HLA-B27 misfolding and spondyloarthropathiesRobert A Colbert
Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Prion 3:15-26. 2009
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- HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats
Monica L DeLay
Cincinnati Children s Hospital Medical Center, and University of Cincinnati College of Medicine, Cincinnati, Ohio
Arthritis Rheum 60:2633-43. 2009
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- Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis
Claas H Hinze
Division of Rheumatology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Arthritis Res Ther 12:R123. 2010
..The aim of this study was to determine the association of this signature with peripheral blood mononuclear cell (PBMC) subpopulations and its specificity for sJIA as compared with related conditions...
- Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis
Michael G Barnes
Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Arthritis Rheum 60:2102-12. 2009
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- Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1
Judith A Smith
William S Rowe Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Eur J Immunol 38:1194-203. 2008
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HLA-B27 up-regulation causes accumulation of misfolded heavy chains and correlates with the magnitude of the unfolded protein response in transgenic rats: Implications for the pathogenesis of spondylarthritis-like diseaseMatthew J Turner
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Arthritis Rheum 56:215-23. 2007
..This study was performed to assess the mechanisms that drive activation of the HLA-B27-induced UPR and to determine whether splenocytes respond in a similar manner...
- HLA-B27 misfolding and spondyloarthropathies
Robert A Colbert
Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Adv Exp Med Biol 649:217-34. 2009
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- Biologic similarities based on age at onset in oligoarticular and polyarticular subtypes of juvenile idiopathic arthritis
Michael G Barnes
William S Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Arthritis Rheum 62:3249-58. 2010
..To explore biologic correlates to age at onset in patients with juvenile idiopathic arthritis (JIA) using peripheral blood mononuclear cell (PBMC) gene expression analysis...
- The immunobiology of HLA-B27: variations on a theme
Robert A Colbert
William S Rowe Division of Rheumatology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Curr Mol Med 4:21-30. 2004
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- Gene expression analysis of macrophages derived from ankylosing spondylitis patients reveals interferon-gamma dysregulation
Judith A Smith
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Arthritis Rheum 58:1640-9. 2008
..To determine whether macrophages, a type of cell implicated in the pathogenesis of ankylosing spondylitis (AS), exhibit a characteristic gene expression pattern...
- HLA-B27 misfolding in transgenic rats is associated with activation of the unfolded protein response
Matthew J Turner
William S. Rowe Division of Rheumatology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
J Immunol 175:2438-48. 2005
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- 2007 annual research and education meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN)
Robert A Colbert
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
J Rheumatol 35:1398-402. 2008
..A presentation was made on basic and clinical science of inflammatory bowel disease, and an educational pre-meeting conference was specifically designed for rheumatology fellows...
- Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets
Thomas A Griffin
William S Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Arthritis Rheum 60:2113-23. 2009
..To determine whether peripheral blood mononuclear cells (PBMCs) from children with recent-onset polyarticular juvenile idiopathic arthritis (JIA) exhibit biologically or clinically informative gene expression signatures...
- The interleukin-23/interleukin-17 axis in spondyloarthritis
Gerlinde Layh-Schmitt
William S Rowe Division of Rheumatology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Cincinnati, Ohio, USA
Curr Opin Rheumatol 20:392-7. 2008
..To inform readers of recent advances in our understanding of the development and function of Th17 T cells and emerging data suggesting that the interleukin-23/interleukin-17 axis may be involved in the pathogenesis of spondyloarthritis...
- Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family-based case-control study
Hulya Bukulmez
William S, Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
Arthritis Res Ther 7:R285-90. 2005
..These results suggest that there is a weak association between systemic onset JRA and the TPSN polymorphism, possibly due to linkage disequilibrium with an as yet unknown susceptibility allele in the centromeric part of chromosome 6...
- HLA-B27 and pathogenesis of spondyloarthropathies
Matthew J Turner
William S. Rowe Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
Curr Opin Rheumatol 14:367-72. 2002
..Elucidating the role of HLA-B27 in the pathogenesis of these conditions will require an integration of information from animal models, genome-wide screens for susceptibility alleles, and translational studies using human samples...
- HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endoplasmic reticulum
Nandita S Dangoria
William S. Rowe Division of Rheumatology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
J Biol Chem 277:23459-68. 2002
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- Gene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome
Ndate Fall
Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Arthritis Rheum 56:3793-804. 2007
..This study was undertaken to better understand the relationship between systemic JIA and macrophage activation syndrome...
- Entheses and bones in spondyloarthritis: 2008 Annual Research and Education Meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN)
Robert A Colbert
Cincinnati Children s Hospital, Cincinnati, Ohio, USA
J Rheumatol 36:1527-31. 2009
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