Maja Peraica

Summary

Affiliation: Institute for Medical Research and Occupational Health
Country: Croatia

Publications

  1. pmc Ochratoxin A contamination of food from Croatia
    Maja Peraica
    Unit of Toxicology, Institute for Medical Research and Occupational Health, Ksaverska c 2, 10000 Zagreb, Croatia
    Toxins (Basel) 2:2098-105. 2010
  2. doi request reprint Mycotoxic and aristolochic acid theories of the development of endemic nephropathy
    Maja Peraica
    Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Arh Hig Rada Toksikol 59:59-65. 2008
  3. ncbi request reprint The occurrence of ochratoxin A in blood in general population of Croatia
    M Peraica
    Unit of Toxicology, Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Toxicol Lett 110:105-12. 1999
  4. ncbi request reprint The involvement of mycotoxins in the development of endemic nephropathy
    Maja Peraica
    Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Wien Klin Wochenschr 120:402-7. 2008
  5. ncbi request reprint Variations of ochratoxin A concentration in the blood of healthy populations in some Croatian cities
    M Peraica
    Unit of Toxicology, Institute for Medical Research and Occupational Health, Kagreb, Croatia
    Arch Toxicol 75:410-4. 2001
  6. ncbi request reprint Fumonisin B1, fumonisin B2, zearalenone and ochratoxin A contamination of maize in Croatia
    Ana Marija Domijan
    Unit of Toxicology, Institute for Medical Research and Occupational Health, Ksaverska c 2, 10000 Zagreb, Croatia
    Food Addit Contam 22:677-80. 2005
  7. ncbi request reprint Mould contamination and co-occurrence of mycotoxins in maize grain in Croatia
    Ana Marija Domijan
    Unit of Toxicology, Institute for Medical Research and Occupational Health, Zagreb Croatia
    Acta Pharm 55:349-56. 2005
  8. ncbi request reprint The involvement of oxidative stress in ochratoxin A and fumonisin B1 toxicity in rats
    Ana Marija Domijan
    Unit of Toxicology, Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Mol Nutr Food Res 51:1147-51. 2007
  9. doi request reprint Fusarium spp. contamination of wheat, maize, soybean, and pea grain in Croatia
    Dario Ivić
    Zagreb University Faculty of Agriculture, Zagreb, Croatia
    Arh Hig Rada Toksikol 60:435-42. 2009
  10. ncbi request reprint Mycotoxin fumonisin B1 alters cellular redox balance and signalling pathways in rat liver and kidney
    Lada Rumora
    Faculty of Pharmacy and Biochemistry, Department of Medical Biochemistry and Haematology, Domagojeva 2, 10000, Zagreb, Croatia
    Toxicology 242:31-8. 2007

Collaborators

Detail Information

Publications39

  1. pmc Ochratoxin A contamination of food from Croatia
    Maja Peraica
    Unit of Toxicology, Institute for Medical Research and Occupational Health, Ksaverska c 2, 10000 Zagreb, Croatia
    Toxins (Basel) 2:2098-105. 2010
    ..There is need to establish control measures through which such contaminations in foods can be managed...
  2. doi request reprint Mycotoxic and aristolochic acid theories of the development of endemic nephropathy
    Maja Peraica
    Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Arh Hig Rada Toksikol 59:59-65. 2008
    ..This paper presents most important studies supporting both theories, indicating also the inconsistencies of each...
  3. ncbi request reprint The occurrence of ochratoxin A in blood in general population of Croatia
    M Peraica
    Unit of Toxicology, Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Toxicol Lett 110:105-12. 1999
    ..24 to 0.91 ng/kg b.w. found in Rijeka and Osijek, respectively) is lower than the tolerable daily intake proposed by Joint FAO/WHO Expert Committee on Food Additives (1995) of 16.0 ng OTA/kg b.w...
  4. ncbi request reprint The involvement of mycotoxins in the development of endemic nephropathy
    Maja Peraica
    Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Wien Klin Wochenschr 120:402-7. 2008
    ..The occurrence of OTA- and aristolochic acid-DNA adducts is also presented...
  5. ncbi request reprint Variations of ochratoxin A concentration in the blood of healthy populations in some Croatian cities
    M Peraica
    Unit of Toxicology, Institute for Medical Research and Occupational Health, Kagreb, Croatia
    Arch Toxicol 75:410-4. 2001
    ..0 ng/kg body weight). Healthy populations of Croatia are exposed to low, but seasonally and regionally variable amounts of OTA...
  6. ncbi request reprint Fumonisin B1, fumonisin B2, zearalenone and ochratoxin A contamination of maize in Croatia
    Ana Marija Domijan
    Unit of Toxicology, Institute for Medical Research and Occupational Health, Ksaverska c 2, 10000 Zagreb, Croatia
    Food Addit Contam 22:677-80. 2005
    ..4, 109.2 and 3084.0 microg kg(-1). Although such low concentrations of mycotoxins are not a significant source of exposure in countries with a European diet, a few samples with extreme values indicate that thorough control is needed...
  7. ncbi request reprint Mould contamination and co-occurrence of mycotoxins in maize grain in Croatia
    Ana Marija Domijan
    Unit of Toxicology, Institute for Medical Research and Occupational Health, Zagreb Croatia
    Acta Pharm 55:349-56. 2005
    ..In general, such low mycotoxin concentrations are not a significant source of exposure to humans, but they may contribute to exposure from other commodities. A few samples with extreme values indicate that strict control is needed...
  8. ncbi request reprint The involvement of oxidative stress in ochratoxin A and fumonisin B1 toxicity in rats
    Ana Marija Domijan
    Unit of Toxicology, Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Mol Nutr Food Res 51:1147-51. 2007
    ..Combinations of OTA+FB1 affected almost all parameters, which indicates their potential to produce oxidative damage...
  9. doi request reprint Fusarium spp. contamination of wheat, maize, soybean, and pea grain in Croatia
    Dario Ivić
    Zagreb University Faculty of Agriculture, Zagreb, Croatia
    Arh Hig Rada Toksikol 60:435-42. 2009
    ..proliferatum on pea (29 % of isolates). Among species identified, F. heterosporum, F. crookwellense, F. pseudograminearum, F. sambucinum, and F. compactum have been reported for the first time in Croatia...
  10. ncbi request reprint Mycotoxin fumonisin B1 alters cellular redox balance and signalling pathways in rat liver and kidney
    Lada Rumora
    Faculty of Pharmacy and Biochemistry, Department of Medical Biochemistry and Haematology, Domagojeva 2, 10000, Zagreb, Croatia
    Toxicology 242:31-8. 2007
    ..In conclusion, FB(1) alters cellular redox balance, which leads to tissue-specific activation and expression of redox-sensitive signalling molecules. It seems that kidney cells are more sensitive to adverse effects of FB(1)...
  11. ncbi request reprint Fumonisin B(1): oxidative status and DNA damage in rats
    Ana Marija Domijan
    Unit of Toxicology, Institute for Medical Research and Occupational Health, Ksaverska c 2, 10000 Zagreb, Croatia
    Toxicology 232:163-9. 2007
    ..The ratio of Sa and So significantly increases in all tissues already after 2-day treatment thus indicating that the metabolism of sphingolipids may have an important role in the DNA damage caused by FB(1)...
  12. doi request reprint Low doses of ochratoxin A upregulate the protein expression of organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney cortex
    Vilim Zlender
    Unit of Toxicology, Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Toxicol Appl Pharmacol 239:284-96. 2009
    ....
  13. doi request reprint Assessment of cytogenetic damage and oxidative stress in personnel occupationally exposed to the pulsed microwave radiation of marine radar equipment
    Vera Garaj-Vrhovac
    Mutagenesis Unit, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia
    Int J Hyg Environ Health 214:59-65. 2011
    ..3.17), indicating oxidative stress. Results suggests that pulsed microwaves from working environment can be the cause of genetic and cell alterations and that oxidative stress can be one of the possible mechanisms of DNA and cell damage...
  14. ncbi request reprint Ochratoxin A-induced apoptosis in rat kidney tissue
    Ana Marija Domijan
    Unit of Toxicology, Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Arh Hig Rada Toksikol 55:243-8. 2004
    ..Long-term administration is associated with continued and increased apoptosis without necrosis, suggestive of OTA's role in the pathogenesis of progressive renal atrophy...
  15. ncbi request reprint Ochratoxin A in wine
    Ana Marija Domijan
    Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Arh Hig Rada Toksikol 56:17-20. 2005
    ..Three OTA-free white wines were from the north of Croatia (inland), while all wines produced in the south (Adriatic coast) were OTA-positive. However, the concentrations were too low to present a risk for a moderate wine consumer...
  16. ncbi request reprint The effect of dichlorvos treatment on butyrylcholinesterase activity and lipid metabolism in rats
    Ana Lucić
    Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Arh Hig Rada Toksikol 53:275-81. 2002
    ..The decrease of BuChE activity and the changes in concentrations of lipids and lipoproteins were observed throughout the experiment. Our results contribute to the hypothesis that BuChE may play a role in lipid and lipoprotein metabolism...
  17. doi request reprint Urine ochratoxin a and sphinganine/sphingosine ratio in residents of the endemic nephropathy area in Croatia
    Ana Marija Domijan
    Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Arh Hig Rada Toksikol 60:387-93. 2009
    ..No control sample contained OTA and had the Sa/So ratio >1 at the same time, while in Kaniza four such samples were collected in 2000 and one in 2005...
  18. ncbi request reprint Two different clean-up procedures for liquid chromatographic determination of ochratoxin A in urine
    Ana Marija Domijan
    Unit of Toxicology, Institute for Medical Research and Occupational Health, Ksaverska c 2, 10000, Zagreb, Croatia
    J Chromatogr B Analyt Technol Biomed Life Sci 798:317-21. 2003
    ..However, the procedure with Chem Elut columns gave higher recovery and lower detection and quantitation limits. It was successfully applied in determining OTA in human urine samples...
  19. ncbi request reprint Standard and Fpg-modified comet assay in kidney cells of ochratoxin A- and fumonisin B(1)-treated rats
    Ana Marija Domijan
    Unit of Toxicology, Institute for Medical Research and Occupational Health, Ksaverska c 2, 10000 Zagreb, Croatia
    Toxicology 222:53-9. 2006
    ....
  20. ncbi request reprint Butyrylcholinesterase activity and plasma lipids in dexamethasone treated rats
    Ana Lucić Vrdoljak
    Unit of Toxicology, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia
    Acta Pharm 55:177-85. 2005
    ..Neither positive correlation between BuChE and triglycerides nor negative correlation between BuChE and HDL was found. Changes in lipid profile during DM treatment were not sex- and time-dependent...
  21. ncbi request reprint Malondialdehyde and 8-oxo-7.8-dihydro-2'deoxyguanosine in the urine of residents from Balkan endemic nephropathy area in Croatia--a pilot study
    Ana Marija Domijan
    University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia
    Coll Antropol 37:1195-8. 2013
    ..However, there was no correlation between MDA and 8-oxodG results. Our results confirm that oxidative stress could be implicated in development of both, BEN and UTT...
  22. ncbi request reprint Prevention of exposure to mycotoxins from food and feed
    Maja Peraica
    Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Arh Hig Rada Toksikol 53:229-37. 2002
    ..Since there is no universal and reliable method of feed decontamination for all mycotoxins, the paper stresses the importance of preventive measures...
  23. ncbi request reprint The effect of ochratoxin A on the concentration of protein carbonyls in rats
    Ana Marija Domijan
    Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Arh Hig Rada Toksikol 56:311-5. 2005
    ..05). These results confirm that oxidative stress is involved in the mechanism of OTA toxicity, and that it causes the oxidation of proteins...
  24. doi request reprint Toxicological properties of citrinin
    Dubravka Flajs
    Institute for Medical Research and Occupational Health, Zagreb, Croatia dfl
    Arh Hig Rada Toksikol 60:457-64. 2009
    ..At present, there are no specific regulations either in Croatia or in the European Union concerning CTN in any kind of commodity...
  25. ncbi request reprint Determination of 8-hydroxy-2'deoxyguanosine in urine using HPLC with electrochemical detection
    Ana Marija Domijan
    Institute for Medical Research and Occupational Health Zagreb, Croatia
    Arh Hig Rada Toksikol 59:277-82. 2008
    ..9995) and the limit of detection was 3 nmol L(-1). Concentrations of 8-oxodG ranged between 3.0 nmol L(-1) and 48.0 nmol L(-1), which is in accordance with values reported for healthy individuals in other studies...
  26. ncbi request reprint Seed-borne fungi and ochratoxin A contamination of dry beans (Phaseolus vulgaris L.) in the Republic of Croatia
    A M Domijan
    Unit of Toxicology, Institute for Medical Research and Occupational Health, P O Box 291, 10000 Zagreb, Croatia
    Food Chem Toxicol 43:427-32. 2005
    ..The OTA contamination of beans in our country is low. Although beans are not severely contaminated with OTA, their consumption may contribute to the exposure to OTA from other commodities...
  27. ncbi request reprint Changes in plasma lipids after a non-lethal dose of cycloheximide in rats
    A Lucic
    Unit of Toxicology, Institute for Medical Research and Occupational Health, Ksaverska c 2, 10000 Zagreb, Croatia
    Hum Exp Toxicol 22:245-8. 2003
    ..The concentration of triglycerides decreased after a lag period of three days when the reserves of apolipoprotein apo B, the main apolipoprotein of very low-density lipoproteins (VLDL)-cholesterols produced in the liver, were consumed...
  28. ncbi request reprint Contamination of food with mycotoxins and human health
    M Peraica
    Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Arh Hig Rada Toksikol 52:23-35. 2001
    ..It also gives a quick review of human carcinogenicity evaluations of the international Agency for Research on Cancer and of regulatory limits of mycotoxin concentrations in various commodities...
  29. doi request reprint A potential role of calcium in apoptosis and aberrant chromatin forms in porcine kidney PK15 cells induced by individual and combined ochratoxin A and citrinin
    Maja Segvić Klarić
    Department of Microbiology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia
    Arch Toxicol 86:97-107. 2012
    ..In conclusion, disturbance of Ca(2+) homeostasis caused by OTA and CTN plays a significant role in cell genotoxicity and death...
  30. ncbi request reprint The effect of cycloheximide on butyrylcholinesterase activity in vivo
    Ana Lucić
    Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Arh Hig Rada Toksikol 53:185-90. 2002
    ..Since there was no effect of CHM on BuChE catalytic activity in plasma, the data suggest that CHM inhibits the synthesis of BuChE rather than its active site...
  31. ncbi request reprint Adamantyl tenocyclidines--adjuvant therapy in poisoning with organophosphorus compounds and carbamates
    Danko Skare
    Institute Ruder Boskovic, Bijenicka c 54, 10000 Zagreb, Croatia
    Arch Toxicol 76:173-7. 2002
    ..40 to 7.12 LD50 of soman. The results suggest that TCP and adamantyl tenocyclidines could be used in combination with atropine as antidotes in carbamate poisoning and as adjuvant therapy to HI-6 and atropine in soman poisoning...
  32. ncbi request reprint DNA damage by ochratoxin A in rat kidney assessed by the alkaline comet assay
    D Zeljezic
    Institute for Medical Research and Occupational Health, Ksaverska c 2, 10001 Zagreb, Croatia
    Braz J Med Biol Res 39:1563-8. 2006
    ..These results confirm the genotoxic potential of OTA, and show that the severity of DNA lesions in kidney correlates with OTA concentration...
  33. pmc Toxic effects of mycotoxins in humans
    M Peraica
    Toxicologist, Unit of Toxicology, Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Bull World Health Organ 77:754-66. 1999
    ....
  34. ncbi request reprint Ochratoxin A in human kidney diseases
    R Fuchs
    Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Food Addit Contam 22:53-7. 2005
    ..Patients with chronic renal insufficiency treated with dialysis have higher blood OTA concentrations than healthy persons, and OTA concentration does not decrease with such treatment...
  35. doi request reprint Early toxic effects of fumonisin B1 in rat liver
    Am Domijan
    Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Hum Exp Toxicol 27:895-900. 2008
    ..w. after 48 hours (1.69 +/- 0.27% DNA; control 0.59 +/- 0.11% DNA). This study proved that FB(1)-induced DNA damage is time- and dose-dependent, and that it could be caused in Wistar rats by a single dose...
  36. ncbi request reprint New molecular and field evidences for the implication of mycotoxins but not aristolochic acid in human nephropathy and urinary tract tumor
    Annie Pfohl-Leszkowicz
    Laboratoire Génie chimique, UMR CNRS INPT UPS 5503, INP ENSA Toulouse, Auzeville Tolosane, France
    Mol Nutr Food Res 51:1131-46. 2007
    ..OTA and CIT are more frequently found in rural area. AA was never detected. All these plead for implication of mycotoxins, especially OTA, in BEN and UTT...
  37. ncbi request reprint Spontaneous mycotoxic nephropathy in Bulgarian chickens with unclarified mycotoxin aetiology
    Stoycho D Stoev
    Department of General and Clinical Pathology, Faculty of Veterinary Medicine, Thracian University, Stara Zagora, Bulgaria
    Vet Res 33:83-93. 2002
    ..The conclusion is that the Bulgarian chicken nephropathy may have a multitoxic aetiology because it cannot be explained by the concentration of ochratoxin A alone...
  38. ncbi request reprint Cereals consumption and risk for renal cell carcinoma: Can be hypothesized a role of mycotoxins?
    Fabio Galvano
    Int J Cancer 121:2116-7. 2007
  39. ncbi request reprint Recent data on endemic nephropathy and related urothelial tumors in Croatia
    Marica Miletić-Medved
    Institute of Public Health of Brodsko Posavska County, Slavonski Brod, Croatia
    Wien Klin Wochenschr 117:604-9. 2005
    ..The much higher specific urothelial-tumor mortality in women than in men (in contrast to the rest of the country) and the higher specific EN mortality indicate that the causative agent of the two nosological entities is the same...