Daisy Crispim



  1. Lemos N, Dieter C, Carlessi R, Rheinheimer J, Brondani L, Leitão C, et al. Renal effects of exendin-4 in an animal model of brain death. Mol Biol Rep. 2019;46:2197-2207 pubmed publisher
    ..Our findings suggest that Ex-4 administration in BD rats reduces BD-induced kidney damage by decreasing the expression of oxidative stress genes and increasing the expression of Bcl2. ..
  2. Assmann T, Recamonde Mendoza M, Costa A, Punales M, Tschiedel B, Canani L, et al. Circulating miRNAs in diabetic kidney disease: case-control study and in silico analyses. Acta Diabetol. 2019;56:55-65 pubmed publisher
    ..Our study found four miRNAs differentially expressed in patients with severe DKD, providing significant information about the biological pathways in which they are involved. ..
  3. Assmann T, Recamonde Mendoza M, de Souza B, Bauer A, Crispim D. MicroRNAs and diabetic kidney disease: Systematic review and bioinformatic analysis. Mol Cell Endocrinol. 2018;477:90-102 pubmed publisher
    ..In conclusion, six miRNAs seem to be dysregulated in patients with different stages of DKD, constituting potential biomarkers of this disease. ..
  4. Carlessi R, Lemos N, Dias A, Oliveira F, Brondani L, Canani L, et al. Exendin-4 protects rat islets against loss of viability and function induced by brain death. Mol Cell Endocrinol. 2015;412:239-50 pubmed publisher
    ..After testing in the human pancreatic islet transplantation setting, this approach might sum to the ongoing effort to achieve consistent and successful single-donor islet transplantation. ..
  5. Assmann T, Recamonde Mendoza M, Punales M, Tschiedel B, Canani L, Crispim D. MicroRNA expression profile in plasma from type 1 diabetic patients: Case-control study and bioinformatic analysis. Diabetes Res Clin Pract. 2018;141:35-46 pubmed publisher
    ..Five miRNAs are dysregulated in recently-diagnosed T1DM patients and target several genes involved in pathways related to T1DM pathogenesis, thus representing potential T1DM biomarkers. ..
  6. Brondani L, Boelter G, Assmann T, Leitão C, Canani L, Crispim D. Irisin-encoding gene (FNDC5) variant is associated with changes in blood pressure and lipid profile in type 2 diabetic women but not in men. Metabolism. 2015;64:952-7 pubmed publisher
  7. Assmann T, Brondani L, Bouças A, Rheinheimer J, de Souza B, Canani L, et al. Nitric oxide levels in patients with diabetes mellitus: A systematic review and meta-analysis. Nitric Oxide. 2016;61:1-9 pubmed publisher
    ..This meta-analysis detected a significant increase in NOx levels in European T1DM patients as well as European and Asian T2DM patients. Further studies in other ethnicities are necessary to confirm these data. ..
  8. Assmann T, Duarte G, Brondani L, de Freitas P, Martins É, Canani L, et al. Polymorphisms in genes encoding miR-155 and miR-146a are associated with protection to type 1 diabetes mellitus. Acta Diabetol. 2017;54:433-441 pubmed publisher
    ..However, miR-375 rs6715345 frequencies did not differ between cases and controls. MiR-146a rs2910164 and miR-155 rs767649 polymorphisms were associated with protection for T1DM. ..
  9. Duarte G, Assmann T, Dieter C, de Souza B, Crispim D. GLIS3 rs7020673 and rs10758593 polymorphisms interact in the susceptibility for type 1 diabetes mellitus. Acta Diabetol. 2017;54:813-821 pubmed publisher
    ..Our results indicate that individually the rs7020673 and rs10758593 SNPs are not significantly associated with T1DM but seem to interact in the predisposition for this disease. ..

More Information


  1. Rheinheimer J, de Souza B, Cardoso N, Bauer A, Crispim D. Current role of the NLRP3 inflammasome on obesity and insulin resistance: A systematic review. Metabolism. 2017;74:1-9 pubmed publisher
    ..NLRP3 rs10754558 polymorphism is associated with risk for T2DM in Chinese Han populations. In conclusion, available studies strongly points for an association between NLRP3 inflammasome and obesity/IR. ..
  2. Assmann T, Recamonde Mendoza M, de Souza B, Crispim D. MicroRNA expression profiles and type 1 diabetes mellitus: systematic review and bioinformatic analysis. Endocr Connect. 2017;6:773-790 pubmed publisher
    ..In conclusion, eleven circulating miRNAs seem to be dysregulated in T1DM patients in different studies, being potential circulating biomarkers of this disease...
  3. Lemos N, Dieter C, Dorfman L, Assmann T, Duarte G, Canani L, et al. The rs2292239 polymorphism in ERBB3 gene is associated with risk for type 1 diabetes mellitus in a Brazilian population. Gene. 2018;644:122-128 pubmed publisher
    ..62, 95% CI 1.02-2.59; P=0.043). Our results suggest that the A/A genotype of the ERBB3 rs2292239 SNP is associated with risk for T1DM in a white Brazilian population. ..