K Pavelic

..These data indicate that clinoptilolite treatment might affect cancer growth by attenuating survival signals and inducing tumor suppressor genes in treated cells...

..Loss of FHIT function may be important in the development and/or progression of various types of cancer...

..These properties make them interesting for pharmaceutical industry and medicine...

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..Together with results obtained on lung cancer, our observations suggest that increased expression of nm23-H1 in cancers of the upper aerodigestive tract may have different implications than elsewhere in the body...

..Our data suggest that tumor cells produce IGF II, and that this in turn stimulates their proliferation by autocrine mechanisms...

..By contrast, in the leiomyosarcoma component, LOH was found at the DCC and p53 genes, proving that these two tumours did not arise from the same stem cell but represent two different neoplastic growths...

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..IGF ligands together with IGF IR could be responsible for hypoglycemia and perhaps the transformed phenotype...

..The data suggest that IGF IR may play an important role in the genesis and progression of malignant haemangiopericytomas...

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..5 to 61.1% along with the severity of the cervical intraepithelial neoplasia (CIN I-IV). HPV type 6/11 was strongly associated with CIN I (33.8%), HPV type 31 with CIN II (22.9%), and HPV type 16 with CIN III (50%)...

..The male population, indeed, represents a reservoir of HPV infection and directly influences cervical cancerogenesis...

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..Our findings may contribute to a better understanding of the genetic profile of neuroendocrine tumours...

..This is the first study to investigate the role of NF1 in sporadic colon cancer...

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..Our results showed that electrophoresis using Spreadex gels provides a simple and rapid non-radioactive method for determination of the most-frequent germ-line mutations in the APC gene...

..It can be concluded that inactivation of the DPC4 gene plays a role in a multistep process of outgrowth and progression of colon cancer...

..Alternatively, p53 and nm23-H1 may have no relation to oral lesion formation, and cannot presently be considered as an early step in benign, tissue transformation...

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..In this paper we propose a new strategy for molecular diagnosis of the fragile X syndrome in which our Expand Long PCR assay is used as the first screening test for fragile X mutation detection...

..Out results suggest that the APC tumor suppressor gene plays a role in renal carcinogenesis. Alterations in this gene are responsible for tumor evolution and progression, but cannot be considered as a first event in tumor initiation...

..Our results also indicate that this syndrome is underdiagnosed in Croatia and that a further effort must be made to detect unrecognised cases...

..normal fibroblasts was found for ureas 3c, 3d and 3g. Results of broad antiviral evaluation showed that pyridine and phenethyl derivatives of urea 3h and 3g exhibited some selective inhibition against cytomegalovirus...

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..Marked anticancer efficacy of compound 2 supports further in vivo investigation into its possible clinical utility...

..358) than HCMV was. Increased HPV infection was strongly associated (P < 0.001) with a higher CIN grade, but there is no evidence that AAV 2 and HCMV infections have any impact on CIN development...

..However, since at the time of diagnosis all affected families had a second or even a third child born, earlier diagnosis should be considered to provide greater benefit to fragile X families...

..Our results indicated that HPV infections, especially those with HPV 16, represent a significant public health concern in Croatia...

..We suggest the use of Expand Long PCR for routine molecular diagnosis of triplet repeat diseases, and present such analysis of the fragile X syndrome, myotonic dystrophy and Huntington's disease...