Kevin Corcoran

Summary

Publications

  1. ncbi request reprint Activity in prelimbic cortex is necessary for the expression of learned, but not innate, fears
    Kevin A Corcoran
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico
    J Neurosci 27:840-4. 2007
  2. pmc NMDA receptors in retrosplenial cortex are necessary for retrieval of recent and remote context fear memory
    Kevin A Corcoran
    Department of Psychiatry and Behavioral Sciences, The Asher Center for the Study and Treatment of Depressive Disorders, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 31:11655-9. 2011
  3. pmc Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease
    Kevin A Corcoran
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Learn Mem 9:243-52. 2002
  4. ncbi request reprint Protein synthesis in the amygdala, but not the auditory thalamus, is required for consolidation of Pavlovian fear conditioning in rats
    Stephen Maren
    Department of Psychology, University of Michigan, 525 E University Avenue, Ann Arbor, MI 48109 1109, USA
    Eur J Neurosci 18:3080-8. 2003
  5. pmc Factors regulating the effects of hippocampal inactivation on renewal of conditional fear after extinction
    Kevin A Corcoran
    Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Learn Mem 11:598-603. 2004
  6. ncbi request reprint Hippocampal inactivation disrupts the acquisition and contextual encoding of fear extinction
    Kevin A Corcoran
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1043, USA
    J Neurosci 25:8978-87. 2005
  7. ncbi request reprint Contextual and temporal modulation of extinction: behavioral and biological mechanisms
    Mark E Bouton
    Department of Psychology, University of Vermont, Burlington, Vermont 05405 0134, USA
    Biol Psychiatry 60:352-60. 2006
  8. ncbi request reprint Inactivation of the ventromedial prefrontal cortex reduces expression of conditioned fear and impairs subsequent recall of extinction
    Demetrio Sierra-Mercado
    Department of Physiology, Ponce School of Medicine, PO Box 7004, Ponce, Puerto Rico
    Eur J Neurosci 24:1751-8. 2006
  9. ncbi request reprint Recalling safety: cooperative functions of the ventromedial prefrontal cortex and the hippocampus in extinction
    Kevin A Corcoran
    Department of Psychiatry, University of Puerto Rico School of Medicine, San Juan, PR, USA
    CNS Spectr 12:200-6. 2007

Research Grants

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Activity in prelimbic cortex is necessary for the expression of learned, but not innate, fears
    Kevin A Corcoran
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico
    J Neurosci 27:840-4. 2007
    ..We suggest that PL integrates information from auditory and contextual inputs and regulates expression of fear memories via projections to the basal nucleus of the amygdala...
  2. pmc NMDA receptors in retrosplenial cortex are necessary for retrieval of recent and remote context fear memory
    Kevin A Corcoran
    Department of Psychiatry and Behavioral Sciences, The Asher Center for the Study and Treatment of Depressive Disorders, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 31:11655-9. 2011
    ..Dysfunction of RSC may thereby contribute significantly to the reexperiencing of traumatic memories in patients with posttraumatic stress disorder...
  3. pmc Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease
    Kevin A Corcoran
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Learn Mem 9:243-52. 2002
    ..Hence, learning and memory deficits in old Tg2576 mice are limited to hippocampus-dependent tasks, despite widespread amyloid deposition in cortex, hippocampus, and amygdala...
  4. ncbi request reprint Protein synthesis in the amygdala, but not the auditory thalamus, is required for consolidation of Pavlovian fear conditioning in rats
    Stephen Maren
    Department of Psychology, University of Michigan, 525 E University Avenue, Ann Arbor, MI 48109 1109, USA
    Eur J Neurosci 18:3080-8. 2003
    ..Forms of synaptic plasticity that depend on protein synthesis, such as long-term potentiation, are likely candidates for the encoding and long-term storage of fear memories in the amygdala...
  5. pmc Factors regulating the effects of hippocampal inactivation on renewal of conditional fear after extinction
    Kevin A Corcoran
    Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Learn Mem 11:598-603. 2004
    ..These results are discussed in terms of theories regarding the role of the hippocampus in contextual memory retrieval...
  6. ncbi request reprint Hippocampal inactivation disrupts the acquisition and contextual encoding of fear extinction
    Kevin A Corcoran
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1043, USA
    J Neurosci 25:8978-87. 2005
    ..Learning and remembering when and where aversive events occur is essential for adaptive emotional regulation...
  7. ncbi request reprint Contextual and temporal modulation of extinction: behavioral and biological mechanisms
    Mark E Bouton
    Department of Psychology, University of Vermont, Burlington, Vermont 05405 0134, USA
    Biol Psychiatry 60:352-60. 2006
    ..This interaction may be mediated by gamma-aminobutyric acid (GABA)-ergic and adrenergic mechanisms...
  8. ncbi request reprint Inactivation of the ventromedial prefrontal cortex reduces expression of conditioned fear and impairs subsequent recall of extinction
    Demetrio Sierra-Mercado
    Department of Physiology, Ponce School of Medicine, PO Box 7004, Ponce, Puerto Rico
    Eur J Neurosci 24:1751-8. 2006
    ..The vmPFC appears to be involved both in stimulating the expression of conditioned fear and in serving as a site of extinction-related plasticity that inhibits fear during recall of extinction...
  9. ncbi request reprint Recalling safety: cooperative functions of the ventromedial prefrontal cortex and the hippocampus in extinction
    Kevin A Corcoran
    Department of Psychiatry, University of Puerto Rico School of Medicine, San Juan, PR, USA
    CNS Spectr 12:200-6. 2007
    ..Imaging studies of human fear conditioning and extinction lend credence to this extinction network. Understanding the neural circuitry underlying extinction recall will lead to more effective therapies for disorders of fear and anxiety...

Research Grants2

  1. Neural Substrates of Contextual Regulation of Extinction
    Kevin Corcoran; Fiscal Year: 2007
    ..Understanding the neural mechanisms of contextual regulation of extinction could lead to more effective therapies for PTSD. ..