Nicola Clementi

Summary

Affiliation: San Raffaele Scientific Institute
Location: Milan, Italy
Summary:
Board Certified Specialist in Microbiology and Virology
Working on the dissection of the human humoral immune response directed against the most important human pathogens such as: HCV, HIV, Influenza Viruses, HSV, CMV, JCV, BK, S. aureus, C. difficile, A. fumigatus, A. niger, A. flavus
Publications:
Hepatitis C virus (HCV) infection may elicit neutralizing antibodies targeting epitopes conserved in all viral genotypes
N Mancini, RA Diotti, M Perotti, G Sautto, N Clementi, G Nitti, AH Patel, JK ...
PloS one 4 (12), e8254


Hepatitis C virus (HCV)-driven stimulation of subfamily-restricted natural IgM antibodies in mixed cryoglobulinemia
M Perotti, N Ghidoli, R Altara, RA Diotti, N Clementi, D De Marco, M Sassi ...
Autoimmunity Reviews 7 (6), 468-472


Monoclonal antibodies isolated from human B cells neutralize a broad range of H1 subtype influenza A viruses including swine-origin Influenza virus (S-OIV)
R Burioni, F Canducci, N Mancini, N Clementi, M Sassi, D De Marco, RA Diotti ...
Virology 399 (1), 144-152


A Human Monoclonal Antibody with Neutralizing Activity against Highly Divergent Influenza Subtypes
N Clementi, D De Marco, N Mancini, L Solforosi, GJ Moreno, LV Gubareva, V ...
PloS one 6 (12), e28001


A Non-VH1-69 Heterosubtypic Neutralizing Human Monoclonal Antibody Protects Mice against H1N1 and H5N1 Viruses
D De Marco, N Clementi, N Mancini, L Solforosi, GJ Moreno, X Sun, TM Tumpey ...
PloS one 7 (4), e34415


A potential role for monoclonal antibodies in prophylactic and therapeutic treatment of influenza
N Mancini, L Solforosi, N Clementi, D De Marco, M Clementi, R Burioni
Antiviral research


Molecular cloning of the first human monoclonal antibodies neutralizing with high potency Swine-origin Influenza A pandemic virus (S-OIV).
R Burioni, F Canducci, N Mancini, N Clementi, M Sassi, D De Marco, D Saita ...
The new microbiologica 32 (4), 319


Anti-HIV-1 response elicited in rabbits by anti-idiotype monoclonal antibodies mimicking the CD4-binding site
R Burioni, N Mancini, D De Marco, N Clementi, M Perotti, G Nitti, M Sassi, F ...
PloS one 3 (10), e3423


Phage Display-based Strategies for Cloning and Optimization of Monoclonal Antibodies Directed against Human Pathogens
N Clementi, N Mancini, L Solforosi, M Castelli, M Clementi, R Burioni
International Journal of Molecular Sciences 13 (7), 8273-8292


A phage display vector optimized for the generation of human antibody combinatorial libraries and the molecular cloning of monoclonal antibody fragments
L Solforosi, N Mancini, F Canducci, N Clementi, GA Sautto, RA Diotti, M ...
NEW MICROBIOLOGICA 35, 289-294


Antigen-driven evolution of B lymphocytes in coronary atherosclerotic plaques
R Burioni, F Canducci, D Saita, M Perotti, N Mancini, D De Marco, N Clementi ...
The Journal of Immunology 183 (4), 2537-2544


Neutralization Interfering Antibodies: A

Publications

  1. ncbi request reprint Hepatitis C virus (HCV)-driven stimulation of subfamily-restricted natural IgM antibodies in mixed cryoglobulinemia
    Mario Perotti
    Laboratorio di Microbiologia e Virologia, Universita Vita Salute San Raffaele, Milan, Italy
    Autoimmun Rev 7:468-72. 2008
  2. ncbi request reprint A phage display vector optimized for the generation of human antibody combinatorial libraries and the molecular cloning of monoclonal antibody fragments
    Laura Solforosi
    Laboratory of Microbiology and Virology, Vita Salute San Raffaele University, Milan, Italy
    New Microbiol 35:289-94. 2012
  3. pmc A non-VH1-69 heterosubtypic neutralizing human monoclonal antibody protects mice against H1N1 and H5N1 viruses
    Donata De Marco
    Laboratory of Microbiology and Virology, Vita Salute San Raffaele University, Milan, Italy
    PLoS ONE 7:e34415. 2012
  4. pmc A human monoclonal antibody with neutralizing activity against highly divergent influenza subtypes
    Nicola Clementi
    Laboratorio di Microbiologia e Virologia, Universita Vita Salute San Raffaele, Milano, Italia
    PLoS ONE 6:e28001. 2011
  5. ncbi request reprint Molecular cloning of the first human monoclonal antibodies neutralizing with high potency swine-origin influenza A pandemic virus (S-OIV)
    Roberto Burioni
    Laboratorio di Microbiologia e Virologia, Universita Vita Salute San Raffaele, Milano, Italy
    New Microbiol 32:319-24. 2009
  6. doi request reprint Monoclonal antibodies isolated from human B cells neutralize a broad range of H1 subtype influenza A viruses including swine-origin Influenza virus (S-OIV)
    Roberto Burioni
    Laboratorio di Microbiologia e Virologia, Universita Vita Salute San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Virology 399:144-52. 2010
  7. pmc Hepatitis C virus (HCV) infection may elicit neutralizing antibodies targeting epitopes conserved in all viral genotypes
    Nicasio Mancini
    Laboratorio di Microbiologia e Virologia, Universita Vita Salute San Raffaele, Milano, Italia
    PLoS ONE 4:e8254. 2009
  8. doi request reprint Antigen-driven evolution of B lymphocytes in coronary atherosclerotic plaques
    Roberto Burioni
    Universita Vita Salute San Raffaele, Milano, Italy
    J Immunol 183:2537-44. 2009
  9. pmc Anti-HIV-1 response elicited in rabbits by anti-idiotype monoclonal antibodies mimicking the CD4-binding site
    Roberto Burioni
    Laboratorio di Microbiologia e Virologia, Universita Vita Salute San Raffaele, Istituto Scientifico San Raffaele, Diagnostica e Ricerca San Raffaele, Milano, Italy
    PLoS ONE 3:e3423. 2008
  10. pmc Phage Display-based Strategies for Cloning and Optimization of Monoclonal Antibodies Directed against Human Pathogens
    Nicola Clementi
    Microbiology and Virology Unit, Vita Salute San Raffaele University, Milan 20132, Italy E Mails N M L S M C M C R B
    Int J Mol Sci 13:8273-92. 2012

Detail Information

Publications10

  1. ncbi request reprint Hepatitis C virus (HCV)-driven stimulation of subfamily-restricted natural IgM antibodies in mixed cryoglobulinemia
    Mario Perotti
    Laboratorio di Microbiologia e Virologia, Universita Vita Salute San Raffaele, Milan, Italy
    Autoimmun Rev 7:468-72. 2008
    ..An antigen-driven stimulation of these subfamilies, and their overexpression as in HCV infection, could lead to a breaking of humoral homeostatic balance exposing the patients to the risk of developing autoimmune disorders...
  2. ncbi request reprint A phage display vector optimized for the generation of human antibody combinatorial libraries and the molecular cloning of monoclonal antibody fragments
    Laura Solforosi
    Laboratory of Microbiology and Virology, Vita Salute San Raffaele University, Milan, Italy
    New Microbiol 35:289-94. 2012
    ..The phagemid pCM was used to generate a human combinatorial phage display antibody library that allowed the selection of a monoclonal Fab fragment antibody directed against the nucleoprotein (NP) of Influenza A virus...
  3. pmc A non-VH1-69 heterosubtypic neutralizing human monoclonal antibody protects mice against H1N1 and H5N1 viruses
    Donata De Marco
    Laboratory of Microbiology and Virology, Vita Salute San Raffaele University, Milan, Italy
    PLoS ONE 7:e34415. 2012
    ..Furthermore, we describe its protective activity in mice after lethal challenge with H1N1 and H5N1 viruses suggesting a potential application in the treatment of influenza virus infections...
  4. pmc A human monoclonal antibody with neutralizing activity against highly divergent influenza subtypes
    Nicola Clementi
    Laboratorio di Microbiologia e Virologia, Universita Vita Salute San Raffaele, Milano, Italia
    PLoS ONE 6:e28001. 2011
    ..A deep characterization of PN-SIA28 features may represent a useful help in the improvement of available anti-influenza therapeutic strategies and can provide new tools for the development of universal vaccinal strategies...
  5. ncbi request reprint Molecular cloning of the first human monoclonal antibodies neutralizing with high potency swine-origin influenza A pandemic virus (S-OIV)
    Roberto Burioni
    Laboratorio di Microbiologia e Virologia, Universita Vita Salute San Raffaele, Milano, Italy
    New Microbiol 32:319-24. 2009
    ..This is the first report of molecular cloning of human monoclonal antibodies against the new pandemic swine-origin influenza virus...
  6. doi request reprint Monoclonal antibodies isolated from human B cells neutralize a broad range of H1 subtype influenza A viruses including swine-origin Influenza virus (S-OIV)
    Roberto Burioni
    Laboratorio di Microbiologia e Virologia, Universita Vita Salute San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Virology 399:144-52. 2010
    ..Finally, the human genes coding for the neutralizing HMabs could be used for generating full human monoclonal IgGs that can be safely administered being potentially useful in the prophylaxis and the treatment of this human infection...
  7. pmc Hepatitis C virus (HCV) infection may elicit neutralizing antibodies targeting epitopes conserved in all viral genotypes
    Nicasio Mancini
    Laboratorio di Microbiologia e Virologia, Universita Vita Salute San Raffaele, Milano, Italia
    PLoS ONE 4:e8254. 2009
    ..Their availability may open new avenues to the understanding of HCV persistence and to the development of strategies for the immune control of this infection...
  8. doi request reprint Antigen-driven evolution of B lymphocytes in coronary atherosclerotic plaques
    Roberto Burioni
    Universita Vita Salute San Raffaele, Milano, Italy
    J Immunol 183:2537-44. 2009
    ..The data document for the first time the presence of a local Ag-driven clonal evolution of B cells in human atherosclerotic plaques...
  9. pmc Anti-HIV-1 response elicited in rabbits by anti-idiotype monoclonal antibodies mimicking the CD4-binding site
    Roberto Burioni
    Laboratorio di Microbiologia e Virologia, Universita Vita Salute San Raffaele, Istituto Scientifico San Raffaele, Diagnostica e Ricerca San Raffaele, Milano, Italy
    PLoS ONE 3:e3423. 2008
    ....
  10. pmc Phage Display-based Strategies for Cloning and Optimization of Monoclonal Antibodies Directed against Human Pathogens
    Nicola Clementi
    Microbiology and Virology Unit, Vita Salute San Raffaele University, Milan 20132, Italy E Mails N M L S M C M C R B
    Int J Mol Sci 13:8273-92. 2012
    ..In this paper, we review the principal phage display strategies used to select anti-infectious mAbs, with particular attention focused on those used against hypervariable pathogens, such as HCV and influenza viruses...