Inimioara Mihaela Cojocaru

Summary

Publications

  1. ncbi request reprint A diagnosis challenge-L4 nerve root compression as the initial presentation of chronic inflammatory demyelinating polyneuropathy
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania
    Rom J Intern Med 50:297-308. 2012
  2. ncbi request reprint Changes in plasma matrix metalloproteinase-9 levels in patients with acute ischemic stroke
    Inimioara Mihaela Cojocarui
    Carol Davila University of Medicine and Pharmacy, Colentina Clinical Hospital, Department of Neurology, Bucharest, Romania
    Rom J Intern Med 50:155-8. 2012
  3. ncbi request reprint Acute intermittent porphyria--diagnostic and treatment traps
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    Rom J Intern Med 50:33-41. 2012
  4. ncbi request reprint Primary Sjögren's syndrome or multiple sclerosis? Our experience concerning the dilemma of clinically isolated syndrome
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania
    Rom J Intern Med 49:301-18. 2011
  5. ncbi request reprint Dermatomyositis and polyradiculoneuritis, a rare association
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania
    Rom J Intern Med 49:217-21. 2011
  6. ncbi request reprint Plasma myeloperoxidase levels in patients with acute ischemic stroke
    Inimoara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania
    Rom J Intern Med 48:101-4. 2010
  7. ncbi request reprint Detecting anti-prothrombin antibodies in young women with acute ischemic stroke
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Clinic of Neurology, Colentina Clinical Hospital, Bucharest
    Rom J Intern Med 46:337-41. 2008
  8. ncbi request reprint Study of antiphospholipid antibodies in type 2 diabetes mellitus with and without diabetic retinopathy
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Department of Neurology, Colentina Clinical Hospital, Bucharest, Rommania
    Rom J Intern Med 47:267-71. 2009
  9. ncbi request reprint Expression of IL-6 activity in patients with acute ischemic stroke
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Department of Neurology, Colentina Clinical Hospital, Bucharest
    Rom J Intern Med 47:393-6. 2009
  10. ncbi request reprint Detection of serum of IgG anti-neuronal antibodies in systemic lupus erythematosus patients with central nervous system manifestations
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania
    Rom J Intern Med 48:267-9. 2010

Collaborators

  • Violeta Sapira
  • Adriana Hristea
  • Adriana Nicolau
  • C Baicus
  • Simona Caraiola
  • Manole Cojocaru
  • M Cojocaru
  • R Tanasescu
  • Isabela Silosi
  • Camelia Doina Vrabie
  • Marina Ticmeanu
  • Inimioara Mihaela Cojocarui
  • Dimela Luca
  • Ruxandra Tănăsescu
  • R Ionescu
  • A Frăsineanu
  • Amalia Ene
  • Simona Alexandra Iacob
  • Cristina Hertea
  • S Paveliu
  • Gabriela Socoliuc
  • Daniela Anghel
  • Eugenia Farcasiu
  • D M Cheta
  • Nina Cheta

Detail Information

Publications44

  1. ncbi request reprint A diagnosis challenge-L4 nerve root compression as the initial presentation of chronic inflammatory demyelinating polyneuropathy
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania
    Rom J Intern Med 50:297-308. 2012
    ..The diagnosis of CIDP involves a team-work composed of neurologist, electroneurophysiologist and neuropathologist...
  2. ncbi request reprint Changes in plasma matrix metalloproteinase-9 levels in patients with acute ischemic stroke
    Inimioara Mihaela Cojocarui
    Carol Davila University of Medicine and Pharmacy, Colentina Clinical Hospital, Department of Neurology, Bucharest, Romania
    Rom J Intern Med 50:155-8. 2012
    ..18; p < 0.014). In conclusion, MMP-9 activity is associated with early acute ischemic stroke. The high levels of MMP-9 in acute ischemic stroke document the involvement of this enzyme in the regulation of inflammation in stroke...
  3. ncbi request reprint Acute intermittent porphyria--diagnostic and treatment traps
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    Rom J Intern Med 50:33-41. 2012
    ..Despite treatment with carbohydrates and hemines, the clinical picture of the patient worsened, with tetraplegia and severe respiratory failure. The patient died seven weeks after the initial presentation of the disease...
  4. ncbi request reprint Primary Sjögren's syndrome or multiple sclerosis? Our experience concerning the dilemma of clinically isolated syndrome
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania
    Rom J Intern Med 49:301-18. 2011
    ....
  5. ncbi request reprint Dermatomyositis and polyradiculoneuritis, a rare association
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania
    Rom J Intern Med 49:217-21. 2011
    ..The discrimination between these two had been made by performing a muscular biopsy and EMG studies. This emphasizes once again their importance in defining the muscular impairment from the neurogenic one...
  6. ncbi request reprint Plasma myeloperoxidase levels in patients with acute ischemic stroke
    Inimoara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania
    Rom J Intern Med 48:101-4. 2010
    ..MPO could be proposed as a potential prognostic marker of such lesions rather than a marker of diagnosis. MPO is a new biomarker and a possible future therapeutic target...
  7. ncbi request reprint Detecting anti-prothrombin antibodies in young women with acute ischemic stroke
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Clinic of Neurology, Colentina Clinical Hospital, Bucharest
    Rom J Intern Med 46:337-41. 2008
    ..03287 [95% CI 0.001794-0.6022], p < 0.001). aCL, LA and anti-beta2-GPI were not found both in nonischemic neurological disorders patients and in healthy controls...
  8. ncbi request reprint Study of antiphospholipid antibodies in type 2 diabetes mellitus with and without diabetic retinopathy
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Department of Neurology, Colentina Clinical Hospital, Bucharest, Rommania
    Rom J Intern Med 47:267-71. 2009
    ..067-10.418]), p < 0.0001. The results suggest the possible participation of anti-beta2-GPI and LA in the pathogenesis of DR, shifting the hemostatic balance toward a pro-thrombotic state increasing the risk of developing thrombosis...
  9. ncbi request reprint Expression of IL-6 activity in patients with acute ischemic stroke
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Department of Neurology, Colentina Clinical Hospital, Bucharest
    Rom J Intern Med 47:393-6. 2009
    ..This observation supports the hypothesis that IL-6 production is an inflammatory response to acute hypoxic-ischemic injury. IL-6 may serve as warning sign, because it increases early in inflammation...
  10. ncbi request reprint Detection of serum of IgG anti-neuronal antibodies in systemic lupus erythematosus patients with central nervous system manifestations
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania
    Rom J Intern Med 48:267-9. 2010
    ..The presence of serum anti-NA could be a useful diagnostic tool for CNS-SLE, the test could help to distinguish SLE from other diseases with similar symptoms. Further studies are needed to evaluate the predictive value of anti-NA in SLE...
  11. ncbi request reprint Acute cerebellar infarcts in a young woman with beta-thalassemia major
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    Rom J Intern Med 49:145-53. 2011
    ..Careful monitoring and imagistic examination may select the patients at risk for a stroke event...
  12. ncbi request reprint An immunological approach to cerebral ischemia (I). Immune cells and adhesion molecules
    R Tanasescu
    Department of Neurology, Colentina Hospital, Bucharest, Romania
    Rom J Intern Med 46:3-8. 2008
    ..This first part will focus on the involvement of immune cells, adhesion molecules and immunological transcription factors in the development of ischemic lesion...
  13. ncbi request reprint Some clinico-immunological aspects in patients with ocular myasthenia gravis associated with inflammatory bowel disease
    Inimioara Mihaela Cojocaru
    C Davila University of Medicine and Pharmacy, Clinic of Neurology, Colentina Clinical Hospital, Romania
    Rom J Intern Med 46:165-8. 2008
    ..The association of IBD with OMG was rare. Autoimmune dysregulation is the central defect in both MG and IBD. Further studies are required to define the nature of this association...
  14. ncbi request reprint Prevalence of anti-neutrophil cytoplasmic antibodies in patients with chronic hepatitis C infection associated mixed cryoglobulinemia
    M Cojocaru
    Colentina Clinical Hospital, Clinical Immunology Department, Bucharest, Romania
    Rom J Intern Med 44:427-31. 2006
    ..Determination of target antigens for ANCA is indispensable. Interpretation and therapeutic decisions concerning ANCA associated HCV should only be performed within the clinical context...
  15. ncbi request reprint Detection of autoantibodies to ribosome P in lupus patients with neurological involvement
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Clinic of Neurology, Colentina Clinical Hospital, Bucharest, Romania
    Rom J Intern Med 46:239-42. 2008
    ..Detection of autoantibodies to ribosome P appears useful for diagnostic purpose. Higher peak of serum autoantibodies to ribosome P levels correlated well with neurological involvement (highly specific)...
  16. ncbi request reprint High prevalence of anticardiolipin antibodies in patients with asymptomatic hepatitis C virus infection associated acute ischemic stroke
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Clinic of Neurology, Colentina Hospital, Bucharest, Romania
    Rom J Intern Med 43:89-95. 2005
    ..The higher prevalence and titre of IgG aCL antibodies in patients with HCV suggests that these humoral factors might be involved in the pathogenesis of ischemic stroke...
  17. ncbi request reprint Lipid peroxidation and catalase in diabetes mellitus with and without ischemic stroke
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Colentina Clinic of Neurology, Bucharest, Romania
    Rom J Intern Med 42:423-9. 2004
    ..We can conclude that in diabetic patients the decrease in plasma CAT activity is the consequence of oxidative modifications. These results suggest that diabetic patients have significantly increased oxidative damage...
  18. ncbi request reprint Study of anti-endothelial cell antibodies in SLE patients with acute ischemic stroke
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania
    Rom J Intern Med 48:173-7. 2010
    ..Further study is needed in order to clarify if AECA presence is related to systemic diseases severity and to situate their importance among other markers of endothelial dysfunction...
  19. ncbi request reprint IgG anti-cardiolipin antibodies-markers of inflammation in diabetic patients with ischemic stroke
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Clinic of Neurology, Colentina Hospital, Bucharest, Romania
    Rom J Intern Med 41:277-81. 2003
    ..Both patients with diabetes and those with diabetes and ischemic stroke had serum IgG aCL. IgG aCL indicate inflammatory conditions in these pathologies...
  20. ncbi request reprint Changes in plasma levels of complement in patients with acute ischemic stroke
    Inimioara Mihaela Cojocaru
    C Davila University of Medicine and Pharmacy, Clinic of Neurology, Colentina Clinical Hospital, Bucharest, Romania
    Rom J Intern Med 46:77-80. 2008
    ..49 +/- 0.07 mg/L (p<0.001). Patients with ischemic stroke who had elevated complement levels (inflammatory marker) at discharge had a worse neurological disability; complement might directly contribute to vascular damage...
  21. ncbi request reprint Study of some markers of inflammation in atherothrombotic pathogenesis of acute ischemic stroke
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Clinic of Neurology, Colentina Clinical Hospital, Sos Stefan cel Mare 19 21, 72202 Bucharest, Romania
    Rom J Intern Med 40:103-16. 2002
    ..The presented data suggest that the studied markers are useful to appreciate the role of the inflammatory reaction in the atherothrombotic pathogenesis of the ischemic stroke...
  22. ncbi request reprint Changes of magnesium serum levels in patients with acute ischemic stroke and acute infections
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Department of Neurology, Intensive Care Unit, Colentina Clinical Hospital, Romania
    Rom J Intern Med 47:169-71. 2009
    ..In conclusion, the measurement of Mg serum in bacterial infections is useful and physicians should maintain a high index of suspicion for hypomagnesemia and implement Mg therapy...
  23. ncbi request reprint Evaluation of granulocyte elastase as a sensitive diagnostic parameter of inflammation in first ischemic stroke
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Clinic of Neurology, Colentina Clinical Hospital, Bucharest, Romania
    Rom J Intern Med 44:317-21. 2006
    ..PMN elastase can be used as a measure for the activity of granulocytes during an inflammatory response. Furthermore it may be possible to treat such disorders with proteinase inhibitors...
  24. ncbi request reprint Study of total homocyst(e)ine levels in type 2 diabetic patients with silent brain infarction
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy and Clinic of Neurology, Colentina Clinical Hospital, Bucharest, Romania
    Rom J Intern Med 41:417-31. 2003
    ..The phenomenon should be considered in any future strategy for the therapy of hyperhomocyst(e)inemia (HHcy)...
  25. ncbi request reprint Clinical relevance of antikeratin antibodies in rheumatoid arthritis and symmetric polyarthritis associated with hepatitis C infection
    M Cojocaru
    Colentina Clinical Hospital, Bucharest, Romania
    Rom J Intern Med 42:709-14. 2004
    ..0001). Antikeratin antibodies were observed in 3/16 (18%) patients of group 3 (p < 0.05). Antikeratin antibodies were not found in the sera of the healthy controls...
  26. ncbi request reprint Study of anti-cardiolipin and anti-beta2-glycoprotein I antibodies in patients with ischemic stroke
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Clinic of Neurology, Colentina Clinical Hospital, Bucharest, Romania
    Rom J Intern Med 41:189-204. 2003
    ..These results showed that aCL and anti-beta2-GPI Abs could be pathogenetically important for ischemic stroke and that anti-beta2-GPI Abs testing might contribute to a better evaluation of ischemic stroke...
  27. ncbi request reprint Evaluation of antiphospholipid antibodies in young women with ischemic stroke
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Clinic of Neurology, Colentina Clinical Hospital, Bucharest, Romania
    Rom J Intern Med 45:201-4. 2007
    ..They should be sought in all stroke patients under the age of 45, especially those with previous histories of deep venous thrombosis, spontaneous abortion or thrombocytopenia...
  28. ncbi request reprint Ischemic stroke accompanied by anti-PR3 antibody-related cerebral vasculitis and hepatitis C virus infection
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Clinic of Neurology, Colentina Hospital, Bucharest, Romania
    Rom J Intern Med 45:47-50. 2007
    ..Hepatitis C virus (HCV) infection has been found to be strikingly associated with autoimmune phenomena. Autoantibodies are commonly found in patients with HCV infection...
  29. ncbi request reprint IgG-autoantibodies against oxidized low-density lipoprotein in ischemic stroke onset
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Colentina Hospital, Clinic of Neurology, Bucharest, Romania
    Rom J Intern Med 44:165-70. 2006
    ..We can deduce that immune response to oxLDL is of variable importance, regarding pathophysiologic process in the ischemic stroke...
  30. ncbi request reprint Cerebral ischemic attack secondary to hepatitis C virus infection
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Clinic of Neurology, Colentina Clinical Hospital, Bucharest Romania
    Rom J Intern Med 43:255-60. 2005
    ..The purified cryoglobulin contained monoclonal IgM-kappa, polyclonal IgG. Cryoglobulinemia is a risk factor for ischemic stroke, as it causes arterial thrombosis...
  31. ncbi request reprint Detection of neopterin as parameter of potential monocyte activation in patients with acute ischemic stroke
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Clinic of Neurology, Colentina Hospital, Bucharest, Romania
    Rom J Intern Med 45:365-9. 2007
    ..In patients with stroke it has been shown that neopterin was determinant of endothelium-dependent vascular dysfunction. However, these preliminary results need to be confirmed by controlled studies...
  32. ncbi request reprint Central pontine and extrapontine myelinolysis
    R Tanasescu
    University of Medicine and Pharmacy Carol Davila, Bucharest, Romania
    Rom J Intern Med 46:199-205. 2008
    ..The aim of this review is to focus on the main characteristics of the disease, which can represent a challenge for the clinicians in respect to its recognition and treatment...
  33. pmc Metabolic syndrome in rheumatoid arthritis
    Manole Cojocaru
    Titu Maiorescu University, Faculty of Medicine, Discipline of Physiology, Center for Rheumatic Diseases, Bucharest, Romania
    Maedica (Buchar) 7:148-52. 2012
    ..This review summarizes recent advances in the field of MS in RA...
  34. pmc Pulmonary manifestations of systemic autoimmune diseases
    Manole Cojocaru
    Carol Davila University of Medicine and Pharmacy, Clinic of Neurology, Colentina Clinical Hospital, Bucharest, Romania
    Maedica (Buchar) 6:224-9. 2011
    ....
  35. ncbi request reprint Antiphospholipid antibodies and migraine: a retrospective study of 428 patients with inflammatory connective tissue diseases
    R Tanasescu
    Carol Davila University of Medicine and Pharmacy, Department of Neurology, Colentina Hospital, Bucharest, Romania
    Rom J Intern Med 45:355-63. 2007
    ....
  36. ncbi request reprint Serum magnesium in patients with acute ischemic stroke
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Clinic of Neurology, Colentina Clinical Hospital, Bucharest, Romania
    Rom J Intern Med 45:269-73. 2007
    ..05). The serum Mg concentration has been suggested to possibly affect the neurologic state. A decrease in the serum Mg concentration indicates the severity of the injury. A magnesium substitution therapy may be useful...
  37. pmc Associated pulmonary arterial hypertension in connective tissue diseases
    Manole Cojocaru
    Titu Maiorescu University, Faculty of Medicine, Discipline of Physiology, Center for Rheumatic Diseases, Bucharest, Romania
    Maedica (Buchar) 6:141-5. 2011
    ..APAH can be a severe complication attracting a high excess mortality in autoimmune diseases. The present review will focus on what is known about autoimmune phenomena in APAH patients...
  38. ncbi request reprint Study of interleukin-6 production in Alzheimer's disease
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania
    Rom J Intern Med 49:55-8. 2011
    ..We find these results very promising for the consideration of future treatment of AD patients...
  39. pmc Extra-articular Manifestations in Rheumatoid Arthritis
    Manole Cojocaru
    Titu Maiorescu University, Faculty of Medicine, Discipline of Physiology, Center for Rheumatic Diseases, Bucharest, Romania
    Maedica (Buchar) 5:286-91. 2010
    ..The occurrence of these systemic manifestations is a major predictor of mortality in patients with RA.This paper focuses on extra-articular manifestations, defined as diseases and symptoms not directly related to the locomotor system...
  40. ncbi request reprint The effect of magnesium deficit on serum immunoglobulin concentrations in type 1 diabetes mellitus
    M Cojocaru
    Colentina Clinical Hospital, Central Clinical Laboratory, Bucharest, Romania
    Rom J Intern Med 44:61-7. 2006
    ..22+/-0.15 g/L; p>0.05). Therefore, magnesium deficit has profound immunosuppressive capabilities in patients with type 1 diabetes mellitus by significantly reducing the number of IgG synthesizing cells and serum IgG concentrations...
  41. pmc Gastrointestinal manifestations in systemic autoimmune diseases
    M Cojocaru
    Department of Physiology, Faculty of Medicine, Titu Maiorescu University, Center for Rheumatic Diseases, Bucharest, Romania
    Maedica (Buchar) 6:45-51. 2011
    ..Clinical workup should be initiated by the patient's subjective complaints. In this review, we analyze the effects of autoimmune diseases on the gastrointestinal tract...
  42. ncbi request reprint Investigation of TNF-alpha, IL-6, IL-8 and of procalcitonin in patients with neurologic complications in sepsis
    Inimioara Mihaela Cojocaru
    C Davila University of Medicine and Pharmacy, Department of Neurology, Institute of Infectious Diseases, Bucharest, Romania
    Rom J Intern Med 41:83-93. 2003
    ..The increased correlation coefficient between cytokines in serum and in CSF suggests the damage of the blood-brain barrier. The raise of PCT in serum, induced by TNF-alpha and IL-6, is an argument of the severity of sepsis...
  43. pmc Reactions of the immune system in epilepsy
    Inimioara Mihaela Cojocaru
    Department of Neurology, Colentina Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    Maedica (Buchar) 5:201-6. 2010
    ..There is some evidence that immune mechanisms play a role in the pathogenesis of some epilepsy syndromes...
  44. pmc Lipoprotein-associated phospholipase A2 as a predictive biomarker of sub-clinical inflammation in cardiovascular diseases
    Manole Cojocaru
    Department of Physiology, Faculty of Medicine, Titu Maiorescu University of Medicine and Pharmacy, Center for Rheumatic Diseases, Bucharest, Romania
    Maedica (Buchar) 5:51-5. 2010
    ..Their relationship to prognosis after stroke is unsettled. The present review article focuses particularly on the characteristics of the Lp(a)-associated Lp-PLA2 and discusses the possible role of this enzyme in view of the new data...