Biomarker discovery for colon cancer using a 761 gene RT-PCR assayKim M Clark-Langone
Genomic Health, Inc, Redwood City, CA, USA
BMC Genomics 8:279. 2007
..This screening strategy remains attractive due to the inherent advantages of maintaining platform consistency from discovery through clinical application...
Analytical validation of the Oncotype DX genomic diagnostic test for recurrence prognosis and therapeutic response prediction in node-negative, estrogen receptor-positive breast cancerMaureen Cronin
Genomic Health, Inc, Redwood City, CA 94063, USA
Clin Chem 53:1084-91. 2007
..Individualized patient management requires strict performance criteria for clinical laboratory tests. We therefore investigated the analytical performance of the assay...
- Measurement of gene expression in archival paraffin-embedded tissues: development and performance of a 92-gene reverse transcriptase-polymerase chain reaction assay
Maureen Cronin
Genomic Health Incorporated, Redwood City, California 94063, USA
Am J Pathol 164:35-42. 2004
..These findings support the development of RT-PCR analysis of FPE tissue RNA as a platform for multianalyte clinical diagnostic tests...
- Universal RNA reference materials for gene expression
Maureen Cronin
Genomic Health, Inc, Redwood City, CA, USA
Clin Chem 50:1464-71. 2004
..Work is underway at NIST and among members of the gene expression array community to further define these materials and make them available...
- Prognostic role of a multigene reverse transcriptase-PCR assay in patients with node-negative breast cancer not receiving adjuvant systemic therapy
Francisco J Esteva
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 11:3315-9. 2005
..A secondary objective was to determine whether the quantitative RT-PCR data correlated with immunohistochemistry assay data regarding estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 status...
- Gene expression profiles in paraffin-embedded core biopsy tissue predict response to chemotherapy in women with locally advanced breast cancer
Luca Gianni
Medical Oncology, Istituto Nazionale Tumori, Via Venezian, 1, 20133 Milano, Italy
J Clin Oncol 23:7265-77. 2005
..We sought to identify gene expression markers that predict the likelihood of chemotherapy response. We also tested whether chemotherapy response is correlated with the 21-gene Recurrence Score assay that quantifies recurrence risk...
- A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
Soonmyung Paik
Division of Pathology, Operation Center, and the Biostatistics Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh 15212, USA
N Engl J Med 351:2817-26. 2004
..The likelihood of distant recurrence in patients with breast cancer who have no involved lymph nodes and estrogen-receptor-positive tumors is poorly defined by clinical and histopathological measures...
- Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer
Soonmyung Paik
Division of Pathology, Operations Center, and Biostatistical Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212, USA
J Clin Oncol 24:3726-34. 2006
..The relationship between the RS and chemotherapy benefit is not known...
- Tumor gene expression and prognosis in breast cancer patients with 10 or more positive lymph nodes
Melody A Cobleigh
Rush University Medical Center, Chicago, Illinois 60612, USA
Clin Cancer Res 11:8623-31. 2005
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- Predicting response to primary chemotherapy: gene expression profiling of paraffin-embedded core biopsy tissue
Lida Mina
Department of Medicine, Indiana University, RT 473, Indianapolis, IN, 46202, USA
Breast Cancer Res Treat 103:197-208. 2007
..We used paraffin-embedded core biopsies from a completed phase II trial to identify genes that correlate with response to primary chemotherapy...
