Myron S Cohen

Summary

Publications

  1. doi The detection of acute HIV infection
    Myron S Cohen
    Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7030, USA
    J Infect Dis 202:S270-7. 2010
  2. pmc The role of acute and early HIV infection in the spread of HIV and implications for transmission prevention strategies in Lilongwe, Malawi: a modelling study
    Kimberly A Powers
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599 7030, USA
    Lancet 378:256-68. 2011
  3. pmc Amplified transmission of HIV-1: comparison of HIV-1 concentrations in semen and blood during acute and chronic infection
    Christopher D Pilcher
    Center for Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    AIDS 21:1723-30. 2007
  4. ncbi Trichomonas vaginalis infection in male sexual partners: implications for diagnosis, treatment, and prevention
    Arlene C Sena
    Division of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Clin Infect Dis 44:13-22. 2007
  5. pmc Predicting partner HIV testing and counseling following a partner notification intervention
    Lillian B Brown
    Department of Epidemiology, CB 7435, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7435, USA
    AIDS Behav 16:1148-55. 2012
  6. pmc Improved detection of acute HIV-1 infection in sub-Saharan Africa: development of a risk score algorithm
    Kimberly A Powers
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    AIDS 21:2237-42. 2007
  7. ncbi Frequent detection of acute primary HIV infection in men in Malawi
    Christopher D Pilcher
    Departments of Medicine and Epidemiology at the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    AIDS 18:517-24. 2004
  8. ncbi The use of specimens from various genitourinary sites in men, to detect Trichomonas vaginalis infection
    S Cornelia Kaydos-Daniels
    Department of Epidemiology, University of North Carolina School of Public Health, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    J Infect Dis 189:1926-31. 2004
  9. pmc Sexual partnership patterns in malawi: implications for HIV/STI transmission
    Kimberly A Powers
    Department s of Epidemiology, The University of North Carolina, Chapel Hill, NC 27599 7030, USA
    Sex Transm Dis 38:657-66. 2011
  10. ncbi The prevalence of trichomoniasis in young adults in the United States
    William C Miller
    Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA
    Sex Transm Dis 32:593-8. 2005

Detail Information

Publications68

  1. doi The detection of acute HIV infection
    Myron S Cohen
    Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7030, USA
    J Infect Dis 202:S270-7. 2010
    ..We conclude that further technical advances are essential to allow more widespread detection of patients with AHI and to affect HIV treatment outcomes and transmission prevention...
  2. pmc The role of acute and early HIV infection in the spread of HIV and implications for transmission prevention strategies in Lilongwe, Malawi: a modelling study
    Kimberly A Powers
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599 7030, USA
    Lancet 378:256-68. 2011
    ..We estimated the contribution of early infection to HIV incidence in Lilongwe, Malawi, and predict the future effect of hypothetical prevention interventions targeted at early infection only, chronic infection only, or both stages...
  3. pmc Amplified transmission of HIV-1: comparison of HIV-1 concentrations in semen and blood during acute and chronic infection
    Christopher D Pilcher
    Center for Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    AIDS 21:1723-30. 2007
    ..This study was conducted to compare viral dynamics in blood and semen between subjects with antibody negative, acute HIV-1 infection and other subjects with later stages of infection...
  4. ncbi Trichomonas vaginalis infection in male sexual partners: implications for diagnosis, treatment, and prevention
    Arlene C Sena
    Division of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Clin Infect Dis 44:13-22. 2007
    ..Nucleic acid amplification tests can increase detection of T. vaginalis in men compared with culture...
  5. pmc Predicting partner HIV testing and counseling following a partner notification intervention
    Lillian B Brown
    Department of Epidemiology, CB 7435, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7435, USA
    AIDS Behav 16:1148-55. 2012
    ..A risk score to target partner notification can reduce the resources required to locate all partners in the community while increasing the testing yield compared to patient-referral...
  6. pmc Improved detection of acute HIV-1 infection in sub-Saharan Africa: development of a risk score algorithm
    Kimberly A Powers
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    AIDS 21:2237-42. 2007
    ..To facilitate the efficient use of these tests, we sought to develop a risk score algorithm for identifying likely AHI cases and targeting the tests towards those individuals...
  7. ncbi Frequent detection of acute primary HIV infection in men in Malawi
    Christopher D Pilcher
    Departments of Medicine and Epidemiology at the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    AIDS 18:517-24. 2004
    ..Acute (antibody-negative) HIV infection is associated with high transmission potential but is rarely recognized...
  8. ncbi The use of specimens from various genitourinary sites in men, to detect Trichomonas vaginalis infection
    S Cornelia Kaydos-Daniels
    Department of Epidemiology, University of North Carolina School of Public Health, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    J Infect Dis 189:1926-31. 2004
    ..Semen was the most sensitive single specimen, and, in 25.6% of cases, only semen specimens tested positive. Thus, prevalence of T. vaginalis infection in men is underestimated if only 1 specimen is tested...
  9. pmc Sexual partnership patterns in malawi: implications for HIV/STI transmission
    Kimberly A Powers
    Department s of Epidemiology, The University of North Carolina, Chapel Hill, NC 27599 7030, USA
    Sex Transm Dis 38:657-66. 2011
    ..To contribute to the understanding of sexual partnership patterns in this region, we estimated partnership lengths, temporal gaps between partners, and periods of overlap across partners at an STI clinic in Lilongwe, Malawi...
  10. ncbi The prevalence of trichomoniasis in young adults in the United States
    William C Miller
    Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA
    Sex Transm Dis 32:593-8. 2005
    ..The prevalence of trichomoniasis in the general population of the United States is unknown. This study provides the first population-based prevalence estimates of trichomoniasis among young adults in the United States...
  11. ncbi Rapid, real-time detection of acute HIV infection in patients in Africa
    Susan A Fiscus
    Department of Microbiology and Immunology, University of North Carolina UNC at Chapel Hill, Chapel Hill, NC 27599 7290, USA
    J Infect Dis 195:416-24. 2007
    ..We conducted a prospective study to evaluate methods of detecting clients with sexually transmitted diseases (STDs) who were acutely coinfected with human immunodeficiency virus (HIV) in Lilongwe, Malawi...
  12. pmc HIV partner notification is effective and feasible in sub-Saharan Africa: opportunities for HIV treatment and prevention
    Lillian B Brown
    Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7435, USA
    J Acquir Immune Defic Syndr 56:437-42. 2011
    ..However, many African countries do not have a standardized protocol for partner notification, and the effectiveness of partner notification has not been evaluated in developing countries ...
  13. ncbi HIV-1 populations in blood and breast milk are similar
    Gavin J Henderson
    UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Virology 330:295-303. 2004
    ..The absence of unique variants and the lack of significant differences in the relative abundance of variants between these compartments support the conclusion that viruses in the blood plasma and breast milk are well equilibrated...
  14. pmc The detection and management of early HIV infection: a clinical and public health emergency
    M Kumi Smith
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Acquir Immune Defic Syndr 63:S187-99. 2013
    ..Although we can anticipate considerable challenges in identifying and linking to care persons in the earliest phases of HIV infection, there are many reasons to pursue this strategy...
  15. pmc Methods for detection of Trichomonas vaginalis in the male partners of infected women: implications for control of trichomoniasis
    Marcia M Hobbs
    Department of Medicine, University of North Carolina at Chapel Hill, 27599, USA
    J Clin Microbiol 44:3994-9. 2006
    ..vaginalis in male partners required multiple specimens. The majority of male sexual partners in this study were infected, emphasizing the importance of partner evaluation and treatment...
  16. pmc Dolutegravir pharmacokinetics in the genital tract and colorectum of HIV-negative men after single and multiple dosing
    Benjamin N Greener
    University of North Carolina at Chapel Hill Eshelman School of Pharmacy, Chapel Hill, NC, USA
    J Acquir Immune Defic Syndr 64:39-44. 2013
    ..To describe first-dose and steady state pharmacokinetics (PKs) of dolutegravir (DTG) in blood plasma (BP), seminal fluid (SF), colorectal tissue (RT), and rectal mucosal fluid (RF) of healthy HIV-negative men...
  17. pmc Differential penetration of raltegravir throughout gastrointestinal tissue: implications for eradication and cure
    Kristine B Patterson
    University of North Carolina Department of Medicine, Chapel Hill, North Carolina 27599 7215, USA
    AIDS 27:1413-9. 2013
    ..To investigate the concentration of the integrase strand inhibitor raltegravir (RAL) throughout gastrointestinal (GI) tissue, especially gut-associated lymphoid tissue (GALT), as an adjunct to current prevention and cure strategies...
  18. ncbi Brief but efficient: acute HIV infection and the sexual transmission of HIV
    Christopher D Pilcher
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Infect Dis 189:1785-92. 2004
    ..We examined whether viral dynamics in the genital tract during the natural history of acute human immunodeficiency virus type 1 (HIV-1) infection could explain efficient heterosexual transmission of HIV...
  19. doi Community viral load as a measure for assessment of HIV treatment as prevention
    William C Miller
    Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Lancet Infect Dis 13:459-64. 2013
    ..These issues need careful assessment as community viral load is being considered as a public health measurement to assess the effect of HIV care on prevention...
  20. pmc Penetration of tenofovir and emtricitabine in mucosal tissues: implications for prevention of HIV-1 transmission
    Kristine B Patterson
    University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Sci Transl Med 3:112re4. 2011
    ..These results demonstrate the need for detailed pharmacological studies to improve the application of ART for PrEP to prevent transmission of HIV...
  21. pmc Amplified transmission of HIV-1: missing link in the HIV pandemic
    Myron S Cohen
    Department of Medicine, Microbiology and Immunology, The Schools of Medicine and Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    Trans Am Clin Climatol Assoc 117:213-24; discussion 225. 2006
    ..Prevention of sexual transmission of HIV likely requires maximal suppression of genital tract HIV viral burden, either through treatment of STDS or use of antiretroviral agents...
  22. ncbi Targeted screening for Trichomonas vaginalis with culture using a two-step method in women presenting for STD evaluation
    Heidi Swygard
    Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, 27599 7030, USA
    Sex Transm Dis 31:659-64. 2004
    ..Trichomonas vaginalis is the most common nonviral sexually transmitted pathogen. Wet mount microscopy performs poorly compared with culture; however, universal screening using culture would be cost-prohibitive...
  23. pmc Continued high risk sexual behavior following diagnosis with acute HIV infection in South Africa and Malawi: implications for prevention
    Audrey Pettifor
    Department of Epidemiology, University of North Carolina at Chapel Hill, CB 7435, McGavran Greenberg Bldg, Chapel Hill, NC 27599 7435, USA
    AIDS Behav 15:1243-50. 2011
    ..Studies are underway to determine the feasibility, acceptability and potential effectiveness of interventions designed for individuals with AHI...
  24. pmc Acute HIV infection among pregnant women in Malawi
    Cynthia L Gay
    Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7030, USA
    Diagn Microbiol Infect Dis 66:356-60. 2010
    ..Dual HIV rapid tests have high sensitivity and specificity. HIV testing should be repeated in the third trimester and/or at delivery...
  25. pmc Keep them in school: the importance of education as a protective factor against HIV infection among young South African women
    Audrey E Pettifor
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Int J Epidemiol 37:1266-73. 2008
    ..This analysis focuses on the subset of sexually experienced young women with only one reported lifetime sex partner (n = 1708)...
  26. pmc Comparison of viral Env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design
    Li Hua Ping
    UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Virol 87:7218-33. 2013
    ..We suggest that the occasional absence of glycosylation sites encoded in the conserved regions of env, further reduced in transmitted viruses, could expose specific surface structures on the protein as antibody targets...
  27. pmc Does ART prevent HIV transmission among MSM?
    Kathryn E Muessig
    Department of Medicine, University of North Carolina, Chapel Hill, USA
    AIDS 26:2267-73. 2012
    ..To review the evidence for antiretroviral 'treatment as prevention' for HIV transmission among MSM...
  28. pmc Single- and multiple-dose pharmacokinetics of darunavir plus ritonavir and etravirine in semen and rectal tissue of HIV-negative men
    Kevin C Brown
    Division of Pharmacotherapy and Experimental Therapeutics University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC, USA
    J Acquir Immune Defic Syndr 61:138-44. 2012
    ..Defining the individual exposure of commercially available antiretroviral therapy in genital secretions and vulnerable mucosal tissues is paramount to designing future prevention interventions...
  29. pmc HIV-1 Populations in Semen Arise through Multiple Mechanisms
    Jeffrey A Anderson
    UNC Center for AIDS Research, University of North Carolina, Chapel Hill, North Carolina, USA
    PLoS Pathog 6:e1001053. 2010
    ..These studies define different relationships between virus in blood and semen that can significantly alter the composition of the viral population at the source that is most proximal to the transmitted virus...
  30. ncbi HIV and sexually transmitted diseases: lethal synergy
    Myron S Cohen
    University of North Carolina Chapel Hill, Chapel Hill, NC, USA
    Top HIV Med 12:104-7. 2004
    ..Greater efforts are needed in identifying acute HIV infection in STD clinics. This article summarizes a presentation by Myron S. Cohen, MD, at the International AIDS Society-USA course in Chicago in May...
  31. ncbi Improving the accuracy of syndromic diagnosis of genital ulcer disease in Malawi
    Cathrine Hoyo
    Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Sex Transm Dis 32:231-7. 2005
    ..However, the etiologic pathogens of GUD vary temporally and geographically, and current criteria may not reflect changes in the prevalence of specific pathogens...
  32. ncbi Detection of acute infections during HIV testing in North Carolina
    Christopher D Pilcher
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, USA
    N Engl J Med 352:1873-83. 2005
    ..North Carolina has added nucleic acid amplification testing for the human immunodeficiency virus (HIV) to standard HIV antibody tests to detect persons with acute HIV infection who are viremic but antibody-negative...
  33. pmc Differential extracellular and intracellular concentrations of zidovudine and lamivudine in semen and plasma of HIV-1-infected men
    Julie B Dumond
    University of North Carolina at Chapel Hill, 3318 Kerr Hall, CB 7360, Chapel Hill, NC 27599 7360, USA
    J Acquir Immune Defic Syndr 48:156-62. 2008
    ..To quantitate extracellular and intracellular zidovudine (ZDV) and lamivudine (3TC) concentrations in blood and semen of HIV-1-infected men...
  34. pmc Antiretroviral treatment of HIV-1 prevents transmission of HIV-1: where do we go from here?
    Myron S Cohen
    Department of Medicine, University of North Carolina, Chapel Hill, NC, USA Department of Microbiology, University of North Carolina, Chapel Hill, NC, USA Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA Electronic address
    Lancet 382:1515-24. 2013
    ..These concerns are very difficult to resolve. Ongoing community-based prospective trials of early ART are likely to help to establish the population-level benefit of ART, and-if successful-to galvanise treatment as prevention...
  35. doi Neisseria gonorrhoeae antimicrobial susceptibility in Lilongwe, Malawi, 2007
    Lillian B Brown
    Division of Infectious Diseases, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Sex Transm Dis 37:169-72. 2010
    ..We sought to establish current laboratory-based Neisseria gonorrhoeae antibiotic susceptibility patterns for Malawi and describe the pattern of susceptibility since syndromic management began...
  36. ncbi Narrative review: antiretroviral therapy to prevent the sexual transmission of HIV-1
    Myron S Cohen
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7030, USA
    Ann Intern Med 146:591-601. 2007
    ..This article provides a review of the data on the use of ART to prevent the sexual transmission of HIV and identify challenges to improving and clarifying this approach...
  37. ncbi Human immunodeficiency virus type 1 RNA in breast-milk components
    Irving F Hoffman
    Center for Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina 27599 7030, USA
    J Infect Dis 188:1209-12. 2003
    ..Whole milk demonstrated higher sensitivity and mean concentration than any other single component. Sensitivity was enhanced by analyzing all 4 components of breast milk...
  38. pmc Investigating a sexual network of black men who have sex with men: implications for transmission and prevention of HIV infection in the United States
    Christopher B Hurt
    Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    J Acquir Immune Defic Syndr 61:515-21. 2012
    ..Incomplete understanding of this trend undermines prevention strategy development. We investigated a sexual network to characterize the risk environment in which young Black MSM acquire HIV...
  39. pmc Immediate antiviral therapy appears to restrict resting CD4+ cell HIV-1 infection without accelerating the decay of latent infection
    Nancie M Archin
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 109:9523-8. 2012
    ..These findings reinforce and extend the concept that new approaches will be needed to eradicate HIV infection, and, in particular, highlight the need to target the extremely small but universal, long-lived latent reservoir...
  40. doi Use of nutritional and water hygiene packages for diarrhoeal prevention among HIV-exposed infants in Lilongwe, Malawi: an evaluation of a pilot prevention of mother-to-child transmission post-natal care service
    Jiayin Xue
    The University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Trop Med Int Health 15:1156-62. 2010
    ..To evaluate a pilot prevention of mother-to-child transmission post-natal programme in Lilongwe, Malawi, through observed retention and infant diarrhoeal rates...
  41. ncbi Thomas Parran Award Lecture: transmission and prevention of transmission of HIV-1
    Myron S Cohen
    Department of Medicine, The Schools of Medicine and Public Health, The University of North Carolina at Chapel Hill, 27599 7030, USA
    Sex Transm Dis 33:338-41. 2006
  42. ncbi Highly efficient HIV transmission to young women in South Africa
    Audrey E Pettifor
    Division of Infectious Diseases, School of Medicine, Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA
    AIDS 21:861-5. 2007
    ..Such findings have led to hypotheses that the probability of HIV transmission from men to women must be far higher than previously appreciated...
  43. pmc Single and multiple dose pharmacokinetics of maraviroc in saliva, semen, and rectal tissue of healthy HIV-negative men
    Kevin C Brown
    Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7569, USA
    J Infect Dis 203:1484-90. 2011
    ..Saliva may be of utility for noninvasively measuring adherence...
  44. ncbi Hormonal contraception and HIV: the methods have confused the message
    Sheree R Schwartz
    aDivision of Infectious Diseases, Department of Medicine bDepartment of Epidemiology, Gillings School of Global Public Health cDivision of Women s Primary Healthcare, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    AIDS 27:S45-53. 2013
    ..To examine different scenarios through which confounding by condom use may lead to inaccurate conclusions about the effect of hormonal contraception on HIV acquisition in women...
  45. pmc The pharmacokinetics and viral activity of tenofovir in the male genital tract
    Manoli Vourvahis
    Division of Pharmacotherapy and Experimental Therapeutics, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599 7360, USA
    J Acquir Immune Defic Syndr 47:329-33. 2008
    ..To measure tenofovir (TFV) concentrations in the male genital tract (GT) after single and multiple doses of tenofovir disoproxil fumarate (TDF) and evaluate the HIV-1 RNA response to monotherapy...
  46. pmc HIV treatment as prevention and HPTN 052
    Myron S Cohen
    Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Curr Opin HIV AIDS 7:99-105. 2012
    ..This review summarizes the development and implementation of a large clinical trial, HIV Prevention Trials Network (HPTN) 052, whose initial results were recently presented and published...
  47. pmc Pre-exposure prophylaxis and antiretroviral resistance: HIV prevention at a cost?
    Christopher B Hurt
    Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    Clin Infect Dis 53:1265-70. 2011
    ..Here, we discuss the impact of signature mutations selected by PrEP, how rapidly these emerge with daily ARV exposure, and the individual-level and public health consequences of ARV resistance...
  48. pmc China's syphilis epidemic: epidemiology, proximate determinants of spread, and control responses
    Joseph D Tucker
    Division of Infectious Disease, UNC Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA
    Curr Opin Infect Dis 24:50-5. 2011
    ..The purpose of this analysis is to provide an overview of recent literature on syphilis proximate determinants and potential public health responses...
  49. doi Preventing sexual transmission of HIV
    Myron S Cohen
    University of North Carolina School of Medicine, Chapel Hill, 27599 7030, USA
    Clin Infect Dis 45:S287-92. 2007
    ..In the absence of more-reliable options, such as a vaccine, factors that define HIV infectivity and susceptibility and factors that amplify the risk of HIV transmission, may serve as critical targets for containment of the HIV epidemic...
  50. pmc Antiretroviral therapy for prevention of HIV infection: new clues from an animal model
    Myron S Cohen
    Institute for Global Health and Infectious Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    PLoS Med 5:e30. 2008
  51. pmc The spread, treatment, and prevention of HIV-1: evolution of a global pandemic
    Myron S Cohen
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA
    J Clin Invest 118:1244-54. 2008
    ....
  52. pmc Rethinking the heterosexual infectivity of HIV-1: a systematic review and meta-analysis
    Kimberly A Powers
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Lancet Infect Dis 8:553-63. 2008
    ..001 was estimated among stable couples with low prevalences of high-risk cofactors, and represents a lower bound. Cofactor effects are important to include in epidemic models, policy considerations, and prevention messages...
  53. pmc Prevention of HIV-1 infection with early antiretroviral therapy
    Myron S Cohen
    University of North Carolina at Chapel Hill, Institute for Global Health and Infectious Diseases, Suite 2115, Bioinformatics Bldg, 130 Mason Farm Rd, CB 7030, Chapel Hill, NC 27599, USA
    N Engl J Med 365:493-505. 2011
    ..Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples...
  54. pmc Antiretroviral pharmacology in mucosal tissues
    Corbin G Thompson
    Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599 7569, USA
    J Acquir Immune Defic Syndr 63:S240-7. 2013
    ..Finally, we suggest how preclinical and clinical data might be practically translated into optimal preexposure prophylaxis dosing strategies for clinical trials testing using mathematical modeling and simulation...
  55. pmc Pharmacokinetic modelling of efavirenz, atazanavir, lamivudine and tenofovir in the female genital tract of HIV-infected pre-menopausal women
    Julie B Dumond
    UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 27599 7569, USA
    Clin Pharmacokinet 51:809-22. 2012
    ..These blood plasma (BP) and cervicovaginal fluid (CVF) data were co-modelled for four antiretrovirals with varying CVF exposures...
  56. ncbi The role of sexually transmitted diseases in HIV transmission
    Shannon R Galvin
    Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina 27599 7030, USA
    Nat Rev Microbiol 2:33-42. 2004
    ..Targeted STD detection and treatment should have a central role in HIV prevention in these emerging epidemics...
  57. ncbi Prevalence of chlamydial and gonococcal infections among young adults in the United States
    William C Miller
    Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill 27599 7435, USA
    JAMA 291:2229-36. 2004
    ..Although screening for Chlamydia trachomatis is widely recommended among young adult women, little information is available regarding the prevalence of chlamydial and gonococcal infections in the general young adult population...
  58. ncbi Potential effect of HIV type 1 antiretroviral and herpes simplex virus type 2 antiviral therapy on transmission and acquisition of HIV type 1 infection
    Connie L Celum
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 191:S107-14. 2005
    ..The rationale for antiretroviral and HSV-2-specific interventions and studies to test these strategies are described...
  59. ncbi Treatment to prevent transmission of HIV-1
    Myron S Cohen
    University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    Clin Infect Dis 50:S85-95. 2010
    ..In this article, we review the data supporting the use of ART to prevent HIV transmission and critically examine the public health implications of this strategy...
  60. pmc Cross-sectional detection of acute HIV infection: timing of transmission, inflammation and antiretroviral therapy
    Cynthia Gay
    Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
    PLoS ONE 6:e19617. 2011
    ..We studied subjects with AHI prospectively to develop better treatment and public health interventions...
  61. pmc HIV-1 treatment as prevention: the good, the bad, and the challenges
    Kumi Smith
    Department of Epidemiology, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599 7030, USA
    Curr Opin HIV AIDS 6:315-25. 2011
    ..This work focuses on the use of antiretroviral agents to prevent the sexual transmission of HIV-1...
  62. doi HIV treatment as prevention: how scientific discovery occurred and translated rapidly into policy for the global response
    Myron S Cohen
    University of North Carolina, Chapel Hill, NC, USA
    Health Aff (Millwood) 31:1439-49. 2012
    ..This article describes the separate PEPFAR and WHO recommendations and outlines the design of prospective new trials to test how best to maximize the benefits of early treatment for prevention...
  63. pmc Antiviral agents and HIV prevention: controversies, conflicts, and consensus
    Myron S Cohen
    aDepartment of Medicine bDepartment of Epidemiology cDepartment of Microbiology and Immunology dSchool of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA
    AIDS 26:1585-98. 2012
    ..Most importantly, the best strategy for use of antiretroviral agents to reduce the spread of HIV at either the individual level or the population level has not been developed, and remains the ultimate goal of this area of investigation...
  64. ncbi Addition of treatment for trichomoniasis to syndromic management of urethritis in Malawi: a randomized clinical trial
    Matthew A Price
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Sex Transm Dis 30:516-22. 2003
    ..Male urethritis is generally treated syndromically, but failure of empirical treatment is common...
  65. pmc Decreasing excess mortality of HIV-infected patients initiating antiretroviral therapy: comparison with mortality in general population in China, 2003-2009
    Hao Zhu
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC Division of Treatment and Care, National Center for AIDS STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China Division of Infectious Diseases, School of Medicine, University of North Carolina, Chapel Hill, NC and Division of Infectious Diseases, Beijing Ditan Hospital Capital Medical University, Beijing, China
    J Acquir Immune Defic Syndr 63:e150-7. 2013
    ..To evaluate excess mortality across calendar time comparing HIV-infected patients receiving combination antiretroviral therapy (cART) with the general Chinese population...
  66. ncbi Syphilis returns to china ... With a vengeance
    Myron S Cohen
    The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Sex Transm Dis 33:724-5. 2006
  67. pmc Acute HIV revisited: new opportunities for treatment and prevention
    Christopher D Pilcher
    Department of Medicine, University of North Carolina at Chapel Hill, 27599 7215, USA
    J Clin Invest 113:937-45. 2004
    ..In this review article, we will highlight critical opportunities for HIV treatment and prevention that are presented by these diagnostic strategies...
  68. ncbi Use of antiretroviral drugs to prevent sexual transmission of HIV
    Myron S Cohen
    Division of Infectious Diseases, University of North Carolina Hospitals, Chapel Hill, North Carolina, USA
    Curr Clin Top Infect Dis 22:214-51. 2002