Research Topics
| Juana AngelSummaryAffiliation: Pontificia Universidad Javeriana Country: Colombia Publications
| Collaborators
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Detail Information
Publications
Rotavirus vaccines: recent developments and future considerationsJuana Angel
Instituto de Genetica Humana, Pontificia Universidad Javeriana, Carrera 7, 40 62, Bogota, Colombia
Nat Rev Microbiol 5:529-39. 2007....
Rotavirus immune responses and correlates of protectionJuana Angel
Instituto de Genetica Humana, Pontificia Universidad Javeriana, Bogota, Colombia
Curr Opin Virol 2:419-25. 2012..Protection against rotavirus following vaccination is substantially heterotypic; nonetheless, a role for homotypic immunity in selection of circulating postvaccination strains needs further study...- Human rotavirus specific T cells: quantification by ELISPOT and expression of homing receptors on CD4+ T cellsOlga Lucía Rojas
Instituto de Genetica Humana, Pontificia Universidad Javeriana, Bogota, Colombia
Virology 314:671-9. 2003.... - Human rotavirus-specific IgM Memory B cells have differential cloning efficiencies and switch capacities and play a role in antiviral immunity in vivoCarlos F Narvaez
Instituto de Genetica Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogota, Colombia
J Virol 86:10829-40. 2012..Thus, RV-IgM(+) mBc are heterogeneous, occur more frequently than estimated by traditional limiting dilution analysis, have the capacity to switch Ig class in vitro as well as in vivo, and can mediate systemic antiviral immunity... - Characterization of rotavirus specific B cells and their relation with serological memoryOlga Lucía Rojas
Instituto de Genetica Humana, Pontificia Universidad Javeriana, Carrera 7 40 62, Bogota, Colombia
Virology 380:234-42. 2008..Our studies contribute to understand the relationship between circulating mBc and serological memory, and enhance our capacity to develop better correlates of protection against RV disease... - Rotavirus-specific B cells induced by recent infection in adults and children predominantly express the intestinal homing receptor alpha4beta7Ana Maria Gonzalez
Instituto de Genetica Humana Pontificia Universidad Javeriana, Bogota, Colombia
Virology 305:93-105. 2003.... 
Human myeloid dendritic cells treated with supernatants of rotavirus infected Caco-2 cells induce a poor Th1 responseLuz Stella Rodríguez
Instituto de Genetica Humana, Pontificia Universidad Javeriana, Bogota, Colombia
Cell Immunol 272:154-61. 2012..The results suggest that the TGF-β1 induced by rotavirus could be an immune evasion mechanism, and may partially explain the poor rotavirus-specific T cell response we have previously evidenced...- A TGF-beta mediated regulatory mechanism modulates the T cell immune response to rotavirus in adults but not in childrenMartha C Mesa
Instituto de Genetica Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Carrera 7 No 40 62, Edificio 32, Bogota, Colombia
Virology 399:77-86. 2010..The ALK5i effect was observed in adults but not in children with RV-GE, who had normal numbers of TGF-beta+ Treg cells. Thus, a TGF-beta-mediated regulatory mechanism that modulates RV-T cells in adults is not evident in children... - Evaluation of circulating intestinally committed memory B cells in children vaccinated with attenuated human rotavirus vaccineOlga Lucía Rojas
Instituto de Genetica Humana, Colombia
Viral Immunol 20:300-11. 2007..However, the correlation coefficients for both tests were low (<0.2), suggesting that other factors are important in explaining protection from disease... - Membrane vesicles released by intestinal epithelial cells infected with rotavirus inhibit T-cell functionAlfonso Barreto
Instituto de Genetica Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogota, Colombia
Viral Immunol 23:595-608. 2010..24 g/mL). Both types of MV from RV-infected cells were more efficient at inhibiting T-cell function than were those from non-infected cells. We propose that RV infection of IEC releases MV that modulate viral immunity... - Interaction of rotavirus with human myeloid dendritic cellsCarlos F Narvaez
Instituto de Genetica Humana, Pontificia Universidad Javeriana, Carrera 7 40 62, Bogota, Colombia
J Virol 79:14526-35. 2005..Finally, IDC treated with RV strongly stimulated naive allogeneic CD4+ T cells to secrete Th1 cytokines. Thus, although RV does not seem to be a strong maturing stimulus for DC, it promotes their capacity to prime Th1 cells... - Interaction of rotavirus with human peripheral blood mononuclear cells: plasmacytoid dendritic cells play a role in stimulating memory rotavirus specific T cells in vitroMartha C Mesa
Instituto de Genetica Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Carrera 7 No 40 62, Edificio 32, Bogota, Colombia
Virology 366:174-84. 2007..Thus, although PBMC are susceptible to the initial steps of RV infection, most PBMC of children with RV-gastroenteritis are not infected... - Immunomodulators released during rotavirus infection of polarized caco-2 cellsLuz Stella Rodríguez
Instituto de Genetica Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogota, Colombia
Viral Immunol 22:163-72. 2009..This set of immunomodulators is known to induce a non-inflammatory (non-Th-1) immune response, and may be determining, in part, the relatively low T-cell immune response observed in blood samples after RV infection... - Immunity and correlates of protection for rotavirus vaccinesManuel A Franco
Instituto de Genetica Humana, Pontificia Universidad Javeriana, Bogota, Colombia
Vaccine 24:2718-31. 2006.... - Frequencies of virus-specific CD4(+) and CD8(+) T lymphocytes secreting gamma interferon after acute natural rotavirus infection in children and adultsMaria C Jaimes
Instituto de Genetica Humana, Pontificia Universidad Javeriana, Bogota, Colombia
J Virol 76:4741-9. 2002..In both adults and children, the frequencies of CD4(+) cells secreting gamma interferon in response to SEB were higher than the frequencies of cells secreting IL-13... - Maturation and trafficking markers on rotavirus-specific B cells during acute infection and convalescence in childrenMaria C Jaimes
V A Palo Alto Health Care System, 3801 Miranda Ave, MC154C, Palo Alto, CA 94304, USA
J Virol 78:10967-76. 2004..Interestingly, RV memory cells generally lack CCR9 and CCR10 and instead express CCR6, which may enable recruitment to diverse epithelial sites of inflammation...