Incentive motivation in first-episode psychosis: a behavioural studyGraham K Murray
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
BMC Psychiatry 8:34. 2008
..It has been proposed that there are abnormalities in incentive motivational processing in psychosis, possibly secondary to subcortical dopamine abnormalities, but few empirical studies have addressed this issue...
- Serotonin and dopamine: unifying affective, activational, and decision functions
Roshan Cools
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Centre for Cognitive Neuroimaging, Nijmegen, The Netherlands
Neuropsychopharmacology 36:98-113. 2011
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Dopaminergic control of the striatum for high-level cognitionRoshan Cools
Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging and Department of Psychiatry, Nijmegen, The Netherlands
Curr Opin Neurobiol 21:402-7. 2011
..This article reviews evidence for an important role of the striatum and its interaction with the prefrontal cortex and suggests a variety of ways by which changes in dopamine transmission can bias high-level cognition...
Acute tryptophan depletion in healthy volunteers enhances punishment prediction but does not affect reward predictionRoshan Cools
Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 33:2291-9. 2008
..Furthermore, the finding highlights the importance of central 5-HT in resilience to adversity and may have implications for a variety of neuropsychiatric disorders including depression and anxiety...
- Impulsive personality predicts dopamine-dependent changes in frontostriatal activity during component processes of working memory
Roshan Cools
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720 3190, USA
J Neurosci 27:5506-14. 2007
..The present results provide a key link between dopamine D2 receptor function, impulsivity, and frontostriatal activity during component processes of working memory...
- The human striatum is necessary for responding to changes in stimulus relevance
R Cools
Behavioral and Clinical Neuroscience Institute, University of Cambridge, UK
J Cogn Neurosci 18:1973-83. 2006
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- L-DOPA disrupts activity in the nucleus accumbens during reversal learning in Parkinson's disease
Roshan Cools
Department of Experimental Psychology, Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 32:180-9. 2007
..These data concur with evidence from studies with experimental animals and indicate an important role for the human nucleus accumbens in the dopaminergic modulation of reversal learning...
- Reversal learning in Parkinson's disease depends on medication status and outcome valence
Roshan Cools
University of Cambridge, Behavioural and Clinical Neuroscience Institute, Cambridge, UK
Neuropsychologia 44:1663-73. 2006
..These data indicate that dopaminergic medication in PD impairs reversal shifting depending on the motivational valence of unexpected outcomes...
- Mood state moderates the role of serotonin in cognitive biases
O J Robinson
Department of Psychiatry, University of Cambridge, Cambridge, UK
J Psychopharmacol 24:573-83. 2010
..We therefore suggest that mood state moderates the effect of ATD on cognitive biases. This, in turn, has important implications for the understanding of the role of 5-HT in psychiatric disorders...
- Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity
L Clark
Department of Experimental Psychology, University of Cambridge, Downing Street, and Department of Medical Genetics, Addenbrooke s Hospital, Cambridge, UK
Psychopharmacology (Berl) 182:570-8. 2005
..Reduced serotonin neurotransmission is implicated in disorders of impulse control, but the involvement of serotonin in inhibitory processes in healthy human subjects remains unclear...
- Mechanisms of cognitive set flexibility in Parkinson's disease
R Cools
Department of Experimental Psychology, Cambridge Centre for Brain Repair, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK
Brain 124:2503-12. 2001
..Finally, the impairment in task-set switching was only apparent when competing information was present, i.e. when the load on selection mechanisms was increased...
- Enhanced frontal function in Parkinson's disease
R Cools
Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen Medical Centre, Department of Psychiatry, The Netherlands
Brain 133:225-33. 2010
..Dopaminergic medication may reinstate distractibility by normalizing the balance between striatal and prefrontal dopamine transmission...
- Switching between abstract rules reflects disease severity but not dopaminergic status in Parkinson's disease
Angie A Kehagia
Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK
Neuropsychologia 47:1117-27. 2009
..These findings suggest that switching entire task sets may be a function of extrastriatal, possibly non-dopaminergic pathology which increases as the disease progresses...
- The neuropsychology of ventral prefrontal cortex: decision-making and reversal learning
L Clark
Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
Brain Cogn 55:41-53. 2004
..Effective decision-making on existing measures requires the ability to adapt behaviour on the basis of changes in emotional significance, and this may underlie the shared neural circuitry with reversal learning...
- Dissociable responses to punishment in distinct striatal regions during reversal learning
Oliver J Robinson
Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, Addenbrooke s Hospital, P O Box 189, Level E4, Hills Road, Cambridge, CB2 2QQ, UK
Neuroimage 51:1459-67. 2010
..These data help to reconcile conflicting findings from previous studies by showing that distinct regions of the striatum exhibit dissociable responses to punishment during reversal learning...
- Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory
Philip L Clatworthy
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
J Neurosci 29:4690-6. 2009
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- Top-down attentional control in Parkinson's disease: salient considerations
Roshan Cools
Donders Institute for Brain, Cognition, and Behavior, Radboud University Nijmegen Medical Centre, The Netherlands
J Cogn Neurosci 22:848-59. 2010
..The results provide a striking reinterpretation of prior set-shifting data and provide the first direct evidence for a failure of top-down attentional control, resembling that seen after catecholamine depletion in the pFC...
- Striatal dopamine predicts outcome-specific reversal learning and its sensitivity to dopaminergic drug administration
Roshan Cools
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
J Neurosci 29:1538-43. 2009
..These data demonstrate that the effects of D(2) receptor stimulation on reversal learning in humans depend on task demands and baseline striatal dopamine synthesis capacity...
- Tryptophan depletion disrupts the motivational guidance of goal-directed behavior as a function of trait impulsivity
Roshan Cools
Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 30:1362-73. 2005
..By contrast, ATD left unaltered the ability to inhibit prepotent responses. Our findings may have implications for a variety of neuropsychiatric disorders including impulsive aggressive disorders and depression...
- Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands
R Cools
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Cereb Cortex 11:1136-43. 2001
..Hence, DA-ergic medication improves or impairs cognitive performance depending on the nature of the task and the basal level of DA function in underlying cortico-striatal circuitry...
- Striatal dopamine mediates the interface between motivational and cognitive control in humans: evidence from genetic imaging
Esther Aarts
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
Neuropsychopharmacology 35:1943-51. 2010
..These data establish a crucial role for human striatal dopamine in the modulation of cognitive flexibility by reward anticipation, thus, elucidating the neurochemical mechanism of the interaction between motivation and cognitive control...
- Dopaminergic modulation of high-level cognition in Parkinson's disease: the role of the prefrontal cortex revealed by PET
Roshan Cools
Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Brain 125:584-94. 2002
..These data suggest that L-dopa ameliorates high-level cognitive deficits in Parkinson's disease by inducing relative blood flow changes in the right dorsolateral prefrontal cortex...
- L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson's disease
Roshan Cools
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB3 9DF, UK
Neuropsychologia 41:1431-41. 2003
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- Using executive heterogeneity to explore the nature of working memory deficits in Parkinson's disease
Simon J G Lewis
Cambridge Centre for Brain Repair, Forvie Site, Addenbrooke s Hospital, University of Cambridge, CB2 2PY, UK
Neuropsychologia 41:645-54. 2003
..The results also suggest that performance on the Tower of London task may prove to be a useful discriminant variable in defining the nature of cognitive heterogeneity in Parkinson's disease...
- Dopaminergic modulation of cognitive function-implications for L-DOPA treatment in Parkinson's disease
Roshan Cools
Helen Wills Neuroscience Institute, University of California, 132 Barker Hall, Berkeley, USA
Neurosci Biobehav Rev 30:1-23. 2006
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- Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion
Jonathan P Roiser
Department of Psychiatry, Addenbrooke s Hospital, Cambridge, UK, and Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
Neuropsychopharmacology 31:2264-72. 2006
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- Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not males
Oliver J Robinson
Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, Addenbrooke s Hospital, P O Box 189, Level E4, Hills Road, Cambridge, CB2 2QQ, UK
Psychopharmacology (Berl) 211:187-95. 2010
..Here, we extend these prior findings by examining the effects of artificially reducing DA synthesis in healthy individuals performing this previously employed task...
- Working memory capacity predicts dopamine synthesis capacity in the human striatum
Roshan Cools
Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720 3190, USA
J Neurosci 28:1208-12. 2008
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- Defining the neural mechanisms of probabilistic reversal learning using event-related functional magnetic resonance imaging
Roshan Cools
Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
J Neurosci 22:4563-7. 2002
..Overall, these data concur with findings in rodents and nonhuman primates of reversal-learning deficits after damage to ventral frontostriatal circuitry, and also support recent clinical findings using this task...
- Differential responses in human striatum and prefrontal cortex to changes in object and rule relevance
Roshan Cools
Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
J Neurosci 24:1129-35. 2004
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- Methylphenidate has differential effects on blood oxygenation level-dependent signal related to cognitive subprocesses of reversal learning
Chris M Dodds
Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
J Neurosci 28:5976-82. 2008
..The results show that the precise neural site of modulation by methylphenidate depends on the nature of the cognitive subprocess recruited...
- Role of dopamine in the motivational and cognitive control of behavior
Roshan Cools
F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, The Netherlands
Neuroscientist 14:381-95. 2008
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- The human basal ganglia modulate frontal-posterior connectivity during attention shifting
Martine R van Schouwenburg
Radboud University Nijmegen, Donders Institute for Brain, Cognition, and Behaviour, Centre for Cognitive Neuroimaging, 6500 HB, Nijmegen, The Netherlands
J Neurosci 30:9910-8. 2010
..These data integrate disparate literatures on top-down control by the prefrontal cortex and selective gating by the basal ganglia and highlight the importance of the basal ganglia for high-level cognitive control...
- Dopaminergic modulation of cognitive control: distinct roles for the prefrontal cortex and the basal ganglia
Martine van Schouwenburg
Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, University Nijmegen, Kapittelweg 29, 6500 HB, Nijmegen, The Netherlands
Curr Pharm Des 16:2026-32. 2010
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- Chemistry of the adaptive mind
Roshan Cools
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Philos Trans A Math Phys Eng Sci 362:2871-88. 2004
..The work has considerable implications for the understanding of and treatment development for abnormalities such as Parkinson's disease, attention deficit hyperactivity disorder and drug addiction...
- Serotoninergic regulation of emotional and behavioural control processes
Roshan Cools
F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Trends Cogn Sci 12:31-40. 2008
..We review evidence from studies with human volunteers and experimental animals that begins to elucidate the neurobiological systems underlying these different effects...
- Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces
Roshan Cools
MRC Behavioural and Clinical Neuroscience Centre
Psychopharmacology (Berl) 180:670-9. 2005
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- Serotonergic modulation of prefrontal cortex during negative feedback in probabilistic reversal learning
Elizabeth A T Evers
Brain and Behavior Institute, University of Maastricht, Maastricht, The Netherlands
Neuropsychopharmacology 30:1138-47. 2005
..These data suggest that ATD affects reversal learning and the processing of aversive signals by modulation of the dorsomedial PFC...
- Effects of levodopa and subthalamic nucleus stimulation on cognitive and affective functioning in Parkinson's disease
Aurélie Funkiewiez
Department of Clinical and Biological Neurosciences, University Hospital of Grenoble, and INSERM U318, Joseph Fourier University of Grenoble, Grenoble, France
Mov Disord 21:1656-62. 2006
..To conclude, there were significant but contrasting effects of levodopa and STN stimulation on cognition and affective functions...
