Continuous renal replacement techniquesWilliam R Clark
NxStage Medical, Inc, Lawrence, Mass, USA
Contrib Nephrol 144:264-77. 2004
- Dose determinants in continuous renal replacement therapy
William R Clark
NxStage Medical, Inc Lawrence, MA, USA
Artif Organs 27:815-20. 2003
..Specifically, differences between postdilution and predilution CVVH will be highlighted, and the importance of blood flow rate in dose delivery for these therapies will be discussed...
- The NxStage System One
William R Clark
NxStage Medical Inc, 439 South Union Street, Lawrence, MA 01843, USA
Semin Dial 17:167-70. 2004
..In both the chronic and acute care environments, the System One presents clinicians with a new platform for delivering patient therapy improvements within real-world constraints...
- Middle molecules and small-molecular-weight proteins in ESRD: properties and strategies for their removal
William R Clark
NxStage Medical, Inc, Indiana University School of Medicine, Indianapolis, USA
Adv Ren Replace Ther 10:270-8. 2003
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- Low-molecular weight proteins in end-stage renal disease: potential toxicity and dialytic removal mechanisms
William R Clark
Renal Division, Baxter Healthcare Corporation, McGaw Park, Indiana, USA
J Am Soc Nephrol 13:S41-7. 2002
..Finally, an overview of LMWP removal mechanisms for both hemodialysis and the convective therapies is provided...
- Recent clinical advances in the management of critically ill patients with acute renal failure
William R Clark
Nephrology Division, Indiana University School of Medicine, Indianapolis, IN, USA
Blood Purif 24:487-98. 2006
..Significant progress has been made in the field of renal replacement therapy for critically ill patients with acute renal failure (ARF) over the past few years. This review highlights these developments...
- Kinetic comparison of different acute dialysis therapies
Zhijie Liao
Department of Mechanical Engineering, University of Kentucky, Lexington, KY, USA
Artif Organs 27:802-7. 2003
..After clinical validation, the quantification method presented in this article could be a useful tool to assist in the dialytic management of critically ill ARF patients...
- Factors influencing low-molecular-weight solute clearance during hemodialysis
Zhongping Huang
Department of Mechanical Engineering, Widener University, Chester, Pennsylvania 19013, USA
Hemodial Int 9:332-7. 2005
..Although the focus of the review is on the manner in which dialyzer characteristics influence small solute clearances, factors related to other aspects of the extracorporeal circuit and to the patient will also be discussed...
- Determinants of small solute clearance in hemodialysis
Zhongping Huang
Center for Biomedical Engineering, University of Kentucky, Louisville, Kentucky, USA
Semin Dial 18:30-5. 2005
..Although the focus of the review is on the manner in which dialyzer characteristics influence small solute clearances, factors related to other aspects of the extracorporeal circuit and to the patient will also be discussed...
- A new method to evaluate the local clearance at different annular rings inside hemodialyzers
Zhongping Huang
Department of Mechanical Engineering, University of Kentucky, Lexington, Kentucky 40506, USA
ASAIO J 49:692-7. 2003
..Hollow fibers at different locations did contribute differently to the solute clearance, which may be caused by the channeling of dialysate flow. A careful design of the dialyzer to minimize the channeling is needed...
- Effect of flow baffles on the dialysate flow distribution of hollow-fiber hemodialyzers: a nonintrusive experimental study using MRI
Churn K Poh
Department of Mechanical Engineering, University of Kentucky, Lexington, KY, USA
J Biomech Eng 125:481-9. 2003
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- A numerical and experimental study of mass transfer in the artificial kidney
Zhijie Liao
Department of Mechanical Engineering, University of Kentucky, Lexington, KY 40506, USA
J Biomech Eng 125:472-80. 2003
..This numerical model presented a clear insight view of mass transfer in an artificial kidney and may be used to help design an optimal artificial kidney and its operation conditions to improve hemodialysis...
- Effect of spacer yarns on the dialysate flow distribution of hemodialyzers: a magnetic resonance imaging study
Churn K Poh
Department of Mechanical Engineering, University of Kentucky, Lexington, KY 40506-0108, USA
ASAIO J 49:440-8. 2003
..Our experimental results showed that these velocity imaging techniques provide an innovative, nonintrusive tool for characterizing flow distribution in hemodialyzers...
- The Acute Dialysis Quality Initiative--part IV: membranes for CRRT
William R Clark
Renal Division, Baxter Healthcare Corporation, Nephrology Section, Indianapolis, IN, USA
Adv Ren Replace Ther 9:265-7. 2002
..These and other issues should be the subject of future clinical research efforts...
- Properties of membranes used for hemodialysis therapy
William R Clark
Renal Division, Baxter Healthcare Corp, McGaw Park, Illinois, USA
Semin Dial 15:191-5. 2002
..A general overview of membrane-related determinants of dialyzer performance is first presented, followed by a discussion of specific characteristics of some of the more commonly used membranes and dialyzers...
- Determinants of uraemic toxin removal
William R Clark
Renal Division, Baxter Healthcare Corp, McGaw Park, IL, USA
Nephrol Dial Transplant 17:30-4. 2002
..All of these issues will be major considerations as new dialytic therapies for end-stage renal disease patients are developed and implemented...
- Solute removal by hollow-fiber dialyzers
William R Clark
Gambro Inc, Lakewood, Colo, USA
Contrib Nephrol 158:20-33. 2007
..The remainder of the chapter emphasizes the major determinants of hollow-fiber dialyzer performance...
