A systematic review of duloxetine for osteoarthritic pain: what is the number needed to treat, number needed to harm, and likelihood to be helped or harmed?Leslie Citrome
New York Medical College, Valhalla, NY, USA
Postgrad Med 124:83-93. 2012
..To describe the efficacy, safety, and tolerability of duloxetine for the treatment of osteoarthritic pain...
- Oral antipsychotic update: a brief review of new and investigational agents for the treatment of schizophrenia
Leslie Citrome
New York Medical College, Valhalla, NY, USA
CNS Spectr 17:1-9. 2012
..We also discuss the utility of depot antipsychotic formulations for improving the chances of attaining long-term therapeutic results...
- Vilazodone for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed?
L Citrome
New York Medical College, Valhalla, NY, USA
Int J Clin Pract 66:356-68. 2012
..To describe the efficacy and safety of vilazodone for the treatment of major depressive disorder (MDD)...
- Lurasidone in schizophrenia: new information about dosage and place in therapy
Leslie Citrome
Clinical Professor of Psychiatry and Behavioral Sciences, New York Medical College, Valhalla, New York, USA
Adv Ther 29:815-25. 2012
..Additional studies are desirable to directly compare and contrast lurasidone's efficacy with other antipsychotic agents...
- Lurasidone for the acute treatment of adults with schizophrenia: what is the number needed to treat, number needed to harm, and likelihood to be helped or harmed?
Leslie Citrome
New York Medical College, Valhalla, NY, USA
Clin Schizophr Relat Psychoses 6:76-85. 2012
..To describe the efficacy, safety and tolerability of lurasidone for the acute treatment of schizophrenia using the metrics number needed to treat (NNT) and number needed to harm (NNH)...
- A systematic review of meta-analyses of the efficacy of oral atypical antipsychotics for the treatment of adult patients with schizophrenia
Leslie Citrome
New York Medical College, 11 Medical Park Drive, Suite 106, Pomona, NY 10970, USA
Expert Opin Pharmacother 13:1545-73. 2012
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- On-label on the table: what the package insert informs us about the tolerability profile of oral atypical antipsychotics, and what it does not
Leslie Citrome
New York Medical College, 11 Medical Park Drive, Suite 106, Pomona, NY 10970, USA
Expert Opin Pharmacother 13:1599-613. 2012
..However, clinicians will need to mind the gap between the efficacy and preliminary safety and tolerability data provided by registration trials and the real-world effectiveness of medications when used in the clinic...
- Oral paliperidone extended-release: chemistry, pharmacodynamics, pharmacokinetics and metabolism, clinical efficacy, safety and tolerability
Leslie Citrome
New York Medical College, Valhalla, NY, USA
Expert Opin Drug Metab Toxicol 8:873-88. 2012
..The use of paliperidone ER will need to be considered within the context of its cost and availability as risperidone is now a generic product...
- Long-term safety and tolerability of lurasidone in schizophrenia: a 12-month, double-blind, active-controlled study
Leslie Citrome
Department of Psychiatry and Behavioral Sciences, New York Medical College, Valhalla, New York, USA
Int Clin Psychopharmacol 27:165-76. 2012
..All-cause discontinuation rates were higher for lurasidone versus risperidone. Long-term treatment with lurasidone was generally well tolerated in this study, with minimal effects on weight and metabolic outcomes...
- Inhaled loxapine for agitation revisited: focus on effect sizes from 2 Phase III randomised controlled trials in persons with schizophrenia or bipolar disorder
L Citrome
New York Medical College, Valhalla, NY, USA
Int J Clin Pract 66:318-25. 2012
..To describe the efficacy of inhaled loxapine for the treatment of agitation associated with schizophrenia or bipolar disorder using different examples of effect size (ES)...
- Iloperidone: a clinical overview
Leslie Citrome
Department of Psychiatry and Behavioral Sciences, New York Medical College, Valhalla, NY, USA
J Clin Psychiatry 72:19-23. 2011
..Iloperidone may be best suited for patients who are sensitive to akathisia or who are unable to tolerate the sedation and weight gain that can occur more frequently with other antipsychotics...
- Weight gain and changes in metabolic variables following olanzapine treatment in schizophrenia and bipolar disorder
Leslie Citrome
Department of Psychiatry, New York University School of Medicine, NY, USA
Clin Drug Investig 31:455-82. 2011
..Long-term weight management programmes have been shown to reduce weight gain in some patients...
- Drug safety evaluation of ziprasidone
Leslie Citrome
New York University School of Medicine, 11 Medical Park Drive, Suite 106, Pomona, NY 10970, USA
Expert Opin Drug Saf 10:437-48. 2011
..Similar to most second-generation antipsychotics, ziprasidone has a lower propensity for extrapyramidal side effects and hyperprolactinemia compared to first-generation antipsychotics...
- Aerosolised antipsychotic assuages agitation: inhaled loxapine for agitation associated with schizophrenia or bipolar disorder
L Citrome
Department of Psychiatry, New York University School of Medicine, New York, NY, USA
Int J Clin Pract 65:330-40. 2011
..To describe the efficacy and safety of inhaled loxapine, a new formulation of an older antipsychotic being developed for the treatment of agitation associated with schizophrenia or bipolar disorder...
- Iloperidone, asenapine, and lurasidone: a brief overview of 3 new second-generation antipsychotics
Leslie Citrome
New York University School of Medicine, Department of Psychiatry, New York, NY, USA
Postgrad Med 123:153-62. 2011
..Longer-term and naturalistic studies will be helpful in evaluating these agents and their role in the psychiatric armamentarium...
- Lurasidone for schizophrenia: a brief review of a new second-generation antipsychotic
Leslie Citrome
Department of Psychiatry, New York University School of Medicine, New York, NY, USA
Clin Schizophr Relat Psychoses 4:251-7. 2011
..Lurasidone is associated with minimal weight gain and no clinically meaningful alterations in glucose, lipids, or the ECG QT interval...
- Lurasidone for schizophrenia: a review of the efficacy and safety profile for this newly approved second-generation antipsychotic
L Citrome
Department of Psychiatry, New York University School of Medicine, New York, NY, USA
Int J Clin Pract 65:189-210. 2011
..To describe the efficacy and safety of lurasidone for the treatment of schizophrenia...
- Olanzapine-fluoxetine combination for the treatment of bipolar depression
Leslie Citrome
New York Medical College, 11 Medical Park Drive, Suite 106, Pomona, Valhalla, NY 10970, USA
Expert Opin Pharmacother 12:2751-8. 2011
..Nonetheless, indirect comparisons indicate similar efficacy outcomes but different tolerability profiles, with quetiapine principally being associated with sedation. Additional approved treatment options would be welcome...
- Efficacy of iloperidone in the short-term treatment of schizophrenia: a post hoc analysis of pooled patient data from four phase III, placebo- and active-controlled trials
Leslie Citrome
New York Medical College, Valhalla, New York, USA
Hum Psychopharmacol 27:24-32. 2012
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- Efficacy of iloperidone in schizophrenia: a PANSS five-factor analysis
Leslie Citrome
New York University School of Medicine, New York, NY, USA
Schizophr Res 131:75-81. 2011
..We conducted a 5-factor analysis for evaluating the efficacy of iloperidone vs. placebo across these different domains in the treatment of schizophrenia...
- Pharmacological management of acute and persistent aggression in forensic psychiatry settings
Leslie Citrome
New York Medical College, Department of Psychiatry and Behavioral Sciences, Valhalla, USA
CNS Drugs 25:1009-21. 2011
..Mood stabilizers such as valproate may be helpful in instances of poor impulsivity and personality disorders. Other agents that have been successfully used include β-adrenoceptor antagonists (β-blockers) and antidepressants...
Atypical antipsychotics in the treatment of the persistently aggressive psychotic patient: methodological concernsJ Volavka
New York University, Department of Psychiatry, Nathan Kline Institue for Psychiatric Research, Orangeburg 10962, USA
Schizophr Res 35:S23-33. 1999
..g. randomization) used in typical designs of psychopharmacological clinical trials. Current research methods should be modified and new ones developed in order to progress in assessing the antiaggressive effects of treatments...
- Iloperidone redux: a dissection of the Drug Approval Package for this newly commercialised second-generation antipsychotic
L Citrome
Department of Psychiatry, New York University School of Medicine and the Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY, USA
Int J Clin Pract 64:707-18. 2010
..To describe the contents of a Drug Approval Package and to describe the efficacy and safety of iloperidone for the treatment of schizophrenia...
- Compelling or irrelevant? Using number needed to treat can help decide
L Citrome
Department of Psychiatry, New York University School of Medicine, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Acta Psychiatr Scand 117:412-9. 2008
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- Iloperidone for schizophrenia: a review of the efficacy and safety profile for this newly commercialised second-generation antipsychotic
L Citrome
New York University School of Medicine, Department of Psychiatry, and Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Int J Clin Pract 63:1237-48. 2009
..The aim of the study was to describe the efficacy and safety of iloperidone for the treatment of schizophrenia...
- Heterogeneity of violence in schizophrenia and implications for long-term treatment
J Volavka
Department of Psychiatry, New York University School of Medicine, New York, NY, USA
Int J Clin Pract 62:1237-45. 2008
..The aim of this review is to address the subtyping of violent behaviour in schizophrenia, and to relate the subtypes to treatment...
- Treatments for bipolar disorder: can number needed to treat/harm help inform clinical decisions?
T A Ketter
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
Acta Psychiatr Scand 123:175-89. 2011
..To compare bipolar treatment interventions, using number needed to treat (NNT) and number needed to harm (NNH)...
- Paliperidone: quo vadis?
L Citrome
Department of Psychiatry, New York University School of Medicine, and the Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Int J Clin Pract 61:653-62. 2007
..With the impending availability of oral risperidone as a generic medication, cost of oral paliperidone will likely become a significant obstacle to its use...
- Violent patients in the emergency setting
L Citrome
Department of Psychiatry, New York University, New York, USA
Psychiatr Clin North Am 22:789-801. 1999
..The use of typical neuroleptics may lead to side effects, such as akathisia, which may in turn precipitate additional agitation. This may be obviated with the introduction of IM preparations of atypical antipsychotics...
- Asenapine for schizophrenia and bipolar disorder: a review of the efficacy and safety profile for this newly approved sublingually absorbed second-generation antipsychotic
L Citrome
Department of Psychiatry, New York University School of Medicine, New York, NY, USA
Int J Clin Pract 63:1762-84. 2009
..To describe the efficacy and safety of asenapine for the treatment of schizophrenia and bipolar disorder...
- Interpreting and applying the EUFEST results using number needed to treat: antipsychotic effectiveness in first-episode schizophrenia
L Citrome
New York University School of Medicine, Department of Psychiatry, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA
Int J Clin Pract 62:837-40. 2008
- Olanzapine pamoate: a stick in time? A review of the efficacy and safety profile of a new depot formulation of a second-generation antipsychotic
L Citrome
New York University School of Medicine, Department of Psychiatry, NY, USA
Int J Clin Pract 63:140-50. 2009
..07% of injections, requiring patients to be observed for 3 h after injection. At present, there are no studies available that directly compare olanzapine pamoate with other antipsychotics other than oral olanzapine...
- Paliperidone palmitate - review of the efficacy, safety and cost of a new second-generation depot antipsychotic medication
L Citrome
Department of Psychiatry, New York University School of Medicine, New York, NY, USA
Int J Clin Pract 64:216-39. 2010
..To describe the efficacy, safety and cost of paliperidone palmitate, a depot antipsychotic medication recently approved for the treatment of schizophrenia...
- When does a difference make a difference? Interpretation of number needed to treat, number needed to harm, and likelihood to be helped or harmed
L Citrome
Psychiatry and Behavioral Sciences, New York Medical College, Valhalla, NY, USA
Int J Clin Pract 67:407-11. 2013
..Additional considerations in interpreting NNT are discussed, including the importance of defining acceptable response, adverse outcomes of interest, the effect of time, and the importance of individual baseline characteristics...
- Relative vs. absolute measures of benefit and risk: what's the difference?
L Citrome
Department of Psychiatry, New York University School of Medicine, New York and Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Acta Psychiatr Scand 121:94-102. 2010
..When appraising evidence clinicians are confronted with two types of comparisons: ratios, such as relative risk, and absolute differences, such as number needed to treat (NNT) or number needed to harm (NNH)...
- Schizophrenia, Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and number needed to treat: how can CATIE inform clinicians?
L Citrome
Department of Psychiatry, New York University School of Medicine, New York, NY, USA
Int J Clin Pract 60:933-40. 2006
..NNT and NNH can help place the wide array of CATIE results into clinical context, and permits quantification of the differences observed between the antipsychotics that were tested...
