- A pilot study of reduced dose cyclosporine and corticosteroids to reduce new onset diabetes mellitus and acute rejection in kidney transplant recipients
Edward H Cole
Toronto General Hospital, 190 Elizabeth Street, M5G 2C4, Toronto, ON, Canada
Transplant Res 2:1. 2013
..New onset diabetes mellitus (NODM) and acute rejection (AR) are important causes of morbidity and risk factors for allograft failure after kidney transplantation...
- A comparison of the effects of C2-cyclosporine and C0-tacrolimus on renal function and cardiovascular risk factors in kidney transplant recipients
S Joseph Kim
Division of Nephrology, University of Toronto, Toronto, Ontario, Canada
Transplantation 82:924-30. 2006
..There are few data directly comparing the effects of two-hour postingestion monitored cyclosporine (C2-CsA) vs. trough-monitored tacrolimus (C0-Tac) on renal function and cardiovascular risk factors...
- Delayed graft function and the risk for death with a functioning graft
Shruti N Tapiawala
Division of Nephrology, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
J Am Soc Nephrol 21:153-61. 2010
..In summary, DGF associates with an increased risk for DWGF; the mechanisms underlying the negative impact of DGF require further study...
- Delayed graft function and the risk of death with graft function in living donor kidney transplant recipients
Division of Nephrology and the Kidney Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
Am J Kidney Dis 56:961-70. 2010
..The link between delayed graft function (DGF) and death with graft function (DWGF) in living donor kidney transplant recipients presently is unknown...
- Impact of deceased donor diabetes mellitus on kidney transplant outcomes: a propensity score-matched study
Kidney Transplant Program, Division of Nephrology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON, Canada M5G 2N2
Transplantation 88:251-60. 2009
..There is a paucity of population-level data on the long-term outcomes of kidney transplants from deceased donors with a history of diabetes mellitus (DM)...
- Impact of acute rejection and new-onset diabetes on long-term transplant graft and patient survival
Edward H Cole
Division of Nephrology and Multiorgan Transplant Programme, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
Clin J Am Soc Nephrol 3:814-21. 2008
..Development of new therapeutic strategies to improve long-term transplant outcomes requires improved understanding of the mechanisms by which these complications limit long-term transplant survival...
- Renal transplantation with early steroid withdrawal
Division of Nephrology and Multi Organ Transplant Program, Toronto General Hospital, University of Toronto, Toronto, ON, Canada
Pediatr Nephrol 24:243-51. 2009
..Most trials lack sufficient follow-up (5 years or more) to assess the impact of the increased acute rejection rate seen with early steroid withdrawal on long-term outcomes. Thus, the use of such protocols remains investigational...
- Reduced incidence of new-onset diabetes mellitus after renal transplantation with 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors (statins)
G V Ramesh Prasad
Division of Nephrology, Department of Medicine, University of Toronto, 61 Queen Street East, 9th Floor, Toronto, ON M5C 2T2, Canada
Am J Transplant 4:1897-903. 2004
..02, HR 1.230[1.023-1.480]) and age > or =45 years (p = 0.01, HR 2.226[1.162-4.261]) were associated with increased diabetes. Statin use is associated with reduced new-onset diabetes development after renal transplantation...
- Comparison of hospitalized solid organ transplant recipients and nonimmunocompromised patients with pandemic H1N1 infection: a retrospective cohort study
Brian J Minnema
Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, ON, Canada
Transplantation 92:230-4. 2011
..We report our experience with severe pH1N1 infection in transplant recipients and compare this group with nonimmunosuppressed patients...