George Coupland



  1. Hyun Y, Vincent C, Tilmes V, Bergonzi S, Kiefer C, Richter R, et al. A regulatory circuit conferring varied flowering response to cold in annual and perennial plants. Science. 2019;363:409-412 pubmed publisher
    ..By reconstructing the annual response in perennials, we conclude that characteristic patterns of reproduction in annuals and perennials are conferred through variation in dependency on distinct flowering pathways acting in parallel. ..
  2. Simon S, Rühl M, de Montaigu A, Wötzel S, Coupland G. Evolution of CONSTANS Regulation and Function after Gene Duplication Produced a Photoperiodic Flowering Switch in the Brassicaceae. Mol Biol Evol. 2015;32:2284-301 pubmed publisher
    ..The origin of CO may have contributed to the range expansion of the Brassicaceae and suggests that in other families CO genes involved in photoperiodic flowering arose by convergent evolution. ..
  3. de Montaigu A, Giakountis A, Rubin M, Tóth R, Cremer F, Sokolova V, et al. Natural diversity in daily rhythms of gene expression contributes to phenotypic variation. Proc Natl Acad Sci U S A. 2015;112:905-10 pubmed publisher
    ..Such alleles could confer an advantage by adjusting the activity of temporally regulated processes without severely disrupting the circadian system. ..
  4. Andrés F, Torti S, Vincent C, Coupland G. Sample Preparation of Arabidopsis thaliana Shoot Apices for Expression Studies of Photoperiod-Induced Genes. Methods Mol Biol. 2016;1398:81-91 pubmed publisher
    ..This method can be specifically optimized for photoperiodic-flowering studies. In this chapter, we describe improved methods to generate plant material and histological samples to be combined with RNA ISH in flowering-related studies. ..
  5. Andres F, Porri A, Torti S, Mateos J, Romera Branchat M, García Martínez J, et al. SHORT VEGETATIVE PHASE reduces gibberellin biosynthesis at the Arabidopsis shoot apex to regulate the floral transition. Proc Natl Acad Sci U S A. 2014;111:E2760-9 pubmed publisher
  6. Berns M, Nordström K, Cremer F, Tóth R, Hartke M, Simon S, et al. Evening expression of arabidopsis GIGANTEA is controlled by combinatorial interactions among evolutionarily conserved regulatory motifs. Plant Cell. 2014;26:3999-4018 pubmed publisher
    ..Thus, combinatorial interactions among EEs and ABRELs confer diurnal patterns of transcription via an evolutionarily conserved module present in GI and other evening-expressed genes. ..
  7. Andrés F, Romera Branchat M, Martínez Gallegos R, Patel V, Schneeberger K, Jang S, et al. Floral Induction in Arabidopsis by FLOWERING LOCUS T Requires Direct Repression of BLADE-ON-PETIOLE Genes by the Homeodomain Protein PENNYWISE. Plant Physiol. 2015;169:2187-99 pubmed publisher
    ..These results demonstrate a direct role for PNY in defining the spatial expression patterns of boundary genes and the significance of this process for floral induction by FT. ..
  8. Hyun Y, Richter R, Vincent C, Martinez Gallegos R, Porri A, Coupland G. Multi-layered Regulation of SPL15 and Cooperation with SOC1 Integrate Endogenous Flowering Pathways at the Arabidopsis Shoot Meristem. Dev Cell. 2016;37:254-66 pubmed publisher
    ..Thus, we present a molecular basis for assimilation of flowering signals and transcriptional control at the SAM during flowering. ..
  9. Hayama R, Sarid Krebs L, Richter R, Fernandez V, Jang S, Coupland G. PSEUDO RESPONSE REGULATORs stabilize CONSTANS protein to promote flowering in response to day length. EMBO J. 2017;36:904-918 pubmed publisher
    ..We propose an additional role for PRRs in which they act upon CO protein to promote flowering, directly coupling information on light exposure to the timekeeper and allowing recognition of LDs. ..

More Information


  1. Mateos J, Tilmes V, Madrigal P, Severing E, Richter R, Rijkenberg C, et al. Divergence of regulatory networks governed by the orthologous transcription factors FLC and PEP1 in Brassicaceae species. Proc Natl Acad Sci U S A. 2017;114:E11037-E11046 pubmed publisher
    ..Analysis of TF BSs in these lineages thus distinguishes widely conserved targets representing the core function of the TF from those that were recruited later in evolution. ..