Gonzalo Arboleda

Summary

Affiliation: Universidad Nacional de Colombia
Country: Colombia

Publications

  1. ncbi request reprint The neonatal progeroid syndrome (Wiedemann-Rautenstrauch): a model for the study of human aging?
    Gonzalo Arboleda
    Grupo de Neurociencias, Facultad de Medicina, Universidad Nacional de Colombia, Bogota, Colombia
    Exp Gerontol 42:939-43. 2007
  2. ncbi request reprint Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells
    Gonzalo Arboleda
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, UK
    Eur J Neurosci 25:3030-8. 2007
  3. ncbi request reprint Inhibition of caspases but not of calpains temporarily protect against C2-ceramide-induced death of CAD cells
    Gonzalo Arboleda
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Neurosci Lett 421:245-9. 2007
  4. doi request reprint Differential regulation of AKT, MAPK and GSK3β during C2-ceramide-induced neuronal death
    Gonzalo Arboleda
    Grupo de Neurociencias, Facultad de Medicina, Universidad Nacional de Colombia, Bogota, Colombia
    Neurotoxicology 31:687-93. 2010
  5. doi request reprint Regulation of ceramide-induced neuronal death: cell metabolism meets neurodegeneration
    Gonzalo Arboleda
    Grupo de Neurociencias, Departamento de Patologia, Facultad de Medicina, Universidad Nacional de Colombia, Bogota, Colombia
    Brain Res Rev 59:333-46. 2009
  6. ncbi request reprint Metabolic activity: a novel indicator of neuronal survival in the murine dopaminergic cell line CAD
    Gonzalo Arboleda
    Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK
    J Mol Neurosci 27:65-77. 2005
  7. doi request reprint Absence of Lamin A/C gene mutations in four Wiedemann-Rautenstrauch syndrome patients
    Luis C Morales
    Grupo de Neurociencias and Programa de Maestría en Neurociencias, Universidad Nacional de Colombia, Bogota, Colombia
    Am J Med Genet A 149:2695-9. 2009
  8. doi request reprint Neonatal progeroid syndrome (Wiedemann-Rautenstrauch syndrome): report of three affected sibs
    Gonzalo Arboleda
    Grupo de Neurociencias and Programa de Maestría en Neurociencias, Universidad Nacional de Colombia, Bogota, Colombia
    Am J Med Genet A 155:1712-5. 2011
  9. doi request reprint PINK1 overexpression protects against C2-ceramide-induced CAD cell death through the PI3K/AKT pathway
    Ruth Mélida Sánchez-Mora
    Universidad Colegio Mayor de Cundinamarca, Bogota, Colombia
    J Mol Neurosci 47:582-94. 2012
  10. ncbi request reprint Analysis of functional polymorphisms in three synaptic plasticity-related genes (BDNF, COMT AND UCHL1) in Alzheimer's disease in Colombia
    Diego A Forero
    Grupo de Neurociencias, Facultad de Medicina e Instituto de Genética, Universidad Nacional de Colombia, Bogota, Colombia
    Neurosci Res 55:334-41. 2006

Collaborators

Detail Information

Publications11

  1. ncbi request reprint The neonatal progeroid syndrome (Wiedemann-Rautenstrauch): a model for the study of human aging?
    Gonzalo Arboleda
    Grupo de Neurociencias, Facultad de Medicina, Universidad Nacional de Colombia, Bogota, Colombia
    Exp Gerontol 42:939-43. 2007
    ..We believe that WRS characteristics indicate that discovery of the gene and the metabolic pathway associated with this syndrome will most likely lead to new knowledge about the physiopathology of human aging...
  2. ncbi request reprint Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells
    Gonzalo Arboleda
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, UK
    Eur J Neurosci 25:3030-8. 2007
    ..This may represent a new early event in the C(2)-ceramide-induced cell death pathway that could coordinate subsequent changes in mitochondria and commitment of neurons to apoptosis...
  3. ncbi request reprint Inhibition of caspases but not of calpains temporarily protect against C2-ceramide-induced death of CAD cells
    Gonzalo Arboleda
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Neurosci Lett 421:245-9. 2007
    ....
  4. doi request reprint Differential regulation of AKT, MAPK and GSK3β during C2-ceramide-induced neuronal death
    Gonzalo Arboleda
    Grupo de Neurociencias, Facultad de Medicina, Universidad Nacional de Colombia, Bogota, Colombia
    Neurotoxicology 31:687-93. 2010
    ..In conclusion, C(2)-ceramide initiates a series of events including an early inactivation of PI3K/AKT and ERK pathways followed by activation of JNK and activation of GSK3β and neuronal death, changes that are counteracted by IGF-1...
  5. doi request reprint Regulation of ceramide-induced neuronal death: cell metabolism meets neurodegeneration
    Gonzalo Arboleda
    Grupo de Neurociencias, Departamento de Patologia, Facultad de Medicina, Universidad Nacional de Colombia, Bogota, Colombia
    Brain Res Rev 59:333-46. 2009
    ..Together they may be determinant steps in downstream events leading to neuronal apoptosis. Therefore, reinforcement of the PI3K/AKT pathway could constitute an important neuroprotective strategy...
  6. ncbi request reprint Metabolic activity: a novel indicator of neuronal survival in the murine dopaminergic cell line CAD
    Gonzalo Arboleda
    Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK
    J Mol Neurosci 27:65-77. 2005
    ....
  7. doi request reprint Absence of Lamin A/C gene mutations in four Wiedemann-Rautenstrauch syndrome patients
    Luis C Morales
    Grupo de Neurociencias and Programa de Maestría en Neurociencias, Universidad Nacional de Colombia, Bogota, Colombia
    Am J Med Genet A 149:2695-9. 2009
    ..These findings suggest that WRS represents a distinct progeroid entity that may be caused by recessive mutations of a different gene...
  8. doi request reprint Neonatal progeroid syndrome (Wiedemann-Rautenstrauch syndrome): report of three affected sibs
    Gonzalo Arboleda
    Grupo de Neurociencias and Programa de Maestría en Neurociencias, Universidad Nacional de Colombia, Bogota, Colombia
    Am J Med Genet A 155:1712-5. 2011
    ..Our findings support autosomal recessive inheritance in WRS and support the possibility of homozygocity mapping as a good approach to find the causative gene...
  9. doi request reprint PINK1 overexpression protects against C2-ceramide-induced CAD cell death through the PI3K/AKT pathway
    Ruth Mélida Sánchez-Mora
    Universidad Colegio Mayor de Cundinamarca, Bogota, Colombia
    J Mol Neurosci 47:582-94. 2012
    ..These effects were abrogated by PINK1 mutations...
  10. ncbi request reprint Analysis of functional polymorphisms in three synaptic plasticity-related genes (BDNF, COMT AND UCHL1) in Alzheimer's disease in Colombia
    Diego A Forero
    Grupo de Neurociencias, Facultad de Medicina e Instituto de Genética, Universidad Nacional de Colombia, Bogota, Colombia
    Neurosci Res 55:334-41. 2006
    ..An exploration of functional variants in these and in other synaptic plasticity-related genes (a synaptogenomics approach) in independent larger samples will be important to discover new genes associated with AD...
  11. ncbi request reprint Follow-up study of Wiedemann-Rautenstrauch syndrome: long-term survival and comparison with Rautenstrauch's patient "G"
    Humberto Arboleda
    Departamento de Pediatria, Facultad de Medicina and Instituto de Genética, Universidad Nacional de Colombia, Bogota, Colombia
    Birth Defects Res A Clin Mol Teratol 73:562-8. 2005
    ..Wiedemann-Rautenstrauch syndrome (WRS) characterizes a neonatal progeroid entity. In the last 30 years, 28 cases have been reported. In most cases of WRS, survival is short and long-term studies are impossible...