Cleo L Crunelle

Summary

Publications

  1. doi request reprint Influence of repeated permanent coloring and bleaching on ethyl glucuronide concentrations in hair from alcohol-dependent patients
    Cleo L Crunelle
    Toxicological Center, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium Electronic address
    Forensic Sci Int 247:18-22. 2015
  2. doi request reprint Hair ethyl glucuronide as a biomarker of alcohol consumption in alcohol-dependent patients: role of gender differences
    Cleo L Crunelle
    Toxicological Center, University of Antwerp, Universiteitsplein 1, B2610 Antwerp, Belgium Electronic address
    Drug Alcohol Depend 141:163-6. 2014
  3. doi request reprint Hair ethyl glucuronide levels as a marker for alcohol use and abuse: a review of the current state of the art
    Cleo L Crunelle
    Toxicological Centre, University of Antwerp, Universiteitsplein 1, B2610 Antwerp, Belgium Collaborative Antwerp Psychiatric Research Institute CAPRI, University of Antwerp, Universiteitsplein 1, B2610 Antwerp, Belgium Electronic address
    Drug Alcohol Depend 134:1-11. 2014
  4. doi request reprint Impulsivity in adult ADHD patients with and without cocaine dependence
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Drug Alcohol Depend 129:18-24. 2013
  5. doi request reprint Low dopamine transporter occupancy by methylphenidate as a possible reason for reduced treatment effectiveness in ADHD patients with cocaine dependence
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research, Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Collaborative Antwerp Psychiatric Research Institute CAPRI, University of Antwerp, Antwerp, Belgium Electronic address
    Eur Neuropsychopharmacol 23:1714-23. 2013
  6. doi request reprint Varenicline increases in vivo striatal dopamine D2/3 receptor binding: an ultra-high-resolution pinhole [123I]IBZM SPECT study in rats
    Cleo L Crunelle
    Department of Psychiatry and Amsterdam Institute for Addiction Research, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Nucl Med Biol 39:640-4. 2012
  7. doi request reprint The nicotinic acetylcholine receptor partial agonist varenicline and the treatment of drug dependence: a review
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 20:69-79. 2010
  8. doi request reprint Reduced striatal brain volumes in non-medicated adult ADHD patients with comorbid cocaine dependence
    Guido A van Wingen
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Drug Alcohol Depend 131:198-203. 2013
  9. doi request reprint Dose-dependent and sustained effects of varenicline on dopamine D2/3 receptor availability in rats
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 21:205-10. 2011
  10. pmc Cannabinoid-1 receptor antagonist rimonabant (SR141716) increases striatal dopamine D2 receptor availability
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, the Netherlands Department of Neuropharmacology, Brain Research Institute, University of Bremen, Germany Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Addict Biol 18:908-11. 2013

Collaborators

Detail Information

Publications17

  1. doi request reprint Influence of repeated permanent coloring and bleaching on ethyl glucuronide concentrations in hair from alcohol-dependent patients
    Cleo L Crunelle
    Toxicological Center, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium Electronic address
    Forensic Sci Int 247:18-22. 2015
    ..In view of this, permanent coloring and bleaching were shown in vitro to alter EtG concentrations in hair, but no in vivo studies are available to prove or disprove this...
  2. doi request reprint Hair ethyl glucuronide as a biomarker of alcohol consumption in alcohol-dependent patients: role of gender differences
    Cleo L Crunelle
    Toxicological Center, University of Antwerp, Universiteitsplein 1, B2610 Antwerp, Belgium Electronic address
    Drug Alcohol Depend 141:163-6. 2014
    ..A correlation between drinking behavior and EtG hair concentrations is observed, but large variability exists...
  3. doi request reprint Hair ethyl glucuronide levels as a marker for alcohol use and abuse: a review of the current state of the art
    Cleo L Crunelle
    Toxicological Centre, University of Antwerp, Universiteitsplein 1, B2610 Antwerp, Belgium Collaborative Antwerp Psychiatric Research Institute CAPRI, University of Antwerp, Universiteitsplein 1, B2610 Antwerp, Belgium Electronic address
    Drug Alcohol Depend 134:1-11. 2014
    ..Ethyl glucuronide (EtG) is a minor alcohol metabolite that has been proposed as a stable marker in hair to detect and quantify alcohol consumption over long time periods...
  4. doi request reprint Impulsivity in adult ADHD patients with and without cocaine dependence
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Drug Alcohol Depend 129:18-24. 2013
    ..However, very little is known about differences in impulse control and other cognitive functions between ADHD patients with and without SUD...
  5. doi request reprint Low dopamine transporter occupancy by methylphenidate as a possible reason for reduced treatment effectiveness in ADHD patients with cocaine dependence
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research, Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Collaborative Antwerp Psychiatric Research Institute CAPRI, University of Antwerp, Antwerp, Belgium Electronic address
    Eur Neuropsychopharmacol 23:1714-23. 2013
    ..This trial is registered at the Dutch Trial Register, www.trialregister.nl, under Trial ID number NTR3127. ..
  6. doi request reprint Varenicline increases in vivo striatal dopamine D2/3 receptor binding: an ultra-high-resolution pinhole [123I]IBZM SPECT study in rats
    Cleo L Crunelle
    Department of Psychiatry and Amsterdam Institute for Addiction Research, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Nucl Med Biol 39:640-4. 2012
    ..Small-animal imaging offers the opportunity to perform serial assessments. We evaluated whether high-resolution pinhole single photon emission computed tomography (SPECT) imaging in rats was able to reproduce previous ex vivo findings...
  7. doi request reprint The nicotinic acetylcholine receptor partial agonist varenicline and the treatment of drug dependence: a review
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 20:69-79. 2010
    ..Based on a review of the available literature, we hypothesize a potential role for varenicline in the prevention of relapse in patients recovering from drug dependence other than nicotine dependence...
  8. doi request reprint Reduced striatal brain volumes in non-medicated adult ADHD patients with comorbid cocaine dependence
    Guido A van Wingen
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Drug Alcohol Depend 131:198-203. 2013
    ..However, little is known about structural brain abnormalities that may differentiate ADHD patients with and without comorbid SUD...
  9. doi request reprint Dose-dependent and sustained effects of varenicline on dopamine D2/3 receptor availability in rats
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur Neuropsychopharmacol 21:205-10. 2011
    ..These observations suggest that increased DRD2/3 availability may contribute to varenicline's efficacy for smoking cessation and show promise for varenicline as a treatment of other types of drug dependence...
  10. pmc Cannabinoid-1 receptor antagonist rimonabant (SR141716) increases striatal dopamine D2 receptor availability
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, the Netherlands Department of Neuropharmacology, Brain Research Institute, University of Bremen, Germany Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Addict Biol 18:908-11. 2013
    ..Thus, up-regulation of striatal DRD2 by chronic rimonabant administration may be an underlying mechanism of action and confirms the interactions of the endocannabinoid and dopaminergic systems. ..
  11. doi request reprint Advances in detection of antipsychotics in biological matrices
    Lisbeth Patteet
    Toxicological Centre, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium Laboratory for TDM and toxicology, ZNA Stuivenberg, Lange Beeldekensstraat 267, B 2060 Antwerp, Belgium Electronic address
    Clin Chim Acta 441:11-22. 2015
    ..This technique is widely used for multi-analyte methods. Only recently, high-resolution mass spectrometry has gained importance when a combination of screening of (un)known metabolites, and quantification is required. ..
  12. doi request reprint Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD
    Cleo L Crunelle
    Cleo L Crunelle, PhD, Collaborative Antwerp Psychiatric Research Institute CAPRI, University of Antwerp, Belgium Amsterdam Institute for Addiction Research and Departments of Psychiatry and Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands Wim van den Brink, MD, PhD, Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands Geert Dom, MD, PhD, Collaborative Antwerp Psychiatric Research Institute CAPRI, University of Antwerp, and Psychiatric Centre Alexian Brothers, Boechout, Belgium Jan Booij, MD, PhD, Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Br J Psychiatry 204:486-7. 2014
    ..This study in 24 adult male patients with ADHD shows that dopamine transporter occupancy by methylphenidate in the putamen correlates with improvements in cognitive but not in motor impulsivity...
  13. doi request reprint Prevalence of attention-deficit hyperactivity disorder in substance use disorder patients: a meta-analysis and meta-regression analysis
    Katelijne van Emmerik-van Oortmerssen
    Arkin Mental Health and Addiction Treatment Centre, Amsterdam, The Netherlands
    Drug Alcohol Depend 122:11-9. 2012
    ..Attention deficit hyperactivity disorder (ADHD) is a comorbid condition associated with both onset and prognosis of SUD. Prevalence estimates of ADHD in SUD vary significantly...
  14. doi request reprint Treatment for outpatients with comorbid schizophrenia and substance use disorders: a review
    Nele A J De Witte
    Collaborative Antwerp Psychiatric Research Institute CAPRI, University of Antwerp, Antwerp, Belgium
    Eur Addict Res 20:105-14. 2014
    ..This review provides evidence of which interventions need to be part of effective outpatient integrated treatment for patients with comorbid schizophrenia and substance use disorders...
  15. doi request reprint Relationship between trait impulsivity and cortical volume, thickness and surface area in male cocaine users and non-drug using controls
    Anne Marije Kaag
    Departement of Radiology, Academic Medical Center, Amsterdam, the Netherlands Brain Imaging Center, Academic Medical Center, Amsterdam, The Netherlands Electronic address
    Drug Alcohol Depend 144:210-7. 2014
    ..As CV is the function of cortical surface area (SA) and cortical thickness (CT) impulsivity may be differently associated to SA than to CT...
  16. doi request reprint Varenicline increases striatal dopamine D(2/3) receptor binding in rats
    Cleo L Crunelle
    Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Addict Biol 14:500-2. 2009
    ..Varenicline increases dopamine D(2/3) receptor availability in drug-naïve rats. Therefore, varenicline may be an effective treatment for addictions other than smoking...