Andrew J S Coats

Summary

Publications

  1. ncbi request reprint Hypertensive subjects with type-2 diabetes, the sympathetic nervous system, and treatment implications
    Andrew J S Coats
    Joint Academic Vice President Monash University, Australia and University of Warwick, UK Electronic address
    Int J Cardiol 174:702-9. 2014
  2. doi request reprint Inconsistencies in the development of the ESC Clinical Practice Guidelines for Heart Failure
    Andrew J Stewart Coats
    Monash University, Melbourne, Australia University of Warwick, Coventry, UK Electronic address
    Int J Cardiol 168:1724-7. 2013
  3. pmc Research on cachexia, sarcopenia and skeletal muscle in cardiology
    Andrew J S Coats
    Monash University Australia and University of Warwick, Warwick, UK
    J Cachexia Sarcopenia Muscle 3:219-23. 2012
  4. doi request reprint Clinical utility of exercise training in chronic systolic heart failure
    Andrew J Stewart Coats
    The Norwich Research Park, University of East Anglia, Colney Lane, Norwich, Norfolk NR4 7TJ, UK
    Nat Rev Cardiol 8:380-92. 2011
  5. ncbi request reprint Origin of symptoms in patients with cachexia with special reference to weakness and shortness of breath
    Andrew J S Coats
    National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Royal Brompton Hospital, London, UK
    Int J Cardiol 85:133-9. 2002
  6. ncbi request reprint Effect of anemia on exercise tolerance in chronic heart failure in men
    Paul R Kalra
    Clinical Cardiology, National Heart and Lung Institute, London, United Kingdom
    Am J Cardiol 91:888-91. 2003
  7. ncbi request reprint Body mass and survival in patients with chronic heart failure without cachexia: the importance of obesity
    Constantinos H Davos
    Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    J Card Fail 9:29-35. 2003
  8. ncbi request reprint Effect of carvedilol on exercise tolerance in patients with chronic heart failure and a restrictive left ventricular filling pattern
    Faisal Al-Nasser
    Clinical Cardiology Department, Royal Brompton Hospital, London, United Kingdom
    Am J Cardiol 91:1281-3. 2003
  9. ncbi request reprint Cellular endotoxin desensitization in patients with severe chronic heart failure
    Rakesh Sharma
    Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Eur J Heart Fail 7:865-8. 2005
  10. ncbi request reprint Putative contribution of prostaglandin and bradykinin to muscle reflex hyperactivity in patients on Ace-inhibitor therapy for chronic heart failure
    Adam C Scott
    Imperial College School of Medicine, and Royal Brompton Hospital, London, UK
    Eur Heart J 25:1806-13. 2004

Collaborators

Detail Information

Publications86

  1. ncbi request reprint Hypertensive subjects with type-2 diabetes, the sympathetic nervous system, and treatment implications
    Andrew J S Coats
    Joint Academic Vice President Monash University, Australia and University of Warwick, UK Electronic address
    Int J Cardiol 174:702-9. 2014
    ..Beta-1 blockade, effective in reversing and stabilising coronary atheromataous plaque, and with possible anti-tumor properties, is superior to ACE-inhibition, and is the treatment of choice in young/middle-aged hypertension with DM2. ..
  2. doi request reprint Inconsistencies in the development of the ESC Clinical Practice Guidelines for Heart Failure
    Andrew J Stewart Coats
    Monash University, Melbourne, Australia University of Warwick, Coventry, UK Electronic address
    Int J Cardiol 168:1724-7. 2013
    ..We propose that more interaction is needed between ESC and stakeholders so each can better understand the processes for producing guidelines to improve some of these aspects. ..
  3. pmc Research on cachexia, sarcopenia and skeletal muscle in cardiology
    Andrew J S Coats
    Monash University Australia and University of Warwick, Warwick, UK
    J Cachexia Sarcopenia Muscle 3:219-23. 2012
    ..The awareness of cardiac cachexia, i.e. involuntary weight loss in patients with underlying cardiovascular disease, has increased over the last two decades...
  4. doi request reprint Clinical utility of exercise training in chronic systolic heart failure
    Andrew J Stewart Coats
    The Norwich Research Park, University of East Anglia, Colney Lane, Norwich, Norfolk NR4 7TJ, UK
    Nat Rev Cardiol 8:380-92. 2011
    ..In this Review, the modes and intensity of exercise training, selection of patients, duration of training effects, and other clinical guidance for using this treatment option are discussed...
  5. ncbi request reprint Origin of symptoms in patients with cachexia with special reference to weakness and shortness of breath
    Andrew J S Coats
    National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Royal Brompton Hospital, London, UK
    Int J Cardiol 85:133-9. 2002
    ..Potential novel therapeutic strategies to combat these cachexia symptoms are reviewed...
  6. ncbi request reprint Effect of anemia on exercise tolerance in chronic heart failure in men
    Paul R Kalra
    Clinical Cardiology, National Heart and Lung Institute, London, United Kingdom
    Am J Cardiol 91:888-91. 2003
  7. ncbi request reprint Body mass and survival in patients with chronic heart failure without cachexia: the importance of obesity
    Constantinos H Davos
    Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    J Card Fail 9:29-35. 2003
    ..Cachexia in chronic heart failure carries a poor prognosis, but little is known about the influence of body mass on the prognosis of noncachectic heart failure patients...
  8. ncbi request reprint Effect of carvedilol on exercise tolerance in patients with chronic heart failure and a restrictive left ventricular filling pattern
    Faisal Al-Nasser
    Clinical Cardiology Department, Royal Brompton Hospital, London, United Kingdom
    Am J Cardiol 91:1281-3. 2003
  9. ncbi request reprint Cellular endotoxin desensitization in patients with severe chronic heart failure
    Rakesh Sharma
    Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Eur J Heart Fail 7:865-8. 2005
    ..It is not known if LPS desensitization occurs in CHF...
  10. ncbi request reprint Putative contribution of prostaglandin and bradykinin to muscle reflex hyperactivity in patients on Ace-inhibitor therapy for chronic heart failure
    Adam C Scott
    Imperial College School of Medicine, and Royal Brompton Hospital, London, UK
    Eur Heart J 25:1806-13. 2004
    ....
  11. ncbi request reprint Skeletal muscle reflex in heart failure patients: role of hydrogen
    Adam C Scott
    National Heart and Lung Institute, and Royal Brompton Hospital, Imperial College School of Science, Technology and Medicine, London, United Kingdom
    Circulation 107:300-6. 2003
    ..With the use of selective infusions and dietary manipulation methods, we sought to identify the role of H+, K+, lactate, and peripheral hemodynamics on ergoreflex overactivation...
  12. ncbi request reprint Elevated circulating levels of inflammatory cytokines and bacterial endotoxin in adults with congenital heart disease
    Rakesh Sharma
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Am J Cardiol 92:188-93. 2003
    ..Congenital heart disease in adults may be amenable to novel anti-inflammatory therapies in selected patients...
  13. ncbi request reprint The relationship between age and production of tumour necrosis factor-alpha in healthy volunteers and patients with chronic heart failure
    Stephan von Haehling
    Department of Clinical Cardiology, National Heart and Lung Institute, London SW3 6LY, UK
    Int J Cardiol 90:197-204. 2003
    ..Elevated plasma levels of tumour necrosis factor-alpha (TNF-alpha) are present in patients with advanced chronic heart failure (CHF). However, the relationship between age and the immune response in CHF is unknown...
  14. ncbi request reprint Heat shock protein 70 in patients with chronic heart failure: relation to disease severity and survival
    Sabine Genth-Zotz
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Int J Cardiol 96:397-401. 2004
    ..We hypothesised that circulating Hsp70 levels are elevated in patients with CHF, more so in cachechtic patients, and that Hsp70 levels would relate to mortality...
  15. ncbi request reprint Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS)
    Marcus D Flather
    Clinical Trials and Evaluation Unit, Royal Brompton and Harefield NHS Trust, London, UK
    Eur Heart J 26:215-25. 2005
    ..The SENIORS study was performed to assess effects of the beta-blocker, nebivolol, in patients >/=70 years, regardless of ejection fraction...
  16. ncbi request reprint Whole blood endotoxin responsiveness in patients with chronic heart failure: the importance of serum lipoproteins
    Rakesh Sharma
    Clinical Cardiology, NHLI, Imperial College School of Medicine, Dovehouse Street, SW3 6LY, London, UK
    Eur J Heart Fail 7:479-84. 2005
    ..We sought to investigate the relationship between whole blood endotoxin responsiveness and serum lipoprotein concentrations. It is not known if low-dose LPS is sufficient to stimulate immune activation...
  17. ncbi request reprint Haemoglobin predicts survival in patients with chronic heart failure: a substudy of the ELITE II trial
    Rakesh Sharma
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London SW3 6LY, UK
    Eur Heart J 25:1021-8. 2004
    ..We aimed to investigate the relationship between the concentration of haemoglobin and survival in CHF...
  18. ncbi request reprint Clinical characteristics and survival of patients with chronic heart failure and prolonged QRS duration
    Paul R Kalra
    Clinical Cardiology, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    Int J Cardiol 86:225-31. 2002
    ..Whilst resynchronisation of ventricular conduction may benefit patients with QRS>150 ms, this has yet to be determined for patients with moderate QRS prolongation...
  19. ncbi request reprint The anti-CD14 antibody IC14 suppresses ex vivo endotoxin stimulated tumor necrosis factor-alpha in patients with chronic heart failure
    Sabine Genth-Zotz
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Eur J Heart Fail 8:366-72. 2006
    ..Plasma LPS activity is elevated in patients with severe chronic heart failure (CHF). An anti-CD14 antibody, IC14, blocks TNF production in healthy volunteers. It is not known whether IC14 prevents TNF production in CHF patients...
  20. ncbi request reprint Global impairment of cardiac autonomic nervous activity late after the Fontan operation
    Constantinos H Davos
    Royal Brompton Adult Congenital Heart Programme, and Department of Clinical Cardiology, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Circulation 108:II180-5. 2003
    ..We examined cardiac autonomic nervous activity, a predictor of arrhythmia and sudden death in other cardiovascular disease, in patients late after the Fontan operation, employing heart rate variability (HRV) and baroreflex sensitivity...
  21. ncbi request reprint Differential contribution of dead space ventilation and low arterial pCO2 to exercise hyperpnea in patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    Roland Wensel
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, United Kingdom
    Am J Cardiol 93:318-23. 2004
    ..Second, this latter component (depression of arterial pCO(2)) was not related to conventional measures of heart failure severity...
  22. ncbi request reprint The relationship between cholesterol and survival in patients with chronic heart failure
    Mathias Rauchhaus
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    J Am Coll Cardiol 42:1933-40. 2003
    ..We sought to describe the relationship between cholesterol and survival in patients with chronic heart failure (CHF)...
  23. ncbi request reprint Abnormal temporal dynamics of blood pressure and RR interval regulation in patients with chronic heart failure: relationship to baroreflex sensitivity
    L Ceri Davies
    National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, UK
    Int J Cardiol 86:107-14. 2002
    ..This may have important implications for the measurement and interpretation of BRS in patient groups where BRS is weak...
  24. ncbi request reprint Haemoglobin concentration and prognosis in new cases of heart failure
    Paul R Kalra
    National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Lancet 362:211-2. 2003
    ..The adverse effects of anaemia on survival might be a consequence of chronic heart failure rather than a separate process causing disease progression...
  25. ncbi request reprint Exercise hyperventilation in chronic heart failure is not caused by systemic lactic acidosis
    Roland Wensel
    National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, UK
    Eur J Heart Fail 7:1105-11. 2005
    ..Patients with heart failure have an abnormally high ventilatory response to exercise associated with gas exchange defects and reduced arterial pCO(2)...
  26. ncbi request reprint Impaired insulin sensitivity as an independent risk factor for mortality in patients with stable chronic heart failure
    Wolfram Doehner
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Am Coll Cardiol 46:1019-26. 2005
    ..The aim of this study was to determine the significance of insulin resistance as an independent risk factor for impaired prognosis in patients with chronic heart failure (CHF)...
  27. ncbi request reprint The cardiac component of cardiac cachexia
    Viorel G Florea
    Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    Am Heart J 144:45-50. 2002
    ..This study sought to assess the cardiac dimensions, mass, and function and changes in these parameters over time in patients with chronic heart failure with and without cachexia...
  28. ncbi request reprint Impact of periodic breathing on measurement of oxygen uptake and respiratory exchange ratio during cardiopulmonary exercise testing
    Darrel P Francis
    National Heart and Lung Institute, London SW3 6LY, UK
    Clin Sci (Lond) 103:543-52. 2002
    ..Clinical reports and research publications describing peak V*O(2) in CHF should be accompanied by details of the averaging technique used...
  29. ncbi request reprint Enhanced prognostic value from cardiopulmonary exercise testing in chronic heart failure by non-linear analysis: oxygen uptake efficiency slope
    Lewis Ceri Davies
    National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, UK
    Eur Heart J 27:684-90. 2006
    ..We evaluated the physiology of OUES and assessed its potential for prognostic information in patients with CHF...
  30. ncbi request reprint Pathophysiologic quantities of endotoxin-induced tumor necrosis factor-alpha release in whole blood from patients with chronic heart failure
    Sabine Genth-Zotz
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    Am J Cardiol 90:1226-30. 2002
    ..These results suggest that elevated plasma endotoxin activity observed in patients with HF is of pathophysiologic relevance...
  31. ncbi request reprint Reproducibility of the measurement of the muscle ergoreflex activity in chronic heart failure
    Adam C Scott
    National Heart and Lung Institute, and Royal Brompton Hospital, Imperial College School of Science, Technology and Medicine, London, UK
    Eur J Heart Fail 5:453-61. 2003
    ..A causative role for symptom generation in heart failure has been attributed to overactive muscle afferents, metaboreflex and mechanoreflex. We examined the reproducibility of the methods commonly used to assess these reflexes...
  32. ncbi request reprint Beta-blocker therapy for dynamic left-ventricular outflow tract obstruction
    Faisal Al-Nasser
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
    Int J Cardiol 86:199-205. 2002
    ..The aim of our study was to investigate the effect of beta-blockade on ventricular physiology and symptoms in patients with DLVOTO...
  33. ncbi request reprint Association of deranged adrenal steroid metabolism with anemia in chronic heart failure
    Darlington O Okonko
    Clinical Cardiology, National Heart and Lung Institute, Imperial College, London, UK
    Am J Cardiol 96:101-3. 2005
    ..The cortisol/DHEA ratio was independently and inversely associated with hemoglobin concentrations, suggesting that alterations of the steroid milieu may play a role in the pathogenesis of anemia in CHF...
  34. ncbi request reprint Chemical mediators of the muscle ergoreflex in chronic heart failure: a putative role for prostaglandins in reflex ventilatory control
    Adam C Scott
    National Heart and Lung Institute, and Royal Brompton Hospital, Imperial College School of Science, Technology and Medicine, London, UK
    Circulation 106:214-20. 2002
    ..We investigated biochemical factors (H+, VCO2, VO2, HCO3, K+, phosphate, lactate, PGE2, PGF(1alpha), and bradykinin) potentially involved in ergoreceptor activation...
  35. doi request reprint Reduced confounding by impaired ventilatory function with oxygen uptake efficiency slope and VE/VCO2 slope rather than peak oxygen consumption to assess exercise physiology in suspected heart failure
    Anthony J Barron
    International Centre for Circulatory Health, Imperial College London and Imperial College NHS Trust, London, UK
    Congest Heart Fail 16:259-64. 2010
    ..OUES in contrast does not show this preferential sensitivity to impaired FEV(1)...
  36. ncbi request reprint Exercise training in chronic heart failure: effects on pro-inflammatory markers
    Josef Niebauer
    Cardiac Medicine, Royal Brompton Hospital and NHLI, London, UK
    Eur J Heart Fail 7:189-93. 2005
    ..In this study, we set out to investigate the impact of chronic exercise training on pro-inflammatory cytokines and markers of endothelial damage...
  37. ncbi request reprint Heart transplantation in heart failure: the prognostic importance of body mass index at time of surgery and subsequent weight changes
    Andrew L Clark
    Department of Cardiology, Univerity of Hull, and Department of Cardiac Surgery, Royal Brompton Hospital, London, UK
    Eur J Heart Fail 9:839-44. 2007
    ..We studied the effect of body mass index (BMI), and the effect of subsequent weight change, on survival following transplantation in 1902 consecutive patients...
  38. ncbi request reprint Meta-analyses of mortality and morbidity effects of an angiotensin receptor blocker in patients with chronic heart failure already receiving an ACE inhibitor (alone or with a beta-blocker)
    Konstantinos Dimopoulos
    National Heart and Lung Institute, and Heart Failure Unit, Royal Brompton Hospital, London, UK
    Int J Cardiol 93:105-11. 2004
    ..Even more controversial is the wisdom of administering ARBs in patients already on an ACEi and beta-blocker...
  39. ncbi request reprint Effect of interleukin-10 on the production of tumor necrosis factor-alpha by peripheral blood mononuclear cells from patients with chronic heart failure
    Aidan P Bolger
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    Am J Cardiol 90:384-9. 2002
    ..IL-10 is, therefore, a potential therapy for use in chronic HF associated with inflammatory immune activation...
  40. ncbi request reprint Neurohormonal activation and the chronic heart failure syndrome in adults with congenital heart disease
    Aidan P Bolger
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, UK
    Circulation 106:92-9. 2002
    ....
  41. ncbi request reprint Global impairment of cardiac autonomic nervous activity late after repair of tetralogy of Fallot
    Constantinos H Davos
    Royal Brompton Adult Congenital Heart Program, the Department of Clinical Cardiology, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Circulation 106:I69-75. 2002
    ....
  42. ncbi request reprint Wasting of the left ventricle in patients with cardiac cachexia: a cardiovascular magnetic resonance study
    Viorel G Florea
    Department of Clinical Cardiology, Imperial College of Science, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    Int J Cardiol 97:15-20. 2004
    ..Cardiovascular magnetic resonance (CMR) has high reproducibility and is more sensitive than other techniques...
  43. ncbi request reprint Influence of valve prosthesis type on the recovery of ventricular dysfunction and subendocardial ischaemia following valve replacement for aortic stenosis
    Julian Collinson
    Clinical Trials and Evaluation Unit, Royal Brompton and Harefield NHS Trust and National Heart and Lung Institute, London, UK
    Int J Cardiol 97:535-41. 2004
    ..Following aortic valve surgery, LV function may improve and this may be accompanied by reversal of ischaemia. There is debate about the differential effects of valve substitutes...
  44. ncbi request reprint Relationship between detrended fluctuation analysis and spectral analysis of heart-rate variability
    Keith Willson
    Department of Biomedical Engineering, Royal Brompton Hospital, London, UK
    Physiol Meas 23:385-401. 2002
    ..We confirm these findings using samples from 20 healthy volunteers and 40 patients with heart failure...
  45. ncbi request reprint The epidemiological enigma of heart failure with preserved systolic function
    Martin D Thomas
    Cardiovascular Medicine, National Heart and Lung Institute, Imperial College, Charing Cross Campus, Fulham Palace Road, London SW3 6LY, UK
    Eur J Heart Fail 6:125-36. 2004
    ..This inconsistency suggests a lack of consensus as to what this condition really is and how it has been characterised for epidemiological studies...
  46. ncbi request reprint A noninvasive measure of baroreflex sensitivity without blood pressure measurement
    L Ceri Davies
    National Heart and Lung Institute, Imperial College of Science, Technology, and Medicine, London, United Kingdom
    Am Heart J 143:441-7. 2002
    ..We examined the possibility of developing a simple protocol that would provide a relatively standardized BP stimulus, which might obviate the need to measure BP beat-by-beat...
  47. ncbi request reprint Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies
    Wolfram Doehner
    Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Circulation 105:2619-24. 2002
    ..We therefore studied the effects of XO inhibition with allopurinol on endothelial function and peripheral blood flow in CHF patients after intra-arterial infusion and after oral administration in 2 independent placebo-controlled studies...
  48. ncbi request reprint Home-based exercise training modulates pro-oxidant substrates in patients with chronic heart failure
    Josef Niebauer
    Cardiac Medicine, Royal Brompton Hospital and NHLI, London, UK
    Eur J Heart Fail 7:183-8. 2005
    ..In chronic heart failure, oxidative stress is thought to lead to endothelial dysfunction. In this study, we assessed the effect of home-based exercise training on variables of the NO and purine pathways...
  49. ncbi request reprint Aerobic exercise physiology in a professional rugby union team
    Adam C Scott
    National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, UK
    Int J Cardiol 87:173-7. 2003
    ..In professional rugby, different positional roles may require different levels of aerobic fitness. Forward and backline players from a team of elite rugby players were tested to evaluate the differences between the two groups...
  50. ncbi request reprint Congenital heart disease: the original heart failure syndrome
    Aidan P Bolger
    Adult Congenital Heart Programme, Royal Brompton Hospital, London, UK
    Eur Heart J 24:970-6. 2003
    ....
  51. ncbi request reprint Nonsurgical reduction of the interventricular septum in patients with hypertrophic cardiomyopathy
    Waqar Shamim
    National Heart and Lung Institute, Royal Brompton and Harefield Hospital, Imperial College of Science, Technology and Medicine, London
    N Engl J Med 347:1326-33. 2002
    ..We investigated the long-term effects of nonsurgical reduction of the septum on functional capacity and electrocardiographic and echocardiographic characteristics...
  52. ncbi request reprint Effects of initiating carvedilol in patients with severe chronic heart failure: results from the COPERNICUS Study
    Henry Krum
    Dept of Medicine and Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, Victoria, 3181 Australia
    JAMA 289:712-8. 2003
    ..Beta-blockers remain underused despite their established utility for improving outcome in heart failure. Concerns that initiation of treatment produces few immediate benefits and may have important risks may be deterring widespread use...
  53. ncbi request reprint Circulating cytokines and chemokines in acute symptomatic parvovirus B19 infection: negative association between levels of pro-inflammatory cytokines and development of B19-associated arthritis
    Jonathan R Kerr
    Department of Microbiology, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Med Virol 74:147-55. 2004
    ..The profile of circulating mediators may provide insights into the possible pathogenesis of particular clinical manifestations of this infection...
  54. ncbi request reprint Insulin resistance in moderate chronic heart failure is related to hyperleptinaemia, but not to norepinephrine or TNF-alpha
    Wolfram Doehner
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse St, London SW3 6LY, UK
    Int J Cardiol 83:73-81. 2002
    ..The purpose of this study was to examine in patients with CHF and in comparison to healthy controls subjects whether norepinephrine, TNFalpha or leptin relate to insulin sensitivity...
  55. ncbi request reprint Is central nervous system processing altered in patients with heart failure?
    Stuart D Rosen
    Department of Respiratory Physiology, National Heart and Lung Institute, Imperial College, Charing Cross Hospital, London W68RP, UK
    Eur Heart J 25:952-62. 2004
    ..Our aim was to assess whether heart failure patients exhibit different patterns of regional brain activation after exercise stress...
  56. ncbi request reprint Do results of the ENABLE (Endothelin Antagonist Bosentan for Lowering Cardiac Events in Heart Failure) study spell the end for non-selective endothelin antagonism in heart failure?
    Paul R Kalra
    Clinical Cardiology, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    Int J Cardiol 85:195-7. 2002
    ..The results from the ENABLE study have, however, thrown further doubt on the potential benefits of non-specific endothelin receptor blockade in heart failure...
  57. doi request reprint Do optimal prognostic thresholds in continuous physiological variables really exist? Analysis of origin of apparent thresholds, with systematic review for peak oxygen consumption, ejection fraction and BNP
    Alberto Giannoni
    International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College, London, United Kingdom Department of Cardiovascular Medicine, Fondazione Toscana G Monasterio, Pisa, Italy
    PLoS ONE 9:e81699. 2014
    ..Clinicians are sometimes advised to make decisions using thresholds in measured variables, derived from prognostic studies...
  58. doi request reprint A statement on ethical standards in publishing scientific articles in the International Journal of Cardiology family of journals
    Louise G Shewan
    Monash University, Australia University of Warwick, Coventry, UK
    Int J Cardiol 170:253-4. 2014
    ..of Cardiology family of journals: The International Journal of Cardiology, IJC Heart & Vessels and IJC Metabolic & Endocrine are required to make a binding statement that they as authors adhere to the following principles: ..
  59. ncbi request reprint The regulation and measurement of plasma volume in heart failure
    Paul R Kalra
    Clinical Cardiology, National Heart and Lung Institute, London, United Kingdom
    J Am Coll Cardiol 39:1901-8. 2002
    ..Further studies evaluating plasma volume in HF may help to improve our understanding of the pathophysiologic mechanisms occurring in the development and progression of this complex condition...
  60. ncbi request reprint Echocardiography-derived variables predict outcome in patients with nonischemic dilated cardiomyopathy with or without a restrictive filling pattern
    Rajaa Faris
    Department of Clinical Cardiology, National Heart and Lung Institute, The Royal Brompton Hospital, Imperial College School of Science, Technology, and Medicine, London, United Kingdom
    Am Heart J 144:343-50. 2002
    ..In this study, we sought to assess the prognostic value of echocardiographic variables in patients with DCM and to assess the impact of a restrictive left ventricle filling pattern...
  61. ncbi request reprint Angiotensin type-1 receptor blockers in heart failure
    Andrew J S Coats
    National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Royal Brompton Hospital, London, UK
    Prog Cardiovasc Dis 44:231-42. 2002
    ..There is a worrying suggestion of a negative interaction when ARBs are added to beta-blockers, which is a reason for caution in using the ARBs, not a reason not to use beta-blockers...
  62. doi request reprint Adherence to ethical standards in publishing scientific articles: A statement from the International Journal of Cardiology
    Louise G Shewan
    Monash University, Australia University of Warwick, United Kingdom
    Int J Cardiol 161:124-5. 2012
    ..All authors of manuscripts in the International Journal of Cardiology are required to make a binding statement that they as authors adhere to the following principles:..
  63. ncbi request reprint Study of the Effects of Nebivolol Intervention on Outcomes and Rehospitalisation in Seniors with Heart Failure (SENIORS). Rationale and design
    Marcelo C Shibata
    Clinical Trials and Evaluation Unit, Royal Brompton and Harefield NHS Trust, London, UK
    Int J Cardiol 86:77-85. 2002
  64. ncbi request reprint A qualitative study of chronic heart failure patients' understanding of their symptoms and drug therapy
    Angie Rogers
    Department of Palliative Care and Policy, Kings College London, London, UK
    Eur J Heart Fail 4:283-7. 2002
    ..To explore patients' understanding of their symptoms and the treatment of their heart failure...
  65. ncbi request reprint Relationship of skeletal muscle metaboreceptors in the upper and lower limbs with the respiratory control in patients with heart failure
    Adam C Scott
    National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Dovehouse St, London SW3 6LY, U K
    Clin Sci (Lond) 102:23-30. 2002
    ..This suggests a unique mechanism responsible for overactivation of this system in the skeletal muscle of heart failure patients...
  66. ncbi request reprint Human pituitary growth hormone and cancer risk
    Paul R Kalra
    Lancet 360:1791-2. 2002
  67. ncbi request reprint Prediction of mortality in chronic heart failure from peak oxygen consumption adjusted for either body weight or lean tissue
    Mariantonietta Cicoira
    Divisione Clinicizzata di Cardiologia, Universita degli Studi di Verona, Italy
    J Card Fail 10:421-6. 2004
    ..We hypothesized that correcting pVO2 for lean tissue rather than total body weight would improve the prediction of prognosis in patients with chronic heart failure (CHF)...
  68. ncbi request reprint Oscillatory ventilation during exercise in patients with chronic heart failure: clinical correlates and prognostic implications
    Ugo Corra
    Division of Cardiology, Salvatore Maugeri Foundation, IRCCS, Veruno, Italy
    Chest 121:1572-80. 2002
    ..The aim of this study was to determine the prevalence, clinical characteristics, and outcome of patients with chronic heart failure and EOV...
  69. ncbi request reprint Influence of pretreatment systolic blood pressure on the effect of carvedilol in patients with severe chronic heart failure: the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) study
    Jean L Rouleau
    Montreal Heart Institute, University of Montreal, Montreal, Canada
    J Am Coll Cardiol 43:1423-9. 2004
    ..We sought to evaluate the influence of pretreatment systolic blood pressure (SBP) on the efficacy and safety of carvedilol in patients with chronic heart failure (CHF)...
  70. ncbi request reprint Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: an observational study
    Stefan D Anker
    Applied Cachexia Research, Department of Cardiology, Charite, Campus Virchow Klinikum, Berlin, Germany
    Lancet 361:1077-83. 2003
    ..We aimed to assess the frequency of weight loss in patients with this disease, whether the degree of weight loss predicts mortality, and whether weight loss can be prevented by angiotensin-converting-enzyme (ACE) inhibitors...
  71. ncbi request reprint NT-proBNP in severe chronic heart failure: rationale, design and preliminary results of the COPERNICUS NT-proBNP substudy
    Franz Hartmann
    Medizinische Klinik II, Universitaetsklinikum Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Eur J Heart Fail 6:343-50. 2004
    ..Neither profiles nor prognostic value of cardiac N-terminal proBNP (NT-proBNP) have been prospectively evaluated in a sufficient number of patients with severe chronic heart failure (CHF) treated with carvedilol or placebo...
  72. ncbi request reprint Uric acid and survival in chronic heart failure: validation and application in metabolic, functional, and hemodynamic staging
    Stefan D Anker
    Applied Cachexia Research Unit, Charite, Campus Virchow Klinikum, Berlin, Germany
    Circulation 107:1991-7. 2003
    ..Serum uric acid (UA) could be a valid prognostic marker and useful for metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF)...
  73. ncbi request reprint Ventricular long axis function is predictive of outcome in patients with chronic heart failure secondary to non-ischemic dilated cardiomyopathy
    Rajaa Faris
    Department of Clinical Cardiology, National Heart and Lung Institute, The Royal Brompton Hospital, Dovehouse Street, London SW3 6LY, U K
    Med Sci Monit 9:CR456-65. 2003
    ..We conducted this study to address this issue, and to determine the prognostic importance of sequential change in long axis function over time in patients with idiopathic DCM...
  74. ncbi request reprint Tolerability and dose-related effects of nebivolol in elderly patients with heart failure: data from the Study of the Effects of Nebivolol Intervention on Outcomes and Rehospitalisation in Seniors with Heart Failure (SENIORS) trial
    Daniela Dobre
    Department of Clinical Pharmacology, University Medical Centre Groningen, University of Groningen, The Netherlands
    Am Heart J 154:109-15. 2007
    ..We aimed to assess tolerability and dose-related effects of the beta-blocker nebivolol in elderly patients from the SENIORS trial...
  75. ncbi request reprint How to RECOVER from RENAISSANCE? The significance of the results of RECOVER, RENAISSANCE, RENEWAL and ATTACH
    Stefan D Anker
    Applied Cachexia Research, Department of Cardiology, Charite, Campus Virchow Klinikum, Berlin, Germany
    Int J Cardiol 86:123-30. 2002
    ..During follow-up, compared to placebo the hazard to reach this endpoint was similar in the medium dose group (RR 0.80, 95%CI 0.22-2.99), but increased in the high dose group (RR 2.84, 95%CI 1.01-7.97, p<0.05)...
  76. ncbi request reprint Effect of darbepoetin alfa on exercise tolerance in anemic patients with symptomatic chronic heart failure: a randomized, double-blind, placebo-controlled trial
    Piotr Ponikowski
    Cardiac Department, Military Hospital, Wroclaw, Poland
    J Am Coll Cardiol 49:753-62. 2007
    ..This study sought to investigate whether darbepoetin alfa, an erythropoiesis-stimulating protein (ESP), improves exercise capacity in patients with symptomatic chronic heart failure (CHF) and anemia...
  77. ncbi request reprint Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study
    Milton Packer
    College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Circulation 106:2194-9. 2002
    ..Beta-blocking agents improve functional status and reduce morbidity in mild-to-moderate heart failure, but it is not known whether they produce such benefits in severe heart failure...
  78. ncbi request reprint Carvedilol reduces the costs of medical care in severe heart failure: an economic analysis of the COPERNICUS study applied to the United Kingdom
    Simon Stewart
    Division of Health Sciences, University of South Australia, City East Campus, Adelaide 5000, Australia
    Int J Cardiol 100:143-9. 2005
    ..The aim of this study was to determine the effects of carvedilol on the costs related to the treatment of severe chronic heart failure (CHF)...
  79. ncbi request reprint Advances in the non-drug, non-surgical, non-device management of chronic heart failure
    Andrew J S Coats
    Int J Cardiol 100:1-4. 2005
    ..The day of the multi-disciplinary patient-centred CHF clinic has arrived and all sufferers deserve experienced management using all these approaches...
  80. ncbi request reprint Patient descriptions of breathlessness in heart failure
    Polly M Edmonds
    Department of Palliative Care and Policy, King s College London, King s Denmark Hill Campus, Weston Education Centre, Cutcombe Road, London SE5 9RJ, UK
    Int J Cardiol 98:61-6. 2005
    ..To explore patient experience of breathlessness in heart failure...
  81. ncbi request reprint Sleep-disordered breathing in a general heart failure population: relationships to neurohumoral activation and subjective symptoms
    Archana Rao
    Queen s Medical Centre, University of Nottingham, Nottingham, UK
    J Sleep Res 15:81-8. 2006
    ..Patients with SDB had higher activation of a neurohumoral marker and more severe HF. Unlike obstructive sleep apnoea, SDB in HF had little discernible effect on sleepiness or quality of life as measured by standard subjective scales...
  82. ncbi request reprint Beta-adrenoceptor antagonists in elderly patients with chronic heart failure: therapeutic potential of third-generation agents
    Andrew J S Coats
    Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
    Drugs Aging 23:93-9. 2006
    ..In conclusion, prescribers are advised that nebivolol should be preferred in elderly patients with CHF, because of its proven efficacy in a representative group of elderly CHF patients...
  83. ncbi request reprint Statin use and survival in patients with chronic heart failure--results from two observational studies with 5200 patients
    Stefan D Anker
    Applied Cachexia Research, Department of Cardiology, Charite Campus Virchow Klinikum, Berlin, Germany
    Int J Cardiol 112:234-42. 2006
    ..Treatment with statins may lead to a lower mortality in CHF, independent of cholesterol levels, CHF etiology and clinical status...
  84. ncbi request reprint The epidemiology of heart failure in Australia
    Anthony S McLean
    Department of Intensive Care Medicine, Nepean Hospital, The University of Sydney, Penrith, New South Wales, Australia
    Int J Cardiol 118:370-4. 2007
    ..Australia has one of the highest rates of cardiovascular disease in the world with heart failure representing a large proportion of this group, yet there is minimal data on the incidence or prevalence...
  85. ncbi request reprint Physical training modulates proinflammatory cytokines and the soluble Fas/soluble Fas ligand system in patients with chronic heart failure
    Stamatis Adamopoulos
    Second Department of Cardiovascular Medicine, Onassis Cardiac Surgery Center, Athens, Greece
    J Am Coll Cardiol 39:653-63. 2002
    ..We sought to investigate the effects of physical training on circulating proinflammatory cytokines and the soluble apoptosis mediators Fas (sFas) and Fas ligand (sFasL) in patients with chronic heart failure (CHF)...