Louis Anthony Tony Cox

Summary

Publications

  1. ncbi request reprint Some limitations of aggregate exposure metrics
    Louis Anthony Cox
    Cox Associates, Inc, 503 Franklin Street, Denver, CO 80218, USA
    Risk Anal 27:439-45. 2007
  2. ncbi request reprint Developing scientific confidence in HTS-derived prediction models: Lessons learned from an endocrine case study
    Louis Anthony Tony Cox
    Cox Associates, 503 Franklin St, Denver, CO 80218, USA Electronic address
    Regul Toxicol Pharmacol 69:443-50. 2014
  3. pmc Enrofloxacin in poultry and human health
    Louis Anthony Cox
    Emerg Infect Dis 12:872-3; author reply 873. 2006
  4. doi request reprint Causal versus spurious spatial exposure-response associations in health risk analysis
    Louis Anthony Tony Cox
    Cox Associates and University of Colorado, Denver, CO 80218, USA
    Crit Rev Toxicol 43:26-38. 2013
  5. doi request reprint Community resilience and decision theory challenges for catastrophic events
    Louis Anthony Cox
    University of Colorado, 503 Franklin St, Denver, CO 80218, USA
    Risk Anal 32:1919-34. 2012
  6. doi request reprint Confronting deep uncertainties in risk analysis
    Louis Anthony Cox
    Associates and University of Colorado, 503 Franklin St, Denver, CO 80218, USA
    Risk Anal 32:1607-29. 2012
  7. doi request reprint Reassessing the human health benefits from cleaner air
    Louis Anthony Cox
    Cox Associates, Denver, CO 80218, USA
    Risk Anal 32:816-29. 2012
  8. ncbi request reprint Hormesis without cell killing
    Louis Anthony Tony Cox
    Cox Associates and University of Colorado, 503 Franklin St, Denver, CO 80218, USA
    Risk Anal 29:393-400. 2009
  9. doi request reprint Could removing arsenic from tobacco smoke significantly reduce smoker risks of lung cancer?
    Louis Anthony Cox
    Cox Associates and University of Colorado, Denver, CO 80218, USA
    Risk Anal 29:3-17. 2009
  10. doi request reprint Why reduced-form regression models of health effects versus exposures should not replace QRA: livestock production and infant mortality as an example
    Louis Anthony Tony Cox
    University of Colorado, Denver, CO 80218, USA
    Risk Anal 29:1664-71. 2009

Detail Information

Publications30

  1. ncbi request reprint Some limitations of aggregate exposure metrics
    Louis Anthony Cox
    Cox Associates, Inc, 503 Franklin Street, Denver, CO 80218, USA
    Risk Anal 27:439-45. 2007
    ....
  2. ncbi request reprint Developing scientific confidence in HTS-derived prediction models: Lessons learned from an endocrine case study
    Louis Anthony Tony Cox
    Cox Associates, 503 Franklin St, Denver, CO 80218, USA Electronic address
    Regul Toxicol Pharmacol 69:443-50. 2014
    ....
  3. pmc Enrofloxacin in poultry and human health
    Louis Anthony Cox
    Emerg Infect Dis 12:872-3; author reply 873. 2006
  4. doi request reprint Causal versus spurious spatial exposure-response associations in health risk analysis
    Louis Anthony Tony Cox
    Cox Associates and University of Colorado, Denver, CO 80218, USA
    Crit Rev Toxicol 43:26-38. 2013
    ..Hence, extreme caution and careful application of spatial statistical methods are warranted before interpreting proximity-based exposure-response relations as evidence of a possible or probable causal relation...
  5. doi request reprint Community resilience and decision theory challenges for catastrophic events
    Louis Anthony Cox
    University of Colorado, 503 Franklin St, Denver, CO 80218, USA
    Risk Anal 32:1919-34. 2012
    ..Recent ideas for building "disaster-resilient" communities can complement traditional normative decision theories, helping to meet the practical need for better ways to manage risks of extreme and catastrophic events...
  6. doi request reprint Confronting deep uncertainties in risk analysis
    Louis Anthony Cox
    Associates and University of Colorado, 503 Franklin St, Denver, CO 80218, USA
    Risk Anal 32:1607-29. 2012
    ..They provide genuine breakthroughs for improving predictions and decisions when the correct model is highly uncertain. We demonstrate their potential by summarizing a variety of practical risk management applications...
  7. doi request reprint Reassessing the human health benefits from cleaner air
    Louis Anthony Cox
    Cox Associates, Denver, CO 80218, USA
    Risk Anal 32:816-29. 2012
    ....
  8. ncbi request reprint Hormesis without cell killing
    Louis Anthony Tony Cox
    Cox Associates and University of Colorado, 503 Franklin St, Denver, CO 80218, USA
    Risk Anal 29:393-400. 2009
    ..In addition, the examples presented emphasize the role of time in hormesis: exposures that monotonically increase risks at younger ages may nonetheless produce a U-shaped or J-shaped dose-response relation for lifetime risk of cancer...
  9. doi request reprint Could removing arsenic from tobacco smoke significantly reduce smoker risks of lung cancer?
    Louis Anthony Cox
    Cox Associates and University of Colorado, Denver, CO 80218, USA
    Risk Anal 29:3-17. 2009
    ..At present, this fraction is unknown (and could be as low as zero), but the possibility that it could be high (close to 1) cannot be ruled out without further data...
  10. doi request reprint Why reduced-form regression models of health effects versus exposures should not replace QRA: livestock production and infant mortality as an example
    Louis Anthony Tony Cox
    University of Colorado, Denver, CO 80218, USA
    Risk Anal 29:1664-71. 2009
    ..Sound risk management requires the extra work needed to identify and model valid causal relations...
  11. doi request reprint A causal model of chronic obstructive pulmonary disease (COPD) risk
    Louis Anthony Tony Cox
    Cox Associates and University of Colorado, 503 Franklin Street, Denver, CO 80218, USA
    Risk Anal 31:38-62. 2011
    ....
  12. doi request reprint An exposure-response threshold for lung diseases and lung cancer caused by crystalline silica
    Louis Anthony Tony Cox
    Cox Associates, 503 Franklin Street, Denver, CO 80218, USA
    Risk Anal 31:1543-60. 2011
    ..Applying this new model to epidemiological data, we conclude that current permissible exposure levels, on the order of 0.1 mg/m³, are probably below the threshold for triggering lung diseases in humans...
  13. doi request reprint Clarifying types of uncertainty: when are models accurate, and uncertainties small?
    Louis Anthony Tony Cox
    Cox Associates and University of Colorado, 503 Franklin St, Denver, CO 80218, USA
    Risk Anal 31:1530-3; discussion 1538-42. 2011
    ....
  14. pmc Reassessing benzene risks using internal doses and Monte-Carlo uncertainty analysis
    L A Cox
    Cox Associates, Denver, Colorado 80218, USA
    Environ Health Perspect 104:1413-29. 1996
    ....
  15. doi request reprint Why risk is not variance: an expository note
    Louis Anthony Tony Cox
    Cox Associates, 503 Franklin Street, Denver, CO 80218, USA
    Risk Anal 28:925-8. 2008
    ..Unlike some previous analyses of limitations of variance as a risk metric, this expository note uses only simple mathematics and does not require the additional framework of von Neumann Morgenstern utility theory...
  16. doi request reprint What's wrong with risk matrices?
    Louis Anthony Cox
    Cox Associates and University of Colorado, 503 Franklin St, Denver, CO 80218, USA
    Risk Anal 28:497-512. 2008
    ..These limitations suggest that risk matrices should be used with caution, and only with careful explanations of embedded judgments...
  17. ncbi request reprint Estimating preventable fractions of disease caused by a specified biological mechanism: PAHs in smoking lung cancers as an example
    Louis Anthony Tony Cox
    Cox Associates, 503 Franklin St, Denver, CO 80218, USA
    Risk Anal 26:881-92. 2006
    ....
  18. ncbi request reprint Some limitations of a proposed linear model for antimicrobial risk management
    Louis Anthony Tony Cox
    Cox Associates, Denver, CO 80218, USA
    Risk Anal 25:1327-32. 2005
    ..quot;..
  19. ncbi request reprint Quantifying potential health impacts of cadmium in cigarettes on smoker risk of lung cancer: a portfolio-of-mechanisms approach
    Louis Anthony Tony Cox
    Cox Associates and University of Colorado, 503 Franklin St, Denver, CO 80218, USA
    Risk Anal 26:1581-99. 2006
    ..Conservative estimates and assumptions made in this calculation suggest that the true impact could be greater for some smokers. This conclusion appears to be robust to many scientific uncertainties about Cd and smoking effects...
  20. doi request reprint Overcoming confirmation bias in causal attribution: a case study of antibiotic resistance risks
    Louis Anthony Tony Cox
    Cox Associates, Denver, CO, USA
    Risk Anal 28:1155-72. 2008
    ....
  21. ncbi request reprint Does concern-driven risk management provide a viable alternative to QRA?
    Louis Anthony Tony Cox
    Cox Associates, 503 Franklin Street, Denver, CO 80218, USA
    Risk Anal 27:27-43. 2007
    ....
  22. doi request reprint What's wrong with hazard-ranking systems? An expository note
    Louis Anthony Tony Cox
    Cox Associates and University of Colorado, USA
    Risk Anal 29:940-8. 2009
    ..Applying portfolio optimization methods instead of risk prioritization ranking, rating, or scoring methods can achieve greater risk-reduction value for resources spent...
  23. doi request reprint Some limitations of frequency as a component of risk: an expository note
    Louis Anthony Cox
    Cox Associates and University of Colorado, Denver, CO 80218, USA
    Risk Anal 29:171-5. 2009
    ..More flexible descriptions of risky processes, such as point process models can avoid these limitations...
  24. doi request reprint A mathematical model of protease-antiprotease homeostasis failure in chronic obstructive pulmonary disease (COPD)
    Louis Anthony Tony Cox
    Cox Associates and University of Colorado, Denver, CO, USA
    Risk Anal 29:576-86. 2009
    ..These and other predictions of the model are consistent with limited available human data...
  25. ncbi request reprint Some limitations of qualitative risk rating systems
    Louis Anthony Tony Cox
    Cox Associates, Inc, Denver, CO 80218, USA
    Risk Anal 25:651-62. 2005
    ..These limitations suggest that it is important to continue to develop and apply practical quantitative risk assessment methods, since qualitative ones are often unreliable...
  26. ncbi request reprint Bayesian Monte Carlo uncertainty analysis of human health risks from animal antimicrobial use in a dynamic model of emerging resistance
    Louis Anthony Cox
    Cox Associates, 503 Franklin Street, Denver, CO 80218, USA
    Risk Anal 24:1153-64. 2004
    ..S. population. Such quantitative estimates complement more qualitative assessments that discuss the possibility of future "resistance epidemics" (or endemics) without quantifying their probabilities...
  27. ncbi request reprint Symmetry, identifiability, and prediction uncertainties in multistage clonal expansion (MSCE) models of carcinogenesis
    Louis Anthony Cox
    Cox Associates, Denver, CO 80218, USA
    Risk Anal 27:1441-53. 2007
    ..From epidemiological data alone, only a set of equally likely alternative predictions can be made for the effects on risk of such interventions...
  28. ncbi request reprint Optimal tracking and testing of U.S. and Canadian herds for BSE: a value-of-information (VOI) approach
    Louis Anthony Cox
    Cox Associates, Denver, CO 80218, USA
    Risk Anal 25:827-40. 2005
    ..If aggressive tracking and testing can win back lost exports, then the VOI of a tracking program may increase to over half a billion dollars per year...
  29. ncbi request reprint Quantifying potential human health impacts of animal antibiotic use: enrofloxacin and macrolides in chickens
    Louis Anthony Cox
    Cox Associates, 503 Franklin Street, Denver, CO 80218 3623, USA
    Risk Anal 26:135-46. 2006
    ..This potentially important aspect of human health risk assessment for animal antibiotics has not previously been quantified...
  30. ncbi request reprint Improving risk-based decision making for terrorism applications
    Louis Anthony Cox
    Cox Associates and University of Colorado, USA
    Risk Anal 29:336-41; discussion 342-3. 2009
    ..These limitations of present scoring methods present exciting technical challenges and opportunities for risk analysts to develop improved methods for protecting facilities and infrastructure against terrorist threats...