I Martin-Kleiner

Summary

Country: Croatia

Publications

  1. ncbi The effect of opioid agonists of delta-class DSLET, mu-class DAMGO, kappa-class U-69593 and an opioid antagonist, naloxone, on MTT activity of NALM-1 leukemic cells
    I Martin-Kleiner
    Ruder Boskovic Institute, Division of Molecular Medicine, PO Box 180, 10002 Zagreb, Croatia
    Biomed Pharmacother 56:458-62. 2002
  2. ncbi Chronic opioid treatment of the mouse thymoma cell lines R1.G1 and R1EGO leads to down-regulation of the kappa opioid receptor without desensitization of adenylyl cyclase activity
    I Martin-Kleiner
    Division of Molecular Medicine, Ruder Boskovic Institute, Bijenicka c 54, 10001 Zagreb, Croatia
    Int Immunopharmacol 1:13-20. 2001
  3. ncbi The effect of the zeolite clinoptilolite on serum chemistry and hematopoiesis in mice
    I Martin-Kleiner
    Rudjer Boskovic Institute, Division of Molecular Medicine, PO Box 180, HR 10002, Zagreb, Croatia
    Food Chem Toxicol 39:717-27. 2001
  4. ncbi The kappa-opioid agonist U-69593 affects intracellular calcium level in R1.1 mouse thymoma cell line
    Irena Martin-Kleiner
    Division of Molecular Medicine, Ruder Boskovic Institute, Zagreb 10002, Croatia
    Int Immunopharmacol 2:975-80. 2002
  5. ncbi Methionine enkephalin suppresses metabolic activity of a leukemic cell line (NALM-1) and enhances CD10 expression
    Irena Martin-Kleiner
    Division of Molecular Medicine, Ruder Boskovic Institute, PO Box 180, 10002 Zagreb, Croatia
    Int Immunopharmacol 3:707-11. 2003
  6. ncbi PMA and doxorubicin decrease viability, MTT activity and expression of CD10 marker on NALM-1 leukemic cells
    I Martin-Kleiner
    Division of Molecular Medicine, Ruder Boskovic Institute, Zagreb, Croatia
    Immunopharmacol Immunotoxicol 28:411-20. 2006
  7. ncbi Selective cytotoxicity of diazenecarboxamides towards human leukemic cell lines
    I Martin-Kleiner
    Ruder Boskovic Institute, Division of Molecular Medicine, Bijenicka cesta 54, HR 10002 Zagreb, Croatia
    Toxicol In Vitro 21:1453-9. 2007
  8. ncbi A pilot study of mitochondrial DNA point mutation A3243G in a sample of Croatian patients having type 2 diabetes mellitus associated with maternal inheritance
    I Martin-Kleiner
    Division of Molecular Medicine, Ruder Boskovic Institute, P O Box 180, HR 10002 Zagreb, Croatia
    Acta Diabetol 41:179-84. 2004
  9. ncbi Pretreatment of human peripheral blood lymphocytes with interleukin-2 or dexamethasone does not alter their response to Met-Enkephalin in a NK-cytotoxic assay
    I Martin-Kleiner
    , Department of Biology and Medicine, Zagreb, Croatia
    Immunopharmacol Immunotoxicol 18:37-57. 1996
  10. ncbi Naloxone modulates NK-cell activity of human peripheral blood lymphocytes like an opioid agonist
    I Martin-Kleiner
    , Department of Experimental Biology and Medicine, Zagreb, Croatia
    Immunopharmacol Immunotoxicol 15:179-97. 1993

Detail Information

Publications10

  1. ncbi The effect of opioid agonists of delta-class DSLET, mu-class DAMGO, kappa-class U-69593 and an opioid antagonist, naloxone, on MTT activity of NALM-1 leukemic cells
    I Martin-Kleiner
    Ruder Boskovic Institute, Division of Molecular Medicine, PO Box 180, 10002 Zagreb, Croatia
    Biomed Pharmacother 56:458-62. 2002
    ..Treatment with opioid agonists, DAMGO, DSLET, U-69593, and an opioid antagonist naloxone for 6, 24, and 48 h, did not trigger DNA fragmentation, which was considered as a possible mechanism of action...
  2. ncbi Chronic opioid treatment of the mouse thymoma cell lines R1.G1 and R1EGO leads to down-regulation of the kappa opioid receptor without desensitization of adenylyl cyclase activity
    I Martin-Kleiner
    Division of Molecular Medicine, Ruder Boskovic Institute, Bijenicka c 54, 10001 Zagreb, Croatia
    Int Immunopharmacol 1:13-20. 2001
    ..This study demonstrates that unlike some neuronal preparations, chronic opioid treatment of the thymoma cell lines resulted in receptor down-regulation without desensitization...
  3. ncbi The effect of the zeolite clinoptilolite on serum chemistry and hematopoiesis in mice
    I Martin-Kleiner
    Rudjer Boskovic Institute, Division of Molecular Medicine, PO Box 180, HR 10002, Zagreb, Croatia
    Food Chem Toxicol 39:717-27. 2001
    ..The clinoptilolite preparations ameliorated the sodium and chloride decline, whereas the effects on hematopoiesis were erratic...
  4. ncbi The kappa-opioid agonist U-69593 affects intracellular calcium level in R1.1 mouse thymoma cell line
    Irena Martin-Kleiner
    Division of Molecular Medicine, Ruder Boskovic Institute, Zagreb 10002, Croatia
    Int Immunopharmacol 2:975-80. 2002
    ..Thus, we have shown that basal intracellular calcium level was decreased in R1.1 by the kappa-opioid agonist U-69593 and increased in R1.1 cells stimulated by Ionophore A23187...
  5. ncbi Methionine enkephalin suppresses metabolic activity of a leukemic cell line (NALM-1) and enhances CD10 expression
    Irena Martin-Kleiner
    Division of Molecular Medicine, Ruder Boskovic Institute, PO Box 180, 10002 Zagreb, Croatia
    Int Immunopharmacol 3:707-11. 2003
    ..5 x 10(-6)-10(-6) M) decreased expression of CD10 at the RNA level. Suppression of the MTT uptake was attributed to the products of Met-enkephalin degradation caused by the enzymatic activity of CD10...
  6. ncbi PMA and doxorubicin decrease viability, MTT activity and expression of CD10 marker on NALM-1 leukemic cells
    I Martin-Kleiner
    Division of Molecular Medicine, Ruder Boskovic Institute, Zagreb, Croatia
    Immunopharmacol Immunotoxicol 28:411-20. 2006
    ..The data in this study are the first evidence that PMA and doxorubicin inhibited viability and MTT activity and induced partial differentiation, by decreasing CD10 on NALM-1 cells...
  7. ncbi Selective cytotoxicity of diazenecarboxamides towards human leukemic cell lines
    I Martin-Kleiner
    Ruder Boskovic Institute, Division of Molecular Medicine, Bijenicka cesta 54, HR 10002 Zagreb, Croatia
    Toxicol In Vitro 21:1453-9. 2007
    ..These compounds may represent new potential agents for the treatment of leukemia patients...
  8. ncbi A pilot study of mitochondrial DNA point mutation A3243G in a sample of Croatian patients having type 2 diabetes mellitus associated with maternal inheritance
    I Martin-Kleiner
    Division of Molecular Medicine, Ruder Boskovic Institute, P O Box 180, HR 10002 Zagreb, Croatia
    Acta Diabetol 41:179-84. 2004
    ..The incidence of mitochondrial DNA point mutation A3243G in this study of Croatian diabetic patients is in line with data in the literature...
  9. ncbi Pretreatment of human peripheral blood lymphocytes with interleukin-2 or dexamethasone does not alter their response to Met-Enkephalin in a NK-cytotoxic assay
    I Martin-Kleiner
    , Department of Biology and Medicine, Zagreb, Croatia
    Immunopharmacol Immunotoxicol 18:37-57. 1996
    ....
  10. ncbi Naloxone modulates NK-cell activity of human peripheral blood lymphocytes like an opioid agonist
    I Martin-Kleiner
    , Department of Experimental Biology and Medicine, Zagreb, Croatia
    Immunopharmacol Immunotoxicol 15:179-97. 1993
    ..Thus, naloxone, the opioid receptor antagonist, modulated the NK-cell activity like opioid peptides, i.e. resembled an opioid agonist, in an individual, donor dependent fashion...