Gonzalo Arboleda

Summary

Affiliation: Universidad Nacional de Colombia
Country: Colombia

Publications

  1. doi request reprint Regulation of ceramide-induced neuronal death: cell metabolism meets neurodegeneration
    Gonzalo Arboleda
    Grupo de Neurociencias, Departamento de Patologia, Facultad de Medicina, Universidad Nacional de Colombia, Bogota, Colombia
    Brain Res Rev 59:333-46. 2009
  2. doi request reprint Differential regulation of AKT, MAPK and GSK3β during C2-ceramide-induced neuronal death
    Gonzalo Arboleda
    Grupo de Neurociencias, Facultad de Medicina, Universidad Nacional de Colombia, Bogota, Colombia
    Neurotoxicology 31:687-93. 2010
  3. ncbi request reprint The neonatal progeroid syndrome (Wiedemann-Rautenstrauch): a model for the study of human aging?
    Gonzalo Arboleda
    Grupo de Neurociencias, Facultad de Medicina, Universidad Nacional de Colombia, Bogota, Colombia
    Exp Gerontol 42:939-43. 2007
  4. ncbi request reprint Inhibition of caspases but not of calpains temporarily protect against C2-ceramide-induced death of CAD cells
    Gonzalo Arboleda
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Neurosci Lett 421:245-9. 2007
  5. ncbi request reprint Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells
    Gonzalo Arboleda
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, UK
    Eur J Neurosci 25:3030-8. 2007
  6. doi request reprint Absence of Lamin A/C gene mutations in four Wiedemann-Rautenstrauch syndrome patients
    Luis C Morales
    Grupo de Neurociencias and Programa de Maestría en Neurociencias, Universidad Nacional de Colombia, Bogota, Colombia
    Am J Med Genet A 149:2695-9. 2009
  7. ncbi request reprint Metabolic activity: a novel indicator of neuronal survival in the murine dopaminergic cell line CAD
    Gonzalo Arboleda
    Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK
    J Mol Neurosci 27:65-77. 2005
  8. doi request reprint Neonatal progeroid syndrome (Wiedemann-Rautenstrauch syndrome): report of three affected sibs
    Gonzalo Arboleda
    Grupo de Neurociencias and Programa de Maestría en Neurociencias, Universidad Nacional de Colombia, Bogota, Colombia
    Am J Med Genet A 155:1712-5. 2011
  9. doi request reprint PINK1 overexpression protects against C2-ceramide-induced CAD cell death through the PI3K/AKT pathway
    Ruth Mélida Sánchez-Mora
    Universidad Colegio Mayor de Cundinamarca, Bogota, Colombia
    J Mol Neurosci 47:582-94. 2012
  10. doi request reprint Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells
    Liliana Rojas-Charry
    Grupos de Neurociencias y Muerte Celular, Facultad de Medicina e Instituto de Genética, Universidad Nacional de Colombia, Bogota, Colombia
    Neurotoxicology 44:140-8. 2014

Collaborators

Detail Information

Publications13

  1. doi request reprint Regulation of ceramide-induced neuronal death: cell metabolism meets neurodegeneration
    Gonzalo Arboleda
    Grupo de Neurociencias, Departamento de Patologia, Facultad de Medicina, Universidad Nacional de Colombia, Bogota, Colombia
    Brain Res Rev 59:333-46. 2009
    ..Together they may be determinant steps in downstream events leading to neuronal apoptosis. Therefore, reinforcement of the PI3K/AKT pathway could constitute an important neuroprotective strategy...
  2. doi request reprint Differential regulation of AKT, MAPK and GSK3β during C2-ceramide-induced neuronal death
    Gonzalo Arboleda
    Grupo de Neurociencias, Facultad de Medicina, Universidad Nacional de Colombia, Bogota, Colombia
    Neurotoxicology 31:687-93. 2010
    ..In conclusion, C(2)-ceramide initiates a series of events including an early inactivation of PI3K/AKT and ERK pathways followed by activation of JNK and activation of GSK3β and neuronal death, changes that are counteracted by IGF-1...
  3. ncbi request reprint The neonatal progeroid syndrome (Wiedemann-Rautenstrauch): a model for the study of human aging?
    Gonzalo Arboleda
    Grupo de Neurociencias, Facultad de Medicina, Universidad Nacional de Colombia, Bogota, Colombia
    Exp Gerontol 42:939-43. 2007
    ..We believe that WRS characteristics indicate that discovery of the gene and the metabolic pathway associated with this syndrome will most likely lead to new knowledge about the physiopathology of human aging...
  4. ncbi request reprint Inhibition of caspases but not of calpains temporarily protect against C2-ceramide-induced death of CAD cells
    Gonzalo Arboleda
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Neurosci Lett 421:245-9. 2007
    ....
  5. ncbi request reprint Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells
    Gonzalo Arboleda
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, UK
    Eur J Neurosci 25:3030-8. 2007
    ..This may represent a new early event in the C(2)-ceramide-induced cell death pathway that could coordinate subsequent changes in mitochondria and commitment of neurons to apoptosis...
  6. doi request reprint Absence of Lamin A/C gene mutations in four Wiedemann-Rautenstrauch syndrome patients
    Luis C Morales
    Grupo de Neurociencias and Programa de Maestría en Neurociencias, Universidad Nacional de Colombia, Bogota, Colombia
    Am J Med Genet A 149:2695-9. 2009
    ..These findings suggest that WRS represents a distinct progeroid entity that may be caused by recessive mutations of a different gene...
  7. ncbi request reprint Metabolic activity: a novel indicator of neuronal survival in the murine dopaminergic cell line CAD
    Gonzalo Arboleda
    Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK
    J Mol Neurosci 27:65-77. 2005
    ....
  8. doi request reprint Neonatal progeroid syndrome (Wiedemann-Rautenstrauch syndrome): report of three affected sibs
    Gonzalo Arboleda
    Grupo de Neurociencias and Programa de Maestría en Neurociencias, Universidad Nacional de Colombia, Bogota, Colombia
    Am J Med Genet A 155:1712-5. 2011
    ..Our findings support autosomal recessive inheritance in WRS and support the possibility of homozygocity mapping as a good approach to find the causative gene...
  9. doi request reprint PINK1 overexpression protects against C2-ceramide-induced CAD cell death through the PI3K/AKT pathway
    Ruth Mélida Sánchez-Mora
    Universidad Colegio Mayor de Cundinamarca, Bogota, Colombia
    J Mol Neurosci 47:582-94. 2012
    ..These effects were abrogated by PINK1 mutations...
  10. doi request reprint Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells
    Liliana Rojas-Charry
    Grupos de Neurociencias y Muerte Celular, Facultad de Medicina e Instituto de Genética, Universidad Nacional de Colombia, Bogota, Colombia
    Neurotoxicology 44:140-8. 2014
    ..Cells lacking Pink1 had lower Drp1 and Mfn2 expression. Based on these data, we propose that Pink1 may exert a neuroprotective role in part by limiting mitochondrial fission. ..
  11. doi request reprint Silencing of PINK1 Inhibits Insulin-Like Growth Factor-1-Mediated Receptor Activation and Neuronal Survival
    María J Contreras-Zárate
    Neuroscience and Cell Death Group, Faculty of Medicine and Institute of Genetics, Universidad Nacional de Colombia, Bogota, Colombia
    J Mol Neurosci 56:188-97. 2015
    ..Our results further suggest that PINK1 may be regulating the PI3K/Akt neuronal survival pathway through tyrosine kinase receptors such as IGF-1 receptor. ..
  12. ncbi request reprint Analysis of functional polymorphisms in three synaptic plasticity-related genes (BDNF, COMT AND UCHL1) in Alzheimer's disease in Colombia
    Diego A Forero
    Grupo de Neurociencias, Facultad de Medicina e Instituto de Genética, Universidad Nacional de Colombia, Bogota, Colombia
    Neurosci Res 55:334-41. 2006
    ..An exploration of functional variants in these and in other synaptic plasticity-related genes (a synaptogenomics approach) in independent larger samples will be important to discover new genes associated with AD...
  13. ncbi request reprint Follow-up study of Wiedemann-Rautenstrauch syndrome: long-term survival and comparison with Rautenstrauch's patient "G"
    Humberto Arboleda
    Departamento de Pediatria, Facultad de Medicina and Instituto de Genética, Universidad Nacional de Colombia, Bogota, Colombia
    Birth Defects Res A Clin Mol Teratol 73:562-8. 2005
    ..Wiedemann-Rautenstrauch syndrome (WRS) characterizes a neonatal progeroid entity. In the last 30 years, 28 cases have been reported. In most cases of WRS, survival is short and long-term studies are impossible...