Thomas W Clarkson

Summary

Publications

  1. ncbi The toxicology of mercury and its chemical compounds
    Thomas W Clarkson
    Department of Environmental Medicine, University of Rochester School of Medicine, New York, USA
    Crit Rev Toxicol 36:609-62. 2006
  2. pmc The three modern faces of mercury
    Thomas W Clarkson
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Environ Health Perspect 110:11-23. 2002
  3. ncbi Mechanisms of mercury disposition in the body
    Thomas W Clarkson
    Department of Environmental Medicine, Rochester School of Medicine, Rochester, New York, USA
    Am J Ind Med 50:757-64. 2007
  4. ncbi Nutritional factors may modify the toxic action of methyl mercury in fish-eating populations
    Thomas W Clarkson
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Nutr 133:1539S-43S. 2003
  5. ncbi The toxicology of mercury--current exposures and clinical manifestations
    Thomas W Clarkson
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    N Engl J Med 349:1731-7. 2003
  6. pmc Prenatal exposure to dental amalgam: evidence from the Seychelles Child Development Study main cohort
    GENE E WATSON
    Eastman Institute for Oral Health, Department of Environmental Medicine, and Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester, N Y, USA
    J Am Dent Assoc 142:1283-94. 2011
  7. pmc Is susceptibility to prenatal methylmercury exposure from fish consumption non-homogeneous? Tree-structured analysis for the Seychelles Child Development Study
    Li Shan Huang
    Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Neurotoxicology 28:1237-44. 2007
  8. pmc Fish consumption and prenatal methylmercury exposure: cognitive and behavioral outcomes in the main cohort at 17 years from the Seychelles child development study
    Philip W Davidson
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Neurotoxicology 32:711-7. 2011
  9. ncbi Methylmercury and neurodevelopment: longitudinal analysis of the Seychelles child development cohort
    Philip W Davidson
    The Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642, USA
    Neurotoxicol Teratol 28:529-35. 2006
  10. pmc Varying coefficient function models to explore interactions between maternal nutritional status and prenatal methylmercury toxicity in the Seychelles Child Development Nutrition Study
    Miranda L Lynch
    Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Environ Res 111:75-80. 2011

Research Grants

  1. DEVELOPMENTAL TOXICITY OF METHYLMERCURY
    Thomas Clarkson; Fiscal Year: 2001
  2. TOXICITY OF METHYL MERCURY IN A FISH EATING POPULATION
    Thomas Clarkson; Fiscal Year: 2005

Detail Information

Publications24

  1. ncbi The toxicology of mercury and its chemical compounds
    Thomas W Clarkson
    Department of Environmental Medicine, University of Rochester School of Medicine, New York, USA
    Crit Rev Toxicol 36:609-62. 2006
    ..The review leads to general discussion of evolutionary aspects of mercury, protective and toxic mechanisms, and ends on a note that mercury is still an "element of mystery."..
  2. pmc The three modern faces of mercury
    Thomas W Clarkson
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Environ Health Perspect 110:11-23. 2002
    ..Mechanisms of action are discussed where possible. Key gaps in our current knowledge are identified from the points of view both of risk assessment and of mechanisms of action...
  3. ncbi Mechanisms of mercury disposition in the body
    Thomas W Clarkson
    Department of Environmental Medicine, Rochester School of Medicine, Rochester, New York, USA
    Am J Ind Med 50:757-64. 2007
    ..The implications of these mechanisms with regard to biological monitoring are discussed...
  4. ncbi Nutritional factors may modify the toxic action of methyl mercury in fish-eating populations
    Thomas W Clarkson
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Nutr 133:1539S-43S. 2003
    ..This article discusses the potential role of micronutrients in fish as a plausible explanation for these findings...
  5. ncbi The toxicology of mercury--current exposures and clinical manifestations
    Thomas W Clarkson
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    N Engl J Med 349:1731-7. 2003
  6. pmc Prenatal exposure to dental amalgam: evidence from the Seychelles Child Development Study main cohort
    GENE E WATSON
    Eastman Institute for Oral Health, Department of Environmental Medicine, and Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester, N Y, USA
    J Am Dent Assoc 142:1283-94. 2011
    ..Controversy surrounds whether fetal exposure to mercury vapor resulting from maternal dental amalgam restorations has neurodevelopmental consequences...
  7. pmc Is susceptibility to prenatal methylmercury exposure from fish consumption non-homogeneous? Tree-structured analysis for the Seychelles Child Development Study
    Li Shan Huang
    Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Neurotoxicology 28:1237-44. 2007
    ..The regression tree results support previous analyses of outcomes in this cohort. However, this analysis raises the intriguing possibility that an effect may be non-homogeneous among children with different backgrounds and IQ levels...
  8. pmc Fish consumption and prenatal methylmercury exposure: cognitive and behavioral outcomes in the main cohort at 17 years from the Seychelles child development study
    Philip W Davidson
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Neurotoxicology 32:711-7. 2011
    ..For some endpoints we found performance improved with increasing prenatal exposure to MeHg. Follow up studies indicate this association is related to the beneficial nutrients present in fish...
  9. ncbi Methylmercury and neurodevelopment: longitudinal analysis of the Seychelles child development cohort
    Philip W Davidson
    The Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642, USA
    Neurotoxicol Teratol 28:529-35. 2006
    ..These findings suggest that the associations observed between MeHg and developmental outcomes may vary with developmental stage...
  10. pmc Varying coefficient function models to explore interactions between maternal nutritional status and prenatal methylmercury toxicity in the Seychelles Child Development Nutrition Study
    Miranda L Lynch
    Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Environ Res 111:75-80. 2011
    ..The results encourage more emphasis on a holistic view of the risks and benefits of fish consumption as it relates to infant development...
  11. ncbi Benchmark concentrations for methyl mercury obtained from the 9-year follow-up of the Seychelles Child Development Study
    Edwin van Wijngaarden
    Department of Community and Preventive Medicine, 601 Elmwood Avenue, Box 644, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Neurotoxicology 27:702-9. 2006
    ..These estimates are somewhat lower than those obtained after 66 months of follow-up. The Seychelles Child Development Study continues to provide a firm scientific basis for the derivation of safe levels of MeHg consumption...
  12. ncbi Exploring nonlinear association between prenatal methylmercury exposure from fish consumption and child development: evaluation of the Seychelles Child Development Study nine-year data using semiparametric additive models
    Li Shan Huang
    Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Environ Res 97:100-8. 2005
    ..We conclude that this reanalysis supports the primary linear analysis, showing little evidence for a prenatal adverse effect...
  13. pmc Association between prenatal exposure to methylmercury and visuospatial ability at 10.7 years in the seychelles child development study
    Philip W Davidson
    University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Neurotoxicology 29:453-9. 2008
    ..04), but not when the single outlier was removed (p=0.07). In a population whose exposure to MeHg is from fish consumption, we continue to find no consistent adverse association between MeHg and visual motor coordination...
  14. pmc Does prenatal methylmercury exposure from fish consumption affect blood pressure in childhood?
    Sally W Thurston
    Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States
    Neurotoxicology 28:924-30. 2007
    ..We examined this relationship in the Seychelles Islands to determine if it was present in a society exposed primarily to MeHg from consuming ocean fish...
  15. pmc Neurodevelopmental effects of maternal nutritional status and exposure to methylmercury from eating fish during pregnancy
    Philip W Davidson
    University of Rochester School of Medicine and Dentistry, Box 671, URMC, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Neurotoxicology 29:767-75. 2008
    ..These findings suggest a possible confounding role of maternal nutrition in studies examining associations between prenatal MeHg exposures and developmental outcomes in children...
  16. ncbi Using measurement error models to assess effects of prenatal and postnatal methylmercury exposure in the Seychelles Child Development Study
    Li Shan Huang
    Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 630, Rochester, NY 14642, USA
    Environ Res 93:115-22. 2003
    ..Our reanalysis indicated that adjustment for measurement errors in explanatory variables had no appreciable effect on the original results...
  17. ncbi Validity of methyl mercury hair analysis: mercury monitoring in human scalp/nude mouse model
    Grazyna Zareba
    Department of Environmental Medicine, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Appl Toxicol 28:535-42. 2008
    ..The grafting of human scalp hair was used as a new application of this method to explore methyl mercury incorporation into human hair and to validate this model for mercury monitoring in hair...
  18. ncbi Thimerosal distribution and metabolism in neonatal mice: comparison with methyl mercury
    Grazyna Zareba
    Department of Environmental Medicine, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Appl Toxicol 27:511-8. 2007
    ..The data showing significant kinetic differences in tissue distribution and metabolism of mercury species challenge the assumption that ethyl mercury is toxicologically identical to methyl mercury...
  19. ncbi Accelerated urinary excretion of methylmercury following administration of its antidote N-acetylcysteine requires Mrp2/Abcc2, the apical multidrug resistance-associated protein
    Michael S Madejczyk
    Department of Environmental Medicine, University of Rochester School of Medicine, 575 Elmwood Avenue, Box EHSC, Rochester, NY 14642, USA
    J Pharmacol Exp Ther 322:378-84. 2007
    ..These results indicate that Mrp2 is involved in urinary MeHg excretion after NAC administration and suggest that the transported molecule is most likely the MeHg-NAC complex...
  20. pmc Silent latency periods in methylmercury poisoning and in neurodegenerative disease
    Bernard Weiss
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Environ Health Perspect 110:851-4. 2002
    ..Parallels are drawn with other diseases that affect the central nervous system, such as Parkinson disease and post-polio syndrome, that also reflect the delayed appearance of central nervous system damage...
  21. ncbi Overview of the clinical toxicity of mercury
    Laszlo Magos
    Ann Clin Biochem 43:257-68. 2006
    ..It covers not only symptoms and signs observed in poisoned individuals by a clinician but also subclinical effects in population studies, the final evaluation of which is the domain of statisticians...
  22. ncbi Attenuation of CD95-induced apoptosis by inorganic mercury: caspase-3 is not a direct target of low levels of Hg2+
    Michael J McCabe
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Box EHSC, 525 Elmwood Ave, Rochester, NY 14642, USA
    Toxicol Lett 155:161-70. 2005
    ..The present study furthers an understanding of the mechanism whereby relatively low and non-cytotoxic concentrations of Hg2+ may disrupt peripheral tolerance leading to sustained autoimmune disease...
  23. pmc Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2
    Tracey A Simmons-Willis
    Department of Environmental Medicine, University of Rochester School of Medicine, 575 Elmwood Avenue, Box EHSC, Rochester, NY 14642, U S A
    Biochem J 367:239-46. 2002
    ..These transport proteins may therefore participate in metal ion homoeostasis and toxicity...
  24. ncbi Prenatal methylmercury exposure from ocean fish consumption in the Seychelles child development study
    Gary J Myers
    Department of Neurology, National Institute for Child Health and Development, National Institutes of Health, Department of Health and Human Services, Bethesda, USA
    Lancet 361:1686-92. 2003
    ..The most common form of prenatal exposure is maternal fish consumption, but whether such exposure harms the fetus is unknown. We aimed to identify adverse neurodevelopmental effects in a fish-consuming population...

Research Grants11

  1. DEVELOPMENTAL TOXICITY OF METHYLMERCURY
    Thomas Clarkson; Fiscal Year: 2001
    ..The population used in the longitudinal study presents a wide range in mercury levels so that the results can be applied in assessing the health risks in the U.S. population due to consumption of methylmercury in fish. ..
  2. TOXICITY OF METHYL MERCURY IN A FISH EATING POPULATION
    Thomas Clarkson; Fiscal Year: 2005
    ..abstract_text> ..