Dysregulation of the microvasculature in nonlesional non-sun-exposed skin of patients with lupus nephritisPeter M Izmirly
Department of Medicine, NYU School of Medicine, New York, NY 10016, USA
J Rheumatol 39:510-5. 2012
..We investigated the hypothesis that changes in the microvasculature are widespread with extension to the dermal vasculature...
From antibody insult to fibrosis in neonatal lupus - the heart of the matterJill P Buyon
Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, USA
Arthritis Res Ther 5:266-70. 2003
..Dissecting the individual components in this fibrotic pathway should provide insights into the rarity of irreversible injury and should form the basis of rational approaches to prevention and treatment...
More to death than dying: apoptosis in the pathogenesis of SSA/Ro-SSB/La-associated congenital heart blockRobert M Clancy
Division of Rheumatology, Department of Medicine, Hospital for Joint Diseases, New York University School of Medicine, 301 East 17th Street, New York, NY 10003, USA
Rheum Dis Clin North Am 30:589-602, x. 2004
....
- Genetic association of cutaneous neonatal lupus with HLA class II and tumor necrosis factor alpha: implications for pathogenesis
Robert M Clancy
Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, New York 10003, USA
Arthritis Rheum 50:2598-603. 2004
..Accordingly, this study was undertaken to seek genetic and histologic evidence for a role of TNFalpha in the pathogenesis of cutaneous neonatal lupus...
- Autoimmune-associated congenital heart block: dissecting the cascade from immunologic insult to relentless fibrosis
Robert M Clancy
Department of Rheumatology, Room 1608, Hospital for Joint Diseases, New York University School of Medicine, 301 East 17th Street, New York, NY 10003, USA
Anat Rec A Discov Mol Cell Evol Biol 280:1027-35. 2004
..Further elucidation of maternal and fetal contributory factors should provide insight into the pathogenesis of CHB and the rarity of irreversible injury...
- Nitric oxide sustains nuclear factor kappaB activation in cytokine-stimulated chondrocytes
R M Clancy
Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, NY 10003, USA
Osteoarthritis Cartilage 12:552-8. 2004
..In the current studies we have examined the effects of nitric oxide, and its redox derivatives peroxynitrite and S-nitrosothiol, S-nitrosocysteine, on nuclear factor kappaB (NF-kappaB) activation in cytokine-stimulated bovine chondrocytes...
- Maternal antibody responses to the 52-kd SSA/RO p200 peptide and the development of fetal conduction defects
Robert M Clancy
Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, New York 10003, USA
Arthritis Rheum 52:3079-86. 2005
..To identify a finer level of antibody specificity for risk of congenital heart block (CHB) than reactivity to 52-kd SSA/Ro (Ro 52)...
- Role of hypoxia and cAMP in the transdifferentiation of human fetal cardiac fibroblasts: implications for progression to scarring in autoimmune-associated congenital heart block
Robert M Clancy
Department of Medicine, Division of Rheumatology, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
Arthritis Rheum 56:4120-31. 2007
..Accordingly, this study was carried out to explore the hypothesis that hypoxia potentiates a profibrosing phenotype of the fetal cardiac fibroblast...
Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs: a novel pathway to autoimmune-associated heart blockRobert M Clancy
Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
J Immunol 184:2148-55. 2010
....
- Endothelial function and its implications for cardiovascular and renal disease in systemic lupus erythematosus
Robert Clancy
NYU Langone School of Medicine, New York, NY, USA
Rheum Dis Clin North Am 36:145-60, ix-x. 2010
....
- Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus
Robert M Clancy
New York University Langone School of Medicine, New York, New York 10003, USA
Arthritis Rheum 62:3415-24. 2010
..There is strong evidence of a genetic contribution to the risk. This study was undertaken to evaluate single-nucleotide polymorphisms (SNPs) for associations with cardiac neonatal lupus...
- Transdifferentiation of cardiac fibroblasts, a fetal factor in anti-SSA/Ro-SSB/La antibody-mediated congenital heart block
Robert M Clancy
Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, NY 10003, USA
J Immunol 169:2156-63. 2002
..These data suggest that transdifferentiation of cardiac fibroblasts to a scarring phenotype is a pathologic process initiated by maternal Abs...
- Cardiac 5-HT(4) serotoninergic receptors, 52kD SSA/Ro and autoimmune-associated congenital heart block
Jill P Buyon
Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, NY 10003, USA
J Autoimmun 19:79-86. 2002
..Although 5-HT(4) receptors are present and functional in the human foetal heart, maternal antibodies to the 5-HT(4) receptor are not associated with the development of CHB...
- Immunohistologic evidence supports apoptosis, IgG deposition, and novel macrophage/fibroblast crosstalk in the pathologic cascade leading to congenital heart block
Robert M Clancy
Hospital for Joint Diseases, New York University School of Medicine, New York, New York 10003, USA
Arthritis Rheum 50:173-82. 2004
....
- Cytokine polymorphisms and histologic expression in autopsy studies: contribution of TNF-alpha and TGF-beta 1 to the pathogenesis of autoimmune-associated congenital heart block
Robert M Clancy
Hospital for Joint Diseases, New York University School of Medicine, Department of Rheumatology, New York, NY 10003, USA
J Immunol 171:3253-61. 2003
..This profibrosing cytokine and its secretion/activation circuitry may provide a novel direction for evaluating fetal factors in the development of a robust animal model of CHB as well as therapeutic strategies in humans...
- Regulation of metalloproteinases and NF-kappaB activation in rabbit synovial fibroblasts via E prostaglandins and Erk: contrasting effects of nabumetone and 6MNA
Michael H Pillinger
The Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
Br J Pharmacol 142:973-82. 2004
..In contrast, nabumetone demonstrates anti-inflammatory and potentially arthroprotective effects that have not been previously appreciated...
- Neonatal lupus syndromes
Jill P Buyon
Department of Medicine, New York University School of Medicine, New York, New York, USA
Curr Opin Rheumatol 15:535-41. 2003
..To further efforts both at the bench and bedside, national research registries established in the United States and Canada are critical...
- Neonatal lupus: review of proposed pathogenesis and clinical data from the US-based Research Registry for Neonatal Lupus
Jill P Buyon
Department of Rheumatology, Room 1608, Hospital for Joint Diseases, New York University School of Medicine, 301 East 17th Street, New York, NY 10003, USA
Autoimmunity 36:41-50. 2003
..S. National Institute of Arthritis, Musculoskeletal and Skin Diseases. Maternal and fetal outcomes are addressed as well as recurrence rates. Laboratory evaluation and management decisions during pregnancy are provided...
- Recurrence rates of cardiac manifestations associated with neonatal lupus and maternal/fetal risk factors
Carolina Llanos
New York University School of Medicine, New York, New York 10016, USA
Arthritis Rheum 60:3091-7. 2009
..Accordingly, this study was undertaken to address the recurrence rates of cardiac NL and associated risk factors in a large US-based cohort...
- Role of the urokinase plasminogen activator receptor in mediating impaired efferocytosis of anti-SSA/Ro-bound apoptotic cardiocytes: Implications in the pathogenesis of congenital heart block
Paraskevi Briassouli
Department of Medicine, New York University School of Medicine, New York, 10016, USA
Circ Res 107:374-87. 2010
....
- Cardiac manifestations of neonatal lupus erythematosus: guidelines to management, integrating clues from the bench and bedside
Jill P Buyon
Division of Rheumatology, New York Medical College, New York, NY, USA
Nat Clin Pract Rheumatol 5:139-48. 2009
..Intravenous immunoglobulin is being evaluated as a potential prophylactic approach in mothers who have previously had an affected child...
- Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and -SSB/La antibodies in the pathogenesis of congenital heart block
Robert M Clancy
Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, New York 10016, USA
J Clin Invest 116:2413-22. 2006
....
- Autoantibody-associated congenital heart block: TGFbeta and the road to scar
Jill P Buyon
Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, Room 1608, 301 East 17th Street, New York, NY 10003, USA
Autoimmun Rev 4:1-7. 2005
..Downregulation of TGFbeta (activation/secretion pathway) may provide the basis of a novel approach to treatment of CHB in the future...
- Maternal autoantibodies and congenital heart block: mediators, markers, and therapeutic approach
Jill P Buyon
Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, NY 10003, USA
Semin Arthritis Rheum 33:140-54. 2003
- Antibody reactivity to alpha-enolase in mothers of children with congenital heart block
Carolina Llanos
Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
J Rheumatol 36:565-9. 2009
....
- Neonatal lupus: basic research and clinical perspectives
Jill P Buyon
Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY, USA
Rheum Dis Clin North Am 31:299-313, vii. 2005
..Better echocardiographic measurements that identify first-degree block in utero may be the optimal approach for pregnant women at risk; prophylactic therapies, including treatment with intravenous immunoglobulin, await larger trials...
- Shedding of endothelial protein C receptor contributes to vasculopathy and renal injury in lupus: in vivo and in vitro evidence
Carlos A Sesin
Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, New York 10003, USA
Kidney Int 68:110-20. 2005
..This study sought correlation between plasma levels of soluble EPCR and disease manifestation/severity, with a focus on lupus nephritis...
- Association of plasma soluble E-selectin and adiponectin with carotid plaque in patients with systemic lupus erythematosus
Harmony R Reynolds
Department of Medicine, Division of Cardiology, New York University Langone School of Medicine, New York, NY 10016, USA
Atherosclerosis 210:569-74. 2010
..Systemic lupus erythematosus (SLE) is associated with premature atherosclerosis but the mechanisms underlying this association are not understood. The role of endothelial dysfunction is hypothesized...
- Clearance of apoptotic cells: TGF-beta in the balance between inflammation and fibrosis
Robert M Clancy
J Leukoc Biol 74:959-60. 2003
..Prolonged secretion of this cytokine may contribute to the exuberant scarring seen in congenital heart block associated with maternal autoantibodies reactive with SSA/Rho and SSB/La antigens...
- Exposure and binding of selected immunodominant La/SSB epitopes on human apoptotic cells
Petra J Neufing
Department of Immunology, Allergy and Arthritis, Flinders University, Adelaide, South Australia, Australia
Arthritis Rheum 52:3934-42. 2005
..Accordingly, the objective of the current study was to delineate the epitope specificity of human La antibodies that are exposed on the surface of apoptotic cells...
- Anti-La/SSB antiidiotypic antibodies in maternal serum: a marker of low risk for neonatal lupus in an offspring
Eleni A Stea
Medical School of Athens, Athens, Greece
Arthritis Rheum 54:2228-34. 2006
..Testing for these antiidiotypic responses may be useful in predicting a decreased risk of NLS...
- Does the cellular localization of antigens in or on apoptotic blebs influence the pathogenicity or benefit of cognate antibodies? Comment on the article by Dieudé et al
Robert M Clancy
Arthritis Rheum 48:2080-2; author reply 2082-3. 2003
- Formation of nitroxyl and hydroxyl radical in solutions of sodium trioxodinitrate: effects of pH and cytotoxicity
Juliana Ivanova
Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Biol Chem 278:42761-8. 2003
..2 than at pH 7.4. Scavengers of.OH impeded the cytotoxicity of Na2N2O3. These results suggest that the formation of HNO may be viewed as a toxicological event in tissues subjected to acidosis...
- Congenital heart block: do fetal factors fuel the fire from inflammation to fibrosis?
Jill P Buyon
Lupus 12:731-4. 2003
