Ann Marie Craig
Connor S, Elegheert J, Xie Y, Craig A. Pumping the brakes: suppression of synapse development by MDGA-neuroligin interactions. Curr Opin Neurobiol. 2019;57:71-80 pubmed publisher
..Behavioral deficits in Mdga mutant mice support genetic links to schizophrenia and autism spectrum disorders and raise the possibility of harnessing these interactions for therapeutic purposes. ..
Zhang P, Lu H, Peixoto R, Pines M, Ge Y, Oku S, et al
. Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships. Cell. 2018;174:1450-1464.e23 pubmed publisher
Zhang P, Craig A. Inhibitory Synapses Get Madd for Neuroligin. Neuron. 2015;86:1321-4 pubmed publisher
..Two studies in this issue of Neuron, Maro et al. (2015) and Tu et al. (2015), identify a new extracellular effector for neuroligin in GABAergic postsynaptic differentiation. ..
Connor S, Ammendrup Johnsen I, Chan A, Kishimoto Y, Murayama C, Kurihara N, et al
. Altered Cortical Dynamics and Cognitive Function upon Haploinsufficiency of the Autism-Linked Excitatory Synaptic Suppressor MDGA2. Neuron. 2016;91:1052-1068 pubmed publisher
Ge Y, Kang Y, Cassidy R, Moon K, Lewis R, Wong R, et al
. Clptm1 Limits Forward Trafficking of GABAA Receptors to Scale Inhibitory Synaptic Strength. Neuron. 2018;97:596-610.e8 pubmed publisher
..Thus, in complement to other GABAAR-associated proteins that promote receptor surface expression, Clptm1 limits GABAAR forward trafficking and regulates inhibitory homeostatic plasticity. ..
Kang Y, Ge Y, Cassidy R, Lam V, Luo L, Moon K, et al
. A combined transgenic proteomic analysis and regulated trafficking of neuroligin-2. J Biol Chem. 2014;289:29350-64 pubmed publisher
..Altogether, we characterize NL2-associated complexes, demonstrate regulated trafficking of NL2, and provide tools for further proteomic and imaging studies of inhibitory synapses. ..
Elegheert J, Cvetkovska V, Clayton A, Heroven C, Vennekens K, Smukowski S, et al
. Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins. Neuron. 2017;95:896-913.e10 pubmed publisher
..These results illustrate a potentially brain-wide regulatory mechanism for NL-NRX signaling modulation. ..
Connor S, Ammendrup Johnsen I, Kishimoto Y, Karimi Tari P, Cvetkovska V, Harada T, et al
. Loss of Synapse Repressor MDGA1 Enhances Perisomatic Inhibition, Confers Resistance to Network Excitation, and Impairs Cognitive Function. Cell Rep. 2017;21:3637-3645 pubmed publisher