P J Clark

Summary

Publications

  1. pmc The association of genetic variants with hepatic steatosis in patients with genotype 1 chronic hepatitis C infection
    Paul J Clark
    Duke Clinical Research Institute, Duke University, PO Box 17969, Durham, NC 27715, USA
    Dig Dis Sci 57:2213-21. 2012
  2. doi request reprint Utility of eosinophilia as a diagnostic clue in lower abdominal pain in northern Australia: a retrospective case-control study
    P J Clark
    Department of Gastroenterology and Hepatology, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Intern Med J 38:278-80. 2008
  3. pmc Interleukin 28B polymorphisms are the only common genetic variants associated with low-density lipoprotein cholesterol (LDL-C) in genotype-1 chronic hepatitis C and determine the association between LDL-C and treatment response
    P J Clark
    Duke Clinical Research Institute, Duke University, Durham, NC 27715, USA
    J Viral Hepat 19:332-40. 2012
  4. ncbi request reprint Inosine triphosphatase deficiency helps predict anaemia, anaemia management and response in chronic hepatitis C therapy
    P J Clark
    GI Hepatology, Duke Clinical Research Institute, Durham, NC, USA Princess Alexandra Hospital, Brisbane, QLD, Australia Queensland Institute of Medical Research, Brisbane, QLD, Australia
    J Viral Hepat 20:858-66. 2013
  5. doi request reprint Genetic variation in IL28B: impact on drug development for chronic hepatitis C infection
    P J Clark
    Duke Clinical Research Institute and Division of Gastroenterology, Duke University Medical Center, Durham, North Carolina, USA
    Clin Pharmacol Ther 88:708-11. 2010
  6. doi request reprint Elevated serum CK18 levels in chronic hepatitis C patients are associated with advanced fibrosis but not steatosis
    A B Jazwinski
    Division of Gastroenterology and Hepatology, Duke Clinical Research Institute and Duke University Medical Center, Durham, NC 27710, USA
    J Viral Hepat 19:278-82. 2012

Detail Information

Publications6

  1. pmc The association of genetic variants with hepatic steatosis in patients with genotype 1 chronic hepatitis C infection
    Paul J Clark
    Duke Clinical Research Institute, Duke University, PO Box 17969, Durham, NC 27715, USA
    Dig Dis Sci 57:2213-21. 2012
    ..Single-nucleotide polymorphisms (SNPs) in the IL28B and PNPLA3 gene regions have been associated with hepatic steatosis in genotype 1 (G1) chronic HCV infection but their clinical impacts remain to be determined...
  2. doi request reprint Utility of eosinophilia as a diagnostic clue in lower abdominal pain in northern Australia: a retrospective case-control study
    P J Clark
    Department of Gastroenterology and Hepatology, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Intern Med J 38:278-80. 2008
    ..The decision to operate remains one of clinical judgement...
  3. pmc Interleukin 28B polymorphisms are the only common genetic variants associated with low-density lipoprotein cholesterol (LDL-C) in genotype-1 chronic hepatitis C and determine the association between LDL-C and treatment response
    P J Clark
    Duke Clinical Research Institute, Duke University, Durham, NC 27715, USA
    J Viral Hepat 19:332-40. 2012
    ..LDL-C remains significantly associated with SVR for heterozygous IL28B genotype patients, where LDL-C and HCV RNA burden may identify those patients with high or low likelihood of cure with pegIFN/RBV therapy...
  4. ncbi request reprint Inosine triphosphatase deficiency helps predict anaemia, anaemia management and response in chronic hepatitis C therapy
    P J Clark
    GI Hepatology, Duke Clinical Research Institute, Durham, NC, USA Princess Alexandra Hospital, Brisbane, QLD, Australia Queensland Institute of Medical Research, Brisbane, QLD, Australia
    J Viral Hepat 20:858-66. 2013
    ..For patients on HCV regimens including peginterferon/ribavirin, testing for ITPA deficiency may have clinical utility...
  5. doi request reprint Genetic variation in IL28B: impact on drug development for chronic hepatitis C infection
    P J Clark
    Duke Clinical Research Institute and Division of Gastroenterology, Duke University Medical Center, Durham, North Carolina, USA
    Clin Pharmacol Ther 88:708-11. 2010
    ....
  6. doi request reprint Elevated serum CK18 levels in chronic hepatitis C patients are associated with advanced fibrosis but not steatosis
    A B Jazwinski
    Division of Gastroenterology and Hepatology, Duke Clinical Research Institute and Duke University Medical Center, Durham, NC 27710, USA
    J Viral Hepat 19:278-82. 2012
    ..Although apoptosis may still contribute to hepatitis C virus (HCV)-mediated steatosis, our results suggest that serum CK-18 will not be a clinically useful test for identifying significant steatosis in CHC...