Cleo L Crunelle

Summary

Publications

  1. ncbi request reprint Hair ethyl glucuronide as a biomarker of alcohol consumption in alcohol-dependent patients: role of gender differences
    Cleo L Crunelle
    Toxicological Center, University of Antwerp, Universiteitsplein 1, B2610 Antwerp, Belgium Electronic address
    Drug Alcohol Depend 141:163-6. 2014
  2. ncbi request reprint Hair ethyl glucuronide levels as a marker for alcohol use and abuse: a review of the current state of the art
    Cleo L Crunelle
    Toxicological Centre, University of Antwerp, Universiteitsplein 1, B2610 Antwerp, Belgium Collaborative Antwerp Psychiatric Research Institute CAPRI, University of Antwerp, Universiteitsplein 1, B2610 Antwerp, Belgium Electronic address
    Drug Alcohol Depend 134:1-11. 2014
  3. doi request reprint Impulsivity in adult ADHD patients with and without cocaine dependence
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Drug Alcohol Depend 129:18-24. 2013
  4. ncbi request reprint Low dopamine transporter occupancy by methylphenidate as a possible reason for reduced treatment effectiveness in ADHD patients with cocaine dependence
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research, Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Collaborative Antwerp Psychiatric Research Institute CAPRI, University of Antwerp, Antwerp, Belgium Electronic address
    Eur Neuropsychopharmacol 23:1714-23. 2013
  5. doi request reprint Varenicline increases in vivo striatal dopamine D2/3 receptor binding: an ultra-high-resolution pinhole [123I]IBZM SPECT study in rats
    Cleo L Crunelle
    Department of Psychiatry and Amsterdam Institute for Addiction Research, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Nucl Med Biol 39:640-4. 2012
  6. doi request reprint The nicotinic acetylcholine receptor partial agonist varenicline and the treatment of drug dependence: a review
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 20:69-79. 2010
  7. ncbi request reprint Reduced striatal brain volumes in non-medicated adult ADHD patients with comorbid cocaine dependence
    Guido A van Wingen
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Drug Alcohol Depend 131:198-203. 2013
  8. doi request reprint Dose-dependent and sustained effects of varenicline on dopamine D2/3 receptor availability in rats
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 21:205-10. 2011
  9. pmc Cannabinoid-1 receptor antagonist rimonabant (SR141716) increases striatal dopamine D2 receptor availability
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, the Netherlands Department of Neuropharmacology, Brain Research Institute, University of Bremen, Germany Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Addict Biol 18:908-11. 2013
  10. ncbi request reprint Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD
    Cleo L Crunelle
    Cleo L Crunelle, PhD, Collaborative Antwerp Psychiatric Research Institute CAPRI, University of Antwerp, Belgium Amsterdam Institute for Addiction Research and Departments of Psychiatry and Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands Wim van den Brink, MD, PhD, Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands Geert Dom, MD, PhD, Collaborative Antwerp Psychiatric Research Institute CAPRI, University of Antwerp, and Psychiatric Centre Alexian Brothers, Boechout, Belgium Jan Booij, MD, PhD, Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Br J Psychiatry 204:486-7. 2014

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Hair ethyl glucuronide as a biomarker of alcohol consumption in alcohol-dependent patients: role of gender differences
    Cleo L Crunelle
    Toxicological Center, University of Antwerp, Universiteitsplein 1, B2610 Antwerp, Belgium Electronic address
    Drug Alcohol Depend 141:163-6. 2014
    ..A correlation between drinking behavior and EtG hair concentrations is observed, but large variability exists...
  2. ncbi request reprint Hair ethyl glucuronide levels as a marker for alcohol use and abuse: a review of the current state of the art
    Cleo L Crunelle
    Toxicological Centre, University of Antwerp, Universiteitsplein 1, B2610 Antwerp, Belgium Collaborative Antwerp Psychiatric Research Institute CAPRI, University of Antwerp, Universiteitsplein 1, B2610 Antwerp, Belgium Electronic address
    Drug Alcohol Depend 134:1-11. 2014
    ..Ethyl glucuronide (EtG) is a minor alcohol metabolite that has been proposed as a stable marker in hair to detect and quantify alcohol consumption over long time periods...
  3. doi request reprint Impulsivity in adult ADHD patients with and without cocaine dependence
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Drug Alcohol Depend 129:18-24. 2013
    ..However, very little is known about differences in impulse control and other cognitive functions between ADHD patients with and without SUD...
  4. ncbi request reprint Low dopamine transporter occupancy by methylphenidate as a possible reason for reduced treatment effectiveness in ADHD patients with cocaine dependence
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research, Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Collaborative Antwerp Psychiatric Research Institute CAPRI, University of Antwerp, Antwerp, Belgium Electronic address
    Eur Neuropsychopharmacol 23:1714-23. 2013
    ..This trial is registered at the Dutch Trial Register, www.trialregister.nl, under Trial ID number NTR3127. ..
  5. doi request reprint Varenicline increases in vivo striatal dopamine D2/3 receptor binding: an ultra-high-resolution pinhole [123I]IBZM SPECT study in rats
    Cleo L Crunelle
    Department of Psychiatry and Amsterdam Institute for Addiction Research, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Nucl Med Biol 39:640-4. 2012
    ..Small-animal imaging offers the opportunity to perform serial assessments. We evaluated whether high-resolution pinhole single photon emission computed tomography (SPECT) imaging in rats was able to reproduce previous ex vivo findings...
  6. doi request reprint The nicotinic acetylcholine receptor partial agonist varenicline and the treatment of drug dependence: a review
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 20:69-79. 2010
    ..Based on a review of the available literature, we hypothesize a potential role for varenicline in the prevention of relapse in patients recovering from drug dependence other than nicotine dependence...
  7. ncbi request reprint Reduced striatal brain volumes in non-medicated adult ADHD patients with comorbid cocaine dependence
    Guido A van Wingen
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Drug Alcohol Depend 131:198-203. 2013
    ..However, little is known about structural brain abnormalities that may differentiate ADHD patients with and without comorbid SUD...
  8. doi request reprint Dose-dependent and sustained effects of varenicline on dopamine D2/3 receptor availability in rats
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 21:205-10. 2011
    ..These observations suggest that increased DRD2/3 availability may contribute to varenicline's efficacy for smoking cessation and show promise for varenicline as a treatment of other types of drug dependence...
  9. pmc Cannabinoid-1 receptor antagonist rimonabant (SR141716) increases striatal dopamine D2 receptor availability
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, the Netherlands Department of Neuropharmacology, Brain Research Institute, University of Bremen, Germany Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Addict Biol 18:908-11. 2013
    ..Thus, up-regulation of striatal DRD2 by chronic rimonabant administration may be an underlying mechanism of action and confirms the interactions of the endocannabinoid and dopaminergic systems. ..
  10. ncbi request reprint Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD
    Cleo L Crunelle
    Cleo L Crunelle, PhD, Collaborative Antwerp Psychiatric Research Institute CAPRI, University of Antwerp, Belgium Amsterdam Institute for Addiction Research and Departments of Psychiatry and Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands Wim van den Brink, MD, PhD, Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands Geert Dom, MD, PhD, Collaborative Antwerp Psychiatric Research Institute CAPRI, University of Antwerp, and Psychiatric Centre Alexian Brothers, Boechout, Belgium Jan Booij, MD, PhD, Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Br J Psychiatry 204:486-7. 2014
    ..This study in 24 adult male patients with ADHD shows that dopamine transporter occupancy by methylphenidate in the putamen correlates with improvements in cognitive but not in motor impulsivity...
  11. doi request reprint Prevalence of attention-deficit hyperactivity disorder in substance use disorder patients: a meta-analysis and meta-regression analysis
    Katelijne van Emmerik-van Oortmerssen
    Arkin Mental Health and Addiction Treatment Centre, Amsterdam, The Netherlands
    Drug Alcohol Depend 122:11-9. 2012
    ..Attention deficit hyperactivity disorder (ADHD) is a comorbid condition associated with both onset and prognosis of SUD. Prevalence estimates of ADHD in SUD vary significantly...
  12. doi request reprint Varenicline increases striatal dopamine D(2/3) receptor binding in rats
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Addict Biol 14:500-2. 2009
    ..Varenicline increases dopamine D(2/3) receptor availability in drug-naïve rats. Therefore, varenicline may be an effective treatment for addictions other than smoking...