Normalizing glycated albumin reduces increased urinary collagen IV and prevents renal insufficiency in diabetic db/db miceMargo P Cohen
Institute of Metabolic Research and Exocell, University City Science Center, Philadelphia, PA, USA
Metabolism 51:901-5. 2002
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- Intervention strategies to prevent pathogenetic effects of glycated albumin
Margo P Cohen
Institute for Metabolic Research, University City Science Center, 3508 Market Street, Suite 420, Philadelphia, PA 19104, USA
Arch Biochem Biophys 419:25-30. 2003
..Potential intervention strategies to lessen the influence of AGE-modified proteins, as well as of other contributory abnormalities, are discussed elsewhere in this volume...
- Inhibiting low-density lipoprotein glycation ameliorates increased cholesteryl ester synthesis in macrophages and hypercholesterolemia and aortic lipid peroxidation in streptozotocin diabetic rats
Margo P Cohen
Glycadia, Inc, Philadelphia, PA 19103, USA
Metabolism 59:658-63. 2010
..These results are the first to demonstrate that inhibiting nonenzymatic glycation of apo B-containing lipoproteins ameliorates abnormalities contributory to hypercholesterolemia and atherogenic risk in diabetes...
- Glycated albumin increases oxidative stress, activates NF-kappa B and extracellular signal-regulated kinase (ERK), and stimulates ERK-dependent transforming growth factor-beta 1 production in macrophage RAW cells
Margo P Cohen
Institute of Metabolic Research, University City Science Center, Research University of Pennsylvania, 3508 Market Street, Suite 420, Philadelphia, PA 19104, USA
J Lab Clin Med 141:242-9. 2003
..The effects of glycated albumin on RAW cell molecular mediators and cytokine production may have pathophysiologic significance with respect to the accelerated atherosclerosis that occurs in diabetes...
- Evidence linking glycated albumin to altered glomerular nephrin and VEGF expression, proteinuria, and diabetic nephropathy
Margo P Cohen
University City Science Center, Institute of Metalboic Research, Philadelphia, Pennsylania 19104, USA
Kidney Int 68:1554-61. 2005
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- Inhibiting albumin glycation in vivo ameliorates glomerular overexpression of TGF-beta1
Margo P Cohen
Institute of Metabolic Research and Exocell, University City Science Center, Philadelphia, PA 19104, USA
Kidney Int 61:2025-32. 2002
..Whether glycated albumin modulates glomerular TGF-beta1 expression in vivo is not known. To address this issue, we assessed glomerular TGF-beta1 expression and pathology in response to reducing the burden of glycated albumin in vivo...
- Amadori-modified glycated serum proteins and accelerated atherosclerosis in diabetes: pathogenic and therapeutic implications
Margo P Cohen
University City Science Center, Philadelphia, Pennsylvania, USA
J Lab Clin Med 147:211-9. 2006
- Measuring glycated proteins: clinical and methodological aspects
M P Cohen
Exocell, Inc, and Institute for Metabolic Research, University City Science Center, Philadelphia, Pennsylvania, USA
Diabetes Technol Ther 1:57-70. 1999
..This article reviews the chemistry, methods for measurement, and clinical relevance of circulating glycated proteins in the management of diabetes...
- Serum type IV collagen in diabetic patients at risk for nephropathy
M P Cohen
Institute for Metabolic Research, University City Science Center, Philadelphia, Pennsylvania 19104, USA
Diabetes Care 24:1324-7. 2001
..We sought to clarify the relationship between early renal dysfunction in diabetes and circulating type IV collagen concentrations...
- Inhibiting albumin glycation attenuates dysregulation of VEGFR-1 and collagen IV subchain production and the development of renal insufficiency
Margo P Cohen
University City Science Center, Philadelphia, Pennsylvania, USA
Am J Physiol Renal Physiol 292:F789-95. 2007
..The findings indicate that inhibiting excess nonenzymatic glycation of serum albumin improves renal molecular biology abnormalities and protects against the development of renal insufficiency in the db/db mouse...
- Increased collagen IV excretion in diabetes. A marker of compromised filtration function
M P Cohen
IMR, University City Science Center, Philadelphia, Pennsylvania 19104, USA
Diabetes Care 24:914-8. 2001
..We postulated that the overproduction of extracellular matrix proteins underlying glomerulosclerosis in diabetes might be associated with the excretion of increased amounts of type IV collagen in the urine...
- Vitreous fluid of db/db mice exhibits alterations in angiogenic and metabolic factors consistent with early diabetic retinopathy
Margo P Cohen
Glycadia, Inc, Philadelphia, PA, USA
Ophthalmic Res 40:5-9. 2008
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- Amelioration of diabetes-associated abnormalities in the vitreous fluid by an inhibitor of albumin glycation
Margo P Cohen
Glycadia, Inc, Philadelphia, Pennsylvania 19103, USA
Invest Ophthalmol Vis Sci 49:5089-93. 2008
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- Inhibiting albumin glycation ameliorates diabetic nephropathy in the db/db mouse
M P Cohen
University City Science Center, Philadelphia, PA, USA
Exp Nephrol 8:135-43. 2000
..We conclude that normalization of plasma glycated albumin concentrations with the glycation inhibitor EXO-226 ameliorates the glomerular structural and functional abnormalities associated with diabetic nephropathy in the db/db mouse...
- Reduction of Abeta42 in brains of transgenic APPswe mice by 2-3-chlorophenylaminophenylacetate
Margo P Cohen
Glycadia Inc, Philadelphia, Pennsylvania 19103, USA
Clin Exp Pharmacol Physiol 36:1099-103. 2009
..5. These results are the first to demonstrate that GLY-230, which exhibits antiglycation but no cyclo-oxygenase inhibitory properties, lowers brain Abeta42 levels in this experimental model of Alzheimer's disease...
- Increased plasma glycated low-density lipoprotein concentrations in diabetes: a marker of atherogenic risk
Margo P Cohen
Institute for Metabolic Research, University City Science Center, Philadelphia, Pennsylvania 19104, USA
Diabetes Technol Ther 6:348-56. 2004
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- Prevention of decline in renal function in the diabetic db/db mouse
M P Cohen
University City Science Center, Philadelphia, Pennsylvania, USA
Diabetologia 39:270-4. 1996
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- Glycated albumin stimulates TGF-beta 1 production and protein kinase C activity in glomerular endothelial cells
S Chen
Renal-Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6144, USA
Kidney Int 59:673-81. 2001
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- ERK mediates effects of glycated albumin in mesangial cells
M P Cohen
Institute of Metabolic Research and Exocell, Inc, University City Science Center, Philadelphia, Pennsylvania, 19104, USA
Biochem Biophys Res Commun 283:641-3. 2001
..These findings indicate that the MAPK/ERK pathway mediates biologic activities of this glycated protein...
- Increased urinary type IV collagen marks the development of glomerular pathology in diabetic d/db mice
M P Cohen
Institute for Metabolic Research, University City Science, Philadelphia, PA, USA
Metabolism 50:1435-40. 2001
..The findings suggest that increased urinary type IV collagen is a better indicator than albuminuria of developing glomerular matrix accumulation that results in compromised renal filtration function...
- The renal TGF-beta system in the db/db mouse model of diabetic nephropathy
M P Cohen
Department of Medicine, University of Pennsylvania, Philadelphia, USA
Exp Nephrol 6:226-33. 1998
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- Identification of calnexin as a binding protein for Amadori-modified glycated albumin
V Y Wu
Institute of Metabolic Research, University City Science Center, Philadelphia, Pennsylvania 19104, USA
Biochem Biophys Res Commun 284:602-6. 2001
..These results indicate that one of the mesangial cell receptors for glycated albumin is a calnexin-like protein...
