John Concato

..g. markers of cell-cycle regulation), in addition to the effect of traditional clinical factors (e.g. anatomical stage, histological grade), in predicting long-term mortality among men newly diagnosed with prostate cancer...

..The impact of BCR on subsequent mortality is uncertain, however, especially given competing causes of death...

..The current study has therefore evaluated the association between LMS-staged COPD and health outcomes, in two separate cohorts of older persons...

..Evidence is limited, however, on whether the LMS method is valid for evaluating respiratory impairment in middle-aged persons...

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..Current methods to assess the prognosis of prostate cancer at the time of diagnosis are limited...

..32)). In older white persons, LMS-defined respiratory impairment is strongly associated with an increased risk of COPD hospitalisation. These results support the LMS method as a basis for defining respiratory impairment in older persons...

..An upward shift has occurred in the distribution of Gleason scores during the past decade; this change was influenced by reports suggesting that lower scores (range, 2-4) should not be assigned to biopsy specimens...

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..6, which could be clinically significant when the count approaches the set minimum. Uniform criteria are necessary to allow for meaningful comparisons between studies on minimal nodal counts for cancer lymphadenectomies...

..Our objective was to determine the proportion of men with castrate-resistant prostate cancer (CRPC) in a clinical setting that would have been excluded from major phase 3 RCTs...

..This study aims to determine whether obstructive sleep apnea independently increases the risk of coronary events, including death from cardiovascular causes...

..As of 2008, the need to counsel patients regarding the possible benefits and harms that can result from screening for (and treating) prostate cancer remains justified...

..Accordingly, we evaluated the sensitivity of prostate-specific antigen (PSA) velocity among men who are diagnosed subsequently with prostate cancer...

..This study was designed to examine relationships of deployment to the Gulf, as well as symptoms after military service, with postdeployment activity of acetylcholinesterase (AChE) and related enzymes...

..The results of studies about dietary fish consumption and stroke risk have been conflicting. We sought to examine the relationship between dietary fish and seafood consumption and the risk of stroke or transient ischemic attack (TIA)...

..Others argue that delays will persist until routine screening is adopted. The Veterans Health Administration (VA) is a unique laboratory to examine whether access to comprehensive health benefits results in earlier entry into HIV care...

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..A review of these (and other) selected projects, based on their type of study design, serves to highlight the strengths, limitations, and potential of CER...

..Evidence is lacking, however, to confirm a survival benefit among screened patients. We evaluated the effectiveness of PSA, with or without DRE, in reducing mortality...

..Further research is needed to identify the reasons for the racial disparity in PSA surveillance and to design interventions to lessen these differences...