Targeting the adiponectin:leptin ratio for postmenopausal breast cancer preventionMargot P Cleary
The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Front Biosci (Schol Ed) 1:329-57. 2009
..Additionally, we propose strategies to alter this ratio and thus provide protection against the development of breast cancer...
- Genotype and diet effects in lean and obese Zucker rats fed either safflower or coconut oil diets
M P Cleary
Hormel Institute, University of Minnesota, Austin 55912, USA
Proc Soc Exp Biol Med 220:153-61. 1999
..However, high-fat feeding did not result in a heterozygous effect in young adult lean male rats. We will next evaluate the role of sex on this effect...
Minireview: Obesity and breast cancer: the estrogen connectionMargot P Cleary
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Endocrinology 150:2537-42. 2009
..Human and relevant preclinical studies are cited. In addition, other growth factors that may be involved in this relationship are considered...
- Restoration of fertility in young obese (Lep(ob) Lep(ob)) male mice with low dose recombinant mouse leptin treatment
M P Cleary
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Int J Obes Relat Metab Disord 25:95-7. 2001
..We investigated the effects of low-dose leptin treatment on restoration of fertility in young adult male leptin deficient obese mice...
- The presence of the "fa" gene in heterozygous (FA/fa) lean female rats, effects on body weight, body fat and serum leptin
M P Cleary
Hormel Institute, University of Minnesota, Austin 55912, USA
Obes Res 7:293-8. 1999
..In the present study, the effect of the "fa" gene on body weight and body fat in lean female rats was investigated...
- Leptin--a growth factor in normal and malignant breast cells and for normal mammary gland development
Xin Hu
The Hormel Institute, University of Minnesota, Austin 55912, USA
J Natl Cancer Inst 94:1704-11. 2002
..Consequently, the leptin pathway should be further studied as a target for interventions to treat or prevent breast cancer...
- Genetically obese MMTV-TGF-alpha/Lep(ob)Lep(ob) female mice do not develop mammary tumors
Margot P Cleary
The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Breast Cancer Res Treat 77:205-15. 2003
..However, the finding that increased body weight is associated with increased oncogene-induced MT development within the normal weight range provides experimental support for the role of body weight in breast cancer...
- Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors
Margot P Cleary
Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
Exp Biol Med (Maywood) 229:182-93. 2004
..This study provides additional evidence that leptin and its cognate receptor may be involved in mammary tumorigenesis...
- Diet-induced obesity and mammary tumor development in relation to estrogen receptor status
Amitabha Ray
Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Cancer Lett 253:291-300. 2007
..In conclusion, diet rather than serum leptin impacted breast cancer cell tumor metabolism...
- Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status
Amitabha Ray
Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Int J Oncol 30:1499-509. 2007
..Continued study on leptin may be helpful for a better understanding of breast cancer development in obese women...
- Effects of high-fat diet and/or body weight on mammary tumor leptin and apoptosis signaling pathways in MMTV-TGF-alpha mice
Soner Dogan
Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
Breast Cancer Res 9:R91. 2007
..One link between obesity and breast cancer is the adipokine, leptin. Here, the focus is on diet-induced obesity and MT and mammary fat pad (MFP) leptin and apoptotic signaling proteins...
- Diet-induced obesity and mammary tumor development in MMTV-neu female mice
Margot P Cleary
Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Nutr Cancer 50:174-80. 2004
..0001). MT latency, incidence, metastasis, and burden were similar for all groups. These findings support that obesity is not a risk factor for development of estrogen-negative breast cancer...
