A Clegg

Summary

Publications

  1. doi request reprint Informing a decision framework for when NICE should recommend the use of health technologies only in the context of an appropriately designed programme of evidence development
    K Claxton
    Centre for Health Economics, University of York, York, UK
    Health Technol Assess 16:1-323. 2012
  2. ncbi request reprint Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care
    M Thompson
    Department of Primary Care Health Sciences, Oxford University, Oxford, UK
    Health Technol Assess 16:1-100. 2012
  3. ncbi request reprint The clinical effectiveness and cost-effectiveness of topotecan for small cell lung cancer: a systematic review and economic evaluation
    E Loveman
    Southampton Health Technology Assessments Centre, University of Southampton Science Park, Southampton, UK
    Health Technol Assess 14:1-204. 2010
  4. ncbi request reprint A rapid and systematic review of the clinical effectiveness and cost-effectiveness of paclitaxel, docetaxel, gemcitabine and vinorelbine in non-small-cell lung cancer
    A Clegg
    Southampton Health Technology Assessments Centre, Wessex Institute for Health Research and Development, University of Southampton, UK
    Health Technol Assess 5:1-195. 2001
  5. ncbi request reprint The clinical and cost-effectiveness of donepezil, rivastigmine, galantamine and memantine for Alzheimer's disease
    E Loveman
    Southampton Health Technology Assessments Centre, Wessex Institute for Health Research and Development, University of Southampton, UK
    Health Technol Assess 10:iii-iv, ix-xi, 1-160. 2006
  6. ncbi request reprint Using process data to understand outcomes in sexual health promotion: an example from a review of school-based programmes to prevent sexually transmitted infections
    J Shepherd
    Southampton Health Technology Assessments Centre SHTAC, University of Southampton, Southampton SO16 7NS, UK, Institute for Health and Human Development, University of East London, London E15 4LZ, UK and Social Science Research Unit, University of London, London WC1H 0AL, UK
    Health Educ Res 29:566-82. 2014
  7. doi request reprint Diagnostic strategies using DNA testing for hereditary haemochromatosis in at-risk populations: a systematic review and economic evaluation
    J Bryant
    Southampton Health Technology Assessments Centre, Wessex Institute for Health Research and Development, University of Southampton, UK
    Health Technol Assess 13:iii, ix-xi, 1-126. 2009
  8. ncbi request reprint Lapatinib for the treatment of HER2-overexpressing breast cancer
    J Jones
    Southampton Health Technology Assessments Centre, Wessex Institute for Health Research and Development, University of Southampton, UK
    Health Technol Assess 13:1-6. 2009
  9. doi request reprint Gemcitabine for the treatment of metastatic breast cancer
    J Jones
    Southampton Health Technology Assessments Centre, Southampton, UK
    Health Technol Assess 13:1-7. 2009
  10. doi request reprint The clinical effectiveness and cost-effectiveness of long-term weight management schemes for adults: a systematic review
    E Loveman
    Southampton Health Technology Assessments Centre, UK
    Health Technol Assess 15:1-182. 2011

Detail Information

Publications23

  1. doi request reprint Informing a decision framework for when NICE should recommend the use of health technologies only in the context of an appropriately designed programme of evidence development
    K Claxton
    Centre for Health Economics, University of York, York, UK
    Health Technol Assess 16:1-323. 2012
    ..Establishing the key principles of what assessments are needed, as well as how they should be made, will enable them to be addressed in an explicit and transparent manner...
  2. ncbi request reprint Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care
    M Thompson
    Department of Primary Care Health Sciences, Oxford University, Oxford, UK
    Health Technol Assess 16:1-100. 2012
    ..This can result in misdiagnosis of children with serious infections, which results in a poorer health outcome, or a tendency to refer or admit children as a precaution; thus, inappropriately utilising secondary-care resources...
  3. ncbi request reprint The clinical effectiveness and cost-effectiveness of topotecan for small cell lung cancer: a systematic review and economic evaluation
    E Loveman
    Southampton Health Technology Assessments Centre, University of Southampton Science Park, Southampton, UK
    Health Technol Assess 14:1-204. 2010
    ..To assess the clinical effectiveness and cost-effectiveness of topotecan as second-line treatment for small cell lung cancer (SCLC)...
  4. ncbi request reprint A rapid and systematic review of the clinical effectiveness and cost-effectiveness of paclitaxel, docetaxel, gemcitabine and vinorelbine in non-small-cell lung cancer
    A Clegg
    Southampton Health Technology Assessments Centre, Wessex Institute for Health Research and Development, University of Southampton, UK
    Health Technol Assess 5:1-195. 2001
    ..This research would be aided by having a greater proportion of patients involved in trials, but there will be infrastructure implications of increased participation...
  5. ncbi request reprint The clinical and cost-effectiveness of donepezil, rivastigmine, galantamine and memantine for Alzheimer's disease
    E Loveman
    Southampton Health Technology Assessments Centre, Wessex Institute for Health Research and Development, University of Southampton, UK
    Health Technol Assess 10:iii-iv, ix-xi, 1-160. 2006
    ....
  6. ncbi request reprint Using process data to understand outcomes in sexual health promotion: an example from a review of school-based programmes to prevent sexually transmitted infections
    J Shepherd
    Southampton Health Technology Assessments Centre SHTAC, University of Southampton, Southampton SO16 7NS, UK, Institute for Health and Human Development, University of East London, London E15 4LZ, UK and Social Science Research Unit, University of London, London WC1H 0AL, UK
    Health Educ Res 29:566-82. 2014
    ..It is recommended that process indicators such as these be assessed in future evaluations of school-based sexual health behavioural interventions, as part of a logic model. ..
  7. doi request reprint Diagnostic strategies using DNA testing for hereditary haemochromatosis in at-risk populations: a systematic review and economic evaluation
    J Bryant
    Southampton Health Technology Assessments Centre, Wessex Institute for Health Research and Development, University of Southampton, UK
    Health Technol Assess 13:iii, ix-xi, 1-126. 2009
    ..To evaluate DNA testing for detecting hereditary haemochromatosis (HHC) in subgroups of patients suspected of having the disorder and in family members of those diagnosed with HHC...
  8. ncbi request reprint Lapatinib for the treatment of HER2-overexpressing breast cancer
    J Jones
    Southampton Health Technology Assessments Centre, Wessex Institute for Health Research and Development, University of Southampton, UK
    Health Technol Assess 13:1-6. 2009
    ..At the time of writing, NICE were still considering the available evidence for this appraisal...
  9. doi request reprint Gemcitabine for the treatment of metastatic breast cancer
    J Jones
    Southampton Health Technology Assessments Centre, Southampton, UK
    Health Technol Assess 13:1-7. 2009
    ....
  10. doi request reprint The clinical effectiveness and cost-effectiveness of long-term weight management schemes for adults: a systematic review
    E Loveman
    Southampton Health Technology Assessments Centre, UK
    Health Technol Assess 15:1-182. 2011
    ..To assess the long-term clinical effectiveness and cost-effectiveness of multicomponent weight management schemes for adults in terms of weight loss and maintenance of weight loss...
  11. ncbi request reprint A decision analysis model for diagnostic strategies using DNA testing for hereditary haemochromatosis in at risk populations
    K Cooper
    Southampton Health Technology Assessments Centre, Boldrewood, University of Southampton, Southampton, SO16 7PX
    QJM 101:631-41. 2008
    ..New techniques for diagnosing hereditary haemochromatosis (HHC) have become available alongside traditional tests such as liver biopsy and serum iron studies...
  12. doi request reprint Dasatinib, high-dose imatinib and nilotinib for the treatment of imatinib-resistant chronic myeloid leukaemia: a systematic review and economic evaluation
    E Loveman
    Southampton Health Technology Assessments Centre SHTAC, University of Southampton, Southampton, UK
    Health Technol Assess 16:iii-xiii, 1-137. 2012
    ....
  13. doi request reprint The effectiveness and cost-effectiveness of behavioural interventions for the prevention of sexually transmitted infections in young people aged 13-19: a systematic review and economic evaluation
    J Shepherd
    Southampton Health Technology Assessments Centre, UK
    Health Technol Assess 14:1-206, iii-iv. 2010
    ....
  14. ncbi request reprint Bortezomib for the treatment of multiple myeloma patients
    C Green
    Southampton Health Technology Assessments Centre, Wessex Institute for Health Research and Development, University of Southampton, UK
    Health Technol Assess 13:29-33. 2009
    ....
  15. ncbi request reprint Infliximab for the treatment of adults with psoriasis
    E Loveman
    Southampton Health Technology Assessments Centre, Wessex Institute for Health Research and Development, University of Southampton, UK
    Health Technol Assess 13:55-60. 2009
    ..In addition, when using the Dermatology Life Quality Index (DLQI), care should be taken to take into account the patient's disabilities, to ensure DLQI continues to be an accurate measure...
  16. ncbi request reprint Are educational interventions to prevent catheter-related bloodstream infections in intensive care unit cost-effective?
    K Cooper
    Southampton Health Technology Assessments Centre, University of Southampton, Southampton, UK Electronic address
    J Hosp Infect 86:47-52. 2014
    ..It is unclear how effective these are at reducing the risk of bloodstream infections from the use of intravascular catheters (catheter-BSIs) and the associated costs and health benefits...
  17. ncbi request reprint Clinical and cost effectiveness of surgery for morbid obesity: a systematic review and economic evaluation
    A Clegg
    Southampton Health Technology Assessments Centre SHTAC, Wessex Institute for Health Research and Development, University of Southampton, Southampton, UK
    Int J Obes Relat Metab Disord 27:1167-77. 2003
    ..To assess the clinical and cost effectiveness of surgery for people with morbid obesity...
  18. ncbi request reprint The clinical and cost-effectiveness of implantable cardioverter defibrillators: a systematic review
    J Bryant
    Southampton Health Technology Assessments Centre, Wessex Institute for Health Research and Development, University of Southampton, UK
    Health Technol Assess 9:1-150, iii. 2005
    ..To consider the clinical effectiveness and cost-effectiveness of implantable cardioverter defibrillators (ICDs) for arrhythmias...
  19. ncbi request reprint A systematic review of the clinical effectiveness of donepezil, rivastigmine and galantamine on cognition, quality of life and adverse events in Alzheimer's disease
    A Takeda
    Southampton Health Technology Assessments Centre SHTAC, University of Southampton, Southampton, UK
    Int J Geriatr Psychiatry 21:17-28. 2006
    ..This article provides the latest evidence that NICE will be using as part of this appraisal process...
  20. ncbi request reprint Cardioprotection against the toxic effects of anthracyclines given to children with cancer: a systematic review
    J Bryant
    Southampton Health Technology Assessments Centre, Wessex Institute for Health Research and Development, University of Southampton, UK
    Health Technol Assess 11:iii, ix-x, 1-84. 2007
    ..To evaluate the technologies used to reduce anthracycline-induced cardiotoxicity in children. Also to evaluate cardiac markers to quantify cardiotoxicity, and identify cost-effectiveness studies and future research priorities...
  21. ncbi request reprint A systematic review of the clinical validity and clinical utility of DNA testing for hereditary haemochromatosis type 1 in at-risk populations
    J Bryant
    Southampton Health Technology Assessments Centre, Mailpoint 728, Boldrewood, University of Southampton, Southampton SO167PX, UK
    J Med Genet 45:513-8. 2008
    ..To evaluate the clinical validity and clinical utility of DNA testing in people suspected of having hereditary haemochromatosis and in family members of those diagnosed with the disorder...
  22. ncbi request reprint Immunomodulatory drugs for multiple sclerosis: a systematic review of clinical and cost effectiveness
    A Clegg
    Southampton Health Technology Assessments Centre, Wessex Institute for Health Research and Development, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, Southampton SO16 7PX, UK
    Expert Opin Pharmacother 2:623-39. 2001
    ..The inadequacies in the evidence of clinical and cost effectiveness on some immunomodulatory drugs for the treatment of people with MS necessitate further rigorous RCTs and comparative economic evaluations of different alternatives...
  23. pmc Clinical and cost effectiveness of paclitaxel, docetaxel, gemcitabine, and vinorelbine in non-small cell lung cancer: a systematic review
    A Clegg
    Southampton Health Technology Assessments Centre, Wessex Institute for Health Research and Development, University of Southampton, Southampton SO16 7PX, UK
    Thorax 57:20-8. 2002
    ..Recent developments in chemotherapy have led to cautious optimism. This paper reviews the evidence on the clinical and cost effectiveness of four of the new generation drugs for patients with lung cancer...