Activity in prelimbic cortex is necessary for the expression of learned, but not innate, fearsKevin A Corcoran
Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico
J Neurosci 27:840-4. 2007
..We suggest that PL integrates information from auditory and contextual inputs and regulates expression of fear memories via projections to the basal nucleus of the amygdala...
NMDA receptors in retrosplenial cortex are necessary for retrieval of recent and remote context fear memoryKevin A Corcoran
Department of Psychiatry and Behavioral Sciences, The Asher Center for the Study and Treatment of Depressive Disorders, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Neurosci 31:11655-9. 2011
..Dysfunction of RSC may thereby contribute significantly to the reexperiencing of traumatic memories in patients with posttraumatic stress disorder...
- Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease
Kevin A Corcoran
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109, USA
Learn Mem 9:243-52. 2002
..Hence, learning and memory deficits in old Tg2576 mice are limited to hippocampus-dependent tasks, despite widespread amyloid deposition in cortex, hippocampus, and amygdala...
- Protein synthesis in the amygdala, but not the auditory thalamus, is required for consolidation of Pavlovian fear conditioning in rats
Stephen Maren
Department of Psychology, University of Michigan, 525 E University Avenue, Ann Arbor, MI 48109 1109, USA
Eur J Neurosci 18:3080-8. 2003
..Forms of synaptic plasticity that depend on protein synthesis, such as long-term potentiation, are likely candidates for the encoding and long-term storage of fear memories in the amygdala...
- Factors regulating the effects of hippocampal inactivation on renewal of conditional fear after extinction
Kevin A Corcoran
Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109, USA
Learn Mem 11:598-603. 2004
..These results are discussed in terms of theories regarding the role of the hippocampus in contextual memory retrieval...
- Hippocampal inactivation disrupts the acquisition and contextual encoding of fear extinction
Kevin A Corcoran
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109-1043, USA
J Neurosci 25:8978-87. 2005
..Learning and remembering when and where aversive events occur is essential for adaptive emotional regulation...
- Contextual and temporal modulation of extinction: behavioral and biological mechanisms
Mark E Bouton
Department of Psychology, University of Vermont, Burlington, Vermont 05405 0134, USA
Biol Psychiatry 60:352-60. 2006
..This interaction may be mediated by gamma-aminobutyric acid (GABA)-ergic and adrenergic mechanisms...
- Inactivation of the ventromedial prefrontal cortex reduces expression of conditioned fear and impairs subsequent recall of extinction
Demetrio Sierra-Mercado
Department of Physiology, Ponce School of Medicine, PO Box 7004, Ponce, Puerto Rico
Eur J Neurosci 24:1751-8. 2006
..The vmPFC appears to be involved both in stimulating the expression of conditioned fear and in serving as a site of extinction-related plasticity that inhibits fear during recall of extinction...
- Recalling safety: cooperative functions of the ventromedial prefrontal cortex and the hippocampus in extinction
Kevin A Corcoran
Department of Psychiatry, University of Puerto Rico School of Medicine, San Juan, PR, USA
CNS Spectr 12:200-6. 2007
..Imaging studies of human fear conditioning and extinction lend credence to this extinction network. Understanding the neural circuitry underlying extinction recall will lead to more effective therapies for disorders of fear and anxiety...
