Gianluca Coppola

Summary

Publications

  1. pmc Electrophysiological correlates of episodic migraine chronification: evidence for thalamic involvement
    Gianluca Coppola
    G, B, Bietti Foundation IRCCS, Department of Neurophysiology of Vision and Neurophthalmology G, B, Bietti Foundation IRCCS, Via Livenza 3, Rome 00198, Italy
    J Headache Pain 14:76. 2013
  2. pmc Habituation and sensitization in primary headaches
    Gianluca Coppola
    Department of Neurophysiology of Vision and Neurophthalmology, G, B, Bietti Foundation IRCCS, Via Livenza 3, 00198, Rome, Italy
    J Headache Pain 14:65. 2013
  3. pmc Lateral inhibition in visual cortex of migraine patients between attacks
    Gianluca Coppola
    Departmen of Neurophysiology of Vision and Neuroophtalmology, G, B, Bietti Foundation IRCCS, Via Livenza 3 00198, Rome, Italy
    J Headache Pain 14:20. 2013
  4. doi request reprint Effects of repetitive transcranial magnetic stimulation on somatosensory evoked potentials and high frequency oscillations in migraine
    Gianluca Coppola
    Department of Neurophysiology of Vision and Neurophthalmology, G B Bietti Foundation IRCCS, Rome, Italy
    Cephalalgia 32:700-9. 2012
  5. doi request reprint Management of acute and chronic migraine
    Gianluca Coppola
    Department of Neurophysiology of Vision and Neuro ophthalmology, G B Bietti Eye Foundation IRCCS, Rome, Italy
    Curr Opin Support Palliat Care 6:177-82. 2012
  6. doi request reprint Habituation and migraine
    Gianluca Coppola
    G B Bietti Eye Foundation IRCCS, Department of Neurophysiology of Vision and Neurophthalmology, Via Livenza 3, 00198 Rome, Italy
    Neurobiol Learn Mem 92:249-59. 2009
  7. pmc Effects of light deprivation on visual evoked potentials in migraine without aura
    Gianluca Coppola
    G B Bietti Eye Foundation IRCCS, Dept of Neurophysiology of Vision and Neuroophtalmology, Rome, Italy
    BMC Neurol 11:91. 2011
  8. pmc Changes in visual-evoked potential habituation induced by hyperventilation in migraine
    Gianluca Coppola
    Department of Neurophysiology of Vision and Neurophthalmology, G B Bietti Eye Foundation IRCCS, Via Livenza 3, 00198, Rome, Italy
    J Headache Pain 11:497-503. 2010
  9. ncbi request reprint Interictal abnormalities of gamma band activity in visual evoked responses in migraine: an indication of thalamocortical dysrhythmia?
    G Coppola
    G B Bietti Eye Foundation IRCCS, Department of Neurophysiology of Vision and Neurophthalmology, Rome, Italy
    Cephalalgia 27:1360-7. 2007
  10. doi request reprint Tonic pain abolishes cortical habituation of visual evoked potentials in healthy subjects
    Gianluca Coppola
    G B Bietti Eye Foundation IRCCS, Dept of Neurophysiology of Vision and Neurophthalmology, Rome, Italy
    J Pain 11:291-6. 2010

Detail Information

Publications36

  1. pmc Electrophysiological correlates of episodic migraine chronification: evidence for thalamic involvement
    Gianluca Coppola
    G, B, Bietti Foundation IRCCS, Department of Neurophysiology of Vision and Neurophthalmology G, B, Bietti Foundation IRCCS, Via Livenza 3, Rome 00198, Italy
    J Headache Pain 14:76. 2013
    ..Here, we study conventional LF-SSEPs and HFOs in episodic migraineurs who developed chronic migraine (CM)...
  2. pmc Habituation and sensitization in primary headaches
    Gianluca Coppola
    Department of Neurophysiology of Vision and Neurophthalmology, G, B, Bietti Foundation IRCCS, Via Livenza 3, 00198, Rome, Italy
    J Headache Pain 14:65. 2013
    ....
  3. pmc Lateral inhibition in visual cortex of migraine patients between attacks
    Gianluca Coppola
    Departmen of Neurophysiology of Vision and Neuroophtalmology, G, B, Bietti Foundation IRCCS, Via Livenza 3 00198, Rome, Italy
    J Headache Pain 14:20. 2013
    ..We investigated lateral inhibition in the visual cortex during the migraine cycle and in healthy subjects by using differential temporal modulations of radial windmill-dartboard (WD) or partial-windmill (PW) visual patterns...
  4. doi request reprint Effects of repetitive transcranial magnetic stimulation on somatosensory evoked potentials and high frequency oscillations in migraine
    Gianluca Coppola
    Department of Neurophysiology of Vision and Neurophthalmology, G B Bietti Foundation IRCCS, Rome, Italy
    Cephalalgia 32:700-9. 2012
    ..Here we study the effects of activating (10 Hz) or inhibiting (1 Hz) rTMS on conventional low-frequency (LF) and high-frequency somatosensory evoked potentials (SSEPs)...
  5. doi request reprint Management of acute and chronic migraine
    Gianluca Coppola
    Department of Neurophysiology of Vision and Neuro ophthalmology, G B Bietti Eye Foundation IRCCS, Rome, Italy
    Curr Opin Support Palliat Care 6:177-82. 2012
    ..We highlight the recent clinical trials for the management of acute and chronic migraine...
  6. doi request reprint Habituation and migraine
    Gianluca Coppola
    G B Bietti Eye Foundation IRCCS, Department of Neurophysiology of Vision and Neurophthalmology, Via Livenza 3, 00198 Rome, Italy
    Neurobiol Learn Mem 92:249-59. 2009
    ....
  7. pmc Effects of light deprivation on visual evoked potentials in migraine without aura
    Gianluca Coppola
    G B Bietti Eye Foundation IRCCS, Dept of Neurophysiology of Vision and Neuroophtalmology, Rome, Italy
    BMC Neurol 11:91. 2011
    ..Abnormal long-term functional plasticity of the visual cortex may play a role and it can be assessed experimentally by light deprivation (LD)...
  8. pmc Changes in visual-evoked potential habituation induced by hyperventilation in migraine
    Gianluca Coppola
    Department of Neurophysiology of Vision and Neurophthalmology, G B Bietti Eye Foundation IRCCS, Via Livenza 3, 00198, Rome, Italy
    J Headache Pain 11:497-503. 2010
    ..Hyperventilation worsens the habituation deficit in migraineurs possibly by increasing dysrhythmia in the brainstem-thalamo-cortical network...
  9. ncbi request reprint Interictal abnormalities of gamma band activity in visual evoked responses in migraine: an indication of thalamocortical dysrhythmia?
    G Coppola
    G B Bietti Eye Foundation IRCCS, Department of Neurophysiology of Vision and Neurophthalmology, Rome, Italy
    Cephalalgia 27:1360-7. 2007
    ....
  10. doi request reprint Tonic pain abolishes cortical habituation of visual evoked potentials in healthy subjects
    Gianluca Coppola
    G B Bietti Eye Foundation IRCCS, Dept of Neurophysiology of Vision and Neurophthalmology, Rome, Italy
    J Pain 11:291-6. 2010
    ..Tonic pain probably abolishes VEP habituation by acting on brainstem neural structures which modulate thalamo-cortical activation thereby changing visual cortex excitability...
  11. pmc Lack of cold pressor test-induced effect on visual-evoked potentials in migraine
    Gianluca Coppola
    Department of Neurophysiology of Vision and Neurophthalmology, G B Bietti Eye Foundation, IRCCS, Via Livenza 3, Rome, Italy
    J Headache Pain 11:115-21. 2010
    ..Whether this abnormality reflects abnormal functional activity in the subcortical structures subserving tonic pain activation remains conjectural...
  12. pmc Abnormal cortical responses to somatosensory stimulation in medication-overuse headache
    Gianluca Coppola
    G B Bietti Eye Foundation IRCCS, Dept of Neurophysiology of Vision and Neurophthalmology, Rome, Italy
    BMC Neurol 10:126. 2010
    ..Whether central sensitization alters this electrophysiological profile is unknown. We therefore sought differences in somatosensory evoked potential (SEP) sensitization and habituation in patients with MOH and episodic MOA...
  13. doi request reprint Nociceptive trigeminocervical reflexes in healthy subjects
    Mariano Serrao
    Sapienza University of Rome, Polo Pontino, Rome, Italy
    Clin Neurophysiol 121:1563-8. 2010
    ..The purpose of this study was to elicit more nociceptive TCR responses through preferential activation of the nociceptive afferents with a concentric surface electrode...
  14. doi request reprint Hand somatosensory subcortical and cortical sources assessed by functional source separation: an EEG study
    Camillo Porcaro
    AFaR, Center of Medical Statistics and IT, Fatebenefratelli Hospital, Rome, Italy
    Hum Brain Mapp 30:660-74. 2009
    ..As FSs are reconstructed along the entire experimental session, directional and dynamic HFO synchronization phenomena can be studied...
  15. doi request reprint Cutaneous silent period in hand muscles is lengthened by tramadol: Evidence for monoaminergic modulation?
    Francesco Pujia
    Sapienza University of Rome, Department of Medico Surgical Sciences and Biotechnologies, Neurology Section, Rome, Italy
    Neurosci Lett 528:78-82. 2012
    ..We suggest that the monoaminergic action of tramadol reinforces the activity of spinal inhibitory interneurons on α-motoneurons for the hand muscles...
  16. doi request reprint Cortical excitability in chronic migraine
    Gianluca Coppola
    Department of Neurophysiology of Vision and Neuroophthalmology, G B Bietti Eye Foundation IRCCS, Rome, Italy
    Curr Pain Headache Rep 16:93-100. 2012
    ..In MOH, overconsumption of triptans or NSAIDs influences cortical excitability differently. Generalized central sensitization is suggested to play an important role in the pathophysiology of headache chronification...
  17. doi request reprint Use of Vitex agnus-castus in migrainous women with premenstrual syndrome: an open-label clinical observation
    Anna Ambrosini
    INM Neuromed, IRCCS, Headache Clinic, Via Atinense, 18, 86077, Pozzilli Isernia, Italy
    Acta Neurol Belg 113:25-9. 2013
    ....
  18. ncbi request reprint Shortened cortical silent period in facial muscles of patients with migraine
    Antonio Curra
    Department of Neurological Sciences, La Sapienza University, Rome, Italy
    Pain 132:124-31. 2007
    ....
  19. pmc Neuroimaging in cluster headache and other trigeminal autonomic cephalalgias
    Elisa Iacovelli
    Neurology Section, Department of Medico Surgical Sciences and Biotechnologies, Sapienza University of Rome, Viale dell Universita 30, 00185, Rome, Italy
    J Headache Pain 13:11-20. 2012
    ....
  20. doi request reprint The upstream Variable Number Tandem Repeat polymorphism of the monoamine oxidase type A gene influences trigeminal pain-related evoked responses
    Cherubino Di Lorenzo
    Don Carlo Gnocchi ONLUS Foundation, Via Maresciallo Caviglia, 30 00135, Rome, Italy
    Eur J Neurosci 39:501-7. 2014
    ..The MAOA-uVNTR polymorphism seemed to influence the brain response in a repeated tPREP paradigm and suggested a role of the MAOA as a modulator of neural plasticity related to cortical pain processing. ..
  21. doi request reprint Electrophysiological assessment of visual function in patients with non-arteritic ischaemic optic neuropathy
    V Parisi
    Neurophthalmology Research Unit, G B Bietti Eye Foundation IRCCS and University of Rome Campus Biomedico, Rome, Italy
    Eur J Neurol 15:839-45. 2008
    ..Our study aims to evaluate retinal function and neural conduction in post-retinal visual pathways of patients with non-arteritic ischaemic optic neuropathy (NION)...
  22. ncbi request reprint Crossed and uncrossed visual pathways are impaired differently in open angle glaucoma patients
    V Parisi
    Eye Clinic, Tor Vergata, University of Rome
    Acta Ophthalmol Scand Suppl 236:50-1. 2002
  23. ncbi request reprint A novel KCNQ2 K+ channel mutation in benign neonatal convulsions and centrotemporal spikes
    G Coppola
    Department of Child Neuropsychiatry, 2nd University of Naples, Italy
    Neurology 61:131-4. 2003
    ..Electrophysiologic studies showed that mutant K+ channel subunits failed to give rise to functional homomeric channels or exert dominant-negative effects when expressed with KCNQ2/KCNQ3 subunits...
  24. ncbi request reprint Impaired neural conduction in crossed visual pathways in patients with ocular hypertension
    V Parisi
    Ophthalmology Department, University of Roma Tor Vergata, Roma Italy
    Eur J Ophthalmol 14:486-94. 2004
    ..To evaluate the neural conduction along crossed and uncrossed visual pathways in patients with ocular hypertension (OHT)...
  25. ncbi request reprint Efficacy and safety of levetiracetam: an add-on trial in children with refractory epilepsy
    S Grosso
    Pediatrics Department, University of Siena, Ospedale Santa Maria alle Scotte, Via M Bracci, 53100 Siena, Italy
    Seizure 14:248-53. 2005
    ..Our preliminary data also indicate that levetiracetam may be a valid therapeutic option for epilepsy in infants and young children...
  26. ncbi request reprint The syndrome of transient headache with neurological deficits and CSF lymphocytosis (HaNDL): electrophysiological findings suggesting a migrainous pathophysiology
    A Fumal
    Department of Neurology, University of Liege, Liege, Belgium
    Cephalalgia 25:754-8. 2005
  27. ncbi request reprint Induction of long-lasting changes of visual cortex excitability by five daily sessions of repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers and migraine patients
    A Fumal
    Department of Neurology, University of Liege, Belgium
    Cephalalgia 26:143-9. 2006
    ..Daily rTMS can thus induce long-lasting changes in cortical excitability and VEP habituation pattern. Whether this effect may be useful in preventative migraine therapy remains to be determined...
  28. ncbi request reprint Levetiracetam monotherapy for children and adolescents with benign rolandic seizures
    A Verrotti
    Department of Pediatrics, University of Chieti, Policlinico Universitario, Via dei Vestini 5, 66100 Chieti, Italy
    Seizure 16:271-5. 2007
    ..5%) patients. Our results support findings that LEV monotherapy is effective and well tolerated in children with BECTS. Prospective, large, long-term double-blind studies are needed to confirm these findings...
  29. ncbi request reprint Interictal habituation deficit of the nociceptive blink reflex: an endophenotypic marker for presymptomatic migraine?
    L Di Clemente
    Headache Research Unit, University Department of Neurology, University of Liege, Liege, Belgium
    Brain 130:765-70. 2007
    ..Surprisingly, the most pronounced habituation deficit is found in asymptomatic individuals with a family history of migraine. Deficient nBR habituation could thus be a trait marker for the genetic predisposition to migraine...
  30. ncbi request reprint Efficacy and safety of levetiracetam in infants and young children with refractory epilepsy
    S Grosso
    Pediatrics Department, University of Siena, Italy
    Seizure 16:345-50. 2007
    ..We conclude that LEV is safe and effective for a wide range of epileptic seizures and epilepsy syndromes and, therefore, represents a valid therapeutic option in infants and young children affected by epilepsy...
  31. ncbi request reprint Search for correlations between genotypes and electrophysiological patterns in migraine: the MTHFR C677T polymorphism and visual evoked potentials
    D Magis
    Headache Research Unit, Department of Neurology, CHR Citadelle, University of Liege, Boulevard du 12ème de Ligne 1, 4000 Liege, Belgium
    Cephalalgia 27:1142-9. 2007
    ..On the other hand, MTHFR C677T homozygosity is linked to a reduction of grand average VEP amplitude with illness duration, which has been attributed to brain damage...
  32. ncbi request reprint Asymmetric distribution of visual evoked potentials in patients with migraine with aura during the interictal phase
    G Coppola
    G B Bietti Eye Foundation, IRCCS, Roma, Italy
    Eur J Ophthalmol 17:828-35. 2007
    ..This study aims to evaluate the bioelectrical activity of both occipital cortices in patients with migraine with visual aura (MA) during the interictal period, and its possible relationship with visual symptoms...
  33. pmc Genome-wide analyses of human perisylvian cerebral cortical patterning
    B S Abrahams
    Program in Neurogenetics and Neurobehavioral Genetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1769, USA
    Proc Natl Acad Sci U S A 104:17849-54. 2007
    ..Genes identified here provide a foundation for understanding molecular aspects of human-cognitive specializations and the disorders that disrupt them...
  34. ncbi request reprint Is the cerebral cortex hyperexcitable or hyperresponsive in migraine?
    G Coppola
    G B Bietti Eye Foundation IRCCS, Department of Neurophysiology of Vision and Neurophthalmology, Rome, Italy
    Cephalalgia 27:1427-39. 2007
    ..Deciphering the precise cellular and molecular underpinnings of this hyperresponsivity remains a challenge for future research. We propose, as a working hypothesis, that a thalamo-cortical dysrhythmia might be the culprit...
  35. doi request reprint Cytidine-5'-diphosphocholine (Citicoline): a pilot study in patients with non-arteritic ischaemic optic neuropathy
    V Parisi
    Department of Neurophysiology of Vision and Neurophthalmology, G B Bietti Eye Foundation IRCCS, Rome, Italy
    Eur J Neurol 15:465-74. 2008
    ..Our work evaluates visual function before and after treatment with cytidine-5-diphosphocholine (Citicoline) in patients with non-arteritic ischaemic optic neuropathy (NION)...
  36. ncbi request reprint Benign idiopathic partial seizures in the velocardiofacial syndrome: report of two cases
    G Coppola
    Department of Pediatrics /Clinic of Child Neuropsychiatry, Second University of Naples, Via Pansini 5, 80131 Naples, Italy
    Am J Med Genet 103:172-5. 2001
    ..Treatment was started only in one patient, with complete seizure control. These two cases show that benign partial epilepsy can be a component manifestation of the central nervous system-related symptoms of the velocardiofacial syndrome...