Jeremy Coplan

Summary

Publications

  1. ncbi request reprint Maternal-infant response to variable foraging demand in nonhuman primates: effects of timing of stressor on cerebrospinal fluid corticotropin-releasing factor and circulating glucocorticoid concentrations
    Jeremy D Coplan
    State University of New York SUNY, Downstate Medical Center Box 120, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Ann N Y Acad Sci 1071:525-33. 2006
  2. ncbi request reprint Dorsolateral prefrontal cortical pathology in generalized anxiety disorder: a proton magnetic resonance spectroscopic imaging study
    Sanjay J Mathew
    Department of Biological Psychiatry, New York State Psychiatric Institute, Columbia Unversity, New York, NY 10032, USA
    Am J Psychiatry 161:1119-21. 2004
  3. ncbi request reprint Prediction of panic response to a respiratory stimulant by reduced orbitofrontal cerebral blood flow in panic disorder
    Justine M Kent
    Department of Psychiatry, Unit 41, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Psychiatry 162:1379-81. 2005
  4. ncbi request reprint Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand
    Jeremy D Coplan
    Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    CNS Spectr 10:530-6. 2005
  5. ncbi request reprint Early-life stress and the development of obesity and insulin resistance in juvenile bonnet macaques
    Daniel Kaufman
    Department of Surgery, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Diabetes 56:1382-6. 2007
  6. pmc The Relationship between Intelligence and Anxiety: An Association with Subcortical White Matter Metabolism
    Jeremy D Coplan
    Division of Neuropsychopharmacology, Department of Psychiatry, State University of New York Downstate Medical Center Brooklyn, NY, USA
    Front Evol Neurosci 3:8. 2011
  7. ncbi request reprint Tardive dyskinesia from atypical antipsychotic agents in patients with mood disorders in a clinical setting
    Jeremy Coplan
    SUNY Downstate Medical Center, Division of Neuropsychopharmacology, 450 Clarkson Ave, Box 120, Brooklyn, NY 11203, USA
    J Affect Disord 150:868-71. 2013
  8. ncbi request reprint Decreased choline and creatine concentrations in centrum semiovale in patients with generalized anxiety disorder: relationship to IQ and early trauma
    Jeremy D Coplan
    Department of Psychiatry, Division of Neuropsychopharmacology, State University of New York, Downstate Medical Center, Brooklyn, 11023, USA
    Psychiatry Res 147:27-39. 2006
  9. pmc The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates
    Jeremy D Coplan
    SUNY Downstate Medical Center, Primate Behavior Laboratory, Brooklyn, NY, USA
    Neurosci Lett 480:93-6. 2010
  10. pmc Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: a pilot study
    Jeremy D Coplan
    State University of New York SUNY, Downstate Medical Center, Department of Psychiatry, Brooklyn, NY 11203, USA
    Psychoneuroendocrinology 36:289-93. 2011

Research Grants

  1. ADVERSE EARLY REARING & GLUTAMATERGIC FUNCTION
    Jeremy Coplan; Fiscal Year: 2003
  2. ADVERSE EARLY REARING & GLUTAMATERGIC FUNCTION
    Jeremy Coplan; Fiscal Year: 2000
  3. ADVERSE EARLY REARING & GLUTAMATERGIC FUNCTION
    Jeremy Coplan; Fiscal Year: 2001
  4. ADVERSE EARLY REARING & GLUTAMATERGIC FUNCTION
    Jeremy Coplan; Fiscal Year: 2002

Detail Information

Publications32

  1. ncbi request reprint Maternal-infant response to variable foraging demand in nonhuman primates: effects of timing of stressor on cerebrospinal fluid corticotropin-releasing factor and circulating glucocorticoid concentrations
    Jeremy D Coplan
    State University of New York SUNY, Downstate Medical Center Box 120, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Ann N Y Acad Sci 1071:525-33. 2006
    ..However, absolute cortisol change was greater in early versus late VFD. Timing of the VFD stressor differentially affects maternal neuroendocrine response, with potential implications for the offspring's developmental trajectory...
  2. ncbi request reprint Dorsolateral prefrontal cortical pathology in generalized anxiety disorder: a proton magnetic resonance spectroscopic imaging study
    Sanjay J Mathew
    Department of Biological Psychiatry, New York State Psychiatric Institute, Columbia Unversity, New York, NY 10032, USA
    Am J Psychiatry 161:1119-21. 2004
    ..The present study used proton magnetic resonance spectroscopy to assess concentrations of N-acetylaspartate, often considered a marker of neuronal viability, in generalized anxiety disorder patients...
  3. ncbi request reprint Prediction of panic response to a respiratory stimulant by reduced orbitofrontal cerebral blood flow in panic disorder
    Justine M Kent
    Department of Psychiatry, Unit 41, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Psychiatry 162:1379-81. 2005
    ..The aim of this study was to examine regional cerebral blood flow changes in response to anxiety/panic provocation in subjects with panic disorder and healthy comparison subjects...
  4. ncbi request reprint Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand
    Jeremy D Coplan
    Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    CNS Spectr 10:530-6. 2005
    ..Environmental contribution to the neurobiology of psychopathology is perhaps most relevant during infancy, where vulnerability to early-life stressors is particularly evident...
  5. ncbi request reprint Early-life stress and the development of obesity and insulin resistance in juvenile bonnet macaques
    Daniel Kaufman
    Department of Surgery, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Diabetes 56:1382-6. 2007
    ..Our data suggest that early-life stress during a critical period of neuro development can result in the peripubertal emergence of obesity and insulin resistance...
  6. pmc The Relationship between Intelligence and Anxiety: An Association with Subcortical White Matter Metabolism
    Jeremy D Coplan
    Division of Neuropsychopharmacology, Department of Psychiatry, State University of New York Downstate Medical Center Brooklyn, NY, USA
    Front Evol Neurosci 3:8. 2011
    ..The collective data suggest that both worry and intelligence are characterized by depletion of metabolic substrate in the subcortical white matter and that intelligence may have co-evolved with worry in humans...
  7. ncbi request reprint Tardive dyskinesia from atypical antipsychotic agents in patients with mood disorders in a clinical setting
    Jeremy Coplan
    SUNY Downstate Medical Center, Division of Neuropsychopharmacology, 450 Clarkson Ave, Box 120, Brooklyn, NY 11203, USA
    J Affect Disord 150:868-71. 2013
    ..There is a paucity of information on the risks and clinical characteristics of tardive dyskinesia with atypical antipsychotic agents in patients with mood and anxiety disorders in clinical practice...
  8. ncbi request reprint Decreased choline and creatine concentrations in centrum semiovale in patients with generalized anxiety disorder: relationship to IQ and early trauma
    Jeremy D Coplan
    Department of Psychiatry, Division of Neuropsychopharmacology, State University of New York, Downstate Medical Center, Brooklyn, 11023, USA
    Psychiatry Res 147:27-39. 2006
    ..These conclusions are deemed preliminary due to small sample size, with further study of cerebral WM in anxiety disorders suggested...
  9. pmc The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates
    Jeremy D Coplan
    SUNY Downstate Medical Center, Primate Behavior Laboratory, Brooklyn, NY, USA
    Neurosci Lett 480:93-6. 2010
    ..Adverse rearing in monkeys persistently impaired frontal white matter tract integrity, a novel substrate for understanding affective susceptibility...
  10. pmc Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: a pilot study
    Jeremy D Coplan
    State University of New York SUNY, Downstate Medical Center, Department of Psychiatry, Brooklyn, NY 11203, USA
    Psychoneuroendocrinology 36:289-93. 2011
    ..CSF CRF concentrations were elevated specifically in the VFD "s/s" and "s/l" allele group in comparison to each of the remaining three groups, indicating a gene-by-environment (G×E) interaction...
  11. pmc Early-life stress and neurometabolites of the hippocampus
    Jeremy D Coplan
    SUNY Downstate Medical Center, Nonhuman Primate Facility, Department of Psychiatry, Brooklyn, NY 11203, USA
    Brain Res 1358:191-9. 2010
    ..Given the importance of the hippocampus in stress-mediated toxicity, validation of these data using absolute quantification is suggested and correlative neurohistological studies of hippocampus are warranted...
  12. pmc Metabolic syndrome and neurometabolic asymmetry of hippocampus in adult bonnet monkeys
    Jeremy D Coplan
    SUNY Downstate Medical Center, Primate Behavior Laboratory, Department of Psychiatry, Brooklyn, NY 11203 2098, USA
    Physiol Behav 103:535-9. 2011
    ....
  13. pmc Course of depression and anxiety diagnosis in patients treated with hemodialysis: a 16-month follow-up
    Daniel Cukor
    Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY 11203 2098, USA
    Clin J Am Soc Nephrol 3:1752-8. 2008
    ..This study reports on the course of depression and anxiety diagnoses and their impact on quality of life and health status...
  14. doi request reprint Lethargy, ulcers, bronchopneumonia and death in two aged female bonnet macaques presumed to be caused by Cercopithicine herpes virus I
    Bruce A Scharf
    Downstate Medical School, Division of Laboratory Animal Resources, Brooklyn, NY, USA
    J Med Primatol 37:60-4. 2008
    ..The emergence of fatal B virus to primates in this pen may have been associated with the combination of age and stress in the affected individuals...
  15. ncbi request reprint Cerebrospinal fluid concentrations of biogenic amines and corticotropin-releasing factor in adolescent non-human primates as a function of the timing of adverse early rearing
    Sanjay J Mathew
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Stress 5:185-93. 2002
    ..Thus, the timing of exposure to VFD conditions early in life evidently determines whether CSF CRF was found to be elevated or decreased, within the context of increased serotonin metabolism, during the course of primate maturation...
  16. ncbi request reprint A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors
    Sanjay J Mathew
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 54:727-35. 2003
    ..Long-term behavioral, immunologic, and neurochemical alterations have been found in primates exposed to adverse early rearing...
  17. doi request reprint Anxiety disorders in adults treated by hemodialysis: a single-center study
    Daniel Cukor
    Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY 11203 2098, USA
    Am J Kidney Dis 52:128-36. 2008
    ..In patients with end-stage renal disease (ESRD), anxiety disorders often are perceived to represent symptoms of depression rather than independent conditions and therefore have been relatively understudied in this medical population...
  18. ncbi request reprint Neurobiology of early life stress: nonhuman primate models
    Jack M Gorman
    Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Semin Clin Neuropsychiatry 7:96-103. 2002
    ..Finally, there appears to be remarkable consistency of key neurobiological findings across species...
  19. ncbi request reprint The human dimension: how the prefrontal cortex modulates the subcortical fear response
    Rachel Lisa Berkowitz
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, Brooklyn, NY, USA
    Rev Neurosci 18:191-207. 2007
    ..Studies of prefrontal cortical function in psychiatric illness should be a fruitful method for identifying effective treatment approaches...
  20. ncbi request reprint Differing concentrations of corticotropin-releasing factor and oxytocin in the cerebrospinal fluid of bonnet and pigtail macaques
    Leonard A Rosenblum
    Department of Psychiatry, SUNY Health Science Center at Brooklyn, State University of New York, 450 Clarkson Avenue, Brooklyn 11203 2098, USA
    Psychoneuroendocrinology 27:651-60. 2002
    ....
  21. ncbi request reprint Debilitation and cachexia in a bonnet macaque (Macaca radiata)
    Max Goldstein
    SUNY Downstate Medical Center, Brooklyn, NY 11203 2098, USA
    Lab Anim (NY) 32:23-5. 2003
  22. ncbi request reprint Doxapram-induced panic attacks and cortisol elevation
    David A Gutman
    Department of Psychiatry, Columbia University School of Medicine, 1051 Riverside Drive, New York, NY 10032, USA
    Psychiatry Res 133:253-61. 2005
    ....
  23. pmc Hippocampal N-acetylaspartate concentration and response to riluzole in generalized anxiety disorder
    Sanjay J Mathew
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 63:891-8. 2008
    ....
  24. ncbi request reprint Transforming growth factor-beta 1 and cortisol in differentially reared primates
    Eric L P Smith
    Primate Behavior Laboratory, Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, 11203, USA
    Brain Behav Immun 16:140-9. 2002
    ..Examination of the relationship between HPA axis and immune function will improve our understanding of the pathophysiological consequences of adverse rearing...
  25. ncbi request reprint Early appearance of the metabolic syndrome in socially reared bonnet macaques
    Daniel Kaufman
    Department of Surgery, Primate Behavior Laboratory, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203, USA
    J Clin Endocrinol Metab 90:404-8. 2005
    ..Socially reared and housed bonnet macaques may provide a useful model for studying the pathogenesis, prevention, and treatment of the metabolic syndrome...
  26. ncbi request reprint Salivary cortisol concentrations before and after carbon-dioxide inhalations in children
    Jeremy D Coplan
    Department of Psychiatry, SUNY Downstate, Brooklyn, NY, USA
    Biol Psychiatry 51:326-33. 2002
    ..If confirmed, this would relate hypothalamic-pituitary adrenal axis activation in juveniles, as in adults, and response to a well-studied respiratory procedure...
  27. doi request reprint Ventricular cerebrospinal fluid lactate is increased in chronic fatigue syndrome compared with generalized anxiety disorder: an in vivo 3.0 T (1)H MRS imaging study
    Sanjay J Mathew
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    NMR Biomed 22:251-8. 2009
    ....
  28. pmc Diffusion tensor imaging in studying white matter complexity: a gap junction hypothesis
    Chadi G Abdallah
    Department of Psychiatry, Division of Neuropsychopharmacology, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11023, USA
    Neurosci Lett 475:161-4. 2010
    ..Moreover, validation of these findings using neurohistological studies and replication in human samples appears warranted...
  29. ncbi request reprint Maternal and fetal 11C-cocaine uptake and kinetics measured in vivo by combined PET and MRI in pregnant nonhuman primates
    Helene Benveniste
    Medical Department, Brookhaven National Laboratory, Upton, New York 11793, USA
    J Nucl Med 46:312-20. 2005
    ..Here, we evaluate the utility of PET to measure the uptake and distribution of (11)C-cocaine in the third-trimester fetus...
  30. ncbi request reprint Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates
    Tarique D Perera
    Department of Biological Psychiatry, New York State Psychiatric Institute New York, New York 10032, USA
    J Neurosci 27:4894-901. 2007
    ..This study demonstrates that ECS is capable of inducing neurogenesis in the nonhuman primate hippocampus and supports the possibility that antidepressant interventions produce similar alterations in the human brain...
  31. ncbi request reprint Open-label trial of riluzole in generalized anxiety disorder
    Sanjay J Mathew
    Department of Biological Psychiatry, New York State Psychiatric Institute, USA
    Am J Psychiatry 162:2379-81. 2005
    ..There is a need to identify novel pharmacotherapies for anxiety disorders. The authors examined the safety and efficacy of riluzole, an antiglutamatergic agent, in adult outpatients with generalized anxiety disorder...
  32. ncbi request reprint Novel treatment approaches for refractory anxiety disorders
    Mark H Pollack
    Harvard Medical School and Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Depress Anxiety 25:467-76. 2008
    ..Progress in the development of new treatments has great promise, but will only succeed through a concerted research effort that systematically evaluates potential areas of importance and properly uses scarce resources...

Research Grants4

  1. ADVERSE EARLY REARING & GLUTAMATERGIC FUNCTION
    Jeremy Coplan; Fiscal Year: 2003
    ..Ongoing neurochemical and behavioral assessments will provide extensive longitudinal documentation of the effects of such reductions. ..
  2. ADVERSE EARLY REARING & GLUTAMATERGIC FUNCTION
    Jeremy Coplan; Fiscal Year: 2000
    ..Ongoing neurochemical and behavioral assessments will provide extensive longitudinal documentation of the effects of such reductions. ..
  3. ADVERSE EARLY REARING & GLUTAMATERGIC FUNCTION
    Jeremy Coplan; Fiscal Year: 2001
    ..Ongoing neurochemical and behavioral assessments will provide extensive longitudinal documentation of the effects of such reductions. ..
  4. ADVERSE EARLY REARING & GLUTAMATERGIC FUNCTION
    Jeremy Coplan; Fiscal Year: 2002
    ..Ongoing neurochemical and behavioral assessments will provide extensive longitudinal documentation of the effects of such reductions. ..