Research Topics
Species | Ana Cecilia RodriguezSummaryAffiliation: San Jos Country: Costa Rica Publications
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Detail Information
Publications
Low risk of type-specific carcinogenic HPV re-appearance with subsequent cervical intraepithelial neoplasia grade 2/3Ana Cecilia Rodriguez
Proyecto Epidemiologico Guanacaste, INCIENSA Foundation, San Jose, Costa Rica
Int J Cancer 131:1874-81. 2012..If confirmed, this argues against vaccination to avoid re-appearance that leads to precursor lesions and against the need of frequent HPV screening after initial negative results...- Alterations of T-cell surface markers in older women with persistent human papillomavirus infectionAna Cecilia Rodriguez
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Int J Cancer 128:597-607. 2011..Whether phenotypic alterations observed predispose to HPV persistence or result from it should be the focus of future studies... - Longitudinal study of human papillomavirus persistence and cervical intraepithelial neoplasia grade 2/3: critical role of duration of infectionAna Cecilia Rodriguez
Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, Torre La Sabana, 7mo piso, Sabana Norte, San José 10203, Costa Rica
J Natl Cancer Inst 102:315-24. 2010.... - Chlamydia trachomatis and risk of prevalent and incident cervical premalignancy in a population-based cohortMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
J Natl Cancer Inst 102:1794-804. 2010..In a large prospective cohort, we assessed the role of C trachomatis in cervical premalignancy and addressed confounding by HPV... 
High load for most high risk human papillomavirus genotypes is associated with prevalent cervical cancer precursors but only HPV16 load predicts the development of incident diseasePatti E Gravitt
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Int J Cancer 121:2787-93. 2007..The extent to which these observations can be translated into clinical practice must be rigorously examined in the context of the method of viral load measurement and the type-specific differences observed for incident >/=CIN2...- Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa RicaSophia S Wang
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS MSC 7234, Bethesda, MD 20892 7234, USA
Cancer Epidemiol Biomarkers Prev 13:1355-60. 2004..Whereas our data support the diagnostic potential for p16INK4a, further prospective studies with detailed follow-up determining the prognostic capacity of this marker are needed... 
Rapid clearance of human papillomavirus and implications for clinical focus on persistent infectionsAna Cecilia Rodriguez
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS, Rm 5032, Rockville, MD 20852, USA
J Natl Cancer Inst 100:513-7. 2008..These findings suggest that the medical community should emphasize persistence of cervical HPV infection, not single-time detection of HPV, in management strategies and health messages...- Short term persistence of human papillomavirus and risk of cervical precancer and cancer: population based cohort studyPhilip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
BMJ 339:b2569. 2009.... - Single nucleotide polymorphisms in the PRDX3 and RPS19 and risk of HPV persistence and cervical precancer/cancerMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
PLoS ONE 7:e33619. 2012..Host genetic factors might affect the risk of progression from infection with carcinogenic human papillomavirus (HPV), the etiologic agent for cervical cancer, to persistent HPV infection, and hence to cervical precancer and cancer... - CIN2 is a much less reproducible and less valid diagnosis than CIN3: results from a histological review of population-based cervical samplesJoseph D Carreon
Division of Cancer Epidemiology and Genetics, The National Cancer Institute, National Institutes of Health, Department of Health and Human Services Rockville, Maryland 20852, USA
Int J Gynecol Pathol 26:441-6. 2007..The CIN3 is a substantially more reproducible diagnosis that can be validated more frequently with HPV tests and cytological interpretations than CIN2... - Rationale and design of a community-based double-blind randomized clinical trial of an HPV 16 and 18 vaccine in Guanacaste, Costa RicaRolando Herrero
Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, Torre La Sabana, 300 Oeste del ICE, Piso 7, Sabana Norte, San Jose, Costa Rica
Vaccine 26:4795-808. 2008..4% agreement for all types, kappa 0.59). Follow up will continue with yearly or more frequent examinations for at least 4 years for each participant... - The natural history of human papillomavirus infection and cervical intraepithelial neoplasia among young women in the Guanacaste cohort shortly after initiation of sexual lifeAna Cecilia Rodriguez
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Rockville, Maryland 20859, USA
Sex Transm Dis 34:494-502. 2007..We wanted to explore early HPV natural history and CIN 3 prospectively... - A prospective study of age trends in cervical human papillomavirus acquisition and persistence in Guanacaste, Costa RicaPhilip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7234, USA
J Infect Dis 191:1808-16. 2005..In some populations, HPV prevalence demonstrates a second peak in older women. Longitudinal data may help to explain this second peak... - Evaluation of the FTA carrier device for human papillomavirus testing in developing countriesPaula Gonzalez
Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, Guanacaste, Costa Rica
J Clin Microbiol 50:3870-6. 2012..FTA cartridges could provide a simpler and more cost-effective method for cervical cell collection, storage, and transportation for HPV-DNA detection in research settings in developing countries... - Determinants of seropositivity among HPV-16/18 DNA positive young womenCarolina Porras
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
BMC Infect Dis 10:238. 2010..We evaluated determinants of seropositivity among 646 women infected with HPV-16 and/or HPV-18... - Long-term persistence of prevalently detected human papillomavirus infections in the absence of detectable cervical precancer and cancerPhilip E Castle
Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7234, USA
J Infect Dis 203:814-22. 2011..Detailed descriptions of long-term persistence of human papillomavirus (HPV) in the absence of cervical precancer are lacking... - Human papillomavirus infection with multiple types: pattern of coinfection and risk of cervical diseaseAnil K Chaturvedi
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7072 Rockville, MD 20852, USA
J Infect Dis 203:910-20. 2011..We investigated coinfection patterns for 25 human papillomavirus (HPV) types and assessed the risk conferred by multiple HPV types toward cervical disease... - Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancerSophia S Wang
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 5104, Rockville, MD 20852 7234, USA
J Infect Dis 199:20-30. 2009..We examined host genetic factors to identify those more common in individuals whose human papillomavirus (HPV) infections were most likely to persist and progress to cervical intraepithelial neoplasia grade 3 (CIN3) and cancer... - Comparison of two PCR-based human papillomavirus genotyping methodsPhilip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5004, EPS MSC 7234, Bethesda, MD 20892 7234
J Clin Microbiol 46:3437-45. 2008..Both approaches are suitable for monitoring the impact of HPV16/18 vaccines in clinical trials... - Determinants and correlation of systemic and cervical concentrations of total IgA and IgGMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Suite 550, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 18:2672-6. 2009..17 and 0.16, respectively). The lack of correlation between systemic and cervical total IgA and IgG suggests that systemic concentrations are not reflective of cervical levels... - A population-based study of vaginal human papillomavirus infection in hysterectomized womenPhilip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7234, USA
J Infect Dis 190:458-67. 2004..e., A3/A4/A15) may have a predilection for vaginal epithelium... - Epidemiological study of anti-HPV16/18 seropositivity and subsequent risk of HPV16 and -18 infectionsMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Ste 550, Rockville, MD 20852, USA
J Natl Cancer Inst 102:1653-62. 2010..Infection with human papillomavirus (HPV) 16 or HPV18 elicits an antibody response, but whether the elicited antibodies protect women against subsequent infection by a homologous HPV type compared with seronegative women is unknown... - A population-based prospective study of carcinogenic human papillomavirus variant lineages, viral persistence, and cervical neoplasiaMark Schiffman
Divisions of Cancer Epidemiology and Genetics and Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20852, USA
Cancer Res 70:3159-69. 2010..Larger viral genomic studies are warranted, especially to identify the genetic basis for HPV16's unique carcinogenicity... - Human papillomavirus types by age in cervical cancer precursors: predominance of human papillomavirus 16 in young womenCarolina Porras
Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, Torre La Sabana, 300 Oeste del ICE, Piso 7, Sabana Norte, San Jose, Costa Rica
Cancer Epidemiol Biomarkers Prev 18:863-5. 2009..It also has implications for prevention, including the need to vaccinate young women before exposure to HPV vaccine-containing types (HPV 16 and HPV 18) to prevent the majority of cervical cancer precursors... - Epidemiology of genital Chlamydia trachomatis infection among young women in Costa RicaCarolina Porras
Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, San Jose, Costa Rica
Sex Transm Dis 35:461-8. 2008..To investigate Chlamydia trachomatis (Ct) epidemiology among 5829 women 18 to 25 years old, in Costa Rica... - PCR testing of pooled longitudinally collected cervical specimens of women to increase the efficiency of studying human papillomavirus infectionPhilip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Room 7074, 6120 Executive Boulevard, EPS MSC 7234, Bethesda, MD 20892 7234, USA
Cancer Epidemiol Biomarkers Prev 14:256-60. 2005..3% (95% CI, 74.7-91.4%), respectively. We conclude that pooling specimens and testing by PCR may be useful for discriminating HPV DNA-positive from completely negative specimen sets in women who are likely to have been HPV DNA-negative.>.. - Behavioral/lifestyle and immunologic factors associated with HPV infection among women older than 45 yearsPaula Gonzalez
Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, Torre Sabana, 300 Oeste del ICE, Piso 7, Sabana Norte, San Jose, Costa Rica
Cancer Epidemiol Biomarkers Prev 19:3044-54. 2010..Cervical human papilloma virus (HPV) detection increases after menopause, but its determinants need clarification... - Proof-of-principle evaluation of the efficacy of fewer than three doses of a bivalent HPV16/18 vaccineAimee R Kreimer
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7084, Rockville, MD 20852, USA
J Natl Cancer Inst 103:1444-51. 2011..Three-dose regimens for human papillomavirus (HPV) vaccines are expensive and difficult to complete, especially in settings where the need for cervical cancer prevention is greatest... - Prevalence of and risk factors for anal human papillomavirus infection among young healthy women in Costa RicaFelipe A Castro
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
J Infect Dis 206:1103-10. 2012..Anal cancer is caused by human papillomavirus (HPV), yet little is known about anal HPV infection among healthy young women... - A comparison between real-time polymerase chain reaction and hybrid capture 2 for human papillomavirus DNA quantitationPatti E Gravitt
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Cancer Epidemiol Biomarkers Prev 12:477-84. 2003..The nonrandom distribution of multiple infections by case-control status and the apparent differential effect of viral load by genotype warrant caution when using HC 2 measurements to infer viral load associations with SIL and cancer... - A large, population-based study of age-related associations between vaginal pH and human papillomavirus infectionMegan A Clarke
Division of Cancer Epidemiology and Genetics, DHHS, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
BMC Infect Dis 12:33. 2012..We examined vaginal pH and the risk of HPV infection, cytological abnormalities, and C. trachomatis infection... - Efficacy of a bivalent HPV 16/18 vaccine against anal HPV 16/18 infection among young women: a nested analysis within the Costa Rica Vaccine TrialAimee R Kreimer
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Lancet Oncol 12:862-70. 2011..Human papillomavirus (HPV) 16 and 18 infections cause most cases of anal cancer. We assessed efficacy of an AS04-adjuvanted HPV 16 and HPV 18 vaccine against anal infection with HPV 16, HPV 18, or both (HPV 16/18)... - The carcinogenicity of human papillomavirus types reflects viral evolutionMark Schiffman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MA, USA
Virology 337:76-84. 2005..These results present several clear clues and research directions in our ongoing efforts to understand HPV carcinogenesis... - A study of the impact of adding HPV types to cervical cancer screening and triage testsMark Schiffman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7234, USA
J Natl Cancer Inst 97:147-50. 2005..The minimal increases in sensitivity and in negative predictive value achieved by adding HPV types to DNA tests must be weighed against the projected burden to thousands of women falsely labeled as being at high risk of cervical cancer... - Comparison of ophthalmic sponges for measurements of immune markers from cervical secretionsPhilip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7234, USA
Clin Diagn Lab Immunol 11:399-405. 2004..These findings require confirmation... - A competitive serological assay shows naturally acquired immunity to human papillomavirus infections in the Guanacaste Natural History StudyNicolas Wentzensen
National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
J Infect Dis 204:94-102. 2011..A competitive Luminex Immunoassay (cLIA) has been developed to measure neutralizing antibodies against human papillomavirus (HPV) types 6, 11, 16 and 18... - Seroprevalence and correlates of human papillomavirus 16/18 seropositivity among young women in Costa RicaSarah Coseo
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS, Room 7079, Rockville, MD 20852, USA
Sex Transm Dis 37:706-14. 2010..We investigated HPV16 and 18 seroepidemiology among young, unvaccinated women aged between 18 and 25... - Treatability by cryotherapy in a screen-and-treat strategyJulia C Gage
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USA
J Low Genit Tract Dis 13:174-81. 2009..We estimated the percentage of women infected with human papillomavirus (HPV+) who cannot be immediately treated with cryotherapy... - HPV16 seropositivity and subsequent HPV16 infection risk in a naturally infected population: comparison of serological assaysShih Wen Lin
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
PLoS ONE 8:e53067. 2013.... - Direct comparison of HPV16 serological assays used to define HPV-naïve women in HPV vaccine trialsMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, NIH, Bethesda, MD, USA
Cancer Epidemiol Biomarkers Prev 21:1547-54. 2012..Some of the variation in estimated vaccine efficacies may be due to the differences in these assays used to define the HPV-naïve subgroups. To guide the interpretation of published results, we compared these assays... - Lack of heterogeneity of HPV16 E7 sequence compared with HPV31 and HPV73 may be related to its unique carcinogenic propertiesMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA
Arch Virol 155:367-70. 2010..The lack of heterogeneity of HPV16 E7 suggests high evolutionary purifying selection that might be related to the unique carcinogenicity of HPV16... - Immune profiling of plasma and cervical secretions using recycling immunoaffinity chromatographyPhilip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7234, USA
Cancer Epidemiol Biomarkers Prev 12:1449-56. 2003.... - Evaluation of the polyclonal ELISA HPV serology assay as a biomarker for human papillomavirus exposureSarah E Coseo
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
Sex Transm Dis 38:976-82. 2011..Overall performance of these assays, as a measure of HPV exposure, has not been evaluated... - An evaluation by midwives and gynecologists of treatability of cervical lesions by cryotherapy among human papillomavirus-positive womenJulia C Gage
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
Int J Gynecol Cancer 19:728-33. 2009..To estimate efficacy of a visual triage of human papillomavirus (HPV)-positive women to either immediate cryotherapy or referral if not treatable (eg, invasive cancer, large precancers)... - Risk of miscarriage with bivalent vaccine against human papillomavirus (HPV) types 16 and 18: pooled analysis of two randomised controlled trialsSholom Wacholder
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852, USA
BMJ 340:c712. 2010..To assess whether vaccination against human papillomavirus (HPV) increases the risk of miscarriage... - Hierarchy of resistance to cervical neoplasia mediated by combinations of killer immunoglobulin-like receptor and human leukocyte antigen lociMary Carrington
Basic Research Program, Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
J Exp Med 201:1069-75. 2005.... - Comparison of the SPF10-LiPA system to the Hybrid Capture 2 Assay for detection of carcinogenic human papillomavirus genotypes among 5,683 young women in Guanacaste, Costa RicaMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Suite 550, Rockville, MD 20852, USA
J Clin Microbiol 45:1447-54. 2007..The crude agreement between the two assays was 88%, with a kappa value of 0.75 (95% confidence limits, 0.73 to 0.76). We observed very good agreement between HC2 and SPF(10)-LiPA for carcinogenic HPV type detection... - Establishment and operation of a biorepository for molecular epidemiologic studies in Costa RicaBernal Cortes
Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, Torre La Sabana, 7mo piso, Sabana Norte, San Jose, Costa Rica
Cancer Epidemiol Biomarkers Prev 19:916-22. 2010.... - Factors associated with fluctuations in IgA and IgG levels at the cervix during the menstrual cycleMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
J Infect Dis 199:455-63. 2009..The objective of this analysis was to describe patterns and determinants of cervical immunoglobulin A (IgA) and G (IgG) levels during the menstrual cycle... - Oral Immunoglobulin Levels are Not a Good Surrogate for Cervical Immunoglobulin LevelsTroy J Kemp
HPV Immunology Laboratory, SAIC Frederick, Inc, NCI Frederick Frederick, MD, USA
Front Oncol 2:61. 2012..Future studies should examine whether antigen-specific antibody responses induced by vaccination correlate across mucosal sites... - A comparison of human papillomavirus genotype-specific DNA and E6/E7 mRNA detection to identify anal precancer among HIV-infected men who have sex with menPhilip E Castle
Albert Einstein College of Medicine, Bronx, NY, USA
Cancer Epidemiol Biomarkers Prev 22:42-9. 2013..Human papillomavirus (HPV) RNA detection is reportedly more specific for the detection of anogenital precancer than HPV DNA but it is unknown whether this is due to detection of RNA or due to HPV genotype restriction... - Preparing digitized cervigrams for colposcopy research and education: determination of optimal resolution and compression parametersJose Jeronimo
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics DCEG, National Cancer Institute, Bethesda, MD 20892, USA
J Low Genit Tract Dis 10:39-44. 2006..The National Cancer Institute and National Library of Medicine are involved in a large effort to improve colposcopic assessment and, in preparation, are conducting methodologic research...