R Cools

Summary

Publications

  1. pmc Incentive motivation in first-episode psychosis: a behavioural study
    Graham K Murray
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
    BMC Psychiatry 8:34. 2008
  2. pmc Serotonin and dopamine: unifying affective, activational, and decision functions
    Roshan Cools
    Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Centre for Cognitive Neuroimaging, Nijmegen, The Netherlands
    Neuropsychopharmacology 36:98-113. 2011
  3. doi Dopaminergic control of the striatum for high-level cognition
    Roshan Cools
    Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging and Department of Psychiatry, Nijmegen, The Netherlands
    Curr Opin Neurobiol 21:402-7. 2011
  4. ncbi Acute tryptophan depletion in healthy volunteers enhances punishment prediction but does not affect reward prediction
    Roshan Cools
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 33:2291-9. 2008
  5. ncbi Impulsive personality predicts dopamine-dependent changes in frontostriatal activity during component processes of working memory
    Roshan Cools
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720 3190, USA
    J Neurosci 27:5506-14. 2007
  6. ncbi The human striatum is necessary for responding to changes in stimulus relevance
    R Cools
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, UK
    J Cogn Neurosci 18:1973-83. 2006
  7. ncbi L-DOPA disrupts activity in the nucleus accumbens during reversal learning in Parkinson's disease
    Roshan Cools
    Department of Experimental Psychology, Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 32:180-9. 2007
  8. ncbi Reversal learning in Parkinson's disease depends on medication status and outcome valence
    Roshan Cools
    University of Cambridge, Behavioural and Clinical Neuroscience Institute, Cambridge, UK
    Neuropsychologia 44:1663-73. 2006
  9. doi Mood state moderates the role of serotonin in cognitive biases
    O J Robinson
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    J Psychopharmacol 24:573-83. 2010
  10. ncbi Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity
    L Clark
    Department of Experimental Psychology, University of Cambridge, Downing Street, and Department of Medical Genetics, Addenbrooke s Hospital, Cambridge, UK
    Psychopharmacology (Berl) 182:570-8. 2005

Collaborators

Detail Information

Publications39

  1. pmc Incentive motivation in first-episode psychosis: a behavioural study
    Graham K Murray
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
    BMC Psychiatry 8:34. 2008
    ..It has been proposed that there are abnormalities in incentive motivational processing in psychosis, possibly secondary to subcortical dopamine abnormalities, but few empirical studies have addressed this issue...
  2. pmc Serotonin and dopamine: unifying affective, activational, and decision functions
    Roshan Cools
    Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Centre for Cognitive Neuroimaging, Nijmegen, The Netherlands
    Neuropsychopharmacology 36:98-113. 2011
    ....
  3. doi Dopaminergic control of the striatum for high-level cognition
    Roshan Cools
    Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging and Department of Psychiatry, Nijmegen, The Netherlands
    Curr Opin Neurobiol 21:402-7. 2011
    ..This article reviews evidence for an important role of the striatum and its interaction with the prefrontal cortex and suggests a variety of ways by which changes in dopamine transmission can bias high-level cognition...
  4. ncbi Acute tryptophan depletion in healthy volunteers enhances punishment prediction but does not affect reward prediction
    Roshan Cools
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 33:2291-9. 2008
    ..Furthermore, the finding highlights the importance of central 5-HT in resilience to adversity and may have implications for a variety of neuropsychiatric disorders including depression and anxiety...
  5. ncbi Impulsive personality predicts dopamine-dependent changes in frontostriatal activity during component processes of working memory
    Roshan Cools
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720 3190, USA
    J Neurosci 27:5506-14. 2007
    ..The present results provide a key link between dopamine D2 receptor function, impulsivity, and frontostriatal activity during component processes of working memory...
  6. ncbi The human striatum is necessary for responding to changes in stimulus relevance
    R Cools
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, UK
    J Cogn Neurosci 18:1973-83. 2006
    ....
  7. ncbi L-DOPA disrupts activity in the nucleus accumbens during reversal learning in Parkinson's disease
    Roshan Cools
    Department of Experimental Psychology, Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 32:180-9. 2007
    ..These data concur with evidence from studies with experimental animals and indicate an important role for the human nucleus accumbens in the dopaminergic modulation of reversal learning...
  8. ncbi Reversal learning in Parkinson's disease depends on medication status and outcome valence
    Roshan Cools
    University of Cambridge, Behavioural and Clinical Neuroscience Institute, Cambridge, UK
    Neuropsychologia 44:1663-73. 2006
    ..These data indicate that dopaminergic medication in PD impairs reversal shifting depending on the motivational valence of unexpected outcomes...
  9. doi Mood state moderates the role of serotonin in cognitive biases
    O J Robinson
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    J Psychopharmacol 24:573-83. 2010
    ..We therefore suggest that mood state moderates the effect of ATD on cognitive biases. This, in turn, has important implications for the understanding of the role of 5-HT in psychiatric disorders...
  10. ncbi Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity
    L Clark
    Department of Experimental Psychology, University of Cambridge, Downing Street, and Department of Medical Genetics, Addenbrooke s Hospital, Cambridge, UK
    Psychopharmacology (Berl) 182:570-8. 2005
    ..Reduced serotonin neurotransmission is implicated in disorders of impulse control, but the involvement of serotonin in inhibitory processes in healthy human subjects remains unclear...
  11. ncbi Mechanisms of cognitive set flexibility in Parkinson's disease
    R Cools
    Department of Experimental Psychology, Cambridge Centre for Brain Repair, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK
    Brain 124:2503-12. 2001
    ..Finally, the impairment in task-set switching was only apparent when competing information was present, i.e. when the load on selection mechanisms was increased...
  12. pmc Enhanced frontal function in Parkinson's disease
    R Cools
    Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen Medical Centre, Department of Psychiatry, The Netherlands
    Brain 133:225-33. 2010
    ..Dopaminergic medication may reinstate distractibility by normalizing the balance between striatal and prefrontal dopamine transmission...
  13. doi Switching between abstract rules reflects disease severity but not dopaminergic status in Parkinson's disease
    Angie A Kehagia
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK
    Neuropsychologia 47:1117-27. 2009
    ..These findings suggest that switching entire task sets may be a function of extrastriatal, possibly non-dopaminergic pathology which increases as the disease progresses...
  14. ncbi The neuropsychology of ventral prefrontal cortex: decision-making and reversal learning
    L Clark
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Brain Cogn 55:41-53. 2004
    ..Effective decision-making on existing measures requires the ability to adapt behaviour on the basis of changes in emotional significance, and this may underlie the shared neural circuitry with reversal learning...
  15. pmc Dissociable responses to punishment in distinct striatal regions during reversal learning
    Oliver J Robinson
    Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, Addenbrooke s Hospital, P O Box 189, Level E4, Hills Road, Cambridge, CB2 2QQ, UK
    Neuroimage 51:1459-67. 2010
    ..These data help to reconcile conflicting findings from previous studies by showing that distinct regions of the striatum exhibit dissociable responses to punishment during reversal learning...
  16. doi Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory
    Philip L Clatworthy
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 29:4690-6. 2009
    ....
  17. doi Top-down attentional control in Parkinson's disease: salient considerations
    Roshan Cools
    Donders Institute for Brain, Cognition, and Behavior, Radboud University Nijmegen Medical Centre, The Netherlands
    J Cogn Neurosci 22:848-59. 2010
    ..The results provide a striking reinterpretation of prior set-shifting data and provide the first direct evidence for a failure of top-down attentional control, resembling that seen after catecholamine depletion in the pFC...
  18. pmc Striatal dopamine predicts outcome-specific reversal learning and its sensitivity to dopaminergic drug administration
    Roshan Cools
    Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Neurosci 29:1538-43. 2009
    ..These data demonstrate that the effects of D(2) receptor stimulation on reversal learning in humans depend on task demands and baseline striatal dopamine synthesis capacity...
  19. ncbi Tryptophan depletion disrupts the motivational guidance of goal-directed behavior as a function of trait impulsivity
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 30:1362-73. 2005
    ..By contrast, ATD left unaltered the ability to inhibit prepotent responses. Our findings may have implications for a variety of neuropsychiatric disorders including impulsive aggressive disorders and depression...
  20. ncbi Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands
    R Cools
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Cereb Cortex 11:1136-43. 2001
    ..Hence, DA-ergic medication improves or impairs cognitive performance depending on the nature of the task and the basal level of DA function in underlying cortico-striatal circuitry...
  21. pmc Striatal dopamine mediates the interface between motivational and cognitive control in humans: evidence from genetic imaging
    Esther Aarts
    Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
    Neuropsychopharmacology 35:1943-51. 2010
    ..These data establish a crucial role for human striatal dopamine in the modulation of cognitive flexibility by reward anticipation, thus, elucidating the neurochemical mechanism of the interaction between motivation and cognitive control...
  22. ncbi Dopaminergic modulation of high-level cognition in Parkinson's disease: the role of the prefrontal cortex revealed by PET
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Brain 125:584-94. 2002
    ..These data suggest that L-dopa ameliorates high-level cognitive deficits in Parkinson's disease by inducing relative blood flow changes in the right dorsolateral prefrontal cortex...
  23. ncbi L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson's disease
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB3 9DF, UK
    Neuropsychologia 41:1431-41. 2003
    ....
  24. ncbi Using executive heterogeneity to explore the nature of working memory deficits in Parkinson's disease
    Simon J G Lewis
    Cambridge Centre for Brain Repair, Forvie Site, Addenbrooke s Hospital, University of Cambridge, CB2 2PY, UK
    Neuropsychologia 41:645-54. 2003
    ..The results also suggest that performance on the Tower of London task may prove to be a useful discriminant variable in defining the nature of cognitive heterogeneity in Parkinson's disease...
  25. ncbi Dopaminergic modulation of cognitive function-implications for L-DOPA treatment in Parkinson's disease
    Roshan Cools
    Helen Wills Neuroscience Institute, University of California, 132 Barker Hall, Berkeley, USA
    Neurosci Biobehav Rev 30:1-23. 2006
    ....
  26. pmc Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion
    Jonathan P Roiser
    Department of Psychiatry, Addenbrooke s Hospital, Cambridge, UK, and Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
    Neuropsychopharmacology 31:2264-72. 2006
    ....
  27. pmc Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not males
    Oliver J Robinson
    Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, Addenbrooke s Hospital, P O Box 189, Level E4, Hills Road, Cambridge, CB2 2QQ, UK
    Psychopharmacology (Berl) 211:187-95. 2010
    ..Here, we extend these prior findings by examining the effects of artificially reducing DA synthesis in healthy individuals performing this previously employed task...
  28. doi Working memory capacity predicts dopamine synthesis capacity in the human striatum
    Roshan Cools
    Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720 3190, USA
    J Neurosci 28:1208-12. 2008
    ....
  29. ncbi Defining the neural mechanisms of probabilistic reversal learning using event-related functional magnetic resonance imaging
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 22:4563-7. 2002
    ..Overall, these data concur with findings in rodents and nonhuman primates of reversal-learning deficits after damage to ventral frontostriatal circuitry, and also support recent clinical findings using this task...
  30. ncbi Differential responses in human striatum and prefrontal cortex to changes in object and rule relevance
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 24:1129-35. 2004
    ....
  31. doi Methylphenidate has differential effects on blood oxygenation level-dependent signal related to cognitive subprocesses of reversal learning
    Chris M Dodds
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 28:5976-82. 2008
    ..The results show that the precise neural site of modulation by methylphenidate depends on the nature of the cognitive subprocess recruited...
  32. doi Role of dopamine in the motivational and cognitive control of behavior
    Roshan Cools
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, The Netherlands
    Neuroscientist 14:381-95. 2008
    ....
  33. doi The human basal ganglia modulate frontal-posterior connectivity during attention shifting
    Martine R van Schouwenburg
    Radboud University Nijmegen, Donders Institute for Brain, Cognition, and Behaviour, Centre for Cognitive Neuroimaging, 6500 HB, Nijmegen, The Netherlands
    J Neurosci 30:9910-8. 2010
    ..These data integrate disparate literatures on top-down control by the prefrontal cortex and selective gating by the basal ganglia and highlight the importance of the basal ganglia for high-level cognitive control...
  34. ncbi Dopaminergic modulation of cognitive control: distinct roles for the prefrontal cortex and the basal ganglia
    Martine van Schouwenburg
    Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, University Nijmegen, Kapittelweg 29, 6500 HB, Nijmegen, The Netherlands
    Curr Pharm Des 16:2026-32. 2010
    ....
  35. ncbi Chemistry of the adaptive mind
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Philos Trans A Math Phys Eng Sci 362:2871-88. 2004
    ..The work has considerable implications for the understanding of and treatment development for abnormalities such as Parkinson's disease, attention deficit hyperactivity disorder and drug addiction...
  36. ncbi Serotoninergic regulation of emotional and behavioural control processes
    Roshan Cools
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Trends Cogn Sci 12:31-40. 2008
    ..We review evidence from studies with human volunteers and experimental animals that begins to elucidate the neurobiological systems underlying these different effects...
  37. ncbi Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces
    Roshan Cools
    MRC Behavioural and Clinical Neuroscience Centre
    Psychopharmacology (Berl) 180:670-9. 2005
    ....
  38. ncbi Serotonergic modulation of prefrontal cortex during negative feedback in probabilistic reversal learning
    Elizabeth A T Evers
    Brain and Behavior Institute, University of Maastricht, Maastricht, The Netherlands
    Neuropsychopharmacology 30:1138-47. 2005
    ..These data suggest that ATD affects reversal learning and the processing of aversive signals by modulation of the dorsomedial PFC...
  39. ncbi Effects of levodopa and subthalamic nucleus stimulation on cognitive and affective functioning in Parkinson's disease
    Aurélie Funkiewiez
    Department of Clinical and Biological Neurosciences, University Hospital of Grenoble, and INSERM U318, Joseph Fourier University of Grenoble, Grenoble, France
    Mov Disord 21:1656-62. 2006
    ..To conclude, there were significant but contrasting effects of levodopa and STN stimulation on cognition and affective functions...