Richard P Ciavarra

Summary

Publications

  1. ncbi Comparison of the lateral tail vein and the retro-orbital venous sinus as routes of intravenous drug delivery in a transgenic mouse model
    Christina D Steel
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Lab Anim (NY) 37:26-32. 2008
  2. ncbi Impact of the tumor microenvironment on host infiltrating cells and the efficacy of flt3-ligand combination immunotherapy evaluated in a treatment model of mouse prostate cancer
    Richard P Ciavarra
    Department of Microbiology, Eastern Virginia Medical School, Norfolk, VA 23501, USA
    Cancer Immunol Immunother 52:535-45. 2003
  3. ncbi Prostate tumor microenvironment alters immune cells and prevents long-term survival in an orthotopic mouse model following flt3-ligand/CD40-ligand immunotherapy
    Richard P Ciavarra
    Departments of Microbiology and Molecular Cell Biology, Virginia Prostate Center, Eastern Virginia Medical School, Norfolk, Virginia 23501, USA
    J Immunother 27:13-26. 2004
  4. ncbi Orthotopic treatment model of prostate cancer and metastasis in the immunocompetent mouse: efficacy of flt3 ligand immunotherapy
    Kenneth D Somers
    Departments of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Int J Cancer 107:773-80. 2003
  5. ncbi Evaluation of immunological paradigms in a virus model: are dendritic cells critical for antiviral immunity and viral clearance?
    Richard P Ciavarra
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 Olney Road, Norfolk, VA 23501, USA
    J Immunol 177:492-500. 2006
  6. pmc Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS
    Christina D Steel
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23501, USA
    J Neuroimmunol 226:81-92. 2010
  7. pmc Peripheral dendritic cells are essential for both the innate and adaptive antiviral immune responses in the central nervous system
    Christina D Steel
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 W Olney Road, Norfolk, VA 23501, USA
    Virology 387:117-26. 2009
  8. ncbi Impact of macrophage and dendritic cell subset elimination on antiviral immunity, viral clearance and production of type 1 interferon
    Richard P Ciavarra
    Department of Microbiology and Molecular and Cell Biology, Eastern Virginia Medical School, 700 Olney Road, Norfolk, VA 23501, USA
    Virology 342:177-89. 2005

Detail Information

Publications8

  1. ncbi Comparison of the lateral tail vein and the retro-orbital venous sinus as routes of intravenous drug delivery in a transgenic mouse model
    Christina D Steel
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Lab Anim (NY) 37:26-32. 2008
    ..Both routes of injection were similarly effective. A separate experiment using BALB/c mice indicated that retro-orbital venous sinus injection was the less stressful of the two methods...
  2. ncbi Impact of the tumor microenvironment on host infiltrating cells and the efficacy of flt3-ligand combination immunotherapy evaluated in a treatment model of mouse prostate cancer
    Richard P Ciavarra
    Department of Microbiology, Eastern Virginia Medical School, Norfolk, VA 23501, USA
    Cancer Immunol Immunother 52:535-45. 2003
    ..These data also highlight the importance of utilizing treatment versus vaccination models in the evaluation of immunotherapeutic modalities...
  3. ncbi Prostate tumor microenvironment alters immune cells and prevents long-term survival in an orthotopic mouse model following flt3-ligand/CD40-ligand immunotherapy
    Richard P Ciavarra
    Departments of Microbiology and Molecular Cell Biology, Virginia Prostate Center, Eastern Virginia Medical School, Norfolk, Virginia 23501, USA
    J Immunother 27:13-26. 2004
    ..Overall, these data suggest that long-term cures of established MHC-negative tumors may not be achieved until therapeutic interventions are engineered to overcome this immunosuppressive microenvironment...
  4. ncbi Orthotopic treatment model of prostate cancer and metastasis in the immunocompetent mouse: efficacy of flt3 ligand immunotherapy
    Kenneth D Somers
    Departments of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Int J Cancer 107:773-80. 2003
    ..We demonstrate that flt3L treatment suppressed orthotopic prostate tumor growth and lymph node metastasis reinforcing a role for flt3L as an immunotherapeutic strategy for prostate cancer...
  5. ncbi Evaluation of immunological paradigms in a virus model: are dendritic cells critical for antiviral immunity and viral clearance?
    Richard P Ciavarra
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 Olney Road, Norfolk, VA 23501, USA
    J Immunol 177:492-500. 2006
    ..Thus, sufficient redundancy exists in the immune system to sustain efficient viral clearance despite loss of an APC considered essential for induction of a primary antiviral immune response...
  6. pmc Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS
    Christina D Steel
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23501, USA
    J Neuroimmunol 226:81-92. 2010
    ..Thus, two anatomically distinct phagocytic populations regulate VSV encephalitis in a non-redundant fashion although neither population is essential for viral clearance in the CNS...
  7. pmc Peripheral dendritic cells are essential for both the innate and adaptive antiviral immune responses in the central nervous system
    Christina D Steel
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 W Olney Road, Norfolk, VA 23501, USA
    Virology 387:117-26. 2009
    ..Thus, both the inflammatory and certain components of the adaptive primary antiviral immune response in the CNS are dependent on peripheral DCs in vivo...
  8. ncbi Impact of macrophage and dendritic cell subset elimination on antiviral immunity, viral clearance and production of type 1 interferon
    Richard P Ciavarra
    Department of Microbiology and Molecular and Cell Biology, Eastern Virginia Medical School, 700 Olney Road, Norfolk, VA 23501, USA
    Virology 342:177-89. 2005
    ..Thus, distinct m Phi subsets are critical for chemokine production and viral clearance, and, in their absence, VSV disseminates even in the presence of high titers of interferon...