John R Couchman

Summary

Publications

  1. doi request reprint Transmembrane signaling proteoglycans
    John R Couchman
    Department of Biomedical Sciences, University of Copenhagen, Copenhagen, 2200 Denmark
    Annu Rev Cell Dev Biol 26:89-114. 2010
  2. pmc An introduction to proteoglycans and their localization
    John R Couchman
    Department of Biomedical Sciences, University of Copenhagen, Copenhagen N, Denmark
    J Histochem Cytochem 60:885-97. 2012
  3. pmc Phosphorylation and mRNA splicing of collapsin response mediator protein-2 determine inhibition of rho-associated protein kinase (ROCK) II function in carcinoma cell migration and invasion
    Marie Morgan-Fisher
    From the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, and Biotech Research and Innovation Centre BRIC, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen N, 2200, Denmark and
    J Biol Chem 288:31229-40. 2013
  4. doi request reprint The newcomer in the integrin family: integrin α9 in biology and cancer
    Anette M Høye
    Department of Biomedical Sciences, The Faculty of Health and Medical Sciences, and Biotech Research and Innovation Centre BRIC, University of Copenhagen, Copenhagen Biocenter, Ole Maaløes Vej 5, Copenhagen N 2200, Denmark
    Adv Biol Regul 52:326-39. 2012
  5. pmc Breast and ovarian cancers: a survey and possible roles for the cell surface heparan sulfate proteoglycans
    Atsuko Yoneda
    Department of Biomedical Sciences, University of Copenhagen, Denmark
    J Histochem Cytochem 60:9-21. 2012
  6. doi request reprint An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state
    Mikael Egebjerg Pedersen
    Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen, Denmark
    Science 341:1404-8. 2013
  7. pmc A collapsin response mediator protein 2 isoform controls myosin II-mediated cell migration and matrix assembly by trapping ROCK II
    Atsuko Yoneda
    Department of Biomedical Sciences, Faculty of Health Sciences, and Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark
    Mol Cell Biol 32:1788-804. 2012
  8. doi request reprint Mapping of matrix metalloproteinase cleavage sites on syndecan-1 and syndecan-4 ectodomains
    Tina Manon-Jensen
    Department of Biomedical Sciences, University of Copenhagen, Denmark
    FEBS J 280:2320-31. 2013
  9. pmc Heparan sulfate biosynthesis: methods for investigation of the heparanosome
    Hinke A B Multhaupt
    Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Histochem Cytochem 60:908-15. 2012
  10. doi request reprint Proteoglycans in health and disease: the multiple roles of syndecan shedding
    Tina Manon-Jensen
    Deparment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    FEBS J 277:3876-89. 2010

Collaborators

Detail Information

Publications12

  1. doi request reprint Transmembrane signaling proteoglycans
    John R Couchman
    Department of Biomedical Sciences, University of Copenhagen, Copenhagen, 2200 Denmark
    Annu Rev Cell Dev Biol 26:89-114. 2010
    ..Here some of the latest developments in the field are examined in hopes of stimulating further interest in this fascinating group of molecules...
  2. pmc An introduction to proteoglycans and their localization
    John R Couchman
    Department of Biomedical Sciences, University of Copenhagen, Copenhagen N, Denmark
    J Histochem Cytochem 60:885-97. 2012
    ..Included are some remarks on proteoglycan and glycosaminoglycan localization techniques, with reference to the special physicochemical properties of these complex molecules...
  3. pmc Phosphorylation and mRNA splicing of collapsin response mediator protein-2 determine inhibition of rho-associated protein kinase (ROCK) II function in carcinoma cell migration and invasion
    Marie Morgan-Fisher
    From the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, and Biotech Research and Innovation Centre BRIC, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen N, 2200, Denmark and
    J Biol Chem 288:31229-40. 2013
    ....
  4. doi request reprint The newcomer in the integrin family: integrin α9 in biology and cancer
    Anette M Høye
    Department of Biomedical Sciences, The Faculty of Health and Medical Sciences, and Biotech Research and Innovation Centre BRIC, University of Copenhagen, Copenhagen Biocenter, Ole Maaløes Vej 5, Copenhagen N 2200, Denmark
    Adv Biol Regul 52:326-39. 2012
    ..This review gives an overview of the recent progress in α9β1-mediated biological and pathological processes, and discusses its potential as a target for cancer diagnosis and therapy...
  5. pmc Breast and ovarian cancers: a survey and possible roles for the cell surface heparan sulfate proteoglycans
    Atsuko Yoneda
    Department of Biomedical Sciences, University of Copenhagen, Denmark
    J Histochem Cytochem 60:9-21. 2012
    ..Both families of proteoglycans have been implicated in cellular responses to growth factors and morphogens, including many now associated with tumor progression...
  6. doi request reprint An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state
    Mikael Egebjerg Pedersen
    Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen, Denmark
    Science 341:1404-8. 2013
    ..Our results identify a regulatory axis controlled by a conserved microRNA that maintains proteoglycan homeostasis in cells. ..
  7. pmc A collapsin response mediator protein 2 isoform controls myosin II-mediated cell migration and matrix assembly by trapping ROCK II
    Atsuko Yoneda
    Department of Biomedical Sciences, Faculty of Health Sciences, and Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark
    Mol Cell Biol 32:1788-804. 2012
    ..This study provides a new insight into CRMP-2 as a controller of myosin II-mediated cellular functions through the inhibition of ROCK II in nonneuronal cells...
  8. doi request reprint Mapping of matrix metalloproteinase cleavage sites on syndecan-1 and syndecan-4 ectodomains
    Tina Manon-Jensen
    Department of Biomedical Sciences, University of Copenhagen, Denmark
    FEBS J 280:2320-31. 2013
    ..The MT1-MMP cleavage sites in syndecan-1 and syndecan-4 were confirmed by site-directed mutagenesis. These findings provide insights into the characteristics of syndecan shedding...
  9. pmc Heparan sulfate biosynthesis: methods for investigation of the heparanosome
    Hinke A B Multhaupt
    Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Histochem Cytochem 60:908-15. 2012
    ....
  10. doi request reprint Proteoglycans in health and disease: the multiple roles of syndecan shedding
    Tina Manon-Jensen
    Deparment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    FEBS J 277:3876-89. 2010
    ..Here, recent research into the shedding of syndecans and its physiological relevance are assessed...
  11. pmc Syndecan-1 and syndecan-4 are independent indicators in breast carcinoma
    Maria E Lendorf
    Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Histochem Cytochem 59:615-29. 2011
    ..These syndecans may, therefore, have distinct roles in regulating breast carcinoma cell behavior...
  12. pmc Heparan sulfate chain valency controls syndecan-4 function in cell adhesion
    Sandeep Gopal
    Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark
    J Biol Chem 285:14247-58. 2010
    ....