Vincenzo Costanzo

Summary

Publications

  1. Terré B, Piergiovanni G, Segura Bayona S, Gil Gómez G, Youssef S, Attolini C, et al. GEMC1 is a critical regulator of multiciliated cell differentiation. EMBO J. 2016;35:942-60 pubmed publisher
    ..Our data demonstrate that GEMC1 is a critical regulator of MCC differentiation and a candidate gene for human RGMC or related disorders. ..
  2. Costanzo V, Bardelli A, Siena S, Abrignani S. Exploring the links between cancer and placenta development. Open Biol. 2018;8: pubmed publisher
  3. Sannino V, Pezzimenti F, Bertora S, Costanzo V. Xenopus laevis as Model System to Study DNA Damage Response and Replication Fork Stability. Methods Enzymol. 2017;591:211-232 pubmed publisher
  4. Kolinjivadi A, Sannino V, De Antoni A, Zadorozhny K, Kilkenny M, Técher H, et al. Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments. Mol Cell. 2017;67:867-881.e7 pubmed publisher
    ..These results indicate that Brca2 and Rad51 prevent formation of abnormal DNA replication intermediates, whose processing by Smarcal1 and Mre11 predisposes to genome instability. ..
  5. Zadorozhny K, Sannino V, Belan O, Mlcousková J, Spirek M, Costanzo V, et al. Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection. Cell Rep. 2017;21:333-340 pubmed publisher
    ..Our results further interconnect the FA pathway with DNA replication and provide mechanistic insight into the role of RAD51 in recombination-independent mechanisms of genome maintenance. ..