Robert A Colbert

Summary

Publications

  1. pmc HLA-B27 misfolding and spondyloarthropathies
    Robert A Colbert
    Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Prion 3:15-26. 2009
  2. pmc HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats
    Monica L DeLay
    Cincinnati Children s Hospital Medical Center, and University of Cincinnati College of Medicine, Cincinnati, Ohio
    Arthritis Rheum 60:2633-43. 2009
  3. pmc Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis
    Claas H Hinze
    Division of Rheumatology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Arthritis Res Ther 12:R123. 2010
  4. pmc Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis
    Michael G Barnes
    Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 60:2102-12. 2009
  5. pmc Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1
    Judith A Smith
    William S Rowe Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Eur J Immunol 38:1194-203. 2008
  6. ncbi request reprint HLA-B27 up-regulation causes accumulation of misfolded heavy chains and correlates with the magnitude of the unfolded protein response in transgenic rats: Implications for the pathogenesis of spondylarthritis-like disease
    Matthew J Turner
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 56:215-23. 2007
  7. ncbi request reprint HLA-B27 misfolding and spondyloarthropathies
    Robert A Colbert
    Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Adv Exp Med Biol 649:217-34. 2009
  8. pmc Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets
    Thomas A Griffin
    William S Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 60:2113-23. 2009
  9. ncbi request reprint The immunobiology of HLA-B27: variations on a theme
    Robert A Colbert
    William S Rowe Division of Rheumatology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Curr Mol Med 4:21-30. 2004
  10. pmc Biologic similarities based on age at onset in oligoarticular and polyarticular subtypes of juvenile idiopathic arthritis
    Michael G Barnes
    William S Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 62:3249-58. 2010

Collaborators

Detail Information

Publications22

  1. pmc HLA-B27 misfolding and spondyloarthropathies
    Robert A Colbert
    Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Prion 3:15-26. 2009
    ....
  2. pmc HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats
    Monica L DeLay
    Cincinnati Children s Hospital Medical Center, and University of Cincinnati College of Medicine, Cincinnati, Ohio
    Arthritis Rheum 60:2633-43. 2009
    ....
  3. pmc Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis
    Claas H Hinze
    Division of Rheumatology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Arthritis Res Ther 12:R123. 2010
    ..The aim of this study was to determine the association of this signature with peripheral blood mononuclear cell (PBMC) subpopulations and its specificity for sJIA as compared with related conditions...
  4. pmc Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis
    Michael G Barnes
    Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 60:2102-12. 2009
    ....
  5. pmc Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1
    Judith A Smith
    William S Rowe Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Eur J Immunol 38:1194-203. 2008
    ....
  6. ncbi request reprint HLA-B27 up-regulation causes accumulation of misfolded heavy chains and correlates with the magnitude of the unfolded protein response in transgenic rats: Implications for the pathogenesis of spondylarthritis-like disease
    Matthew J Turner
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 56:215-23. 2007
    ..This study was performed to assess the mechanisms that drive activation of the HLA-B27-induced UPR and to determine whether splenocytes respond in a similar manner...
  7. ncbi request reprint HLA-B27 misfolding and spondyloarthropathies
    Robert A Colbert
    Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Adv Exp Med Biol 649:217-34. 2009
    ....
  8. pmc Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets
    Thomas A Griffin
    William S Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 60:2113-23. 2009
    ..To determine whether peripheral blood mononuclear cells (PBMCs) from children with recent-onset polyarticular juvenile idiopathic arthritis (JIA) exhibit biologically or clinically informative gene expression signatures...
  9. ncbi request reprint The immunobiology of HLA-B27: variations on a theme
    Robert A Colbert
    William S Rowe Division of Rheumatology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Curr Mol Med 4:21-30. 2004
    ....
  10. pmc Biologic similarities based on age at onset in oligoarticular and polyarticular subtypes of juvenile idiopathic arthritis
    Michael G Barnes
    William S Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 62:3249-58. 2010
    ..To explore biologic correlates to age at onset in patients with juvenile idiopathic arthritis (JIA) using peripheral blood mononuclear cell (PBMC) gene expression analysis...
  11. ncbi request reprint HLA-B27 misfolding in transgenic rats is associated with activation of the unfolded protein response
    Matthew J Turner
    William S Rowe Division of Rheumatology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 175:2438-48. 2005
    ....
  12. pmc Gene expression analysis of macrophages derived from ankylosing spondylitis patients reveals interferon-gamma dysregulation
    Judith A Smith
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Arthritis Rheum 58:1640-9. 2008
    ..To determine whether macrophages, a type of cell implicated in the pathogenesis of ankylosing spondylitis (AS), exhibit a characteristic gene expression pattern...
  13. ncbi request reprint 2007 annual research and education meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN)
    Robert A Colbert
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Rheumatol 35:1398-402. 2008
    ..A presentation was made on basic and clinical science of inflammatory bowel disease, and an educational pre-meeting conference was specifically designed for rheumatology fellows...
  14. pmc Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family-based case-control study
    Hulya Bukulmez
    William S, Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Arthritis Res Ther 7:R285-90. 2005
    ..These results suggest that there is a weak association between systemic onset JRA and the TPSN polymorphism, possibly due to linkage disequilibrium with an as yet unknown susceptibility allele in the centromeric part of chromosome 6...
  15. pmc The interleukin-23/interleukin-17 axis in spondyloarthritis
    Gerlinde Layh-Schmitt
    William S Rowe Division of Rheumatology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Cincinnati, Ohio, USA
    Curr Opin Rheumatol 20:392-7. 2008
    ..To inform readers of recent advances in our understanding of the development and function of Th17 T cells and emerging data suggesting that the interleukin-23/interleukin-17 axis may be involved in the pathogenesis of spondyloarthritis...
  16. ncbi request reprint HLA-B27 and pathogenesis of spondyloarthropathies
    Matthew J Turner
    William S Rowe Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Curr Opin Rheumatol 14:367-72. 2002
    ..Elucidating the role of HLA-B27 in the pathogenesis of these conditions will require an integration of information from animal models, genome-wide screens for susceptibility alleles, and translational studies using human samples...
  17. pmc Update on juvenile spondyloarthritis
    Anusha Ramanathan
    Division of Rheumatology, Keck School of Medicine of USC, Children s Hospital of Los Angeles, 4650 Sunset Boulevard, MS 60, Los Angeles, CA 90027, USA
    Rheum Dis Clin North Am 39:767-88. 2013
    ..This article highlights these differences, what has been learned about genetics and pathogenesis of SpA, and important unmet needs for future studies. ..
  18. ncbi request reprint HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endoplasmic reticulum
    Nandita S Dangoria
    William S Rowe Division of Rheumatology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 277:23459-68. 2002
    ....
  19. doi request reprint B-cell depletion in Wegener's granulomatosis
    Claas H Hinze
    Division of Rheumatology ML 4010, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Clin Rev Allergy Immunol 34:372-9. 2008
    ..B-cell depletion therapy was generally well tolerated. A large prospective, randomized, double-blind clinical trial evaluating the efficacy of B-cell depletion therapy in WG is pending...
  20. ncbi request reprint Juvenile spondyloarthropathies and related arthritis
    Hulya Bukulmez
    William S Rowe Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
    Curr Opin Rheumatol 14:531-5. 2002
    ..Several studies using the TNF inhibitors infliximab and etanercept suggest that these agents hold great promise for ameliorating symptoms and improving function, while long-term effects on disease progression remain to be evaluated...
  21. pmc Entheses and bones in spondyloarthritis: 2008 Annual Research and Education Meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN)
    Robert A Colbert
    Cincinnati Children s Hospital, Cincinnati, Ohio, USA
    J Rheumatol 36:1527-31. 2009
    ....
  22. ncbi request reprint Gene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome
    Ndate Fall
    Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 56:3793-804. 2007
    ..This study was undertaken to better understand the relationship between systemic JIA and macrophage activation syndrome...