Hum Mutat 34:363-73. 2013
    ..001) with the most common indel creating one long contiguous imperfect G(4) C(2) repeat, which is likely more prone to replication slippage and pathological expansion...
  26. ncbi request reprint A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques
    Bart Dermaut
    Department of Molecular Genetics, Flanders Interuniversity Institute of Biotechnology VIB8, University of Antwerp, Antwerpen, Belgium
    Ann Neurol 55:617-26. 2004
    ..Our results suggest PS1 as a candidate gene for Pick-type tauopathy without MAPT mutations...
  27. doi request reprint Molecular pathways of frontotemporal lobar degeneration
    Kristel Sleegers
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Universiteitsplein 1, B 2610 Antwerpen, Belgium
    Annu Rev Neurosci 33:71-88. 2010
    ..g., the role of FUS in amyotrophic lateral sclerosis...
  28. pmc Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update
    Karen Nuytemans
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium
    Hum Mutat 31:763-80. 2010
    ....
  29. doi request reprint Loss of progranulin function in frontotemporal lobar degeneration
    Marc Cruts
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium
    Trends Genet 24:186-94. 2008
    ..The high variability in onset age and age-dependent penetrance suggests that the PGRN pathway is highly susceptible to modulating factors that might be exploited to delay the disease processes...
  30. doi request reprint Explorative genetic study of UBQLN2 and PFN1 in an extended Flanders-Belgian cohort of frontotemporal lobar degeneration patients
    Lubina Dillen
    Department of Molecular Genetics, VIB, Antwerp, Belgium
    Neurobiol Aging 34:1711.e1-5. 2013
    ..P440L carrier's mother (67 years). No mutations were observed in PFN1. In summary, we conclude that genetic variations in UBQLN2 and PFN1 in a predominantly Flanders-Belgian cohort of FTLD and ALS patients are extremely rare...
  31. pmc novoSNP, a novel computational tool for sequence variation discovery
    Stefan Weckx
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium
    Genome Res 15:436-42. 2005
    ....
  32. ncbi request reprint Genetics of early-onset Alzheimer dementia
    Rosa Rademakers
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology (VIB, University of Antwerp, Antwerpen, Belgium
    ScientificWorldJournal 3:497-519. 2003
    ..Now, transgenic mice are produced to study the influence of EOAD mutations in vivo, eventually leading to the development of novel therapeutic strategies...
  33. ncbi request reprint Molecular pathogenesis of frontotemporal lobar degeneration: basic science seminar in neurology
    Kristel Sleegers
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Institute for Biotechnology, Flanders, and Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium
    Arch Neurol 65:700-4. 2008
  34. doi request reprint The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects
    Kristel Sleegers
    Neurodegenerative Brain Diseases Group, VIB Department of Molecular Genetics Universiteitsplein 1, B 2610 Antwerp, Belgium
    Trends Genet 26:84-93. 2010
    ..We discuss how these and future findings can be translated into efforts to ameliorate patient care by genetic profiling for risk prediction and pharmacogenetics and by guiding drug development...
  35. pmc The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample
    Bart Dermaut
    Department of Molecular Genetics, University of Antwerp, Universiteitsplein 1, B 2610 Antwerpen, Belgium
    Am J Hum Genet 70:1568-74. 2002
    ..1; 95% confidence interval 1.2-13.3; P=.01). These results are compatible with an important role of gamma-secretase dysfunction in the etiology of familial EOAD...