Philip W Connelly

Summary

Publications

  1. pmc Paraoxonase 1 Phenotype and Mass in South Asian versus Caucasian Renal Transplant Recipients
    Philip W Connelly
    Department of Medicine, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, ON, Canada M5B 1W8
    J Lipids 2012:608580. 2012
  2. doi request reprint Adiponectin in renal disease--a review of the evidence as a risk factor for cardiovascular and all-cause mortality
    Philip W Connelly
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Crit Rev Clin Lab Sci 49:218-31. 2012
  3. pmc Cardiovascular disease risk profile and microvascular complications of diabetes: comparison of Indigenous cohorts with diabetes in Australia and Canada
    Louise J Maple-Brown
    Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
    Cardiovasc Diabetol 11:30. 2012
  4. pmc HNF1A G319S variant, active cigarette smoking and incident type 2 diabetes in Aboriginal Canadians: a population-based epidemiological study
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    BMC Med Genet 12:1. 2011
  5. pmc Assessing the association of the HNF1A G319S variant with C-reactive protein in Aboriginal Canadians: a population-based epidemiological study
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Cardiovasc Diabetol 9:39. 2010
  6. pmc Hepatic insulin resistance is an early determinant of declining β-cell function in the first year postpartum after glucose intolerance in pregnancy
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Diabetes Care 34:2431-4. 2011
  7. doi request reprint The graded relationship between glucose tolerance status in pregnancy and postpartum levels of low-density-lipoprotein cholesterol and apolipoprotein B in young women: implications for future cardiovascular risk
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, 60 Murray Street, Suite L5 039, Mailbox 21, Toronto, Ontario, Canada M5T 3L9
    J Clin Endocrinol Metab 95:4345-53. 2010
  8. doi request reprint Risk of early progression to prediabetes or diabetes in women with recent gestational dysglycaemia but normal glucose tolerance at 3-month postpartum
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada
    Clin Endocrinol (Oxf) 73:476-83. 2010
  9. pmc The antepartum glucose values that predict neonatal macrosomia differ from those that predict postpartum prediabetes or diabetes: implications for the diagnostic criteria for gestational diabetes
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada M5T3L9
    J Clin Endocrinol Metab 94:840-5. 2009
  10. pmc Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice
    Lauren Hager
    Keenan Research Centre, Li Ka Shing Knowledge Institute, Department of Medicine, St Michael s Hospital, Toronto M5B 1W8, Canada
    J Biol Chem 287:20755-68. 2012

Collaborators

Detail Information

Publications29

  1. pmc Paraoxonase 1 Phenotype and Mass in South Asian versus Caucasian Renal Transplant Recipients
    Philip W Connelly
    Department of Medicine, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, ON, Canada M5B 1W8
    J Lipids 2012:608580. 2012
    ..The two-substrate method for determining PON1 phenotype may be of value for future studies of cardiovascular complications in renal transplant recipients...
  2. doi request reprint Adiponectin in renal disease--a review of the evidence as a risk factor for cardiovascular and all-cause mortality
    Philip W Connelly
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Crit Rev Clin Lab Sci 49:218-31. 2012
    ..We review here the basic science evidence and clinical studies of the role of renal function and kidney disease as a determinant of adiponectin...
  3. pmc Cardiovascular disease risk profile and microvascular complications of diabetes: comparison of Indigenous cohorts with diabetes in Australia and Canada
    Louise J Maple-Brown
    Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
    Cardiovasc Diabetol 11:30. 2012
    ..Our goal was to compare cardiovascular (CVD) risk profile and diabetes complications from three recent comprehensive studies of diabetes complications in different Indigenous populations in Australia and Canada...
  4. pmc HNF1A G319S variant, active cigarette smoking and incident type 2 diabetes in Aboriginal Canadians: a population-based epidemiological study
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    BMC Med Genet 12:1. 2011
    ..We aimed to investigate the association of the HNF1A G319S polymorphism with incident type 2 diabetes and to assess whether clinical risk variables for type 2 diabetes influence the association in an Aboriginal population...
  5. pmc Assessing the association of the HNF1A G319S variant with C-reactive protein in Aboriginal Canadians: a population-based epidemiological study
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Cardiovasc Diabetol 9:39. 2010
    ..We aimed to investigate whether CRP was mediating the association between HNF1A G319S and type 2 diabetes in an Aboriginal Canadian population with a high prevalence of diabetes...
  6. pmc Hepatic insulin resistance is an early determinant of declining β-cell function in the first year postpartum after glucose intolerance in pregnancy
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Diabetes Care 34:2431-4. 2011
    ..13 [95% CI 0.06-0.29]; P < 0.0001). CONCLUSIONS Hepatic insulin resistance is an early determinant of declining β-cell function after gestational dysglycemia...
  7. doi request reprint The graded relationship between glucose tolerance status in pregnancy and postpartum levels of low-density-lipoprotein cholesterol and apolipoprotein B in young women: implications for future cardiovascular risk
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, 60 Murray Street, Suite L5 039, Mailbox 21, Toronto, Ontario, Canada M5T 3L9
    J Clin Endocrinol Metab 95:4345-53. 2010
    ..Because lipid factors can contribute to cardiovascular risk, we sought to characterize the relationship between gestational glucose tolerance status and lipid profile in pregnancy and the postpartum...
  8. doi request reprint Risk of early progression to prediabetes or diabetes in women with recent gestational dysglycaemia but normal glucose tolerance at 3-month postpartum
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada
    Clin Endocrinol (Oxf) 73:476-83. 2010
    ..In this context, we sought to evaluate the risk of early progression to dysglycaemia in women with NGT at 3-month postpartum and identify predictors thereof...
  9. pmc The antepartum glucose values that predict neonatal macrosomia differ from those that predict postpartum prediabetes or diabetes: implications for the diagnostic criteria for gestational diabetes
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada M5T3L9
    J Clin Endocrinol Metab 94:840-5. 2009
    ..Thus, to test this assumption, we sought to evaluate the predictive capacity of each glucose value on antepartum OGTT in relation to LGA and postpartum prediabetes/diabetes...
  10. pmc Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice
    Lauren Hager
    Keenan Research Centre, Li Ka Shing Knowledge Institute, Department of Medicine, St Michael s Hospital, Toronto M5B 1W8, Canada
    J Biol Chem 287:20755-68. 2012
    ..Thus, factors influencing the accumulation of ER cholesterol may be important for the development of hepatic insulin resistance...
  11. pmc Postpartum metabolic function in women delivering a macrosomic infant in the absence of gestational diabetes mellitus
    Simone Kew
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 34:2608-13. 2011
    ..Thus, to test this hypothesis, we assessed metabolic function during and after pregnancy in a cohort of women stratified according to the presence/absence of GDM and LGA delivery, respectively...
  12. doi request reprint Association of apolipoprotein B with incident type 2 diabetes in an aboriginal Canadian population
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Clin Chem 56:666-70. 2010
    ..We assessed the association of apo B with incident type 2 diabetes and compared it with traditional lipid variables as a risk predictor in aboriginal Canadians...
  13. doi request reprint Comparison of National Diabetes Data Group and American Diabetes Association diagnostic criteria for gestational diabetes in their identification of postpartum risk of glucose intolerance
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Diabetes Res Clin Pract 85:40-6. 2009
    ....
  14. ncbi request reprint Fasting capillary glucose as a screening test for ruling out gestational diabetes mellitus
    Valerie Anderson
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    J Obstet Gynaecol Can 35:515-22. 2013
    ..Thus, we sought to identify a threshold level of FCG below which GDM could be ruled out following a positive GCT, without need for the OGTT...
  15. pmc Gestational diabetes and postpartum physical activity: evidence of lifestyle change 1 year after delivery
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Obesity (Silver Spring) 18:1323-9. 2010
    ..83, P = 0.005). In conclusion, women with GDM successfully increased their leisure-time activity in the first year postpartum, reflecting an element of lifestyle change following this diagnosis...
  16. pmc Circadian variation in the response to the glucose challenge test in pregnancy: implications for screening for gestational diabetes mellitus
    Robert J Goldberg
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 35:1578-84. 2012
    ..Thus, using their subsequent OGTT (performed in the morning), we sought to characterize the metabolic function of women with positive GCTs in relation to the timing of their test...
  17. pmc Beta-cell function declines within the first year postpartum in women with recent glucose intolerance in pregnancy
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Diabetes Care 33:1798-804. 2010
    ..In this context, we queried whether metabolic changes that occur in the 1st year postpartum vary in relation to gestational glucose tolerance status...
  18. pmc Metabolic syndrome and its components as predictors of incident type 2 diabetes mellitus in an Aboriginal community
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Ont
    CMAJ 180:617-24. 2009
    ..We aimed to determine the incidence of type 2 diabetes in an Aboriginal community and to evaluate prospective associations with metabolic syndrome and its components...
  19. pmc Determinants of insulin resistance in infants at age 1 year: impact of gestational diabetes mellitus
    Carla A Borgono
    Division of General Internal Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 35:1795-7. 2012
    ..Thus, we sought to identify early life determinants of insulin resistance in infants of women with and without GDM...
  20. pmc APOC1 T45S polymorphism is associated with reduced obesity indices and lower plasma concentrations of leptin and apolipoprotein C-I in aboriginal Canadians
    Piya Lahiry
    Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
    J Lipid Res 51:843-8. 2010
    ..0001), using a newly developed ELISA-based method. Taken together, these results suggest that at the whole human phenotype level, apo C-I is associated with the complex metabolic trait of obesity as well as with serum leptin levels...
  21. ncbi request reprint Cardiometabolic implications of postpartum weight changes in the first year after delivery
    Simone Kew
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 37:1998-2006. 2014
    ..In this context, we sought to evaluate the cardiometabolic implications of patterns of postpartum weight change and the time course thereof in the first year after pregnancy...
  22. doi request reprint NF-kappaB -94Ins/Del ATTG polymorphism modifies the association between dietary polyunsaturated fatty acids and HDL-cholesterol in two distinct populations
    Bénédicte Fontaine-Bisson
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada
    Atherosclerosis 204:465-70. 2009
    ..05). These findings show that this functional polymorphism in the NF-kB gene modifies the association between PUFA intake and plasma HDL-cholesterol in two distinct populations...
  23. doi request reprint Effect of a dietary portfolio of cholesterol-lowering foods given at 2 levels of intensity of dietary advice on serum lipids in hyperlipidemia: a randomized controlled trial
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, 61 Queen St E, Toronto, ON M5C 2T2, Canada
    JAMA 306:831-9. 2011
    ..Combining foods with recognized cholesterol-lowering properties (dietary portfolio) has proven highly effective in lowering serum cholesterol under metabolically controlled conditions...
  24. pmc Lecithin cholesterol acyltransferase null mice are protected from diet-induced obesity and insulin resistance in a gender-specific manner through multiple pathways
    Lixin Li
    Keenan Research Centre, Li Ka Shing Knowledge Institute, Department of Medicine, St Michael s Hospital, Toronto M5B 1W8, Canada
    J Biol Chem 286:17809-20. 2011
    ....
  25. pmc An abnormal screening glucose challenge test in pregnancy predicts postpartum metabolic dysfunction, even when the antepartum oral glucose tolerance test is normal
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Division of Endocrinology, University of Toronto, Toronto, Canada
    Clin Endocrinol (Oxf) 71:208-14. 2009
    ..Thus, we sought to characterize the obstetrical and postpartum metabolic significance of an abnormal GCT in women with normal glucose tolerance (NGT) on antepartum OGTT...
  26. doi request reprint Mouse serum paraoxonase-1 lactonase activity is specific for medium-chain length fatty acid lactones
    Philip W Connelly
    Department of Medicine, University of Toronto, Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Biochim Biophys Acta 1811:39-45. 2011
    ..In contrast, medium-chain length fatty acid lactones are stable in mouse serum in the absence of PON1, suggesting that PON1 plays a specific role in the metabolism of these compounds...
  27. pmc Determination of lipoprotein(a) kringle repeat number from genomic DNA: copy number variation genotyping using qPCR
    Matthew B Lanktree
    Robarts Research Institute, Departments of Medicine and Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Lipid Res 50:768-72. 2009
    ....
  28. pmc Association of the novel cardiovascular risk factors paraoxonase 1 and cystatin C in type 2 diabetes
    Philip W Connelly
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Canada
    J Lipid Res 50:1216-22. 2009
    ..73 m(2). The lower mass of PON1, an anti-inflammatory HDL-associated enzyme, in T2DM with cystatin C-eGFR <60 ml/min per 1.73 m(2) may contribute to their increased risk for cardiovascular disease...
  29. pmc Adding monounsaturated fatty acids to a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, Toronto, Ont, Canada
    CMAJ 182:1961-7. 2010
    ....