MARGOT CLEARY

Summary

Publications

  1. ncbi request reprint Targeting the adiponectin:leptin ratio for postmenopausal breast cancer prevention
    Margot P Cleary
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Front Biosci (Schol Ed) 1:329-57. 2009
  2. ncbi request reprint Genotype and diet effects in lean and obese Zucker rats fed either safflower or coconut oil diets
    M P Cleary
    Hormel Institute, University of Minnesota, Austin 55912, USA
    Proc Soc Exp Biol Med 220:153-61. 1999
  3. pmc Minireview: Obesity and breast cancer: the estrogen connection
    Margot P Cleary
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Endocrinology 150:2537-42. 2009
  4. ncbi request reprint Restoration of fertility in young obese (Lep(ob) Lep(ob)) male mice with low dose recombinant mouse leptin treatment
    M P Cleary
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Int J Obes Relat Metab Disord 25:95-7. 2001
  5. ncbi request reprint The presence of the "fa" gene in heterozygous (FA/fa) lean female rats, effects on body weight, body fat and serum leptin
    M P Cleary
    Hormel Institute, University of Minnesota, Austin 55912, USA
    Obes Res 7:293-8. 1999
  6. ncbi request reprint Leptin--a growth factor in normal and malignant breast cells and for normal mammary gland development
    Xin Hu
    The Hormel Institute, University of Minnesota, Austin 55912, USA
    J Natl Cancer Inst 94:1704-11. 2002
  7. ncbi request reprint Genetically obese MMTV-TGF-alpha/Lep(ob)Lep(ob) female mice do not develop mammary tumors
    Margot P Cleary
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Breast Cancer Res Treat 77:205-15. 2003
  8. ncbi request reprint Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors
    Margot P Cleary
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Exp Biol Med (Maywood) 229:182-93. 2004
  9. ncbi request reprint Diet-induced obesity and mammary tumor development in relation to estrogen receptor status
    Amitabha Ray
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Cancer Lett 253:291-300. 2007
  10. ncbi request reprint Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status
    Amitabha Ray
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Int J Oncol 30:1499-509. 2007

Research Grants

Collaborators

  • Amitabha Ray
  • Xin Hu
  • Soner Dogan
  • Nita J Maihle
  • Joseph P Grande
  • Yan Zhang
  • Subhash C Juneja

Detail Information

Publications12

  1. ncbi request reprint Targeting the adiponectin:leptin ratio for postmenopausal breast cancer prevention
    Margot P Cleary
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Front Biosci (Schol Ed) 1:329-57. 2009
    ..Additionally, we propose strategies to alter this ratio and thus provide protection against the development of breast cancer...
  2. ncbi request reprint Genotype and diet effects in lean and obese Zucker rats fed either safflower or coconut oil diets
    M P Cleary
    Hormel Institute, University of Minnesota, Austin 55912, USA
    Proc Soc Exp Biol Med 220:153-61. 1999
    ..However, high-fat feeding did not result in a heterozygous effect in young adult lean male rats. We will next evaluate the role of sex on this effect...
  3. pmc Minireview: Obesity and breast cancer: the estrogen connection
    Margot P Cleary
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Endocrinology 150:2537-42. 2009
    ..Human and relevant preclinical studies are cited. In addition, other growth factors that may be involved in this relationship are considered...
  4. ncbi request reprint Restoration of fertility in young obese (Lep(ob) Lep(ob)) male mice with low dose recombinant mouse leptin treatment
    M P Cleary
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Int J Obes Relat Metab Disord 25:95-7. 2001
    ..We investigated the effects of low-dose leptin treatment on restoration of fertility in young adult male leptin deficient obese mice...
  5. ncbi request reprint The presence of the "fa" gene in heterozygous (FA/fa) lean female rats, effects on body weight, body fat and serum leptin
    M P Cleary
    Hormel Institute, University of Minnesota, Austin 55912, USA
    Obes Res 7:293-8. 1999
    ..In the present study, the effect of the "fa" gene on body weight and body fat in lean female rats was investigated...
  6. ncbi request reprint Leptin--a growth factor in normal and malignant breast cells and for normal mammary gland development
    Xin Hu
    The Hormel Institute, University of Minnesota, Austin 55912, USA
    J Natl Cancer Inst 94:1704-11. 2002
    ....
  7. ncbi request reprint Genetically obese MMTV-TGF-alpha/Lep(ob)Lep(ob) female mice do not develop mammary tumors
    Margot P Cleary
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Breast Cancer Res Treat 77:205-15. 2003
    ..However, the finding that increased body weight is associated with increased oncogene-induced MT development within the normal weight range provides experimental support for the role of body weight in breast cancer...
  8. ncbi request reprint Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors
    Margot P Cleary
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Exp Biol Med (Maywood) 229:182-93. 2004
    ..This study provides additional evidence that leptin and its cognate receptor may be involved in mammary tumorigenesis...
  9. ncbi request reprint Diet-induced obesity and mammary tumor development in relation to estrogen receptor status
    Amitabha Ray
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Cancer Lett 253:291-300. 2007
    ..In conclusion, diet rather than serum leptin impacted breast cancer cell tumor metabolism...
  10. ncbi request reprint Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status
    Amitabha Ray
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Int J Oncol 30:1499-509. 2007
    ..Continued study on leptin may be helpful for a better understanding of breast cancer development in obese women...
  11. pmc Effects of high-fat diet and/or body weight on mammary tumor leptin and apoptosis signaling pathways in MMTV-TGF-alpha mice
    Soner Dogan
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Breast Cancer Res 9:R91. 2007
    ..One link between obesity and breast cancer is the adipokine, leptin. Here, the focus is on diet-induced obesity and MT and mammary fat pad (MFP) leptin and apoptotic signaling proteins...
  12. ncbi request reprint Diet-induced obesity and mammary tumor development in MMTV-neu female mice
    Margot P Cleary
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Nutr Cancer 50:174-80. 2004
    ..0001). MT latency, incidence, metastasis, and burden were similar for all groups. These findings support that obesity is not a risk factor for development of estrogen-negative breast cancer...

Research Grants5

  1. Intermittent food restriction prevents mammary tumors
    MARGOT CLEARY; Fiscal Year: 2006
    ..Our long-term objectives are to establish nutrition intervention strategies applicable to humans and/or to provide insights leading to the development of chemopreventive agents to mimic this protective effect. ..
  2. Intermittent food restriction prevents mammary tumors
    MARGOT CLEARY; Fiscal Year: 2007
    ..Our long-term objectives are to establish nutrition intervention strategies applicable to humans and/or to provide insights leading to the development of chemopreventive agents to mimic this protective effect. ..