Research Topics
Genomes and Genes | Dubravka HranilovicSummaryAffiliation: Faculty of Science Country: Croatia Publications
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Detail Information
Publications
Population-based study of genetic variation in individuals with autism spectrum disorders from CroatiaLi San Wang
Department of Pathology, Laboratory Medicine, Biomedical Graduate Studies, University of Pennsylvania, Philadelphia 19104, USA
BMC Med Genet 11:134. 2010..Genome-wide studies on autism spectrum disorders (ASDs) have mostly focused on large-scale population samples, but examination of rare variations in isolated populations may provide additional insights into the disease pathogenesis...
Hyperserotonemia in autism: activity of 5HT-associated platelet proteinsDubravka Hranilovic
Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10 000, Zagreb, Croatia
J Neural Transm 116:493-501. 2009..The results suggest a possibility of upregulation of monoaminergic synthesis/degradation and, probably consequential, downregulation of 5HT(2A)r in autistic subjects...
The effects of the perinatal treatment with 5-hydroxytryptophan or tranylcypromine on the peripheral and central serotonin homeostasis in adult ratsDubravka Hranilovic
Department of Animal Physiology, Division of Biology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000 Zagreb, Croatia
Neurochem Int 59:202-7. 2011..Further studies are planned in order to explore the nature of the different disturbances of 5HT homeostasis induced by the two compounds, and their results are expected to shed some light on the role of hyperserotonemia in autism...
Alcohol dependence and polymorphisms of serotonin-related genes: association studiesGordana Mokrovic
Department of Molecular Biology, Ruder Bogkovid Institute, Zagreb, Croatia
Coll Antropol 32:127-31. 2008..The increase of sample size (in progress) is expected to enable search of more subtle differences, as well as re-evaluation of these preliminary findings...
Functional promoter polymorphism of the neuronal isoform of tryptophan hydroxylase (Tph2) in suicideJasminka Stefulj
Laboratory of Neurochemistry and Molecular Neurobiology, Rudjer Boskovic Institute, Zagreb, Croatia
Psychiatry Res 186:446-7. 2011..No significant differences were found between the groups. Obtained results do not support involvement of the investigated polymorphism in the susceptibility to suicide completion...
Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expressionDubravka Hranilovic
Laboratory of Neurochemistry and Molecular Neurobiology, Department of Molecular Genetics, Rudjer Boskovic Institute, Zagreb, Croatia
Biol Psychiatry 55:1090-4. 2004..02). CONCLUSIONS: Our results indicate weak individual influence, but possible combined effect, of 5-HTTLPR and VNTR-2 polymorphisms on 5-HTT gene expression...
Hyperserotonemia in autism: the potential role of 5HT-related gene variantsDubravka Hranilovic
Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia
Coll Antropol 32:75-80. 2008..These results suggest a possible synergistic effect of genes regulating 5HT synthesis/degradation in dysregulation of the peripheral 5HT homeostasis of autistic patients...
5-HT2A receptor gene polymorphisms in Croatian subjects with autistic disorderDubravka Hranilovic
Department of Animal Physiology, Faculty of Science, University of Zagreb, and Psychiatric Hospital for Children and Youth, Zagreb, Croatia
Psychiatry Res 178:556-8. 2010..Significant overrepresentation of the G allele and the GG genotype of the -1438 A/G polymorphism was observed in group of autistic subjects, supporting the possible involvement of the 5-HT2A receptor in the development of autism...
Anxiety-like behavior and cognitive flexibility in adult rats perinatally exposed to increased serotonin concentrationsSofia Blazevic
Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, HR 10 000 Zagreb, Croatia
Behav Brain Res 230:175-81. 2012....
Hyperserotonemia in adults with autistic disorderDubravka Hranilovic
Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10 000 Zagreb, Croatia
J Autism Dev Disord 37:1934-40. 2007..However, significant negative relationship was observed between PSL and speech development, indicating the relationship between the peripheral 5HT concentrations and verbal abilities in autistic subjects...
Emotional response in dopamine D2L receptor-deficient miceDubravka Hranilovic
Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia
Behav Brain Res 195:246-50. 2008..Our findings contribute to a better understanding of the molecular and cellular mechanisms underlying emotional responses...
Serotonin transporter gene promoter (5-HTTLPR) and intron 2 (VNTR) polymorphisms in Croatian suicide victimsDubravka Hranilovic
Laboratory of Neurochemistry and Molecular Neurobiology, Rudjer Boskovic Institute, Zagreb, Croatia
Biol Psychiatry 54:884-9. 2003....
