No evidence of association or linkage disequilibrium between polymorphisms in the 5' upstream and coding regions of the dopamine D4 receptor gene and schizophrenia in a Portuguese populationAlda M Ambrósio
Center for Neuroscience of Coimbra, Department of Neurochemistry, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Am J Med Genet B Neuropsychiatr Genet 125:20-4. 2004
..These data suggest that polymorphisms (-C616G, -C521T, and 48 bp repeat) at the DRD4 gene do not have a minor effect in the susceptibility to schizophrenia in our sample...
- Nonparametric linkage analysis between schizophrenia and candidate genes of dopaminergic and serotonergic systems
Alda M Ambrósio
Department of Neurochemistry, University of Coimbra, Coimbra, Portugal
CNS Spectr 9:302-8. 2004
..This study was performed to assess the possible involvement of the dopamine receptor genes D2 (DRD2), D3, D4, serotonin receptor genes 1Da, 1Db, and 2A in the etiology of schizophrenia...
- Family association study between DRD2 and DRD3 gene polymorphisms and schizophrenia in a Portuguese population
Alda M Ambrósio
Department of Neurochemistry, Faculty of Medicine, Center for Neuroscience of Coimbra, University of Coimbra, 3004 517 Coimbra, Portugal
Psychiatry Res 125:185-91. 2004
..Therefore, we conclude that neither the DRD2 nor the DRD3 gene polymorphisms investigated are associated with schizophrenia in our sample...
- Lack of association or linkage disequilibrium between schizophrenia and polymorphisms in the 5-HT1Dalpha and 5-HT1Dbeta autoreceptor genes: family-based association study
Alda M Ambrósio
Center for Neuroscience of Coimbra, Department of Neurochemistry, Faculty of Medicine, University of Coimbra, 3004 517 Coimbra, Portugal
Am J Med Genet B Neuropsychiatr Genet 128:1-5. 2004
..Thus, our data provide no support for the hypothesis that polymorphisms at 5-HT1Dalpha (TaqI) and 5-HT1Dbeta (T261G and G861C) genes contributes to susceptibility to schizophrenia in the Portuguese population...
- A linkage study between the GABAA beta2 and GABAA gamma2 subunit genes and major psychoses
Alda M Ambrósio
Unit of Clinical and Molecular Genetics, National Institute of Legal Medicine, Faculty of Medicine, University of Coimbra, Largo da Se Nova, 3000 213 Coimbra, Portugal
CNS Spectr 10:57-61. 2005
..Alterations of the gamma-aminobutyric acid (GABA) system have been implicated in the pathophysiology of major psychoses...
- Genotypes at the APOE and SCA2 loci do not predict the course of multiple sclerosis in patients of Portuguese origin
Monica Santos
UnIGENe IBMC, Univ Porto
Mult Scler 10:153-7. 2004
..However, globally in the Portuguese population, the APOE and SCA2 genes do not seem to be useful in the clinical context as prognostic markers of this disorder...
- NR4A2 and schizophrenia: lack of association in a Portuguese/Brazilian study
Dina Ruano
Health Sciences School, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
Am J Med Genet B Neuropsychiatr Genet 128:41-5. 2004
..The study failed to identify any of the described mutations in patients or controls. Nevertheless, these negative results do not exclude altered expression of nuclear receptors in schizophrenia or the presence of other mutations...
