Karen Colwill

Summary

Publications

  1. doi request reprint A roadmap to generate renewable protein binders to the human proteome
    Karen Colwill
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nat Methods 8:551-8. 2011
  2. ncbi request reprint A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells
    Clark D Wells
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Cell 125:535-48. 2006
  3. pmc NetworKIN: a resource for exploring cellular phosphorylation networks
    Rune Linding
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Nucleic Acids Res 36:D695-9. 2008
  4. doi request reprint Temporal regulation of EGF signalling networks by the scaffold protein Shc1
    Yong Zheng
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Canada
    Nature 499:166-71. 2013
  5. pmc Characterization of the yeast amphiphysins Rvs161p and Rvs167p reveals roles for the Rvs heterodimer in vivo
    Helena Friesen
    Department of Medical Genetics and Microbiology, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Mol Biol Cell 17:1306-21. 2006
  6. pmc WW domains provide a platform for the assembly of multiprotein networks
    Robert J Ingham
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Cell Biol 25:7092-106. 2005
  7. pmc Modification of the Creator recombination system for proteomics applications--improved expression by addition of splice sites
    Karen Colwill
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    BMC Biotechnol 6:13. 2006
  8. pmc Systematic discovery of in vivo phosphorylation networks
    Rune Linding
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Cell 129:1415-26. 2007
  9. pmc Large-scale mapping of human protein-protein interactions by mass spectrometry
    Rob M Ewing
    Protana, Toronto, Ontario, Canada
    Mol Syst Biol 3:89. 2007
  10. pmc Interaction of the Saccharomyces cerevisiae cortical actin patch protein Rvs167p with proteins involved in ER to Golgi vesicle trafficking
    Helena Friesen
    Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
    Genetics 170:555-68. 2005

Collaborators

Detail Information

Publications10

  1. doi request reprint A roadmap to generate renewable protein binders to the human proteome
    Karen Colwill
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nat Methods 8:551-8. 2011
    ..We believe that this work serves as a foundation and template for future larger-scale studies to create renewable protein binders...
  2. ncbi request reprint A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells
    Clark D Wells
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Cell 125:535-48. 2006
    ..We propose that Rich1 and Amot maintain TJ integrity by the coordinate regulation of Cdc42 and by linking specific components of the TJ to intracellular protein trafficking...
  3. pmc NetworKIN: a resource for exploring cellular phosphorylation networks
    Rune Linding
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Nucleic Acids Res 36:D695-9. 2008
    ..The database currently contains a predicted phosphorylation network with 20,224 site-specific interactions involving 3978 phosphoproteins and 73 human kinases from 20 families...
  4. doi request reprint Temporal regulation of EGF signalling networks by the scaffold protein Shc1
    Yong Zheng
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Canada
    Nature 499:166-71. 2013
    ..The Shc1 scaffold therefore directs the temporal flow of signalling information after EGF stimulation. ..
  5. pmc Characterization of the yeast amphiphysins Rvs161p and Rvs167p reveals roles for the Rvs heterodimer in vivo
    Helena Friesen
    Department of Medical Genetics and Microbiology, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Mol Biol Cell 17:1306-21. 2006
    ..Our studies implicate heterodimerization of amphiphysin family proteins in various functions related to cell polarity, cell integrity, and vesicle trafficking during vegetative growth and the mating response...
  6. pmc WW domains provide a platform for the assembly of multiprotein networks
    Robert J Ingham
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Cell Biol 25:7092-106. 2005
    ..These data suggest that WW domains provide a versatile platform to link individual proteins into physiologically important networks...
  7. pmc Modification of the Creator recombination system for proteomics applications--improved expression by addition of splice sites
    Karen Colwill
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    BMC Biotechnol 6:13. 2006
    ..Usability of the Creator system is impacted by the ability to easily manipulate DNA, the number of acceptor vectors for downstream applications, and the level of protein expression from Creator vectors...
  8. pmc Systematic discovery of in vivo phosphorylation networks
    Rune Linding
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Cell 129:1415-26. 2007
    ..Applying this approach to DNA damage signaling, we show that 53BP1 and Rad50 are phosphorylated by CDK1 and ATM, respectively. We describe a scalable strategy to evaluate predictions, which suggests that BCLAF1 is a GSK-3 substrate...
  9. pmc Large-scale mapping of human protein-protein interactions by mass spectrometry
    Rob M Ewing
    Protana, Toronto, Ontario, Canada
    Mol Syst Biol 3:89. 2007
    ..In addition, via our preliminary analysis, we report many novel protein interactions and pathway associations...
  10. pmc Interaction of the Saccharomyces cerevisiae cortical actin patch protein Rvs167p with proteins involved in ER to Golgi vesicle trafficking
    Helena Friesen
    Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
    Genetics 170:555-68. 2005
    ..Since Rvs167p has a previously characterized role in endocytosis and we have shown here that it interacts with proteins involved in Golgi vesicle trafficking, we suggest that Rvs167p may have a general role in vesicle trafficking...