Robert Clancy

Summary

Publications

  1. doi request reprint Dysregulation of the microvasculature in nonlesional non-sun-exposed skin of patients with lupus nephritis
    Peter M Izmirly
    Department of Medicine, NYU School of Medicine, New York, NY 10016, USA
    J Rheumatol 39:510-5. 2012
  2. pmc From antibody insult to fibrosis in neonatal lupus - the heart of the matter
    Jill P Buyon
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, USA
    Arthritis Res Ther 5:266-70. 2003
  3. ncbi request reprint More to death than dying: apoptosis in the pathogenesis of SSA/Ro-SSB/La-associated congenital heart block
    Robert M Clancy
    Division of Rheumatology, Department of Medicine, Hospital for Joint Diseases, New York University School of Medicine, 301 East 17th Street, New York, NY 10003, USA
    Rheum Dis Clin North Am 30:589-602, x. 2004
  4. ncbi request reprint Genetic association of cutaneous neonatal lupus with HLA class II and tumor necrosis factor alpha: implications for pathogenesis
    Robert M Clancy
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, New York 10003, USA
    Arthritis Rheum 50:2598-603. 2004
  5. ncbi request reprint Autoimmune-associated congenital heart block: dissecting the cascade from immunologic insult to relentless fibrosis
    Robert M Clancy
    Department of Rheumatology, Room 1608, Hospital for Joint Diseases, New York University School of Medicine, 301 East 17th Street, New York, NY 10003, USA
    Anat Rec A Discov Mol Cell Evol Biol 280:1027-35. 2004
  6. ncbi request reprint Nitric oxide sustains nuclear factor kappaB activation in cytokine-stimulated chondrocytes
    R M Clancy
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, NY 10003, USA
    Osteoarthritis Cartilage 12:552-8. 2004
  7. ncbi request reprint Maternal antibody responses to the 52-kd SSA/RO p200 peptide and the development of fetal conduction defects
    Robert M Clancy
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, New York 10003, USA
    Arthritis Rheum 52:3079-86. 2005
  8. ncbi request reprint Role of hypoxia and cAMP in the transdifferentiation of human fetal cardiac fibroblasts: implications for progression to scarring in autoimmune-associated congenital heart block
    Robert M Clancy
    Department of Medicine, Division of Rheumatology, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
    Arthritis Rheum 56:4120-31. 2007
  9. pmc Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs: a novel pathway to autoimmune-associated heart block
    Robert M Clancy
    Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 184:2148-55. 2010
  10. doi request reprint Endothelial function and its implications for cardiovascular and renal disease in systemic lupus erythematosus
    Robert Clancy
    NYU Langone School of Medicine, New York, NY, USA
    Rheum Dis Clin North Am 36:145-60, ix-x. 2010

Detail Information

Publications34

  1. doi request reprint Dysregulation of the microvasculature in nonlesional non-sun-exposed skin of patients with lupus nephritis
    Peter M Izmirly
    Department of Medicine, NYU School of Medicine, New York, NY 10016, USA
    J Rheumatol 39:510-5. 2012
    ..We investigated the hypothesis that changes in the microvasculature are widespread with extension to the dermal vasculature...
  2. pmc From antibody insult to fibrosis in neonatal lupus - the heart of the matter
    Jill P Buyon
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, USA
    Arthritis Res Ther 5:266-70. 2003
    ..Dissecting the individual components in this fibrotic pathway should provide insights into the rarity of irreversible injury and should form the basis of rational approaches to prevention and treatment...
  3. ncbi request reprint More to death than dying: apoptosis in the pathogenesis of SSA/Ro-SSB/La-associated congenital heart block
    Robert M Clancy
    Division of Rheumatology, Department of Medicine, Hospital for Joint Diseases, New York University School of Medicine, 301 East 17th Street, New York, NY 10003, USA
    Rheum Dis Clin North Am 30:589-602, x. 2004
    ....
  4. ncbi request reprint Genetic association of cutaneous neonatal lupus with HLA class II and tumor necrosis factor alpha: implications for pathogenesis
    Robert M Clancy
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, New York 10003, USA
    Arthritis Rheum 50:2598-603. 2004
    ..Accordingly, this study was undertaken to seek genetic and histologic evidence for a role of TNFalpha in the pathogenesis of cutaneous neonatal lupus...
  5. ncbi request reprint Autoimmune-associated congenital heart block: dissecting the cascade from immunologic insult to relentless fibrosis
    Robert M Clancy
    Department of Rheumatology, Room 1608, Hospital for Joint Diseases, New York University School of Medicine, 301 East 17th Street, New York, NY 10003, USA
    Anat Rec A Discov Mol Cell Evol Biol 280:1027-35. 2004
    ..Further elucidation of maternal and fetal contributory factors should provide insight into the pathogenesis of CHB and the rarity of irreversible injury...
  6. ncbi request reprint Nitric oxide sustains nuclear factor kappaB activation in cytokine-stimulated chondrocytes
    R M Clancy
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, NY 10003, USA
    Osteoarthritis Cartilage 12:552-8. 2004
    ..In the current studies we have examined the effects of nitric oxide, and its redox derivatives peroxynitrite and S-nitrosothiol, S-nitrosocysteine, on nuclear factor kappaB (NF-kappaB) activation in cytokine-stimulated bovine chondrocytes...
  7. ncbi request reprint Maternal antibody responses to the 52-kd SSA/RO p200 peptide and the development of fetal conduction defects
    Robert M Clancy
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, New York 10003, USA
    Arthritis Rheum 52:3079-86. 2005
    ..To identify a finer level of antibody specificity for risk of congenital heart block (CHB) than reactivity to 52-kd SSA/Ro (Ro 52)...
  8. ncbi request reprint Role of hypoxia and cAMP in the transdifferentiation of human fetal cardiac fibroblasts: implications for progression to scarring in autoimmune-associated congenital heart block
    Robert M Clancy
    Department of Medicine, Division of Rheumatology, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
    Arthritis Rheum 56:4120-31. 2007
    ..Accordingly, this study was carried out to explore the hypothesis that hypoxia potentiates a profibrosing phenotype of the fetal cardiac fibroblast...
  9. pmc Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs: a novel pathway to autoimmune-associated heart block
    Robert M Clancy
    Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 184:2148-55. 2010
    ....
  10. doi request reprint Endothelial function and its implications for cardiovascular and renal disease in systemic lupus erythematosus
    Robert Clancy
    NYU Langone School of Medicine, New York, NY, USA
    Rheum Dis Clin North Am 36:145-60, ix-x. 2010
    ....
  11. pmc Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus
    Robert M Clancy
    New York University Langone School of Medicine, New York, New York 10003, USA
    Arthritis Rheum 62:3415-24. 2010
    ..There is strong evidence of a genetic contribution to the risk. This study was undertaken to evaluate single-nucleotide polymorphisms (SNPs) for associations with cardiac neonatal lupus...
  12. ncbi request reprint Transdifferentiation of cardiac fibroblasts, a fetal factor in anti-SSA/Ro-SSB/La antibody-mediated congenital heart block
    Robert M Clancy
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, NY 10003, USA
    J Immunol 169:2156-63. 2002
    ..These data suggest that transdifferentiation of cardiac fibroblasts to a scarring phenotype is a pathologic process initiated by maternal Abs...
  13. ncbi request reprint Cardiac 5-HT(4) serotoninergic receptors, 52kD SSA/Ro and autoimmune-associated congenital heart block
    Jill P Buyon
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, NY 10003, USA
    J Autoimmun 19:79-86. 2002
    ..Although 5-HT(4) receptors are present and functional in the human foetal heart, maternal antibodies to the 5-HT(4) receptor are not associated with the development of CHB...
  14. ncbi request reprint Immunohistologic evidence supports apoptosis, IgG deposition, and novel macrophage/fibroblast crosstalk in the pathologic cascade leading to congenital heart block
    Robert M Clancy
    Hospital for Joint Diseases, New York University School of Medicine, New York, New York 10003, USA
    Arthritis Rheum 50:173-82. 2004
    ..These opsonized cardiocytes are phagocytosed by macrophages, which secrete factors inducing fibrosis...
  15. ncbi request reprint Cytokine polymorphisms and histologic expression in autopsy studies: contribution of TNF-alpha and TGF-beta 1 to the pathogenesis of autoimmune-associated congenital heart block
    Robert M Clancy
    Hospital for Joint Diseases, New York University School of Medicine, Department of Rheumatology, New York, NY 10003, USA
    J Immunol 171:3253-61. 2003
    ..This profibrosing cytokine and its secretion/activation circuitry may provide a novel direction for evaluating fetal factors in the development of a robust animal model of CHB as well as therapeutic strategies in humans...
  16. pmc Regulation of metalloproteinases and NF-kappaB activation in rabbit synovial fibroblasts via E prostaglandins and Erk: contrasting effects of nabumetone and 6MNA
    Michael H Pillinger
    The Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Br J Pharmacol 142:973-82. 2004
    ..In contrast, nabumetone demonstrates anti-inflammatory and potentially arthroprotective effects that have not been previously appreciated...
  17. ncbi request reprint Neonatal lupus syndromes
    Jill P Buyon
    Department of Medicine, New York University School of Medicine, New York, New York, USA
    Curr Opin Rheumatol 15:535-41. 2003
    ..To further efforts both at the bench and bedside, national research registries established in the United States and Canada are critical...
  18. ncbi request reprint Neonatal lupus: review of proposed pathogenesis and clinical data from the US-based Research Registry for Neonatal Lupus
    Jill P Buyon
    Department of Rheumatology, Room 1608, Hospital for Joint Diseases, New York University School of Medicine, 301 East 17th Street, New York, NY 10003, USA
    Autoimmunity 36:41-50. 2003
    ..S. National Institute of Arthritis, Musculoskeletal and Skin Diseases. Maternal and fetal outcomes are addressed as well as recurrence rates. Laboratory evaluation and management decisions during pregnancy are provided...
  19. pmc Recurrence rates of cardiac manifestations associated with neonatal lupus and maternal/fetal risk factors
    Carolina Llanos
    New York University School of Medicine, New York, New York 10016, USA
    Arthritis Rheum 60:3091-7. 2009
    ..Accordingly, this study was undertaken to address the recurrence rates of cardiac NL and associated risk factors in a large US-based cohort...
  20. doi request reprint Role of the urokinase plasminogen activator receptor in mediating impaired efferocytosis of anti-SSA/Ro-bound apoptotic cardiocytes: Implications in the pathogenesis of congenital heart block
    Paraskevi Briassouli
    Department of Medicine, New York University School of Medicine, New York, 10016, USA
    Circ Res 107:374-87. 2010
    ....
  21. doi request reprint Cardiac manifestations of neonatal lupus erythematosus: guidelines to management, integrating clues from the bench and bedside
    Jill P Buyon
    Division of Rheumatology, New York Medical College, New York, NY, USA
    Nat Clin Pract Rheumatol 5:139-48. 2009
    ..Intravenous immunoglobulin is being evaluated as a potential prophylactic approach in mothers who have previously had an affected child...
  22. pmc Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and -SSB/La antibodies in the pathogenesis of congenital heart block
    Robert M Clancy
    Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, New York 10016, USA
    J Clin Invest 116:2413-22. 2006
    ....
  23. ncbi request reprint Autoantibody-associated congenital heart block: TGFbeta and the road to scar
    Jill P Buyon
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, Room 1608, 301 East 17th Street, New York, NY 10003, USA
    Autoimmun Rev 4:1-7. 2005
    ..Downregulation of TGFbeta (activation/secretion pathway) may provide the basis of a novel approach to treatment of CHB in the future...
  24. ncbi request reprint Maternal autoantibodies and congenital heart block: mediators, markers, and therapeutic approach
    Jill P Buyon
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, NY 10003, USA
    Semin Arthritis Rheum 33:140-54. 2003
  25. doi request reprint Antibody reactivity to alpha-enolase in mothers of children with congenital heart block
    Carolina Llanos
    Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Rheumatol 36:565-9. 2009
    ....
  26. ncbi request reprint Neonatal lupus: basic research and clinical perspectives
    Jill P Buyon
    Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY, USA
    Rheum Dis Clin North Am 31:299-313, vii. 2005
    ..Better echocardiographic measurements that identify first-degree block in utero may be the optimal approach for pregnant women at risk; prophylactic therapies, including treatment with intravenous immunoglobulin, await larger trials...
  27. ncbi request reprint Shedding of endothelial protein C receptor contributes to vasculopathy and renal injury in lupus: in vivo and in vitro evidence
    Carlos A Sesin
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, New York 10003, USA
    Kidney Int 68:110-20. 2005
    ..This study sought correlation between plasma levels of soluble EPCR and disease manifestation/severity, with a focus on lupus nephritis...
  28. doi request reprint Association of plasma soluble E-selectin and adiponectin with carotid plaque in patients with systemic lupus erythematosus
    Harmony R Reynolds
    Department of Medicine, Division of Cardiology, New York University Langone School of Medicine, New York, NY 10016, USA
    Atherosclerosis 210:569-74. 2010
    ..Systemic lupus erythematosus (SLE) is associated with premature atherosclerosis but the mechanisms underlying this association are not understood. The role of endothelial dysfunction is hypothesized...
  29. ncbi request reprint Clearance of apoptotic cells: TGF-beta in the balance between inflammation and fibrosis
    Robert M Clancy
    J Leukoc Biol 74:959-60. 2003
    ..Prolonged secretion of this cytokine may contribute to the exuberant scarring seen in congenital heart block associated with maternal autoantibodies reactive with SSA/Rho and SSB/La antigens...
  30. ncbi request reprint Exposure and binding of selected immunodominant La/SSB epitopes on human apoptotic cells
    Petra J Neufing
    Department of Immunology, Allergy and Arthritis, Flinders University, Adelaide, South Australia, Australia
    Arthritis Rheum 52:3934-42. 2005
    ..Accordingly, the objective of the current study was to delineate the epitope specificity of human La antibodies that are exposed on the surface of apoptotic cells...
  31. ncbi request reprint Anti-La/SSB antiidiotypic antibodies in maternal serum: a marker of low risk for neonatal lupus in an offspring
    Eleni A Stea
    Medical School of Athens, Athens, Greece
    Arthritis Rheum 54:2228-34. 2006
    ..This study evaluated the role of this network in pregnant women with anti-Ro/SSA and/or anti-La/SSB antibodies in the development of neonatal lupus syndrome (NLS)...
  32. ncbi request reprint Does the cellular localization of antigens in or on apoptotic blebs influence the pathogenicity or benefit of cognate antibodies? Comment on the article by Dieudé et al
    Robert M Clancy
    Arthritis Rheum 48:2080-2; author reply 2082-3. 2003
  33. ncbi request reprint Formation of nitroxyl and hydroxyl radical in solutions of sodium trioxodinitrate: effects of pH and cytotoxicity
    Juliana Ivanova
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 278:42761-8. 2003
    ..2 than at pH 7.4. Scavengers of.OH impeded the cytotoxicity of Na2N2O3. These results suggest that the formation of HNO may be viewed as a toxicological event in tissues subjected to acidosis...
  34. ncbi request reprint Congenital heart block: do fetal factors fuel the fire from inflammation to fibrosis?
    Jill P Buyon
    Lupus 12:731-4. 2003

Research Grants6

  1. Cardiac myofibroblasts in autoimmune-associated CHB
    Robert Clancy; Fiscal Year: 2002
    ....
  2. Endothelial reactivity and nitric oxide synthetase activity in the ALMS (Aspreva
    Robert Clancy; Fiscal Year: 2007
    ..Relevance to public health: The association of markers/indices of NOS2 expression with mechanism of action of a successful drug treatment in lupus nephritis would be a major advance. ..
  3. Endothelial reactivity and nitric oxide synthetase activity in the ALMS (Aspreva
    Robert Clancy; Fiscal Year: 2009
    ..Relevance to public health: The association of markers/indices of NOS2 expression with mechanism of action of a successful drug treatment in lupus nephritis would be a major advance. ..