John M. González

Summary

Affiliation: Universidad de los Andes
Location: Bogotá, Colombia

Publications

  1. pmc Chagasic patients are able to respond against a viral antigen from influenza virus
    Paola Lasso
    Laboratorio de Parasitologia Molecular, Pontificia Universidad Javeriana, Bogota, Colombia
    BMC Infect Dis 12:198. 2012
  2. ncbi request reprint Glia expression of MHC during CNS infection by neurotropic coronavirus
    Karen E Malone
    Cleveland Clinic Foundation, OH 44106, USA
    Adv Exp Med Biol 581:543-6. 2006
  3. ncbi request reprint Immunological and structural characterization of an epitope from the Trypanosoma cruzi KMP-11 protein
    H Diez
    Laboratorio de Parasitologia Molecular, Pontificia Universidad Javeriana, Bogota, Colombia
    Peptides 28:1520-6. 2007
  4. doi request reprint Natural CD4(+) T-cell responses against Trypanosoma cruzi KMP-11 protein in chronic chagasic patients
    Adriana Cuellar
    Grupo de Inmunobiología y Biología Celular, Departamento de Microbiologia, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota, Colombia
    Immunol Cell Biol 87:149-53. 2009
  5. pmc Characterising the KMP-11 and HSP-70 recombinant antigens' humoral immune response profile in chagasic patients
    Ivonne D Flechas
    Laboratorio de Parasitologia Molecular, Pontificia Universidad Javeriana, CRA, 7a No, 43 82, ED, 50, Lab, 113, Bogota, Colombia
    BMC Infect Dis 9:186. 2009
  6. doi request reprint Frequency of specific CD8+ T cells for a promiscuous epitope derived from Trypanosoma cruzi KMP-11 protein in chagasic patients
    P Lasso
    Laboratorio de Parasitologia Molecular, Pontificia Universidad Javeriana, Bogota, Colombia
    Parasite Immunol 32:494-502. 2010
  7. pmc Increased CD4+/CD8+ double-positive T cells in chronic Chagasic patients
    Nicolas A Giraldo
    Grupo de Ciencias Básicas Médicas, Facultad de Medicina, Universidad de Los Andes, Bogota, Colombia
    PLoS Negl Trop Dis 5:e1294. 2011
  8. ncbi request reprint [Expression of IL-10, IL-4 and IFN-γ in active skin lesions of children with papular urticaria]
    Elizabeth Garcia
    Sección de Alergia Pediátrica, Fundacion Santa Fe de Bogota, DC, Colombia
    Biomedica 31:525-31. 2011
  9. doi request reprint Rabbit serum against K1 peptide, an immunogenic epitope of the Trypanosoma cruzi KMP-11, decreases parasite invasion to cells
    Juan Camilo Diaz-Soto
    Grupo de Ciencias Básicas Médicas, Facultad de Medicina, Universidad de Los Andes, Bogota, D C, Colombia
    Acta Trop 123:224-9. 2012
  10. doi request reprint Differences in systemic and skin migrating-specific CD4 T cells in papular urticaria by flea bite
    Omar Dominguez-Amorocho
    Departamento de Microbiologia, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota, Colombia
    Int Arch Allergy Immunol 160:165-72. 2013

Collaborators

Detail Information

Publications27

  1. pmc Chagasic patients are able to respond against a viral antigen from influenza virus
    Paola Lasso
    Laboratorio de Parasitologia Molecular, Pontificia Universidad Javeriana, Bogota, Colombia
    BMC Infect Dis 12:198. 2012
    ..Although an immune-suppressive effect of T. cruzi on the acute phase of the disease has been described, little is known about the capacity of CD8+ T cell from chronic chagasic patients to respond to a non-T. cruzi microbial antigen...
  2. ncbi request reprint Glia expression of MHC during CNS infection by neurotropic coronavirus
    Karen E Malone
    Cleveland Clinic Foundation, OH 44106, USA
    Adv Exp Med Biol 581:543-6. 2006
  3. ncbi request reprint Immunological and structural characterization of an epitope from the Trypanosoma cruzi KMP-11 protein
    H Diez
    Laboratorio de Parasitologia Molecular, Pontificia Universidad Javeriana, Bogota, Colombia
    Peptides 28:1520-6. 2007
    ..Antibody response subclass specificity to the K1 peptide was IgG1 and IgG3. Taken together these results support the idea that the K1 peptide acts as a B-cell-inducer epitope during Chagas' disease...
  4. doi request reprint Natural CD4(+) T-cell responses against Trypanosoma cruzi KMP-11 protein in chronic chagasic patients
    Adriana Cuellar
    Grupo de Inmunobiología y Biología Celular, Departamento de Microbiologia, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota, Colombia
    Immunol Cell Biol 87:149-53. 2009
    ..This is the first description of T. cruzi KMP-11 protein recognition by CD4(+) T cells in chronic chagasic patients...
  5. pmc Characterising the KMP-11 and HSP-70 recombinant antigens' humoral immune response profile in chagasic patients
    Ivonne D Flechas
    Laboratorio de Parasitologia Molecular, Pontificia Universidad Javeriana, CRA, 7a No, 43 82, ED, 50, Lab, 113, Bogota, Colombia
    BMC Infect Dis 9:186. 2009
    ..cruzi extract and three recombinant antigens: the T. cruzi kinetoplastid membrane protein-11 (rKMP-11), an internal fragment of the T. cruzi HSP-70 protein 192-433, and the entire Trypanosoma rangeli HSP-70 protein...
  6. doi request reprint Frequency of specific CD8+ T cells for a promiscuous epitope derived from Trypanosoma cruzi KMP-11 protein in chagasic patients
    P Lasso
    Laboratorio de Parasitologia Molecular, Pontificia Universidad Javeriana, Bogota, Colombia
    Parasite Immunol 32:494-502. 2010
    ..These findings support that K1 peptide is a promiscuous epitope presented by HLA-A2 supertype molecules and is highly recognized by chagasic patients...
  7. pmc Increased CD4+/CD8+ double-positive T cells in chronic Chagasic patients
    Nicolas A Giraldo
    Grupo de Ciencias Básicas Médicas, Facultad de Medicina, Universidad de Los Andes, Bogota, Colombia
    PLoS Negl Trop Dis 5:e1294. 2011
    ..In chronic viral infections, this cell subset has effector memory phenotype and displays antigen specificity. No previous studies of double positive T cells in parasite infections have been carried out...
  8. ncbi request reprint [Expression of IL-10, IL-4 and IFN-γ in active skin lesions of children with papular urticaria]
    Elizabeth Garcia
    Sección de Alergia Pediátrica, Fundacion Santa Fe de Bogota, DC, Colombia
    Biomedica 31:525-31. 2011
    ..Papular urticaria caused by the bites of fleas traditionally has been defined as a chronic allergic disease. However, currently no clear relationship has been described between this pathology and common allergic diseases...
  9. doi request reprint Rabbit serum against K1 peptide, an immunogenic epitope of the Trypanosoma cruzi KMP-11, decreases parasite invasion to cells
    Juan Camilo Diaz-Soto
    Grupo de Ciencias Básicas Médicas, Facultad de Medicina, Universidad de Los Andes, Bogota, D C, Colombia
    Acta Trop 123:224-9. 2012
    ..Taken together, these results support the idea that the K1 peptide induces antibodies than can have a potential role in protective immunity in Chagas disease...
  10. doi request reprint Differences in systemic and skin migrating-specific CD4 T cells in papular urticaria by flea bite
    Omar Dominguez-Amorocho
    Departamento de Microbiologia, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota, Colombia
    Int Arch Allergy Immunol 160:165-72. 2013
    ....
  11. pmc Inhibition of interferon-gamma signaling in oligodendroglia delays coronavirus clearance without altering demyelination
    John M Gonzalez
    Department of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Am J Pathol 168:796-804. 2006
    ..In addition, the absence of a correlation between increased oligodendroglial infection and the extent of demyelination suggests a complex pathobiology of myelin loss in which infection of oligodendroglia is required but not sufficient...
  12. ncbi request reprint Evaluation of IFN-gamma production by CD8 T lymphocytes in response to the K1 peptide from KMP-11 protein in patients infected with Trypanosoma cruzi
    H Diez
    Laboratorio de Parasitologia Molecular, Pontificia Universidad Javeriana, Bogota, Colombia
    Parasite Immunol 28:101-5. 2006
    ..It is shown here for the first time that the K1 peptide is efficiently processed, presented and recognized by CD8+ T lymphocytes during the natural course of Chagas disease...
  13. ncbi request reprint Astrocyte expression of a dominant-negative interferon-gamma receptor
    Claudia Hindinger
    Department of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    J Neurosci Res 82:20-31. 2005
    ..Transgenic mice with impaired astrocyte responsiveness to IFN-gamma provide a model for studying the selective astrocyte-dependent effects of this critical cytokine in CNS immunopathology...
  14. ncbi request reprint Synthetic polypeptides corresponding to the non-repeat regions from the circumsporozoite protein of Plasmodium falciparum: recognition by human T-cells and immunogenicity in owl monkeys
    J A Lopez
    Institut de Biochimie, Universite de Lausanne, Switzerland
    Ann Trop Med Parasitol 91:253-65. 1997
    ....
  15. ncbi request reprint Unstable, low-level transmission of malaria on the Colombian Pacific Coast
    J M Gonzalez
    Instituto de Inmunologia, Universidad del Valle, Cali, Colombia
    Ann Trop Med Parasitol 91:349-58. 1997
    ..A better understanding of the dynamics of the different elements influencing malaria in areas of low, unstable transmission, such as the one described here, is essential for the design of new malaria-control strategies...
  16. ncbi request reprint Mapping and comparison of the B-cell epitopes recognized on the Plasmodium vivax circumsporozoite protein by immune Colombians and immunized Aotus monkeys
    M Arevalo-Herrera
    Instituto de Inmunologia, Universidad del Valle, Cali, Colombia
    Ann Trop Med Parasitol 92:539-51. 1998
    ..vivax CSP...
  17. ncbi request reprint Variants of the Plasmodium vivax circumsporozoite protein (VK210 and VK247) in Colombian isolates
    J M Gonzalez
    Instituto de Inmunología del Valle, Universidad del Valle, Cali, Colombia
    Mem Inst Oswaldo Cruz 96:709-12. 2001
    ..Previous studies in the same region have shown a higher prevalence of anti-VK210 antibodies which in theory may suggest their role in blocking the development of sporozoites carrying the CSP VK210 sequence...
  18. ncbi request reprint Identification of HLA-A2 restricted CD8(+) T-lymphocyte responses to Plasmodium vivax circumsporozoite protein in individuals naturally exposed to malaria
    Myriam Arevalo-Herrera
    Instituto de Immunologiá del Valle, Universidad del Valle, Cali, Colombia
    Parasite Immunol 24:161-9. 2002
    ..The potential of these peptides to induce specific cytolysis and that of long synthetic peptides comprising these epitopes as P. vivax malaria vaccine subunits are being studied...
  19. ncbi request reprint Stress-induced release of HSC70 from human tumors
    Alfonso Barreto
    Grupo de Inmunobiología and Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota, Colombia
    Cell Immunol 222:97-104. 2003
    ..This mechanism may account for the potent chaperokine activity of heat shock proteins recently observed during heat shock protein-based immunotherapy against a variety of cancers...
  20. ncbi request reprint Expression of calcitonin gene-related peptide (CGRP) in irreversible acute pulpitis
    Javier Caviedes-Bucheli
    School of Dentistry, Graduate Studies Department, Pontificia Universidad Javeriana, Bogota, Colombia
    J Endod 30:201-4. 2004
    ..These findings support the hypothesis that the CGRP system is active in human pulpal inflammation and may modulate the inflammatory response...
  21. ncbi request reprint Expression of a dominant negative IFN-gammareceptor on mouse oligodendrocytes
    John M Gonzalez
    Department of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Glia 51:22-34. 2005
    ..This model will allow evaluation of oligodendrocyte responses to this critical cytokine during CNS inflammation...
  22. ncbi request reprint Anti-glucuronoxylomannan IgG1 specific antibodies production in Cryptococcus neoformans resistant mice
    Claudia Parra
    Grupo de Inmunobiología, Departamento de Microbiologia, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota, D C, Colombia
    Biomedica 25:110-9. 2005
    ..Cryptococcus neoformans has a polysaccharide capsule composed of glucuronoxylomannan (GXM), which acts as a major virulence factor and is considered to be a thymus independent type-2 antigen (TI-2)...
  23. pmc T lymphocytes from chagasic patients are activated but lack proliferative capacity and down-regulate CD28 and CD3ζ
    Nicolas A Giraldo
    Grupo de Ciencias Básicas Médicas, Facultad de Medicina, Universidad de Los Andes, Bogota, Colombia
    PLoS Negl Trop Dis 7:e2038. 2013
    ..The aim of this study was to compare the activation status, the proliferative potential and the expression of CD28 and CD3ζ chain on T lymphocytes between chronic chagasic patients and uninfected controls...