- Common skin cancers in older adults: approach to diagnosis and management
M Laurin Council
Center for Dermatologic and Cosmetic Surgery, Department of Internal Medicine, Washington University School of Medicine, 969 North Mason Road, Suite 200, St Louis, MO 63141, USA
Clin Geriatr Med 29:361-72. 2013
..Epidemiology, clinical diagnosis, staging, and treatment are discussed for each of these malignancies...
- Frequent mutation of BAP1 in metastasizing uveal melanomas
J William Harbour
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
Science 330:1410-3. 2010
..These findings implicate loss of BAP1 in uveal melanoma metastasis and suggest that the BAP1 pathway may be a valuable therapeutic target...
- Oncogenic mutations in GNAQ occur early in uveal melanoma
Michael D Onken
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
Invest Ophthalmol Vis Sci 49:5230-4. 2008
..An extensive search for such mutations was undertaken, focusing on the RAF/MEK/ERK pathway, which is often the target of initiating mutations in other types of cancer...
- Contribution of genetic factors for melanoma susceptibility in sporadic US melanoma patients
M Laurin Council
Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
Exp Dermatol 18:485-7. 2009
..One MM patient with a family history of MM, who had developed other skin cancers, was homozygous for a novel TYR variant (P406L) of unknown significance. Hence, rare variants in TYR may be important risk factors for skin cancer...