Glenn Cruse

Summary

Publications

  1. pmc A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells
    Glenn Cruse
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 38:906-17. 2013
  2. pmc A novel FcεRIβ-chain truncation regulates human mast cell proliferation and survival
    Glenn Cruse
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, Glenfield Hospital, University of Leicester, Leicester, UK
    FASEB J 24:4047-57. 2010
  3. pmc Functional KCa3.1 K+ channels are required for human lung mast cell migration
    G Cruse
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Thorax 61:880-5. 2006
  4. doi request reprint Human lung mast cells mediate pneumococcal cell death in response to activation by pneumolysin
    Glenn Cruse
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester Medical School, Leicester, United Kingdom
    J Immunol 184:7108-15. 2010
  5. doi request reprint Counterregulation of beta(2)-adrenoceptor function in human mast cells by stem cell factor
    Glenn Cruse
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 125:257-63.e1-5. 2010
  6. pmc IgE alone promotes human lung mast cell survival through the autocrine production of IL-6
    Glenn Cruse
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester and Warwick Medical School, University of Leicester, University Road, Leicester, LE1 9HN, UK
    BMC Immunol 9:2. 2008
  7. ncbi request reprint Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6
    Fay Hollins
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester Medical School, United Kingdom
    J Immunol 181:2772-80. 2008
  8. ncbi request reprint Mast cells promote airway smooth muscle cell differentiation via autocrine up-regulation of TGF-beta 1
    Lucy Woodman
    Institute for Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, Leicester, United Kingdom
    J Immunol 181:5001-7. 2008
  9. pmc Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration
    S Mark Duffy
    The Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, UK
    Eur J Immunol 38:2548-56. 2008
  10. pmc Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor
    S Mark Duffy
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, and Glenfield Hospital, Leicester, UK
    Eur J Immunol 37:1653-62. 2007

Collaborators

Detail Information

Publications15

  1. pmc A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells
    Glenn Cruse
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 38:906-17. 2013
    ..Because t-FcεRIβ has this critical function, it represents a therapeutic target for the downregulation of allergic inflammation...
  2. pmc A novel FcεRIβ-chain truncation regulates human mast cell proliferation and survival
    Glenn Cruse
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, Glenfield Hospital, University of Leicester, Leicester, UK
    FASEB J 24:4047-57. 2010
    ..By understanding the mechanisms regulating its function, it might be possible to induce its expression in mast cells in vivo, which could lead to better treatments for diseases such as mastocytosis and asthma...
  3. pmc Functional KCa3.1 K+ channels are required for human lung mast cell migration
    G Cruse
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Thorax 61:880-5. 2006
    ..A study was undertaken to test the hypothesis that blockade of K(Ca)3.1 would attenuate HLMC proliferation and migration...
  4. doi request reprint Human lung mast cells mediate pneumococcal cell death in response to activation by pneumolysin
    Glenn Cruse
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester Medical School, Leicester, United Kingdom
    J Immunol 184:7108-15. 2010
    ..This suggests that mast cells provide an early warning system and potentially limit pneumococcal dissemination early in the course of invasive pulmonary pneumococcal disease...
  5. doi request reprint Counterregulation of beta(2)-adrenoceptor function in human mast cells by stem cell factor
    Glenn Cruse
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 125:257-63.e1-5. 2010
    ..Short-acting beta(2)-adrenoceptor drugs such as albuterol inhibit human lung mast cell (HLMC) degranulation in vitro in the absence of SCF, but their effect in the presence of SCF is not known...
  6. pmc IgE alone promotes human lung mast cell survival through the autocrine production of IL-6
    Glenn Cruse
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester and Warwick Medical School, University of Leicester, University Road, Leicester, LE1 9HN, UK
    BMC Immunol 9:2. 2008
    ..In this study we have examined whether IgE alone enhances human lung mast cell (HLMC) survival...
  7. ncbi request reprint Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6
    Fay Hollins
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester Medical School, United Kingdom
    J Immunol 181:2772-80. 2008
    ..Targeting these interactions in asthma might offer a new strategy for the treatment of this common disease...
  8. ncbi request reprint Mast cells promote airway smooth muscle cell differentiation via autocrine up-regulation of TGF-beta 1
    Lucy Woodman
    Institute for Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, Leicester, United Kingdom
    J Immunol 181:5001-7. 2008
    ....
  9. pmc Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration
    S Mark Duffy
    The Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, UK
    Eur J Immunol 38:2548-56. 2008
    ..1 in HLMC and attenuates both chemokine- and PGE(2)-dependent HLMC migration. EP(2) receptor agonists with K(Ca)3.1 modulating function may be useful for the treatment of mast cell-mediated disease...
  10. pmc Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor
    S Mark Duffy
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, and Glenfield Hospital, Leicester, UK
    Eur J Immunol 37:1653-62. 2007
    ..1, providing a clearly defined mechanism by which adenosine inhibits HLMC migration and degranulation. A2A receptor agonists with channel-modulating function may be useful for the treatment of mast cell-mediated disease...
  11. ncbi request reprint The K+ channel iKCA1 potentiates Ca2+ influx and degranulation in human lung mast cells
    S Mark Duffy
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester Medical School, UK
    J Allergy Clin Immunol 114:66-72. 2004
    ..This channel is predicted to enhance IgE-dependent mast cell responses...
  12. ncbi request reprint Beta2-adrenoceptor regulation of the K+ channel iKCa1 in human mast cells
    S Mark Duffy
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
    FASEB J 19:1006-8. 2005
    ..Furthermore, the degree of constitutive beta2-receptor "tone" may control the threshold for human mast cell activation through the regulation of iKCa1...
  13. pmc Functional KCa3.1 K+ channels are required for human fibrocyte migration
    Glenn Cruse
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 128:1303-1309.e2. 2011
    ..Targeting fibrocyte migration might therefore offer a new approach for the treatment of these diseases. Ion channels play key roles in cell function, but the ion-channel repertoire of human fibrocytes is unknown...
  14. pmc IL-13 expression by blood T cells and not eosinophils is increased in asthma compared to non-asthmatic eosinophilic bronchitis
    Salman Siddiqui
    Institute of Lung Health, University of Leicester, Leicester, UK
    BMC Pulm Med 9:34. 2009
    ..In asthma interleukin (IL)-13 is increased in the airway compared with non-asthmatic eosinophilic bronchitis. Whether this differential expression is specific to the airway or is more generalised is uncertain...
  15. ncbi request reprint KCa3.1 Ca2+ activated K+ channels regulate human airway smooth muscle proliferation
    Malcolm C Shepherd
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom
    Am J Respir Cell Mol Biol 37:525-31. 2007
    ..1 channels in HASM cells. In addition, we have shown that K(Ca)3.1 channels are important in HASM cell proliferation, making these channels a potential therapeutic target in airway remodeling...